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Entry version 62 (29 Sep 2021)
Sequence version 3 (22 Jul 2015)
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Protein
Submitted name:

Angiomotin-like 1

Gene

Amotl1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-2028269, Signaling by Hippo

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Angiomotin-like 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Amotl1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
1305268, Amotl1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1LZQ6

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
F1LZQ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000008990, Expressed in skeletal muscle tissue and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000058333

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini616 – 821Angiomotin_CInterPro annotationAdd BLAST206

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni156 – 348DisorderedSequence analysisAdd BLAST193
Regioni385 – 417DisorderedSequence analysisAdd BLAST33
Regioni784 – 832DisorderedSequence analysisAdd BLAST49
Regioni851 – 967DisorderedSequence analysisAdd BLAST117

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili449 – 469Sequence analysisAdd BLAST21
Coiled coili480 – 500Sequence analysisAdd BLAST21
Coiled coili519 – 546Sequence analysisAdd BLAST28
Coiled coili561 – 581Sequence analysisAdd BLAST21
Coiled coili589 – 643Sequence analysisAdd BLAST55
Coiled coili681 – 701Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi181 – 226Polar residuesSequence analysisAdd BLAST46
Compositional biasi240 – 254Polar residuesSequence analysisAdd BLAST15
Compositional biasi256 – 271Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi278 – 296Polar residuesSequence analysisAdd BLAST19
Compositional biasi315 – 329Pro residuesSequence analysisAdd BLAST15
Compositional biasi389 – 415Polar residuesSequence analysisAdd BLAST27
Compositional biasi797 – 825Polar residuesSequence analysisAdd BLAST29
Compositional biasi863 – 896Polar residuesSequence analysisAdd BLAST34
Compositional biasi936 – 950Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the angiomotin family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVI5, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160158

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009937_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1LZQ6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009114, Angiomotin
IPR024646, Angiomotin_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12240, Angiomotin_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01807, ANGIOMOTIN

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1LZQ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRAKSRRGP CEPVLRAPPP ICYSPGSPAQ ILEDHAYFYP DLQLYSGRHE
60 70 80 90 100
APTLTVEANG GLRGKSVRNP CARDFSFHHF HTPQIPRRVL ECILEGKALS
110 120 130 140 150
CHTEVQLLTP GPSENLPQKH KKHKVTFSPT PGLAAVHLQQ LRDVWQPDLP
160 170 180 190 200
ASLLGYKMGS QGGSEEGVNT SFEKEDRNTQ TNMHNTLPTY RESPSVKHFS
210 220 230 240 250
NNQDTNKTQG WEDNQQQQQG QGPSSTLYYM FREVLXSQKS RTEGRPTVNR
260 270 280 290 300
ANSGQAHKDE ALKELKQGHV RSLSERIMQL SLERNGTKQH LPSSGNGKSF
310 320 330 340 350
KAGGEPSPAQ PVCKALDPRG PPPEYPFKTK PMKSPVSKNQ DHGLYYSDQH
360 370 380 390 400
PGVLHEMVKP YPAPQPARTE VAVLRYQPPP EYGVTSRPCQ LPFPSTVQQH
410 420 430 440 450
SPMSSQTSSI SGPLHSVSLP LPLPMSLAAP QPPPASPSQQ LGPDAFAIVE
460 470 480 490 500
RAQQMVEILT EENRVLHQEL QGCYDNADKL HKFEKELQSI SEAYESLVKS
510 520 530 540 550
TTKRESLDKA MRNKLEGEIR RLHDFNRDLR DRLETANRQL SSREYEGHED
560 570 580 590 600
KAAESHHMSQ NKEFLKEKEK LEMELAAVRT ASEDHRRHIE ILDQALSNAQ
610 620 630 640 650
ARVIKLEEEL REKQAYVEKV EKLQQALTQL QSACEKRGQM ERRLRTWLER
660 670 680 690 700
ELDALRTQQK HGNGQPVNLP EYNAPALMEL VREKEERILA LEADMTKWEQ
710 720 730 740 750
KYLEESTIRH FAMSAAAAAT AERDTTISNH SRNGSYGESS LEAHIWPEEE
760 770 780 790 800
EVVQANRRCQ DMEYTIKNLH AKIIEKDAMI KVLQQRSRKD AGKTDSSSLR
810 820 830 840 850
PARSVPSIAA ATGTHSRQTS LTSGQLAEDK KEEKTWKGSI GFLLGKEHQG
860 870 880 890 900
QASAPLLPAT PASALSPPTS TTSASSTHAK TGSKDSSTQT DKITELFWPS
910 920 930 940 950
MASLPSRGRL STAPSNSPVL KHPAAKGTVE KQENSPGHGK SSEHRGRVSS
960
LLQKPEFPDG EIMEVLI
Length:967
Mass (Da):108,078
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55BCC01704F01A87
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07069220 Genomic DNA No translation available.
AABR07069221 Genomic DNA No translation available.
AABR07069222 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000061616; ENSRNOP00000058333; ENSRNOG00000008990

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069220 Genomic DNA No translation available.
AABR07069221 Genomic DNA No translation available.
AABR07069222 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058333

PTM databases

PhosphoSitePlusiF1LZQ6

Proteomic databases

PaxDbiF1LZQ6

Genome annotation databases

EnsembliENSRNOT00000061616; ENSRNOP00000058333; ENSRNOG00000008990

Organism-specific databases

RGDi1305268, Amotl1

Phylogenomic databases

eggNOGiENOG502QVI5, Eukaryota
GeneTreeiENSGT00940000160158
HOGENOMiCLU_009937_1_0_1
InParanoidiF1LZQ6

Enzyme and pathway databases

ReactomeiR-RNO-2028269, Signaling by Hippo

Gene expression databases

BgeeiENSRNOG00000008990, Expressed in skeletal muscle tissue and 20 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR009114, Angiomotin
IPR024646, Angiomotin_C
PfamiView protein in Pfam
PF12240, Angiomotin_C, 1 hit
PRINTSiPR01807, ANGIOMOTIN

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1LZQ6_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1LZQ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: September 29, 2021
This is version 62 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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