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Protein
Submitted name:

Rho GTPase-activating protein 42

Gene

Arhgap42

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • GTPase activator activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGTPase activationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Submitted name:
Rho GTPase-activating protein 42Imported
Gene namesi
Name:Arhgap42Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1564081 Arhgap42

PTM / Processingi

Proteomic databases

PaxDbiF1M2Q1
PeptideAtlasiF1M2Q1
PRIDEiF1M2Q1

Expressioni

Gene expression databases

BgeeiENSRNOG00000026821 Expressed in 9 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037659

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini216 – 325PHInterPro annotationAdd BLAST110
Domaini327 – 523Rho-GAPInterPro annotationAdd BLAST197
Domaini768 – 826SH3InterPro annotationAdd BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili38 – 58Sequence analysisAdd BLAST21
Coiled coili176 – 210Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1451 Eukaryota
ENOG410YJPS LUCA
GeneTreeiENSGT00930000150818
InParanoidiF1M2Q1
OMAiMFLNEAG
OrthoDBiEOG091G01TT
TreeFamiTF316851

Family and domain databases

Gene3Di1.10.555.10, 1 hit
1.20.1270.60, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00620 RhoGAP, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

F1M2Q1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDLSMAVQK FSQSLQDFQF ECIGDAETDD EISIAQSLKE FARLLIAVEE
60 70 80 90 100
ERRRLIQNAN DVLIAPLEKF RKEQIGAAKD GKKKFDKESE KYYSILDKHL
110 120 130 140 150
NLSAKKKESH LQEADSQIGR EHQNFYEASL EYVFKIQEVQ EKKKFEFVEP
160 170 180 190 200
LLSFLQGLFT FYHEGYELAQ EFAPYKQQLQ FNLQNTRNNF ESTRQEVERL
210 220 230 240 250
MQRMKAANQD YRPPSQWTME GYLYVQEKRP LGFTWTKHYC TYDKGSKMFT
260 270 280 290 300
MSVSDVKASG KMNGLVTGSP EMFKLKSCIR RKTDSIDKRF CFDIEVVERH
310 320 330 340 350
GIITLQAFSE ANRKLWLEAM DGKEPIYTLP AIISKKEEMY LNEAGFNFVR
360 370 380 390 400
KCIQAVETRG INILGLYRIG GVNSKVQKLM NTTFSPKSPP DMDIDIELWD
410 420 430 440 450
NKTITSGLKN YLRCLAEPLM TYKLHKDFII AVKSDDQNYR VEAVHALVHK
460 470 480 490 500
LPEKNREMLD ILIKHLLKVS LHSQQNLMTI SNLGVIFGPT LMRAQEETVA
510 520 530 540 550
AMMNIKFQNI VVEILIEHYE KIFHTAPDPN IPLPQPQSRS GSRRTRAICL
560 570 580 590 600
STGSRKPRGR YTPCLAEPDS DSYSSSPDST PMGSIESLSS HSSEQNSTTK
610 620 630 640 650
STSCQPREKS GGIPWIAAPS SSNGQKSLGL WTTSPESSSR EDATKTDVES
660 670 680 690 700
DCQSVASVTS PGDVSPPIDL VKKGPYGLSG LKRSSASSSL RSISAAEGNK
710 720 730 740 750
SYSGSIQSLT SIGSKESPKA TPNPELPPKM CRRLRLDTAS SNGYQRPGSV
760 770 780 790 800
VAAKAQLFEN AGSLKPVSSG RQAKAMYSCK AEHSHELSFP QGAIFSNVHP
810 820
SVEPGWLKAT YEGRTGLVPE NYVVFL
Length:826
Mass (Da):92,896
Last modified:July 22, 2015 - v3
Checksum:i4C9A322541CB555C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069070 Genomic DNA No translation available.
RefSeqiXP_006226363.1, XM_006226301.2
XP_006242577.1, XM_006242515.2

Genome annotation databases

EnsembliENSRNOT00000031492; ENSRNOP00000037659; ENSRNOG00000026821
GeneIDi500943

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069070 Genomic DNA No translation available.
RefSeqiXP_006226363.1, XM_006226301.2
XP_006242577.1, XM_006242515.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037659

Proteomic databases

PaxDbiF1M2Q1
PeptideAtlasiF1M2Q1
PRIDEiF1M2Q1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000031492; ENSRNOP00000037659; ENSRNOG00000026821
GeneIDi500943

Organism-specific databases

CTDi143872
RGDi1564081 Arhgap42

Phylogenomic databases

eggNOGiKOG1451 Eukaryota
ENOG410YJPS LUCA
GeneTreeiENSGT00930000150818
InParanoidiF1M2Q1
OMAiMFLNEAG
OrthoDBiEOG091G01TT
TreeFamiTF316851

Enzyme and pathway databases

ReactomeiR-RNO-194840 Rho GTPase cycle

Gene expression databases

BgeeiENSRNOG00000026821 Expressed in 9 organ(s), highest expression level in liver

Family and domain databases

Gene3Di1.10.555.10, 1 hit
1.20.1270.60, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00620 RhoGAP, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1M2Q1_RAT
AccessioniPrimary (citable) accession number: F1M2Q1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: November 7, 2018
This is version 68 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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