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Protein
Submitted name:

RAR-related orphan receptor A

Gene

Rora

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-4090294 SUMOylation of intracellular receptors

Names & Taxonomyi

Protein namesi
Submitted name:
RAR-related orphan receptor AImported
Gene namesi
Name:RoraImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1308419 Rora

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiF1LZZ3
PRIDEiF1LZZ3

Expressioni

Gene expression databases

BgeeiENSRNOG00000027145 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013142

Structurei

3D structure databases

ProteinModelPortaliF1LZZ3
SMRiF1LZZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 89Nuclear receptorInterPro annotationAdd BLAST76
Domaini216 – 454NR LBDInterPro annotationAdd BLAST239

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4216 Eukaryota
ENOG410XUGR LUCA
GeneTreeiENSGT00870000136388
InParanoidiF1LZZ3
OMAiYQNKPRE
OrthoDBiEOG091G0649

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003079 ROR_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01293 RORNUCRECPTR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

F1LZZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYFVIAAMKA QIEIIPCKIC GDKSSGIHYG VITCEGCKGF FRRSQQSNAT
60 70 80 90 100
YSCPRQKNCL IDRTSRNRCQ HCRLQKCLAV GMSRDAVKFG RMSKKQRDSL
110 120 130 140 150
YAEVQKHRMQ QQQRDHQQQP GEAEPLTPTY NISANGLTEL HDDLSTYMDG
160 170 180 190 200
HTPEGSKADS AVSSFYLDIQ PSPDQSGLDI NGIKPEPICD YTPASGFFPY
210 220 230 240 250
CSFTNGETSP TVSMAELEHL AQNISKSHLE TCQYLREELQ QITWQTFLQE
260 270 280 290 300
EIENYQNKQR EVMWQLCAIK ITEAIQYVVE FAKRIDGFME LCQNDQIVLL
310 320 330 340 350
KAGSLEVVFI RMCRAFDSQN NTVYFDGKYA SPDVFKSLGC EDFISFVFEF
360 370 380 390 400
GKSLCSMHLT EDEIALFSAF VLMSADRSWL QEKVKIEKLQ QKIQLALQHV
410 420 430 440 450
LQKNHREDGI LTKLICKVST LRALCGRHTE KLMAFKAIYP DIVRLHFPPL
460
YKELFTSEFE PAMQIDG
Length:467
Mass (Da):53,414
Last modified:July 22, 2015 - v3
Checksum:i5621E275EC282A54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07070578 Genomic DNA No translation available.
AABR07070579 Genomic DNA No translation available.
AABR07070580 Genomic DNA No translation available.
RefSeqiXP_008764632.1, XM_008766410.2
UniGeneiRn.39327

Genome annotation databases

EnsembliENSRNOT00000013142; ENSRNOP00000013142; ENSRNOG00000027145
GeneIDi300807

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07070578 Genomic DNA No translation available.
AABR07070579 Genomic DNA No translation available.
AABR07070580 Genomic DNA No translation available.
RefSeqiXP_008764632.1, XM_008766410.2
UniGeneiRn.39327

3D structure databases

ProteinModelPortaliF1LZZ3
SMRiF1LZZ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013142

Proteomic databases

PaxDbiF1LZZ3
PRIDEiF1LZZ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013142; ENSRNOP00000013142; ENSRNOG00000027145
GeneIDi300807

Organism-specific databases

CTDi6095
RGDi1308419 Rora

Phylogenomic databases

eggNOGiKOG4216 Eukaryota
ENOG410XUGR LUCA
GeneTreeiENSGT00870000136388
InParanoidiF1LZZ3
OMAiYQNKPRE
OrthoDBiEOG091G0649

Enzyme and pathway databases

ReactomeiR-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-4090294 SUMOylation of intracellular receptors

Gene expression databases

BgeeiENSRNOG00000027145 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003079 ROR_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01293 RORNUCRECPTR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1LZZ3_RAT
AccessioniPrimary (citable) accession number: F1LZZ3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: November 7, 2018
This is version 70 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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