GLI family zinc finger 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: RGDInferred from sequence orthologyⁱ
  • "GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis."
    Hu M.C., Mo R., Bhella S., Wilson C.W., Chuang P.T., Hui C.C., Rosenblum N.D.
    Development 133:569-578(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling."
    Zhao M., Qiao M., Harris S.E., Chen D., Oyajobi B.O., Mundy G.R.
    Mol. Cell. Biol. 26:6197-6208(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2."
    Roessler E., Ermilov A.N., Grange D.K., Wang A., Grachtchouk M., Dlugosz A.A., Muenke M.
    Hum. Mol. Genet. 14:2181-2188(2005) [PubMed] [Europe PMC] [Abstract]
  • "The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling."
    Zhao M., Qiao M., Harris S.E., Chen D., Oyajobi B.O., Mundy G.R.
    Mol. Cell. Biol. 26:6197-6208(2006) [PubMed] [Europe PMC] [Abstract]
  • "Cloning of novel isoforms of the human Gli2 oncogene and their activities to enhance tax-dependent transcription of the human T-cell leukemia virus type 1 genome."
    Tanimura A., Dan S., Yoshida M.
    J. Virol. 72:3958-3964(1998) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• promoter-specific chromatin binding Source: RGDInferred from sequence orthologyⁱ
  • "The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification."
    Yoshida M., Hata K., Takashima R., Ono K., Nakamura E., Takahata Y., Murakami T., Iseki S., Takano-Yamamoto T., Nishimura R., Yoneda T.
    Nat. Commun. 6:6653-6653(2015) [PubMed] [Europe PMC] [Abstract]
  • "FOXC1 activates smoothened-independent Hedgehog signaling in basal-like breast cancer."
    Han B., Qu Y., Jin Y., Yu Y., Deng N., Wawrowsky K., Zhang X., Li N., Bose S., Wang Q., Sakkiah S., Abrol R., Jensen T.W., Berman B.P., Tanaka H., Johnson J., Gao B., Hao J.

    , Liu Z., Buttyan R., Ray P.S., Hung M.C., Giuliano A.E., Cui X.
    Cell Rep. 13:1046-1058(2015) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain."
    Saitsu H., Komada M., Suzuki M., Nakayama R., Motoyama J., Shiota K., Ishibashi M.
    Dev. Dyn. 232:282-292(2005) [PubMed] [Europe PMC] [Abstract]
  • "The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling."
    Zhao M., Qiao M., Harris S.E., Chen D., Oyajobi B.O., Mundy G.R.
    Mol. Cell. Biol. 26:6197-6208(2006) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter."
    Ikram M.S., Neill G.W., Regl G., Eichberger T., Frischauf A.M., Aberger F., Quinn A., Philpott M.
    J. Invest. Dermatol. 122:1503-1509(2004) [PubMed] [Europe PMC] [Abstract]
  • "Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation."
    Pan Y., Bai C.B., Joyner A.L., Wang B.
    Mol. Cell. Biol. 26:3365-3377(2006) [PubMed] [Europe PMC] [Abstract]
  • "FOXC1 activates smoothened-independent Hedgehog signaling in basal-like breast cancer."
    Han B., Qu Y., Jin Y., Yu Y., Deng N., Wawrowsky K., Zhang X., Li N., Bose S., Wang Q., Sakkiah S., Abrol R., Jensen T.W., Berman B.P., Tanaka H., Johnson J., Gao B., Hao J.

    , Liu Z., Buttyan R., Ray P.S., Hung M.C., Giuliano A.E., Cui X.
    Cell Rep. 13:1046-1058(2015) [PubMed] [Europe PMC] [Abstract]
  • "Cloning of novel isoforms of the human Gli2 oncogene and their activities to enhance tax-dependent transcription of the human T-cell leukemia virus type 1 genome."
    Tanimura A., Dan S., Yoshida M.
    J. Virol. 72:3958-3964(1998) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification."
    Yoshida M., Hata K., Takashima R., Ono K., Nakamura E., Takahata Y., Murakami T., Iseki S., Takano-Yamamoto T., Nishimura R., Yoneda T.
    Nat. Commun. 6:6653-6653(2015) [PubMed] [Europe PMC] [Abstract]
  • "FOXC1 activates smoothened-independent Hedgehog signaling in basal-like breast cancer."
    Han B., Qu Y., Jin Y., Yu Y., Deng N., Wawrowsky K., Zhang X., Li N., Bose S., Wang Q., Sakkiah S., Abrol R., Jensen T.W., Berman B.P., Tanaka H., Johnson J., Gao B., Hao J.

    , Liu Z., Buttyan R., Ray P.S., Hung M.C., Giuliano A.E., Cui X.
    Cell Rep. 13:1046-1058(2015) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity."
    Wall D.S., Mears A.J., McNeill B., Mazerolle C., Thurig S., Wang Y., Kageyama R., Wallace V.A.
    J. Cell Biol. 184:101-112(2009) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: RGDInferred from sequence orthologyⁱ
  • "Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers."
    Pavletich N.P., Pabo C.O.
    Science 261:1701-1707(1993) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• anatomical structure development Source: RGDInferred from sequence orthologyⁱ
  • "Anorectal malformations caused by defects in sonic hedgehog signaling."
    Mo R., Kim J.H., Zhang J., Chiang C., Hui C.C., Kim P.C.
    Am. J. Pathol. 159:765-774(2001) [PubMed] [Europe PMC] [Abstract]
• anatomical structure formation involved in morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus."
    Motoyama J., Liu J., Mo R., Ding Q., Post M., Hui C.C.
    Nat. Genet. 20:54-57(1998) [PubMed] [Europe PMC] [Abstract]
• anterior/posterior pattern specification Source: RGDInferred from sequence orthologyⁱ
  • "Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3."
    Bowers M., Eng L., Lao Z., Turnbull R.K., Bao X., Riedel E., Mackem S., Joyner A.L.
    Dev. Biol. 370:110-124(2012) [PubMed] [Europe PMC] [Abstract]
• axon guidance Source: RGDInferred from sequence orthologyⁱ
  • "Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord."
    Matise M.P., Lustig M., Sakurai T., Grumet M., Joyner A.L.
    Development 126:3649-3659(1999) [PubMed] [Europe PMC] [Abstract]
• branching morphogenesis of an epithelial tube Source: RGDInferred from sequence orthologyⁱ
  • "Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus."
    Motoyama J., Liu J., Mo R., Ding Q., Post M., Hui C.C.
    Nat. Genet. 20:54-57(1998) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice."
    Ding Q., Motoyama J., Gasca S., Mo R., Sasaki H., Rossant J., Hui C.C.
    Development 125:2533-2543(1998) [PubMed] [Europe PMC] [Abstract]
  • "Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system."
    Matise M.P., Epstein D.J., Park H.L., Platt K.A., Joyner A.L.
    Development 125:2759-2770(1998) [PubMed] [Europe PMC] [Abstract]
• cellular response to organic cyclic compound Source: RGDInferred from sequence orthologyⁱ
  • "Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2."
    Zhao M., Ko S.Y., Liu J.H., Chen D., Zhang J., Wang B., Harris S.E., Oyajobi B.O., Mundy G.R.
    Mol. Cell. Biol. 29:1291-1305(2009) [PubMed] [Europe PMC] [Abstract]
• cellular response to virus Source: RGDInferred from sequence orthologyⁱ
  • "Cloning of novel isoforms of the human Gli2 oncogene and their activities to enhance tax-dependent transcription of the human T-cell leukemia virus type 1 genome."
    Tanimura A., Dan S., Yoshida M.
    J. Virol. 72:3958-3964(1998) [PubMed] [Europe PMC] [Abstract]
• cerebellar cortex morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation."
    Corrales J.D., Blaess S., Mahoney E.M., Joyner A.L.
    Development 133:1811-1821(2006) [PubMed] [Europe PMC] [Abstract]
• chondrocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways."
    Wang C., Yuan X., Yang S.
    Exp. Cell Res. 319:623-632(2013) [PubMed] [Europe PMC] [Abstract]
• cochlea morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear."
    Bok J., Dolson D.K., Hill P., Ruther U., Epstein D.J., Wu D.K.
    Development 134:1713-1722(2007) [PubMed] [Europe PMC] [Abstract]
• developmental growth Source: RGDInferred from sequence orthologyⁱ
  • "Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region."
    Blaess S., Corrales J.D., Joyner A.L.
    Development 133:1799-1809(2006) [PubMed] [Europe PMC] [Abstract]
• dorsal/ventral neural tube patterning Source: RGDInferred from sequence orthologyⁱ
  • "FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism."
    Cho A., Ko H.W., Eggenschwiler J.T.
    Dev. Biol. 321:27-39(2008) [PubMed] [Europe PMC] [Abstract]
  • "Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling."
    Norman R.X., Ko H.W., Huang V., Eun C.M., Abler L.L., Zhang Z., Sun X., Eggenschwiler J.T.
    Hum. Mol. Genet. 18:1740-1754(2009) [PubMed] [Europe PMC] [Abstract]
  • "Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1."
    Hynes M., Stone D.M., Dowd M., Pitts-Meek S., Goddard A., Gurney A., Rosenthal A.
    Neuron 19:15-26(1997) [PubMed] [Europe PMC] [Abstract]
• dorsal/ventral pattern formation Source: RGDInferred from sequence orthologyⁱ
  • "Complementary Gli activity mediates early patterning of the mouse visual system."
    Furimsky M., Wallace V.A.
    Dev. Dyn. 235:594-605(2006) [PubMed] [Europe PMC] [Abstract]
• embryonic digestive tract development Source: RGDInferred from sequence orthologyⁱ
  • "New mouse models of congenital anorectal malformations."
    Kimmel S.G., Mo R., Hui C.C., Kim P.C.
    J. Pediatr. Surg. 35:227-230(2000) [PubMed] [Europe PMC] [Abstract]
• embryonic digit morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development."
    Pan Y., Wang C., Wang B.
    Dev. Biol. 326:177-189(2009) [PubMed] [Europe PMC] [Abstract]
• epidermal cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma."
    Regl G., Neill G.W., Eichberger T., Kasper M., Ikram M.S., Koller J., Hintner H., Quinn A.G., Frischauf A.M., Aberger F.
    Oncogene 21:5529-5539(2002) [PubMed] [Europe PMC] [Abstract]
• floor plate formation Source: RGDInferred from sequence orthologyⁱ
  • "Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice."
    Ding Q., Motoyama J., Gasca S., Mo R., Sasaki H., Rossant J., Hui C.C.
    Development 125:2533-2543(1998) [PubMed] [Europe PMC] [Abstract]
  • "Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system."
    Matise M.P., Epstein D.J., Park H.L., Platt K.A., Joyner A.L.
    Development 125:2759-2770(1998) [PubMed] [Europe PMC] [Abstract]
• hair follicle morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2."
    Roessler E., Ermilov A.N., Grange D.K., Wang A., Grachtchouk M., Dlugosz A.A., Muenke M.
    Hum. Mol. Genet. 14:2181-2188(2005) [PubMed] [Europe PMC] [Abstract]
• head development Source: RGDInferred from sequence orthologyⁱ
  • "Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development."
    Pan Y., Wang C., Wang B.
    Dev. Biol. 326:177-189(2009) [PubMed] [Europe PMC] [Abstract]
• heart development Source: RGDInferred from sequence orthologyⁱ
  • "Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway."
    Kim P.C., Mo R., Hui Cc C.
    J. Pediatr. Surg. 36:381-384(2001) [PubMed] [Europe PMC] [Abstract]
• hindbrain development Source: RGDInferred from sequence orthologyⁱ
  • "Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development."
    Corrales J.D., Rocco G.L., Blaess S., Guo Q., Joyner A.L.
    Development 131:5581-5590(2004) [PubMed] [Europe PMC] [Abstract]
  • "A role for En-2 and other murine homologues of Drosophila segment polarity genes in regulating positional information in the developing cerebellum."
    Millen K.J., Hui C.C., Joyner A.L.
    Development 121:3935-3945(1995) [PubMed] [Europe PMC] [Abstract]
• hindgut morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Anorectal malformations caused by defects in sonic hedgehog signaling."
    Mo R., Kim J.H., Zhang J., Chiang C., Hui C.C., Kim P.C.
    Am. J. Pathol. 159:765-774(2001) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: RGDInferred from sequence orthologyⁱ
  • "Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development."
    Pan Y., Wang C., Wang B.
    Dev. Biol. 326:177-189(2009) [PubMed] [Europe PMC] [Abstract]
• kidney development Source: RGDInferred from sequence orthologyⁱ
  • "Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway."
    Kim P.C., Mo R., Hui Cc C.
    J. Pediatr. Surg. 36:381-384(2001) [PubMed] [Europe PMC] [Abstract]
• lung development Source: RGDInferred from sequence orthologyⁱ
  • "Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation."
    Park H.L., Bai C., Platt K.A., Matise M.P., Beeghly A., Hui C.C., Nakashima M., Joyner A.L.
    Development 127:1593-1605(2000) [PubMed] [Europe PMC] [Abstract]
  • "Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus."
    Motoyama J., Liu J., Mo R., Ding Q., Post M., Hui C.C.
    Nat. Genet. 20:54-57(1998) [PubMed] [Europe PMC] [Abstract]
• mammary gland development Source: RGDInferred from sequence orthologyⁱ
  • "The Gli2 transcription factor is required for normal mouse mammary gland development."
    Lewis M.T., Ross S., Strickland P.A., Sugnet C.W., Jimenez E., Hui C., Daniel C.W.
    Dev. Biol. 238:133-144(2001) [PubMed] [Europe PMC] [Abstract]
• mammary gland duct morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "The Gli2 transcription factor is required for normal mouse mammary gland development."
    Lewis M.T., Ross S., Strickland P.A., Sugnet C.W., Jimenez E., Hui C., Daniel C.W.
    Dev. Biol. 238:133-144(2001) [PubMed] [Europe PMC] [Abstract]
• morphogenesis of an epithelium Source: RGDInferred from sequence orthologyⁱ
  • "Functional compensation in Hedgehog signaling during mouse prostate development."
    Doles J., Cook C., Shi X., Valosky J., Lipinski R., Bushman W.
    Dev. Biol. 295:13-25(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: RGDInferred from sequence orthologyⁱ
  • "Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development."
    Pan Y., Wang C., Wang B.
    Dev. Biol. 326:177-189(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of chondrocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms."
    Mau E., Whetstone H., Yu C., Hopyan S., Wunder J.S., Alman B.A.
    Dev. Biol. 305:28-39(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2."
    Roessler E., Ermilov A.N., Grange D.K., Wang A., Grachtchouk M., Dlugosz A.A., Muenke M.
    Hum. Mol. Genet. 14:2181-2188(2005) [PubMed] [Europe PMC] [Abstract]
  • "Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation."
    Pan Y., Bai C.B., Joyner A.L., Wang B.
    Mol. Cell. Biol. 26:3365-3377(2006) [PubMed] [Europe PMC] [Abstract]
• neural tube development Source: RGDInferred from sequence orthologyⁱ
  • "Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development."
    Pan Y., Wang C., Wang B.
    Dev. Biol. 326:177-189(2009) [PubMed] [Europe PMC] [Abstract]
• neuron development Source: RGDInferred from sequence orthologyⁱ
  • "Molecular control of spinal accessory motor neuron/axon development in the mouse spinal cord."
    Dillon A.K., Fujita S.C., Matise M.P., Jarjour A.A., Kennedy T.E., Kollmus H., Arnold H.H., Weiner J.A., Sanes J.R., Kaprielian Z.
    J. Neurosci. 25:10119-10130(2005) [PubMed] [Europe PMC] [Abstract]
• notochord regression Source: RGDInferred from sequence orthologyⁱ
  • "Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation."
    Park H.L., Bai C., Platt K.A., Matise M.P., Beeghly A., Hui C.C., Nakashima M., Joyner A.L.
    Development 127:1593-1605(2000) [PubMed] [Europe PMC] [Abstract]
• odontogenesis of dentin-containing tooth Source: RGDInferred from sequence orthologyⁱ
  • "The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants."
    Hardcastle Z., Mo R., Hui C.C., Sharpe P.T.
    Development 125:2803-2811(1998) [PubMed] [Europe PMC] [Abstract]
• osteoblast development Source: RGDInferred from sequence orthologyⁱ
  • "The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling."
    Zhao M., Qiao M., Harris S.E., Chen D., Oyajobi B.O., Mundy G.R.
    Mol. Cell. Biol. 26:6197-6208(2006) [PubMed] [Europe PMC] [Abstract]
• osteoblast differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma."
    Regl G., Neill G.W., Eichberger T., Kasper M., Ikram M.S., Koller J., Hintner H., Quinn A.G., Frischauf A.M., Aberger F.
    Oncogene 21:5529-5539(2002) [PubMed] [Europe PMC] [Abstract]
  • "The intraflagellar transport protein IFT80 is required for cilia formation and osteogenesis."
    Yang S., Wang C.
    Bone 51:407-417(2012) [PubMed] [Europe PMC] [Abstract]
• pattern specification process Source: RGDInferred from sequence orthologyⁱ
  • "Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction."
    Buttitta L., Mo R., Hui C.C., Fan C.M.
    Development 130:6233-6243(2003) [PubMed] [Europe PMC] [Abstract]
  • "A role for En-2 and other murine homologues of Drosophila segment polarity genes in regulating positional information in the developing cerebellum."
    Millen K.J., Hui C.C., Joyner A.L.
    Development 121:3935-3945(1995) [PubMed] [Europe PMC] [Abstract]
• pituitary gland development Source: RGDInferred from sequence orthologyⁱ
  • "Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation."
    Park H.L., Bai C., Platt K.A., Matise M.P., Beeghly A., Hui C.C., Nakashima M., Joyner A.L.
    Development 127:1593-1605(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: RGDInferred from sequence orthologyⁱ
  • "Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development."
    Corrales J.D., Rocco G.L., Blaess S., Guo Q., Joyner A.L.
    Development 131:5581-5590(2004) [PubMed] [Europe PMC] [Abstract]
  • "Shh controls epithelial proliferation via independent pathways that converge on N-Myc."
    Mill P., Mo R., Hu M.C., Dagnino L., Rosenblum N.D., Hui C.C.
    Dev. Cell 9:293-303(2005) [PubMed] [Europe PMC] [Abstract]
  • "Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development."
    Pan Y., Wang C., Wang B.
    Dev. Biol. 326:177-189(2009) [PubMed] [Europe PMC] [Abstract]
  • "Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus."
    Motoyama J., Liu J., Mo R., Ding Q., Post M., Hui C.C.
    Nat. Genet. 20:54-57(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA replication Source: RGDInferred from sequence orthologyⁱ
  • "Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma."
    Regl G., Neill G.W., Eichberger T., Kasper M., Ikram M.S., Koller J., Hintner H., Quinn A.G., Frischauf A.M., Aberger F.
    Oncogene 21:5529-5539(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube."
    Lei Q., Jeong Y., Misra K., Li S., Zelman A.K., Epstein D.J., Matise M.P.
    Dev. Cell 11:325-337(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma."
    Regl G., Neill G.W., Eichberger T., Kasper M., Ikram M.S., Koller J., Hintner H., Quinn A.G., Frischauf A.M., Aberger F.
    Oncogene 21:5529-5539(2002) [PubMed] [Europe PMC] [Abstract]
  • "GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter."
    Ikram M.S., Neill G.W., Regl G., Eichberger T., Frischauf A.M., Aberger F., Quinn A., Philpott M.
    J. Invest. Dermatol. 122:1503-1509(2004) [PubMed] [Europe PMC] [Abstract]
  • "Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain."
    Saitsu H., Komada M., Suzuki M., Nakayama R., Motoyama J., Shiota K., Ishibashi M.
    Dev. Dyn. 232:282-292(2005) [PubMed] [Europe PMC] [Abstract]
  • "Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function."
    Haycraft C.J., Banizs B., Aydin-Son Y., Zhang Q., Michaud E.J., Yoder B.K.
    PLoS Genet. 1:e53-e53(2005) [PubMed] [Europe PMC] [Abstract]
  • "Suppressing Wnt signaling by the hedgehog pathway through sFRP-1."
    He J., Sheng T., Stelter A.A., Li C., Zhang X., Sinha M., Luxon B.A., Xie J.
    J. Biol. Chem. 281:35598-35602(2006) [PubMed] [Europe PMC] [Abstract]
  • "PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms."
    Mau E., Whetstone H., Yu C., Hopyan S., Wunder J.S., Alman B.A.
    Dev. Biol. 305:28-39(2007) [PubMed] [Europe PMC] [Abstract]
  • "FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism."
    Cho A., Ko H.W., Eggenschwiler J.T.
    Dev. Biol. 321:27-39(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma."
    Regl G., Neill G.W., Eichberger T., Kasper M., Ikram M.S., Koller J., Hintner H., Quinn A.G., Frischauf A.M., Aberger F.
    Oncogene 21:5529-5539(2002) [PubMed] [Europe PMC] [Abstract]
  • "A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2."
    Roessler E., Ermilov A.N., Grange D.K., Wang A., Grachtchouk M., Dlugosz A.A., Muenke M.
    Hum. Mol. Genet. 14:2181-2188(2005) [PubMed] [Europe PMC] [Abstract]
  • "A potential role of alternative splicing in the regulation of the transcriptional activity of human GLI2 in gonadal tissues."
    Speek M., Njunkova O., Pata I., Valdre E., Kogerman P.
    BMC Mol. Biol. 7:13-13(2006) [PubMed] [Europe PMC] [Abstract]
  • "Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation."
    Pan Y., Bai C.B., Joyner A.L., Wang B.
    Mol. Cell. Biol. 26:3365-3377(2006) [PubMed] [Europe PMC] [Abstract]
  • "The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling."
    Zhao M., Qiao M., Harris S.E., Chen D., Oyajobi B.O., Mundy G.R.
    Mol. Cell. Biol. 26:6197-6208(2006) [PubMed] [Europe PMC] [Abstract]
  • "Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube."
    Lei Q., Jeong Y., Misra K., Li S., Zelman A.K., Epstein D.J., Matise M.P.
    Dev. Cell 11:325-337(2006) [PubMed] [Europe PMC] [Abstract]
  • "Cloning of novel isoforms of the human Gli2 oncogene and their activities to enhance tax-dependent transcription of the human T-cell leukemia virus type 1 genome."
    Tanimura A., Dan S., Yoshida M.
    J. Virol. 72:3958-3964(1998) [PubMed] [Europe PMC] [Abstract]
• prostate gland development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching."
    Pu Y., Huang L., Prins G.S.
    Dev. Biol. 273:257-275(2004) [PubMed] [Europe PMC] [Abstract]
• prostatic bud formation Source: RGDInferred from sequence orthologyⁱ
  • "Functional compensation in Hedgehog signaling during mouse prostate development."
    Doles J., Cook C., Shi X., Valosky J., Lipinski R., Bushman W.
    Dev. Biol. 295:13-25(2006) [PubMed] [Europe PMC] [Abstract]
• proximal/distal pattern formation Source: RGDInferred from sequence orthologyⁱ
  • "Complementary Gli activity mediates early patterning of the mouse visual system."
    Furimsky M., Wallace V.A.
    Dev. Dyn. 235:594-605(2006) [PubMed] [Europe PMC] [Abstract]
• response to mechanical stimulus Source: RGDInferred from expression patternⁱ
  • "Biomechanical regulation of hedgehog signaling in vascular smooth muscle cells in vitro and in vivo."
    Morrow D., Sweeney C., Birney Y.A., Guha S., Collins N., Cummins P.M., Murphy R., Walls D., Redmond E.M., Cahill P.A.
    Am. J. Physiol., Cell Physiol. 292:C488-96(2007) [PubMed] [Europe PMC] [Abstract]
• skeletal system development Source: RGDInferred from sequence orthologyⁱ
  • "Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development."
    Mo R., Freer A.M., Zinyk D.L., Crackower M.A., Michaud J., Heng H.H., Chik K.W., Shi X.M., Tsui L.C., Cheng S.H., Joyner A.L., Hui C.
    Development 124:113-123(1997) [PubMed] [Europe PMC] [Abstract]
• smoothened signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2."
    Roessler E., Ermilov A.N., Grange D.K., Wang A., Grachtchouk M., Dlugosz A.A., Muenke M.
    Hum. Mol. Genet. 14:2181-2188(2005) [PubMed] [Europe PMC] [Abstract]
  • "Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development."
    Pan Y., Wang C., Wang B.
    Dev. Biol. 326:177-189(2009) [PubMed] [Europe PMC] [Abstract]
  • "Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity."
    Wall D.S., Mears A.J., McNeill B., Mazerolle C., Thurig S., Wang Y., Kageyama R., Wallace V.A.
    J. Cell Biol. 184:101-112(2009) [PubMed] [Europe PMC] [Abstract]
• smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: RGDInferred from sequence orthologyⁱ
  • "Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear."
    Bok J., Dolson D.K., Hill P., Ruther U., Epstein D.J., Wu D.K.
    Development 134:1713-1722(2007) [PubMed] [Europe PMC] [Abstract]
  • "Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction."
    Ko H.W., Norman R.X., Tran J., Fuller K.P., Fukuda M., Eggenschwiler J.T.
    Dev. Cell 18:237-247(2010) [PubMed] [Europe PMC] [Abstract]
• smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation."
    Corrales J.D., Blaess S., Mahoney E.M., Joyner A.L.
    Development 133:1811-1821(2006) [PubMed] [Europe PMC] [Abstract]
• smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Source: RGDInferred from sequence orthologyⁱ
  • "Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord."
    Lei Q., Zelman A.K., Kuang E., Li S., Matise M.P.
    Development 131:3593-3604(2004) [PubMed] [Europe PMC] [Abstract]
• smoothened signaling pathway involved in ventral spinal cord interneuron specification Source: RGDInferred from sequence orthologyⁱ
  • "Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord."
    Lei Q., Zelman A.K., Kuang E., Li S., Matise M.P.
    Development 131:3593-3604(2004) [PubMed] [Europe PMC] [Abstract]
• spinal cord dorsal/ventral patterning Source: RGDInferred from sequence orthologyⁱ
  • "Gli1 can rescue the in vivo function of Gli2."
    Bai C.B., Joyner A.L.
    Development 128:5161-5172(2001) [PubMed] [Europe PMC] [Abstract]
  • "Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord."
    Lei Q., Zelman A.K., Kuang E., Li S., Matise M.P.
    Development 131:3593-3604(2004) [PubMed] [Europe PMC] [Abstract]
  • "Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins."
    Eggenschwiler J.T., Bulgakov O.V., Qin J., Li T., Anderson K.V.
    Dev. Biol. 290:1-12(2006) [PubMed] [Europe PMC] [Abstract]
• spinal cord motor neuron differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Complex interactions between genes controlling trafficking in primary cilia."
    Ocbina P.J., Eggenschwiler J.T., Moskowitz I., Anderson K.V.
    Nat. Genet. 43:547-553(2011) [PubMed] [Europe PMC] [Abstract]
• spinal cord ventral commissure morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord."
    Matise M.P., Lustig M., Sakurai T., Grumet M., Joyner A.L.
    Development 126:3649-3659(1999) [PubMed] [Europe PMC] [Abstract]
• tube development Source: RGDInferred from sequence orthologyⁱ
  • "Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus."
    Motoyama J., Liu J., Mo R., Ding Q., Post M., Hui C.C.
    Nat. Genet. 20:54-57(1998) [PubMed] [Europe PMC] [Abstract]
• ventral midline development Source: RGDInferred from sequence orthologyⁱ
  • "Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation."
    Park H.L., Bai C., Platt K.A., Matise M.P., Beeghly A., Hui C.C., Nakashima M., Joyner A.L.
    Development 127:1593-1605(2000) [PubMed] [Europe PMC] [Abstract]
• ventral spinal cord development Source: RGDInferred from sequence orthologyⁱ
  • "Gli1 can rescue the in vivo function of Gli2."
    Bai C.B., Joyner A.L.
    Development 128:5161-5172(2001) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification."
    Yoshida M., Hata K., Takashima R., Ono K., Nakamura E., Takahata Y., Murakami T., Iseki S., Takano-Yamamoto T., Nishimura R., Yoneda T.
    Nat. Commun. 6:6653-6653(2015) [PubMed] [Europe PMC] [Abstract]
  • "FOXC1 activates smoothened-independent Hedgehog signaling in basal-like breast cancer."
    Han B., Qu Y., Jin Y., Yu Y., Deng N., Wawrowsky K., Zhang X., Li N., Bose S., Wang Q., Sakkiah S., Abrol R., Jensen T.W., Berman B.P., Tanaka H., Johnson J., Gao B., Hao J.

    , Liu Z., Buttyan R., Ray P.S., Hung M.C., Giuliano A.E., Cui X.
    Cell Rep. 13:1046-1058(2015) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
METSAQAPAL EKKEAKSGLL EDSSFPDPGK KACPLAVAAP AAAVAAQGVP 
        60         70         80         90        100
QQLLPSFHVP LPIDMRHQEG RYHYDPHPVH GVHGPPTLSG SPVISDISLI 
       110        120        130        140        150
RLSPHPAGPG ESPFSAHHPY MNPHMEHYLR SVHSSPTLSM ISAARGLSPA 
       160        170        180        190        200
DVAHEHLKER GLFSLAAPGT NPSDYYHQMT LMASHPTPYG DILMQSGGAA 
       210        220        230        240        250
SAPHLHDYLN PVDASRFSSP RVTPRLSRKR ALSISPLSDA SLDLQRMIRT 
       260        270        280        290        300
SPNSLVAYIN NSRSSSAASG SYGHLSAGAL SPAFTFPHPI NPVAYQQILS 
       310        320        330        340        350
QQRGLGSAFG HTPPLIQPSP TFLAQQPMTL TSITVPTQLG SNSSNCISDA 
       360        370        380        390        400
NQNKQNSESA VSSTVNPITI HKRSKVKTEA EGLRPASPLG LTQEQLADLK 
       410        420        430        440        450
EDLDRDDCKQ EAEVVIYETN CHWADCTKEY DTQEQLVHHI NNEHIHGEKK 
       460        470        480        490        500
EFVCRWQACT REQKPFKAQY MLVVHMRRHT GEKPHKCTFE GCSKAYSRLE 
       510        520        530        540        550
NLKTHLRSHT GEKPYVCEHE GCNKAFSNAS DRAKHQNRTH SNEKPYICKI 
       560        570        580        590        600
PGCTKRYTDP SSLRKHVKTV HGPDAHVTKK QRNDVHLRAP LLKENGDNEA 
       610        620        630        640        650
GAEPGGRGPE ESVEASSTSH TAEDCLHIKA IKTESSGLCQ SSPGAQSSCS 
       660        670        680        690        700
SEPSPLGSVP NNDSGVEMPG TGPGSLGDLT ALDDTSPGAD TSALAVPSTG 
       710        720        730        740        750
GLQLRKHMTT MHRFEQLKRE KLKSLKDSCS WAGPAPHTRN TKLPPLPVNG 
       760        770        780        790        800
SVLENFNNTG GCGPAGLLPN QRLPELTEVT MLSQLQERRD SSTSTMSSAY 
       810        820        830        840        850
TVSRRSSGIS PYFSSRRSSE ASPLGGIRPH NASSADSYDP ISTDASRRSS 
       860        870        880        890        900
EASQCSGGGP GLLNLTPAQQ YSLRAKYAAA TGGPPPTPLP GLDRVSLRTR 
       910        920        930        940        950
LALLDAPERA LPGACPQPLG PRRGSDGPTY NHGHGYVGAA PALPHEGPNG 
       960        970        980        990       1000
STRRASDPVR RPDPLVLPRV QRFHSIHNMN PGPLPPCTDR RGLHLQSHPS 
      1010       1020       1030       1040       1050
VDGSLTRHAY SPRPPSINEN VVMEAVAAGV EGAGLESDLG LVEDDLVLPD 
      1060       1070       1080       1090       1100
DVVQYIKAHT GGALDDSTRQ VYPTEGTGFP ENSKLPSPGL QGHRRLAAAD 
      1110       1120       1130       1140       1150
SNMSPSAPGL GGCQLSYSPS SSLNKSNMPV QWNEVSSGTV DALPTQVKPP 
      1160       1170       1180       1190       1200
SFPQSNLVQQ KPAFAHYPGY SPQALQSGSG GLDSTQPHLQ LRGAPSASRG 
      1210       1220       1230       1240       1250
SYTQQPRLPA TGSQCLGVTA AMSPQANYSQ THHQLSPNVV SGSLNQFAPS 
      1260       1270       1280       1290       1300
CSNMAAKPSH LGLPQQMEVV PNATIISGHQ RELGIASSSL AAVSQPHPVL 
      1310       1320       1330       1340       1350
GYPQQDGYQQ VSGLPSSHQP SFMESQQNTG FGLMQPRPPL EPNTASRHRG 
      1360       1370       1380       1390       1400
VRSGQQQQQL YARTAGQAVV TSANQETAEA MPKGTAGTVV SLTPQPSQDT 
      1410       1420       1430       1440       1450
GRSQDQNTLY YYGQIHMYEQ NGGCPAMQPQ PPQPQGCSDN IQPEPLPSPG 
      1460       1470       1480       1490       1500
VNQVSSTVDS QLLEPPQIDF DAIMDDGDHS SLFSGALSPS LLHNLSQNSS 
      1510       1520       1530       1540 
RLTTPRNSLT LPSIPVGISN MAVGDMSSML TSLAEENKFL NMMT       

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ