Rora

Functionⁱ

GO - Molecular functionⁱ

beta-catenin binding Source: Ensembl
nuclear receptor activity Source: InterPro
oxysterol binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
steroid hormone receptor activity Source: InterPro
transcription coactivator binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription corepressor binding Source: Ensembl
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis Source: Ensembl
cellular response to hypoxia Source: Ensembl
cellular response to interleukin-1 Source: Ensembl
cellular response to sterol Source: Ensembl
cellular response to tumor necrosis factor Source: Ensembl
cerebellar granule cell precursor proliferation Source: Ensembl
cerebellar Purkinje cell differentiation Source: Ensembl
cGMP metabolic process Source: Ensembl
cholesterol homeostasis Source: Ensembl
circadian regulation of gene expression Source: Ensembl
circadian rhythm
Source: RGD
Inferred from expression patternⁱ
- 15781226
muscle cell differentiation Source: Ensembl
negative regulation of fat cell differentiation Source: Ensembl
negative regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
negative regulation of inflammatory response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nitric oxide biosynthetic process Source: Ensembl
positive regulation of circadian rhythm Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of vascular endothelial growth factor production Source: Ensembl
regulation of glucose metabolic process Source: Ensembl
regulation of macrophage activation Source: Ensembl
regulation of smoothened signaling pathway Source: Ensembl
regulation of steroid metabolic process Source: Ensembl
regulation of transcription involved in cell fate commitment Source: Ensembl
T-helper 17 cell differentiation Source: Ensembl
transcription, DNA-templated Source: UniProtKB-UniRule
triglyceride homeostasis Source: Ensembl
xenobiotic metabolic process Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological process	Transcription, Transcription regulationUniRule annotationSAAS annotation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-RNO-383280 Nuclear Receptor transcription pathway R-RNO-4090294 SUMOylation of intracellular receptors

Reactomeⁱ

R-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-4090294 SUMOylation of intracellular receptors

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: RAR-related orphan receptor AImported
Gene namesⁱ	Name:RoraImported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 8

Organism-specific databases

Rat genome database More...RGDⁱ	1308419 Rora

RGDⁱ

1308419 Rora

Keywords - Cellular componentⁱ

NucleusUniRule annotationSAAS annotation

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	F1LZZ3
PRIDEⁱ	F1LZZ3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000027145 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Bgeeⁱ

ENSRNOG00000027145 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Interactionⁱ

GO - Molecular functionⁱ

beta-catenin binding Source: Ensembl
transcription coactivator binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription corepressor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000013142

STRINGⁱ

10116.ENSRNOP00000013142

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	F1LZZ3
SMRⁱ	F1LZZ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	14 – 89	Nuclear receptorInterPro annotationAdd BLAST		76
Domainⁱ	216 – 454	NR LBDInterPro annotationAdd BLAST		239

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG4216 Eukaryota ENOG410XUGR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136388
InParanoidⁱ	F1LZZ3
OMAⁱ	YQNKPRE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0649

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003079 ROR_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01293 RORNUCRECPTR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

F1LZZ3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MYFVIAAMKA QIEIIPCKIC GDKSSGIHYG VITCEGCKGF FRRSQQSNAT 
        60         70         80         90        100
YSCPRQKNCL IDRTSRNRCQ HCRLQKCLAV GMSRDAVKFG RMSKKQRDSL 
       110        120        130        140        150
YAEVQKHRMQ QQQRDHQQQP GEAEPLTPTY NISANGLTEL HDDLSTYMDG 
       160        170        180        190        200
HTPEGSKADS AVSSFYLDIQ PSPDQSGLDI NGIKPEPICD YTPASGFFPY 
       210        220        230        240        250
CSFTNGETSP TVSMAELEHL AQNISKSHLE TCQYLREELQ QITWQTFLQE 
       260        270        280        290        300
EIENYQNKQR EVMWQLCAIK ITEAIQYVVE FAKRIDGFME LCQNDQIVLL 
       310        320        330        340        350
KAGSLEVVFI RMCRAFDSQN NTVYFDGKYA SPDVFKSLGC EDFISFVFEF 
       360        370        380        390        400
GKSLCSMHLT EDEIALFSAF VLMSADRSWL QEKVKIEKLQ QKIQLALQHV 
       410        420        430        440        450
LQKNHREDGI LTKLICKVST LRALCGRHTE KLMAFKAIYP DIVRLHFPPL 
       460 
YKELFTSEFE PAMQIDG

Length:467

Mass (Da):53,414

Last modified:July 22, 2015 - v3

Checksum:ⁱ5621E275EC282A54

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07070578 Genomic DNA No translation available. AABR07070579 Genomic DNA No translation available. AABR07070580 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_008764632.1, XM_008766410.2
UniGeneⁱ	Rn.39327

Genome annotation databases

Ensemblⁱ	ENSRNOT00000013142; ENSRNOP00000013142; ENSRNOG00000027145
GeneIDⁱ	300807

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
F1LZZ3	Uncharacterized protein		MOUSE		467	UniRef100_Q3U1P4
Uncharacterized protein		AOTNA		468
nuclear receptor ROR-alpha		DIPOR		468
nuclear receptor ROR-alpha isoform X1		MESAU		467
Isoform 4 of Nuclear receptor ROR-alpha		MOUSE		467

Protein	Similar proteins		Species	Score	Length	Source
F1LZZ3	Isoform 4 of Nuclear receptor ROR-alpha		HUMAN		468	UniRef90_P35398-4
Nuclear receptor ROR-alpha (Fragment)		FUKDA		582
RAR related orphan receptor A		ANAPL		469
Uncharacterized protein		COLAP		469
Uncharacterized protein		CERAT		469
+69

Protein	Similar proteins		Species	Score	Length	Source
F1LZZ3	Nuclear receptor ROR-alpha	)	HUMAN		523	UniRef50_P35398
Nuclear receptor ROR-alpha		MOUSE		523
Nuclear receptor ROR-beta	)	RAT		470
RAR related orphan receptor A		PANTR		523
RORA isoform 1		PONAB		523
+915

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07070578 Genomic DNA No translation available. AABR07070579 Genomic DNA No translation available. AABR07070580 Genomic DNA No translation available.
RefSeqⁱ	XP_008764632.1, XM_008766410.2
UniGeneⁱ	Rn.39327

3D structure databases

ProteinModelPortalⁱ	F1LZZ3
SMRⁱ	F1LZZ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000013142

STRINGⁱ

10116.ENSRNOP00000013142

Proteomic databases

PaxDbⁱ	F1LZZ3
PRIDEⁱ	F1LZZ3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000013142; ENSRNOP00000013142; ENSRNOG00000027145
GeneIDⁱ	300807

Organism-specific databases

CTDⁱ	6095
RGDⁱ	1308419 Rora

Phylogenomic databases

eggNOGⁱ	KOG4216 Eukaryota ENOG410XUGR LUCA
GeneTreeⁱ	ENSGT00870000136388
InParanoidⁱ	F1LZZ3
OMAⁱ	YQNKPRE
OrthoDBⁱ	EOG091G0649

Enzyme and pathway databases

Reactomeⁱ	R-RNO-383280 Nuclear Receptor transcription pathway R-RNO-4090294 SUMOylation of intracellular receptors

Reactomeⁱ

R-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-4090294 SUMOylation of intracellular receptors

Gene expression databases

Bgeeⁱ	ENSRNOG00000027145 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Bgeeⁱ

ENSRNOG00000027145 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003079 ROR_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01293 RORNUCRECPTR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F1LZZ3_RAT
Accessionⁱ	F1LZZ3Primary (citable) accession number: F1LZZ3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 3, 2011
	Last sequence update:	July 22, 2015
	Last modified:	November 7, 2018
	This is version 70 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F1LZZ3 (F1LZZ3_RAT)

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RAR-related orphan receptor A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ