RAR-related orphan receptor A

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• beta-catenin binding Source: RGDInferred from sequence orthologyⁱ
  • "RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways."
    Gold D.A., Baek S.H., Schork N.J., Rose D.W., Larsen D.D., Sachs B.D., Rosenfeld M.G., Hamilton B.A.
    Neuron 40:1119-1131(2003) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha."
    Raspe E., Duez H., Gervois P., Fievet C., Fruchart J.C., Besnard S., Mariani J., Tedgui A., Staels B.
    J. Biol. Chem. 276:2865-2871(2001) [PubMed] [Europe PMC] [Abstract]
  • "RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR."
    Lau P., Nixon S.J., Parton R.G., Muscat G.E.
    J. Biol. Chem. 279:36828-36840(2004) [PubMed] [Europe PMC] [Abstract]
  • "T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma."
    Yang X.O., Pappu B.P., Nurieva R., Akimzhanov A., Kang H.S., Chung Y., Ma L., Shah B., Panopoulos A.D., Schluns K.S., Watowich S.S., Tian Q., Jetten A.M., Dong C.
    Immunity 28:29-39(2008) [PubMed] [Europe PMC] [Abstract]
  • "Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors."
    Forman B.M., Chen J., Blumberg B., Kliewer S.A., Henshaw R., Ong E., Evans R.M.
    Mol. Endocrinol. 8:1253-1261(1994) [PubMed] [Europe PMC] [Abstract]
  • "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors."
    Giguere V., Tini M., Flock G., Ong E., Evans R.M., Otulakowski G.
    Genes Dev. 8:538-553(1994) [PubMed] [Europe PMC] [Abstract]
  • "Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development."
    Harding H.P., Atkins G.B., Jaffe A.B., Seo W.J., Lazar M.A.
    Mol. Endocrinol. 11:1737-1746(1997) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha."
    Raspe E., Duez H., Gervois P., Fievet C., Fruchart J.C., Besnard S., Mariani J., Tedgui A., Staels B.
    J. Biol. Chem. 276:2865-2871(2001) [PubMed] [Europe PMC] [Abstract]
  • "Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione."
    Tordjman J., Leroyer S., Chauvet G., Quette J., Chauvet C., Tomkiewicz C., Chapron C., Barouki R., Forest C., Aggerbeck M., Antoine B.
    J. Biol. Chem. 282:23591-23602(2007) [PubMed] [Europe PMC] [Abstract]
  • "Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling."
    Kim E.J., Yoo Y.G., Yang W.K., Lim Y.S., Na T.Y., Lee I.K., Lee M.O.
    Arterioscler. Thromb. Vasc. Biol. 28:1796-1802(2008) [PubMed] [Europe PMC] [Abstract]
  • "RORgamma directly regulates the circadian expression of clock genes and downstream targets in vivo."
    Takeda Y., Jothi R., Birault V., Jetten A.M.
    Nucleic Acids Res. 40:8519-8535(2012) [PubMed] [Europe PMC] [Abstract]
  • "Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator."
    Retnakaran R., Flock G., Giguere V.
    Mol. Endocrinol. 8:1234-1244(1994) [PubMed] [Europe PMC] [Abstract]
  • "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors."
    Giguere V., Tini M., Flock G., Ong E., Evans R.M., Otulakowski G.
    Genes Dev. 8:538-553(1994) [PubMed] [Europe PMC] [Abstract]
  • "Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development."
    Harding H.P., Atkins G.B., Jaffe A.B., Seo W.J., Lazar M.A.
    Mol. Endocrinol. 11:1737-1746(1997) [PubMed] [Europe PMC] [Abstract]
• ligand-activated transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands."
    Wang Y., Kumar N., Solt L.A., Richardson T.I., Helvering L.M., Crumbley C., Garcia-Ordonez R.D., Stayrook K.R., Zhang X., Novick S., Chalmers M.J., Griffin P.R., Burris T.P.
    J. Biol. Chem. 285:5013-5025(2010) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor activity Source: InterPro
• oxysterol binding Source: RGDInferred from sequence orthologyⁱ
  • "Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands."
    Wang Y., Kumar N., Solt L.A., Richardson T.I., Helvering L.M., Crumbley C., Garcia-Ordonez R.D., Stayrook K.R., Zhang X., Novick S., Chalmers M.J., Griffin P.R., Burris T.P.
    J. Biol. Chem. 285:5013-5025(2010) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140)."
    Poliandri A.H., Gamsby J.J., Christian M., Spinella M.J., Loros J.J., Dunlap J.C., Parker M.G.
    J. Biol. Rhythms 26:187-199(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes."
    Journiac N., Jolly S., Jarvis C., Gautheron V., Rogard M., Trembleau A., Blondeau J.P., Mariani J., Vernet-der Garabedian B.
    Proc. Natl. Acad. Sci. U.S.A. 106:21365-21370(2009) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha."
    Raspe E., Duez H., Gervois P., Fievet C., Fruchart J.C., Besnard S., Mariani J., Tedgui A., Staels B.
    J. Biol. Chem. 276:2865-2871(2001) [PubMed] [Europe PMC] [Abstract]
  • "Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)."
    Wada T., Kang H.S., Angers M., Gong H., Bhatia S., Khadem S., Ren S., Ellis E., Strom S.C., Jetten A.M., Xie W.
    Mol. Pharmacol. 73:891-899(2008) [PubMed] [Europe PMC] [Abstract]
  • "T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma."
    Yang X.O., Pappu B.P., Nurieva R., Akimzhanov A., Kang H.S., Chung Y., Ma L., Shah B., Panopoulos A.D., Schluns K.S., Watowich S.S., Tian Q., Jetten A.M., Dong C.
    Immunity 28:29-39(2008) [PubMed] [Europe PMC] [Abstract]
• steroid hormone receptor activity Source: InterPro
• transcription coactivator binding Source: RGDInferred from sequence orthologyⁱ
  • "Coactivators for the orphan nuclear receptor RORalpha."
    Atkins G.B., Hu X., Guenther M.G., Rachez C., Freedman L.P., Lazar M.A.
    Mol. Endocrinol. 13:1550-1557(1999) [PubMed] [Europe PMC] [Abstract]
  • "Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism."
    Liu C., Li S., Liu T., Borjigin J., Lin J.D.
    Nature 447:477-481(2007) [PubMed] [Europe PMC] [Abstract]
  • "Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease."
    Chopra A.R., Louet J.F., Saha P., An J., Demayo F., Xu J., York B., Karpen S., Finegold M., Moore D., Chan L., Newgard C.B., O'Malley B.W.
    Science 322:1395-1399(2008) [PubMed] [Europe PMC] [Abstract]
  • "Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD."
    Lau P., Bailey P., Dowhan D.H., Muscat G.E.
    Nucleic Acids Res. 27:411-420(1999) [PubMed] [Europe PMC] [Abstract]
• transcription corepressor binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development."
    Harding H.P., Atkins G.B., Jaffe A.B., Seo W.J., Lazar M.A.
    Mol. Endocrinol. 11:1737-1746(1997) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling."
    Kim E.J., Yoo Y.G., Yang W.K., Lim Y.S., Na T.Y., Lee I.K., Lee M.O.
    Arterioscler. Thromb. Vasc. Biol. 28:1796-1802(2008) [PubMed] [Europe PMC] [Abstract]
  • "Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD."
    Lau P., Bailey P., Dowhan D.H., Muscat G.E.
    Nucleic Acids Res. 27:411-420(1999) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• angiogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling."
    Kim E.J., Yoo Y.G., Yang W.K., Lim Y.S., Na T.Y., Lee I.K., Lee M.O.
    Arterioscler. Thromb. Vasc. Biol. 28:1796-1802(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to hypoxia Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling."
    Kim E.J., Yoo Y.G., Yang W.K., Lim Y.S., Na T.Y., Lee I.K., Lee M.O.
    Arterioscler. Thromb. Vasc. Biol. 28:1796-1802(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to interleukin-1 Source: RGDInferred from sequence orthologyⁱ
  • "The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes."
    Journiac N., Jolly S., Jarvis C., Gautheron V., Rogard M., Trembleau A., Blondeau J.P., Mariani J., Vernet-der Garabedian B.
    Proc. Natl. Acad. Sci. U.S.A. 106:21365-21370(2009) [PubMed] [Europe PMC] [Abstract]
• cellular response to sterol Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling."
    Kim E.J., Yoo Y.G., Yang W.K., Lim Y.S., Na T.Y., Lee I.K., Lee M.O.
    Arterioscler. Thromb. Vasc. Biol. 28:1796-1802(2008) [PubMed] [Europe PMC] [Abstract]
  • "Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands."
    Wang Y., Kumar N., Solt L.A., Richardson T.I., Helvering L.M., Crumbley C., Garcia-Ordonez R.D., Stayrook K.R., Zhang X., Novick S., Chalmers M.J., Griffin P.R., Burris T.P.
    J. Biol. Chem. 285:5013-5025(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to tumor necrosis factor Source: RGDInferred from sequence orthologyⁱ
  • "The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes."
    Journiac N., Jolly S., Jarvis C., Gautheron V., Rogard M., Trembleau A., Blondeau J.P., Mariani J., Vernet-der Garabedian B.
    Proc. Natl. Acad. Sci. U.S.A. 106:21365-21370(2009) [PubMed] [Europe PMC] [Abstract]
• cerebellar granule cell precursor proliferation Source: RGDInferred from sequence orthologyⁱ
  • "RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways."
    Gold D.A., Baek S.H., Schork N.J., Rose D.W., Larsen D.D., Sachs B.D., Rosenfeld M.G., Hamilton B.A.
    Neuron 40:1119-1131(2003) [PubMed] [Europe PMC] [Abstract]
• cerebellar Purkinje cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Altered gene expression of the N-methyl-D-aspartate receptor channel subunits in Purkinje cells of the staggerer mutant mouse."
    Nakagawa S., Watanabe M., Inoue Y.
    Eur. J. Neurosci. 8:2644-2651(1996) [PubMed] [Europe PMC] [Abstract]
• cGMP metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Cerebellar nitric oxide synthase, cGMP and motor function in two lines of cerebellar mutant mice, Staggerer and Wriggle Mouse Sagami."
    Ikeda M., Matsui K., Ishihara Y., Morita I., Murota S., Yuasa T., Miyatake T.
    Neurosci. Lett. 168:65-68(1994) [PubMed] [Europe PMC] [Abstract]
• cholesterol homeostasis Source: RGDInferred from sequence orthologyⁱ
  • "Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)."
    Wada T., Kang H.S., Angers M., Gong H., Bhatia S., Khadem S., Ren S., Ellis E., Strom S.C., Jetten A.M., Xie W.
    Mol. Pharmacol. 73:891-899(2008) [PubMed] [Europe PMC] [Abstract]
• circadian regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "RORgamma directly regulates the circadian expression of clock genes and downstream targets in vivo."
    Takeda Y., Jothi R., Birault V., Jetten A.M.
    Nucleic Acids Res. 40:8519-8535(2012) [PubMed] [Europe PMC] [Abstract]
• circadian rhythm Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Circadian expression of clock genes and clock-controlled genes in the rat retina."
    Kamphuis W., Cailotto C., Dijk F., Bergen A., Buijs R.M.
    Biochem. Biophys. Res. Commun. 330:18-26(2005) [PubMed] [Europe PMC] [Abstract]
• intracellular receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands."
    Wang Y., Kumar N., Solt L.A., Richardson T.I., Helvering L.M., Crumbley C., Garcia-Ordonez R.D., Stayrook K.R., Zhang X., Novick S., Chalmers M.J., Griffin P.R., Burris T.P.
    J. Biol. Chem. 285:5013-5025(2010) [PubMed] [Europe PMC] [Abstract]
• muscle cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD."
    Lau P., Bailey P., Dowhan D.H., Muscat G.E.
    Nucleic Acids Res. 27:411-420(1999) [PubMed] [Europe PMC] [Abstract]
• negative regulation of fat cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "The orphan nuclear receptor RORalpha restrains adipocyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expression."
    Ohoka N., Kato S., Takahashi Y., Hayashi H., Sato R.
    Mol. Endocrinol. 23:759-771(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of I-kappaB kinase/NF-kappaB signaling Source: RGDInferred from sequence orthologyⁱ
  • "The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response."
    Delerive P., Monte D., Dubois G., Trottein F., Fruchart-Najib J., Mariani J., Fruchart J.C., Staels B.
    EMBO Rep. 2:42-48(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of inflammatory response Source: RGDInferred from sequence orthologyⁱ
  • "The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response."
    Delerive P., Monte D., Dubois G., Trottein F., Fruchart-Najib J., Mariani J., Fruchart J.C., Staels B.
    EMBO Rep. 2:42-48(2001) [PubMed] [Europe PMC] [Abstract]
• nitric oxide biosynthetic process Source: RGDInferred from sequence orthologyⁱ
  • "Cerebellar nitric oxide synthase, cGMP and motor function in two lines of cerebellar mutant mice, Staggerer and Wriggle Mouse Sagami."
    Ikeda M., Matsui K., Ishihara Y., Morita I., Murota S., Yuasa T., Miyatake T.
    Neurosci. Lett. 168:65-68(1994) [PubMed] [Europe PMC] [Abstract]
• positive regulation of circadian rhythm Source: RGDInferred from sequence orthologyⁱ
  • "RORgamma directly regulates the circadian expression of clock genes and downstream targets in vivo."
    Takeda Y., Jothi R., Birault V., Jetten A.M.
    Nucleic Acids Res. 40:8519-8535(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140)."
    Poliandri A.H., Gamsby J.J., Christian M., Spinella M.J., Loros J.J., Dunlap J.C., Parker M.G.
    J. Biol. Rhythms 26:187-199(2011) [PubMed] [Europe PMC] [Abstract]
  • "Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors alpha- and gamma-mediated transactivation."
    Takeda Y., Jetten A.M.
    Nucleic Acids Res. 41:6992-7008(2013) [PubMed] [Europe PMC] [Abstract]
  • "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors."
    Giguere V., Tini M., Flock G., Ong E., Evans R.M., Otulakowski G.
    Genes Dev. 8:538-553(1994) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR."
    Lau P., Nixon S.J., Parton R.G., Muscat G.E.
    J. Biol. Chem. 279:36828-36840(2004) [PubMed] [Europe PMC] [Abstract]
  • "Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione."
    Tordjman J., Leroyer S., Chauvet G., Quette J., Chauvet C., Tomkiewicz C., Chapron C., Barouki R., Forest C., Aggerbeck M., Antoine B.
    J. Biol. Chem. 282:23591-23602(2007) [PubMed] [Europe PMC] [Abstract]
  • "The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes."
    Journiac N., Jolly S., Jarvis C., Gautheron V., Rogard M., Trembleau A., Blondeau J.P., Mariani J., Vernet-der Garabedian B.
    Proc. Natl. Acad. Sci. U.S.A. 106:21365-21370(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of vascular endothelial growth factor production Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling."
    Kim E.J., Yoo Y.G., Yang W.K., Lim Y.S., Na T.Y., Lee I.K., Lee M.O.
    Arterioscler. Thromb. Vasc. Biol. 28:1796-1802(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of circadian rhythm Source: RGDInferred from sequence orthologyⁱ
  • "Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility."
    Saito T., Hirano M., Ide T., Ichiki T., Koibuchi N., Sunagawa K., Hirano K.
    Circulation 127:104-114(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of glucose metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands."
    Wang Y., Kumar N., Solt L.A., Richardson T.I., Helvering L.M., Crumbley C., Garcia-Ordonez R.D., Stayrook K.R., Zhang X., Novick S., Chalmers M.J., Griffin P.R., Burris T.P.
    J. Biol. Chem. 285:5013-5025(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of macrophage activation Source: RGDInferred from sequence orthologyⁱ
  • "Peripheral macrophage abnormalities in mutant mice with spinocerebellar degeneration."
    Bakalian A., Kopmels B., Messer A., Fradelizi D., Delhaye-Bouchaud N., Wollman E., Mariani J.
    Res. Immunol. 143:129-139(1992) [PubMed] [Europe PMC] [Abstract]
• regulation of smoothened signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways."
    Gold D.A., Baek S.H., Schork N.J., Rose D.W., Larsen D.D., Sachs B.D., Rosenfeld M.G., Hamilton B.A.
    Neuron 40:1119-1131(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of steroid metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism."
    Kang H.S., Angers M., Beak J.Y., Wu X., Gimble J.M., Wada T., Xie W., Collins J.B., Grissom S.F., Jetten A.M.
    Physiol. Genomics 31:281-294(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)."
    Wada T., Kang H.S., Angers M., Gong H., Bhatia S., Khadem S., Ren S., Ellis E., Strom S.C., Jetten A.M., Xie W.
    Mol. Pharmacol. 73:891-899(2008) [PubMed] [Europe PMC] [Abstract]
  • "Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator."
    Retnakaran R., Flock G., Giguere V.
    Mol. Endocrinol. 8:1234-1244(1994) [PubMed] [Europe PMC] [Abstract]
  • "Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development."
    Harding H.P., Atkins G.B., Jaffe A.B., Seo W.J., Lazar M.A.
    Mol. Endocrinol. 11:1737-1746(1997) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription involved in cell fate commitment Source: RGDInferred from sequence orthologyⁱ
  • "T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma."
    Yang X.O., Pappu B.P., Nurieva R., Akimzhanov A., Kang H.S., Chung Y., Ma L., Shah B., Panopoulos A.D., Schluns K.S., Watowich S.S., Tian Q., Jetten A.M., Dong C.
    Immunity 28:29-39(2008) [PubMed] [Europe PMC] [Abstract]
  • "The orphan nuclear receptor RORalpha restrains adipocyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expression."
    Ohoka N., Kato S., Takahashi Y., Hayashi H., Sato R.
    Mol. Endocrinol. 23:759-771(2009) [PubMed] [Europe PMC] [Abstract]
• T-helper 17 cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma."
    Yang X.O., Pappu B.P., Nurieva R., Akimzhanov A., Kang H.S., Chung Y., Ma L., Shah B., Panopoulos A.D., Schluns K.S., Watowich S.S., Tian Q., Jetten A.M., Dong C.
    Immunity 28:29-39(2008) [PubMed] [Europe PMC] [Abstract]
• triglyceride homeostasis Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha."
    Raspe E., Duez H., Gervois P., Fievet C., Fruchart J.C., Besnard S., Mariani J., Tedgui A., Staels B.
    J. Biol. Chem. 276:2865-2871(2001) [PubMed] [Europe PMC] [Abstract]
  • "Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)."
    Wada T., Kang H.S., Angers M., Gong H., Bhatia S., Khadem S., Ren S., Ellis E., Strom S.C., Jetten A.M., Xie W.
    Mol. Pharmacol. 73:891-899(2008) [PubMed] [Europe PMC] [Abstract]
• xenobiotic metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism."
    Kang H.S., Angers M., Beak J.Y., Wu X., Gimble J.M., Wada T., Xie W., Collins J.B., Grissom S.F., Jetten A.M.
    Physiol. Genomics 31:281-294(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• beta-catenin binding Source: RGDInferred from sequence orthologyⁱ
  • "RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways."
    Gold D.A., Baek S.H., Schork N.J., Rose D.W., Larsen D.D., Sachs B.D., Rosenfeld M.G., Hamilton B.A.
    Neuron 40:1119-1131(2003) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator binding Source: RGDInferred from sequence orthologyⁱ
  • "Coactivators for the orphan nuclear receptor RORalpha."
    Atkins G.B., Hu X., Guenther M.G., Rachez C., Freedman L.P., Lazar M.A.
    Mol. Endocrinol. 13:1550-1557(1999) [PubMed] [Europe PMC] [Abstract]
  • "Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism."
    Liu C., Li S., Liu T., Borjigin J., Lin J.D.
    Nature 447:477-481(2007) [PubMed] [Europe PMC] [Abstract]
  • "Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease."
    Chopra A.R., Louet J.F., Saha P., An J., Demayo F., Xu J., York B., Karpen S., Finegold M., Moore D., Chan L., Newgard C.B., O'Malley B.W.
    Science 322:1395-1399(2008) [PubMed] [Europe PMC] [Abstract]
  • "Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD."
    Lau P., Bailey P., Dowhan D.H., Muscat G.E.
    Nucleic Acids Res. 27:411-420(1999) [PubMed] [Europe PMC] [Abstract]
• transcription corepressor binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development."
    Harding H.P., Atkins G.B., Jaffe A.B., Seo W.J., Lazar M.A.
    Mol. Endocrinol. 11:1737-1746(1997) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling."
    Kim E.J., Yoo Y.G., Yang W.K., Lim Y.S., Na T.Y., Lee I.K., Lee M.O.
    Arterioscler. Thromb. Vasc. Biol. 28:1796-1802(2008) [PubMed] [Europe PMC] [Abstract]
  • "Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD."
    Lau P., Bailey P., Dowhan D.H., Muscat G.E.
    Nucleic Acids Res. 27:411-420(1999) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MYFVIAAMKA QIEIIPCKIC GDKSSGIHYG VITCEGCKGF FRRSQQSNAT 
        60         70         80         90        100
YSCPRQKNCL IDRTSRNRCQ HCRLQKCLAV GMSRDAVKFG RMSKKQRDSL 
       110        120        130        140        150
YAEVQKHRMQ QQQRDHQQQP GEAEPLTPTY NISANGLTEL HDDLSTYMDG 
       160        170        180        190        200
HTPEGSKADS AVSSFYLDIQ PSPDQSGLDI NGIKPEPICD YTPASGFFPY 
       210        220        230        240        250
CSFTNGETSP TVSMAELEHL AQNISKSHLE TCQYLREELQ QITWQTFLQE 
       260        270        280        290        300
EIENYQNKQR EVMWQLCAIK ITEAIQYVVE FAKRIDGFME LCQNDQIVLL 
       310        320        330        340        350
KAGSLEVVFI RMCRAFDSQN NTVYFDGKYA SPDVFKSLGC EDFISFVFEF 
       360        370        380        390        400
GKSLCSMHLT EDEIALFSAF VLMSADRSWL QEKVKIEKLQ QKIQLALQHV 
       410        420        430        440        450
LQKNHREDGI LTKLICKVST LRALCGRHTE KLMAFKAIYP DIVRLHFPPL 
       460 
YKELFTSEFE PAMQIDG                                     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ