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UniProtKB - F1M2B7 (F1M2B7_RAT)
Protein
Submitted name:
GLI family zinc finger 2
Gene
Gli2
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- promoter-specific chromatin binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
- transcription cis-regulatory region binding Source: RGD
- zinc ion binding Source: RGD
GO - Biological processi
- anatomical structure development Source: RGD
- anatomical structure formation involved in morphogenesis Source: RGD
- anterior/posterior pattern specification Source: RGD
- axon guidance Source: RGD
- branching morphogenesis of an epithelial tube Source: RGD
- cell differentiation Source: RGD
- cellular response to organic cyclic compound Source: RGD
- cerebellar cortex morphogenesis Source: RGD
- chondrocyte differentiation Source: RGD
- cochlea morphogenesis Source: RGD
- developmental growth Source: RGD
- dorsal/ventral neural tube patterning Source: RGD
- dorsal/ventral pattern formation Source: RGD
- embryonic digestive tract development Source: RGD
- embryonic digit morphogenesis Source: RGD
- floor plate formation Source: RGD
- hair follicle morphogenesis Source: RGD
- head development Source: RGD
- heart development Source: RGD
- hindbrain development Source: RGD
- hindgut morphogenesis Source: RGD
- in utero embryonic development Source: RGD
- kidney development Source: RGD
- lung development Source: RGD
- mammary gland development Source: RGD
- mammary gland duct morphogenesis Source: RGD
- morphogenesis of an epithelium Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of chondrocyte differentiation Source: RGD
- negative regulation of smoothened signaling pathway Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- neural tube development Source: RGD
- neuron development Source: RGD
- notochord regression Source: RGD
- odontogenesis of dentin-containing tooth Source: RGD
- osteoblast development Source: RGD
- osteoblast differentiation Source: RGD
- pattern specification process Source: RGD
- pituitary gland development Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of DNA replication Source: RGD
- positive regulation of neuron differentiation Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- prostate gland development Source: RGD
- prostatic bud formation Source: RGD
- proximal/distal pattern formation Source: RGD
- regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to mechanical stimulus Source: RGD
- skeletal system development Source: RGD
- smoothened signaling pathway Source: RGD
- smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: RGD
- smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: RGD
- smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Source: RGD
- smoothened signaling pathway involved in ventral spinal cord interneuron specification Source: RGD
- spinal cord dorsal/ventral patterning Source: RGD
- spinal cord motor neuron differentiation Source: RGD
- spinal cord ventral commissure morphogenesis Source: RGD
- tube development Source: RGD
- ventral midline development Source: RGD
- ventral spinal cord development Source: RGD
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingARBA annotation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-5610787, Hedgehog 'off' state R-RNO-5632684, Hedgehog 'on' state |
Names & Taxonomyi
Protein namesi | Submitted name: GLI family zinc finger 2Imported |
Gene namesi | Name:Gli2Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1309270, Gli2 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytoskeleton
- axoneme Source: RGD
Nucleus
- nuclear speck Source: RGD
- nucleus Source: RGD
Other locations
- ciliary tip Source: RGD
- cilium Source: RGD
- cytoplasm Source: RGD
- membrane Source: RGD
- motile cilium Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000007261, Expressed in skeletal muscle tissue and 20 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 457 – 484 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 485 – 514 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 515 – 545 | C2H2-typeInterPro annotationAdd BLAST | 31 | |
Domaini | 546 – 576 | C2H2-typeInterPro annotationAdd BLAST | 31 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 29 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 559 – 621 | DisorderedSequence analysisAdd BLAST | 63 | |
Regioni | 637 – 701 | DisorderedSequence analysisAdd BLAST | 65 | |
Regioni | 807 – 863 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 937 – 963 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 1067 – 1088 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1172 – 1211 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 1336 – 1357 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1372 – 1404 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 1423 – 1457 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 559 – 593 | Basic and acidic residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 637 – 665 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 807 – 821 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 835 – 863 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1388 – 1404 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1439 – 1457 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the GLI C2H2-type zinc-finger protein family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155925 |
HOGENOMi | CLU_003666_2_0_1 |
OMAi | GAQDHSM |
OrthoDBi | 56870at2759 |
TreeFami | TF350216 |
Family and domain databases
InterProi | View protein in InterPro IPR043359, GLI-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR45718, PTHR45718, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
F1M2B7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METSAQAPAL EKKEAKSGLL EDSSFPDPGK KACPLAVAAP AAAVAAQGVP
60 70 80 90 100
QQLLPSFHVP LPIDMRHQEG RYHYDPHPVH GVHGPPTLSG SPVISDISLI
110 120 130 140 150
RLSPHPAGPG ESPFSAHHPY MNPHMEHYLR SVHSSPTLSM ISAARGLSPA
160 170 180 190 200
DVAHEHLKER GLFSLAAPGT NPSDYYHQMT LMASHPTPYG DILMQSGGAA
210 220 230 240 250
SAPHLHDYLN PVDASRFSSP RVTPRLSRKR ALSISPLSDA SLDLQRMIRT
260 270 280 290 300
SPNSLVAYIN NSRSSSAASG SYGHLSAGAL SPAFTFPHPI NPVAYQQILS
310 320 330 340 350
QQRGLGSAFG HTPPLIQPSP TFLAQQPMTL TSITVPTQLG SNSSNCISDA
360 370 380 390 400
NQNKQNSESA VSSTVNPITI HKRSKVKTEA EGLRPASPLG LTQEQLADLK
410 420 430 440 450
EDLDRDDCKQ EAEVVIYETN CHWADCTKEY DTQEQLVHHI NNEHIHGEKK
460 470 480 490 500
EFVCRWQACT REQKPFKAQY MLVVHMRRHT GEKPHKCTFE GCSKAYSRLE
510 520 530 540 550
NLKTHLRSHT GEKPYVCEHE GCNKAFSNAS DRAKHQNRTH SNEKPYICKI
560 570 580 590 600
PGCTKRYTDP SSLRKHVKTV HGPDAHVTKK QRNDVHLRAP LLKENGDNEA
610 620 630 640 650
GAEPGGRGPE ESVEASSTSH TAEDCLHIKA IKTESSGLCQ SSPGAQSSCS
660 670 680 690 700
SEPSPLGSVP NNDSGVEMPG TGPGSLGDLT ALDDTSPGAD TSALAVPSTG
710 720 730 740 750
GLQLRKHMTT MHRFEQLKRE KLKSLKDSCS WAGPAPHTRN TKLPPLPVNG
760 770 780 790 800
SVLENFNNTG GCGPAGLLPN QRLPELTEVT MLSQLQERRD SSTSTMSSAY
810 820 830 840 850
TVSRRSSGIS PYFSSRRSSE ASPLGGIRPH NASSADSYDP ISTDASRRSS
860 870 880 890 900
EASQCSGGGP GLLNLTPAQQ YSLRAKYAAA TGGPPPTPLP GLDRVSLRTR
910 920 930 940 950
LALLDAPERA LPGACPQPLG PRRGSDGPTY NHGHGYVGAA PALPHEGPNG
960 970 980 990 1000
STRRASDPVR RPDPLVLPRV QRFHSIHNMN PGPLPPCTDR RGLHLQSHPS
1010 1020 1030 1040 1050
VDGSLTRHAY SPRPPSINEN VVMEAVAAGV EGAGLESDLG LVEDDLVLPD
1060 1070 1080 1090 1100
DVVQYIKAHT GGALDDSTRQ VYPTEGTGFP ENSKLPSPGL QGHRRLAAAD
1110 1120 1130 1140 1150
SNMSPSAPGL GGCQLSYSPS SSLNKSNMPV QWNEVSSGTV DALPTQVKPP
1160 1170 1180 1190 1200
SFPQSNLVQQ KPAFAHYPGY SPQALQSGSG GLDSTQPHLQ LRGAPSASRG
1210 1220 1230 1240 1250
SYTQQPRLPA TGSQCLGVTA AMSPQANYSQ THHQLSPNVV SGSLNQFAPS
1260 1270 1280 1290 1300
CSNMAAKPSH LGLPQQMEVV PNATIISGHQ RELGIASSSL AAVSQPHPVL
1310 1320 1330 1340 1350
GYPQQDGYQQ VSGLPSSHQP SFMESQQNTG FGLMQPRPPL EPNTASRHRG
1360 1370 1380 1390 1400
VRSGQQQQQL YARTAGQAVV TSANQETAEA MPKGTAGTVV SLTPQPSQDT
1410 1420 1430 1440 1450
GRSQDQNTLY YYGQIHMYEQ NGGCPAMQPQ PPQPQGCSDN IQPEPLPSPG
1460 1470 1480 1490 1500
VNQVSSTVDS QLLEPPQIDF DAIMDDGDHS SLFSGALSPS LLHNLSQNSS
1510 1520 1530 1540
RLTTPRNSLT LPSIPVGISN MAVGDMSSML TSLAEENKFL NMMT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07020674 Genomic DNA No translation available. AABR07020675 Genomic DNA No translation available. AABR07020676 Genomic DNA No translation available. AABR07020677 Genomic DNA No translation available. |
RefSeqi | XP_008767677.1, XM_008769455.2 XP_017454273.1, XM_017598784.1 |
Genome annotation databases
Ensembli | ENSRNOT00000009963; ENSRNOP00000009963; ENSRNOG00000007261 |
GeneIDi | 304729 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07020674 Genomic DNA No translation available. AABR07020675 Genomic DNA No translation available. AABR07020676 Genomic DNA No translation available. AABR07020677 Genomic DNA No translation available. |
RefSeqi | XP_008767677.1, XM_008769455.2 XP_017454273.1, XM_017598784.1 |
3D structure databases
SMRi | F1M2B7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000009963 |
Proteomic databases
PaxDbi | F1M2B7 |
Genome annotation databases
Ensembli | ENSRNOT00000009963; ENSRNOP00000009963; ENSRNOG00000007261 |
GeneIDi | 304729 |
Organism-specific databases
CTDi | 2736 |
RGDi | 1309270, Gli2 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155925 |
HOGENOMi | CLU_003666_2_0_1 |
OMAi | GAQDHSM |
OrthoDBi | 56870at2759 |
TreeFami | TF350216 |
Enzyme and pathway databases
Reactomei | R-RNO-5610787, Hedgehog 'off' state R-RNO-5632684, Hedgehog 'on' state |
Gene expression databases
Bgeei | ENSRNOG00000007261, Expressed in skeletal muscle tissue and 20 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR043359, GLI-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR45718, PTHR45718, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | F1M2B7_RAT | |
Accessioni | F1M2B7Primary (citable) accession number: F1M2B7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | July 22, 2015 | |
Last modified: | January 19, 2022 | |
This is version 84 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |