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UniProtKB - F1LZZ3 (F1LZZ3_RAT)
Protein
Submitted name:
RAR-related orphan receptor A
Gene
Rora
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- beta-catenin binding Source: RGD
- DNA binding Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
- ligand-activated transcription factor activity Source: RGD
- nuclear receptor activity Source: GO_Central
- oxysterol binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific DNA binding Source: RGD
- transcription coactivator binding Source: RGD
- transcription coregulator binding Source: RGD
- transcription corepressor binding Source: RGD
- zinc ion binding Source: InterPro
GO - Biological processi
- angiogenesis Source: RGD
- cellular response to hypoxia Source: RGD
- cellular response to interleukin-1 Source: RGD
- cellular response to sterol Source: RGD
- cellular response to tumor necrosis factor Source: RGD
- cerebellar granule cell precursor proliferation Source: RGD
- cerebellar Purkinje cell differentiation Source: RGD
- cGMP metabolic process Source: RGD
- cholesterol homeostasis Source: RGD
- circadian regulation of gene expression Source: RGD
- circadian rhythm Source: RGD
- intracellular receptor signaling pathway Source: RGD
- muscle cell differentiation Source: RGD
- negative regulation of fat cell differentiation Source: RGD
- negative regulation of I-kappaB kinase/NF-kappaB signaling Source: RGD
- negative regulation of inflammatory response Source: RGD
- nitric oxide biosynthetic process Source: RGD
- positive regulation of circadian rhythm Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of vascular endothelial growth factor production Source: RGD
- regulation of circadian rhythm Source: RGD
- regulation of glucose metabolic process Source: RGD
- regulation of macrophage activation Source: RGD
- regulation of smoothened signaling pathway Source: RGD
- regulation of steroid metabolic process Source: RGD
- regulation of transcription, DNA-templated Source: RGD
- regulation of transcription by RNA polymerase II Source: RGD
- T-helper 17 cell differentiation Source: RGD
- triglyceride homeostasis Source: RGD
- xenobiotic metabolic process Source: RGD
Keywordsi
Molecular function | Developmental proteinARBA annotation, DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-383280, Nuclear Receptor transcription pathway R-RNO-4090294, SUMOylation of intracellular receptors |
Names & Taxonomyi
Protein namesi | Submitted name: RAR-related orphan receptor A |
Gene namesi | Name:RoraImported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1308419, Rora |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nucleus Source: RGD
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000027145, Expressed in skeletal muscle tissue and 20 other tissues |
Interactioni
GO - Molecular functioni
- beta-catenin binding Source: RGD
- transcription coactivator binding Source: RGD
- transcription coregulator binding Source: RGD
- transcription corepressor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000013142 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 89 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 216 – 454 | NR LBDInterPro annotationAdd BLAST | 239 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 100 – 126 | DisorderedSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG4216, Eukaryota |
GeneTreei | ENSGT00940000157387 |
HOGENOMi | CLU_007368_2_0_1 |
InParanoidi | F1LZZ3 |
OMAi | VRKQTCS |
OrthoDBi | 583704at2759 |
Family and domain databases
CDDi | cd06968, NR_DBD_ROR, 1 hit |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR044101, NR_DBD_ROR IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003079, ROR_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01293, RORNUCRECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F1LZZ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYFVIAAMKA QIEIIPCKIC GDKSSGIHYG VITCEGCKGF FRRSQQSNAT
60 70 80 90 100
YSCPRQKNCL IDRTSRNRCQ HCRLQKCLAV GMSRDAVKFG RMSKKQRDSL
110 120 130 140 150
YAEVQKHRMQ QQQRDHQQQP GEAEPLTPTY NISANGLTEL HDDLSTYMDG
160 170 180 190 200
HTPEGSKADS AVSSFYLDIQ PSPDQSGLDI NGIKPEPICD YTPASGFFPY
210 220 230 240 250
CSFTNGETSP TVSMAELEHL AQNISKSHLE TCQYLREELQ QITWQTFLQE
260 270 280 290 300
EIENYQNKQR EVMWQLCAIK ITEAIQYVVE FAKRIDGFME LCQNDQIVLL
310 320 330 340 350
KAGSLEVVFI RMCRAFDSQN NTVYFDGKYA SPDVFKSLGC EDFISFVFEF
360 370 380 390 400
GKSLCSMHLT EDEIALFSAF VLMSADRSWL QEKVKIEKLQ QKIQLALQHV
410 420 430 440 450
LQKNHREDGI LTKLICKVST LRALCGRHTE KLMAFKAIYP DIVRLHFPPL
460
YKELFTSEFE PAMQIDG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A8I6A803 | A0A8I6A803_RAT | RAR-related orphan receptor A | Rora | 523 | Annotation score: |
Sequence databases
RefSeqi | XP_008764632.1, XM_008766410.2 |
Genome annotation databases
Ensembli | ENSRNOT00000013142.8; ENSRNOP00000013142.7; ENSRNOG00000027145.7 |
GeneIDi | 300807 |
KEGGi | rno:300807 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_008764632.1, XM_008766410.2 |
3D structure databases
AlphaFoldDBi | F1LZZ3 |
SMRi | F1LZZ3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000013142 |
Proteomic databases
PaxDbi | F1LZZ3 |
Genome annotation databases
Ensembli | ENSRNOT00000013142.8; ENSRNOP00000013142.7; ENSRNOG00000027145.7 |
GeneIDi | 300807 |
KEGGi | rno:300807 |
Organism-specific databases
CTDi | 6095 |
RGDi | 1308419, Rora |
Phylogenomic databases
eggNOGi | KOG4216, Eukaryota |
GeneTreei | ENSGT00940000157387 |
HOGENOMi | CLU_007368_2_0_1 |
InParanoidi | F1LZZ3 |
OMAi | VRKQTCS |
OrthoDBi | 583704at2759 |
Enzyme and pathway databases
Reactomei | R-RNO-383280, Nuclear Receptor transcription pathway R-RNO-4090294, SUMOylation of intracellular receptors |
Gene expression databases
Bgeei | ENSRNOG00000027145, Expressed in skeletal muscle tissue and 20 other tissues |
Family and domain databases
CDDi | cd06968, NR_DBD_ROR, 1 hit |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR044101, NR_DBD_ROR IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003079, ROR_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01293, RORNUCRECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F1LZZ3_RAT | |
Accessioni | F1LZZ3Primary (citable) accession number: F1LZZ3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | July 22, 2015 | |
Last modified: | May 25, 2022 | |
This is version 87 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |