Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 61 (08 May 2019)
Sequence version 2 (03 Apr 2013)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Ankyrin repeat domain 50

Gene

Ankrd50

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin repeat domain 50Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ankrd50Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Rat genome database

More...
RGDi
1311665 Ankrd50

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1LWB9

PeptideAtlas

More...
PeptideAtlasi
F1LWB9

PRoteomics IDEntifications database

More...
PRIDEi
F1LWB9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
F1LWB9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
F1LWB9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000010534 Expressed in 9 organ(s), highest expression level in lung

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000043031

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1LWB9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini495 – 1103ANK_REP_REGIONInterPro annotationAdd BLAST609
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati544 – 576ANKPROSITE-ProRule annotationAdd BLAST33
Repeati577 – 609ANKPROSITE-ProRule annotationAdd BLAST33
Repeati610 – 642ANKPROSITE-ProRule annotationAdd BLAST33
Repeati643 – 675ANKPROSITE-ProRule annotationAdd BLAST33
Repeati676 – 708ANKPROSITE-ProRule annotationAdd BLAST33
Repeati709 – 746ANKPROSITE-ProRule annotationAdd BLAST38
Repeati747 – 779ANKPROSITE-ProRule annotationAdd BLAST33
Repeati780 – 812ANKPROSITE-ProRule annotationAdd BLAST33
Repeati813 – 845ANKPROSITE-ProRule annotationAdd BLAST33
Repeati846 – 878ANKPROSITE-ProRule annotationAdd BLAST33
Repeati879 – 911ANKPROSITE-ProRule annotationAdd BLAST33
Repeati912 – 944ANKPROSITE-ProRule annotationAdd BLAST33
Repeati945 – 977ANKPROSITE-ProRule annotationAdd BLAST33
Repeati978 – 1010ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1011 – 1043ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1044 – 1076ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1077 – 1103ANKPROSITE-ProRule annotationAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
KOG4369 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155116

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1LWB9

KEGG Orthology (KO)

More...
KOi
K21440

Identification of Orthologs from Complete Genome Data

More...
OMAi
VLITYHA

Database of Orthologous Groups

More...
OrthoDBi
1073736at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 17 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1LWB9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNPWEEKVC KMAQTSLLQG KQFYCREWVF HKLQHCLQEK SSRCFSAANA
60 70 80 90 100
QSLVGDAGNN ASALSGKGAS WGVLLVGGPG SGKTALCTEL LWPSSPASLQ
110 120 130 140 150
RGLHRQALAF HFCKAQDSDT LCVGGFIRGL VAQICQSGLL QGYEDKLRDP
160 170 180 190 200
AVQSLLEPGE CERNPAEAFK RCVLLPLLGM KPPPQSLYLL VDSVDEGCNV
210 220 230 240 250
VEGEQTSPNL SGTVAELLAG HHEFFPPWLL LLCSARKQSR AVTKMFTGFR
260 270 280 290 300
KISLDDLRKA YIVKDVQQYI LHRLDQEEAL RQHLTKETAE TLNQLHIKSS
310 320 330 340 350
GCFLYLERVL DGVVENFIML REIRDIPGTL NGLYLWLCQR LFVRKQFAKV
360 370 380 390 400
QPILNVILAA CRPLTMTELY HAVWTKNMSL TLEDFQRKLD VLSKLLVDGL
410 420 430 440 450
GSTKILFHHS FAEWLLDVKH CTQKYLCNAA EGHRMLAMSY TCQARNLTPL
460 470 480 490 500
EAQEFALHLI NSNLQLEPAE LALWMIWNGT PVKDSLSTLI PKEQEVLQLL
510 520 530 540 550
IRAGAHVNSE DDRTSCIVRQ ALEREDSIRT LLDSGASVNQ CDSNGRTLLA
560 570 580 590 600
NAAYSGSLDV VNLLVSRGAD LEIEDTHGHT PLTLAARQGH TKVVNCLIGC
610 620 630 640 650
GANINHTDQD GWTALRSAAW GGHTEVVSAL LYAGVKVDCA DADSRTALRA
660 670 680 690 700
AAWGGHEDIV LNLLQHGAEV NKADNEGRTA LIAAAYMGHR EIVEHLLDHG
710 720 730 740 750
AEVNHEDVDG RTALSVAALC VPASKGHASV VSLLIDRGAE VDHCDKDGMT
760 770 780 790 800
PLLVAAYEGH VDVVDLLLEG GADVDHTDNN GRTPLLAAAS MGHASVVNTL
810 820 830 840 850
LFWGAAVDSI DSEGRTVLSI ASAQGNVEVV RTLLDRGLDE SHRDDAGWTP
860 870 880 890 900
LHMAAFEGHR LICEALIEQG ARTNEIDNDG RIPFILASQE GHYDCVQILL
910 920 930 940 950
ENKSNIDQRG YDGRNALRVA ALEGHRDIVE LLFSHGADVN YKDADGRPTL
960 970 980 990 1000
YILALENQLT MAEYFLENGA NVEASDAEGR TALHVSCWQG HVEMVRVLIA
1010 1020 1030 1040 1050
CHADVNAADN EKRSALQSAA WQGHVKVVQL LIEHGAVVDH TCNQGATALC
1060 1070 1080 1090 1100
IAAQEGHVDV VQVLLEHGAD PNHADQFGRT AMRVAAKNGH SQIIKLLEKY
1110 1120 1130 1140 1150
GASSLNGCSP SPVHTMEQKP PQSTPSKMQS LTIRSNSSGG TGGGDLQPSL
1160 1170 1180 1190 1200
RGLPNGPAHA FSSPSESPDS TVDRQKSSLS NNSLKSSKNS SLRTTSSTAT
1210 1220 1230 1240 1250
AQTVPIDSFH SLSFTEQIQQ HSLPRSRSRQ SVVSPSSTTQ SLGHSHNSPS
1260 1270 1280 1290 1300
SEFEWSQVKP SLKSTKSNKG GKSENSSKSG SAGKKAKQNN SSQPKVLEYE
1310 1320 1330 1340 1350
MTQFDKRGPV AKSGSSPPKQ MPAESQCKIM VPSSQDSNRA QPQFLIHQQG
1360 1370 1380 1390 1400
GEQKRRNGIM TNPNYHLQSN QVFLGRVSVP RTLQERGHQE VLEGFPPSET
1410 1420
ELNLKQALKL QIEGSDPSFN YKKETPL
Length:1,427
Mass (Da):155,594
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i647FE7D49469CEA6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07010136 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001178535.1, NM_001191606.1
XP_008759142.1, XM_008760920.2
XP_008759143.1, XM_008760921.2
XP_008759144.1, XM_008760922.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000045837; ENSRNOP00000043031; ENSRNOG00000010534

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
294988

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:294988

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07010136 Genomic DNA No translation available.
RefSeqiNP_001178535.1, NM_001191606.1
XP_008759142.1, XM_008760920.2
XP_008759143.1, XM_008760921.2
XP_008759144.1, XM_008760922.2

3D structure databases

SMRiF1LWB9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043031

PTM databases

iPTMnetiF1LWB9
PhosphoSitePlusiF1LWB9

Proteomic databases

PaxDbiF1LWB9
PeptideAtlasiF1LWB9
PRIDEiF1LWB9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045837; ENSRNOP00000043031; ENSRNOG00000010534
GeneIDi294988
KEGGirno:294988

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57182
RGDi1311665 Ankrd50

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
KOG4369 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000155116
InParanoidiF1LWB9
KOiK21440
OMAiVLITYHA
OrthoDBi1073736at2759

Gene expression databases

BgeeiENSRNOG00000010534 Expressed in 9 organ(s), highest expression level in lung

Family and domain databases

CDDicd00204 ANK, 6 hits
Gene3Di1.25.40.20, 6 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 5 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 17 hits
SUPFAMiSSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 17 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1LWB9_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1LWB9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: May 8, 2019
This is version 61 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again