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Entry version 73 (07 Apr 2021)
Sequence version 2 (03 Apr 2013)
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Protein
Submitted name:

Myosin VC

Gene

Myo5c

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi161 – 168ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationARBA annotation, Motor protein, MyosinPROSITE-ProRule annotationARBA annotation
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Myosin VCImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myo5cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
1309994, Myo5c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1M111

PRoteomics IDEntifications database

More...
PRIDEi
F1M111

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000008356, Expressed in lung and 19 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000011768

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1M111

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 62Myosin N-terminal SH3-likeInterPro annotationAdd BLAST55
Domaini67 – 753Myosin motorInterPro annotationAdd BLAST687
Domaini1421 – 1697DiluteInterPro annotationAdd BLAST277

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni632 – 654Actin-bindingPROSITE-ProRule annotationAdd BLAST23
Regioni1232 – 1274DisorderedSequence analysisAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili884 – 911Sequence analysisAdd BLAST28
Coiled coili926 – 946Sequence analysisAdd BLAST21
Coiled coili951 – 996Sequence analysisAdd BLAST46
Coiled coili1012 – 1046Sequence analysisAdd BLAST35
Coiled coili1064 – 1098Sequence analysisAdd BLAST35
Coiled coili1303 – 1351Sequence analysisAdd BLAST49

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0160, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157971

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000192_9_4_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1M111

Identification of Orthologs from Complete Genome Data

More...
OMAi
KWTVKKQ

Database of Orthologous Groups

More...
OrthoDBi
311886at2759

TreeFam database of animal gene trees

More...
TreeFami
TF328771

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15476, Myo5c_CBD, 1 hit
cd01380, MYSc_Myo5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002710, Dilute_dom
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR037991, Myo5c_CBD
IPR001609, Myosin_head_motor_dom
IPR004009, Myosin_N
IPR008989, Myosin_S1_N
IPR036103, MYSc_Myo5
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01843, DIL, 1 hit
PF00612, IQ, 4 hits
PF00063, Myosin_head, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01132, DIL, 1 hit
SM00015, IQ, 5 hits
SM00242, MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51126, DILUTE, 1 hit
PS50096, IQ, 5 hits
PS51456, MYOSIN_MOTOR, 1 hit
PS51844, SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1M111-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVAELYAQY NRVWIPDPEE VWKSAEIAKD YRVGDQVLRL LLEDGTELDY
60 70 80 90 100
PVDPGSLPPL RNPDILVGEN DLTALSYLHE PAVLHNLRIR FAESKLIYTY
110 120 130 140 150
SGIILVAMNP YKQLPIYGDA IIHAYSGQNM GDMDPHIFAV AEEAYKQMAR
160 170 180 190 200
NNRNQSIIVS GESGAGKTVS ARYAMRYFAT VSKSSSNAHV EEKVLASNPI
210 220 230 240 250
TEAVGNAKTT RNDNSSRFGK YTEISFDERN QIIGANMRTY LLEKSRVVFQ
260 270 280 290 300
SENERNYHIF YQLCASAQQS EFKHLKLGSA EEFNYTRMGG NTVIEGVDDR
310 320 330 340 350
ADMAETQKTF TLLGFKKDFQ MDVFKILAAI LHLGNVQVTT VGNERSAVSE
360 370 380 390 400
DDSHLKVFCE LLGLETIKVA QWLCNRKIVT SSETVVKPMT RPQAINARDA
410 420 430 440 450
LAKKIYAHLF DFIVEQINQA LHFSGKQHTF IGVLDIYGFE TFDVNSFEQF
460 470 480 490 500
CINYANEKLQ QQFNLHVFKL EQEEYMKEDI PWTLIDFYDN QPVIDLIEAK
510 520 530 540 550
MGILELLDEE CLLPHGTDEN WLQKLYNNFV NKNSLFEKPR MSNSSFIIQH
560 570 580 590 600
FADKVEYQCE GFLEKNRDTV YDMLVEVLRA SKFHLCAAFF QESPVPSSPF
610 620 630 640 650
GAMITVKSAK QVIKPNTKHF RTTVGNKFRS SLFLLMETLN ATTPHYVRCI
660 670 680 690 700
KPNDEKLPFE FDSKRIVQQL RACGVLETIR ISAQSYPSRW TYLEFYSRYG
710 720 730 740 750
VLMTQQELSL SDKKEVCKVV LHRLIQDSNQ YQFGRTKIFF RAGQVAYLEK
760 770 780 790 800
LRLDKLRQGC IVIQKHVRGW LQRKKFLRER RAALTIQQYF RGQQTVRKAI
810 820 830 840 850
TATALKEAWA AIILQKHCRG YLVRNLYQLI RVATITIQAH TRGFLARRRY
860 870 880 890 900
RKLLQEHKAV ILQKYARAWL ARRRFQNIRR FVLNIQLTYR VQRLQKKLED
910 920 930 940 950
QNRENHGLVE KLTSLAALRV GDLEKVQRLE AELEKAATHR HSYEEKGRRY
960 970 980 990 1000
RDSMEERLSK LQKHNAELES QRERAEQSLQ ERTEELKEKM DQLTRQLFDD
1010 1020 1030 1040 1050
VQKEEQQRLL LEKSFELKTQ AYEKEIESLR EEIKALKDER TQLHHQLEEG
1060 1070 1080 1090 1100
RVTSDSLKGE VARLSKQAKT ISEFEKEIEL LQAQKIDVEK HVQSQKREMR
1110 1120 1130 1140 1150
ERMSEVTKQL LESYDIEDVR SRLSVEDLEH LNEDGELWFA YEGLKKATRV
1160 1170 1180 1190 1200
LESHFQSQKD CYEKEIEGLN FKVVHLSQEI NHLQKLFREE TDINESIRHE
1210 1220 1230 1240 1250
VTRLTSENMM IPDFKQQISE LERQKQDLES RLKEQAEKME GKQEEPFSHL
1260 1270 1280 1290 1300
NRGLEEEGRQ GKAVEAQSET HPEGKERLVG KIQEPQEAIK FPKKQAEAEE
1310 1320 1330 1340 1350
EVESILRQEA SRLSLENRDL EEELDMKDRM IRKLQDQVKT LTRTIEKANS
1360 1370 1380 1390 1400
VPLPSGSREY LGMLEYKKED ETKLIQNLIL DLKPRGVVVN MIPGLPAHIL
1410 1420 1430 1440 1450
FMCVRYADSL NDANMLKSLM NSAINGIKHV VKEHFEDLEM LSFWLSNTCH
1460 1470 1480 1490 1500
FLNCLKQYSG EEEFMKCNSP QQNKNCLNNF DLTEYRQILS DVAIRIYHQF
1510 1520 1530 1540 1550
ILVMENNLQP IIVPGMLEYE SLQGISGLKP TGFRKRSSSI DDTDAYTMTS
1560 1570 1580 1590 1600
ILQQLSYFYS TMCQNGLDPE IVRQAVKQLF YLIGAVTLNS LLLRKDMCSC
1610 1620 1630 1640 1650
RKGMQIRCNI SFLEEWLKDK NLQNSLAKET LEPLSQAAWL LQVKKTTDSD
1660 1670 1680 1690 1700
AKEISQCCTS LSAVQIIKIL NSYTPIDDFE KRVNPSFVRK VQALLNNRGD
1710 1720 1730 1740
SSQLMLDTKY LFQVTFPFTA SPHALEMTQI PSSFKLGFLR RL
Length:1,742
Mass (Da):202,306
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD4371D1E9FD2EA66
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07070734 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_008756041.1, XM_008757819.1
XP_008764638.1, XM_008766416.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000011768; ENSRNOP00000011768; ENSRNOG00000008356

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
315820

UCSC genome browser

More...
UCSCi
RGD:1309994, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07070734 Genomic DNA No translation available.
RefSeqiXP_008756041.1, XM_008757819.1
XP_008764638.1, XM_008766416.1

3D structure databases

SMRiF1M111
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011768

Proteomic databases

PaxDbiF1M111
PRIDEiF1M111

Genome annotation databases

EnsembliENSRNOT00000011768; ENSRNOP00000011768; ENSRNOG00000008356
GeneIDi315820
UCSCiRGD:1309994, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55930
RGDi1309994, Myo5c

Phylogenomic databases

eggNOGiKOG0160, Eukaryota
GeneTreeiENSGT00940000157971
HOGENOMiCLU_000192_9_4_1
InParanoidiF1M111
OMAiKWTVKKQ
OrthoDBi311886at2759
TreeFamiTF328771

Gene expression databases

BgeeiENSRNOG00000008356, Expressed in lung and 19 other tissues

Family and domain databases

CDDicd15476, Myo5c_CBD, 1 hit
cd01380, MYSc_Myo5, 1 hit
Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR002710, Dilute_dom
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR037991, Myo5c_CBD
IPR001609, Myosin_head_motor_dom
IPR004009, Myosin_N
IPR008989, Myosin_S1_N
IPR036103, MYSc_Myo5
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF01843, DIL, 1 hit
PF00612, IQ, 4 hits
PF00063, Myosin_head, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM01132, DIL, 1 hit
SM00015, IQ, 5 hits
SM00242, MYSc, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51126, DILUTE, 1 hit
PS50096, IQ, 5 hits
PS51456, MYOSIN_MOTOR, 1 hit
PS51844, SH3_LIKE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1M111_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1M111
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: April 7, 2021
This is version 73 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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