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Entry version 76 (02 Jun 2021)
Sequence version 2 (22 Jul 2015)
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Protein

G2/mitotic-specific cyclin-B3

Gene

Ccnb3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclinUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B3ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ccnb3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Rat genome database

More...
RGDi
1564367, Ccnb3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000002951, Expressed in female gonad and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000003954

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1175 – 1206Cyclin N-terminalInterPro annotationAdd BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 45DisorderedSequence analysisAdd BLAST45
Regioni313 – 394DisorderedSequence analysisAdd BLAST82
Regioni430 – 450DisorderedSequence analysisAdd BLAST21
Regioni462 – 502DisorderedSequence analysisAdd BLAST41
Regioni613 – 634DisorderedSequence analysisAdd BLAST22
Regioni651 – 671DisorderedSequence analysisAdd BLAST21
Regioni765 – 784DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 29Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi30 – 45Polar residuesSequence analysisAdd BLAST16
Compositional biasi313 – 337Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi364 – 381Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi462 – 478Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0653, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160459

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006366_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1LVT0

Identification of Orthologs from Complete Genome Data

More...
OMAi
HMKKPLV

Database of Orthologous Groups

More...
OrthoDBi
993640at2759

TreeFam database of animal gene trees

More...
TreeFami
TF101001

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00043, CYCLIN, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR015452, Cyclin_B3
IPR004367, Cyclin_C-dom
IPR006671, Cyclin_N

The PANTHER Classification System

More...
PANTHERi
PTHR10177, PTHR10177, 1 hit
PTHR10177:SF214, PTHR10177:SF214, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00385, CYCLIN, 2 hits
SM01332, Cyclin_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47954, SSF47954, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00292, CYCLINS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1LVT0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPKRSKLET EKPQSIKITP REEQQSEKIG KSNHTASASS QGTIKKRSAF
60 70 80 90 100
EDVTNASYVQ CVQPKEDNTE LKSHISKRTR KGVGEITQKK IKSSKLGHVT
110 120 130 140 150
SLSNVEKEFI LDIPNKPKTL TTEEPPVFPK TLVLNEQHAT EETSLMRKTL
160 170 180 190 200
KSCAFYQETF LMEKPQTLLE KTKDYKEFDS ELMTSRRKDK PEEATIIEEM
210 220 230 240 250
TDLKEPDLGK VTLTSSPLYL KNKHAVQEEK HAIQGKSSFK KKSLAMKVVT
260 270 280 290 300
TKENSPVKKP HFRKKKPTTE LKSLLQEQSS LQEKYNTQGD ASILKKPRVL
310 320 330 340 350
QKNINNKVDT LTEPVTLKRK HSTNEAIHTK KLSSSKNNHD TQGKGTNLRP
360 370 380 390 400
LGVQPVTHEN EPLSSKKSTT KKKDSHFHGP SVLPDKHSPQ MKVSTAKNSL
410 420 430 440 450
ALQNPTTEEM MLHFPVAPVL KMGQNMEEAP CLKKPSPLRK QQQLPKRSRS
460 470 480 490 500
FSKCAVQETV TSKSLSFKKS NTKKDPSFQG PFALQKKRNS PGKLSKQKKR
510 520 530 540 550
YVPPKHCMEK DSHFQLDSAF KKQHIREEPA STHKPLILEM QQTTKGTEFR
560 570 580 590 600
LRNPLVLPTV TSGTKSLTKE PPSFKKENTP LLKRKCATHT ITLQQAQLEL
610 620 630 640 650
EETTGEDRNL FSTRPELHKK EPTPGLLQDP LPQNENCLIP QQLSFSMPLD
660 670 680 690 700
SQKITSQERA HSKESVTSND DNNFFSQDLF SPFSSTDEDT LKFHKSLDFQ
710 720 730 740 750
EKVDRKNDSP TKMSDSQDSV SEEESFLRKL FCKGRHSSSE ESSQERPVAL
760 770 780 790 800
EQEFLLKKVL NENTSSDVEG PLSHQSPHIQ NHSGTTKEAL EALDALEALD
810 820 830 840 850
ALEALEASET LEALEALEAS GALEEPLNIQ EELSSEDIVA IMKSLITEDE
860 870 880 890 900
SIKEAFIRSY TTATEAPAEK SLSLEETSIN EVATLKEPLS SQEKHRAELV
910 920 930 940 950
TVLKELLVLV KNPRLERLAL AFQENPPSNV ETLLREVLAL VEKSTGEEST
960 970 980 990 1000
LNEPLALQEK LSTKAELSPK ELLALEDNPS FKKASPQGSL TFDHKPDIEK
1010 1020 1030 1040 1050
DEITRMSFSF EEFSIDSLYE KVLALSEGFT TTEQLSFTDL QNFDESKIVD
1060 1070 1080 1090 1100
EEDIFKSFFV FENENNPNLS SNGFESRKDN SSAPMPSLEA FNSVMNSEPC
1110 1120 1130 1140 1150
VSATKSSQSS LGGKETEVII LDDSDTQESF VKEDSDLLLS STYAKNIFIY
1160 1170 1180 1190 1200
LKEREEKFIV TKYMDEQMEL TSDMRAILVD WMVEVQANFR MSHETLYLAV
1210 1220 1230 1240 1250
KLMDRYLMKA QCEKNHLQLL GSTAYMIAAK FEESYPPSLT EFLYICEDLY
1260 1270 1280 1290 1300
PKSEMVSLER NILKTLNFDI NIPIAYHFLR RYASCIHASM KTLTLSRFIC
1310 1320 1330 1340 1350
EMTLQEYDYI DERPSKLAAA SFILALYMRN LKDCVPSLEY STGYQLAELH
1360 1370 1380 1390 1400
ILVRKLNHLL NFRSRTVLKN VFEKYSEETY FEVAKIPPLS MKDLEDLLNC

ALFS
Length:1,404
Mass (Da):159,338
Last modified:July 22, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F0503D6C2FDE89C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07037213 Genomic DNA No translation available.
AABR07037214 Genomic DNA No translation available.
AABR07037215 Genomic DNA No translation available.
AABR07037216 Genomic DNA No translation available.
AABR07037217 Genomic DNA No translation available.
HQ634292 mRNA Translation: ADX01544.1

NCBI Reference Sequences

More...
RefSeqi
XP_001064448.1, XM_001064448.3
XP_017443666.1, XM_017588177.1
XP_017443667.1, XM_017588178.1
XP_017457747.1, XM_017602258.1
XP_017457748.1, XM_017602259.1
XP_228779.4, XM_228779.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000003954; ENSRNOP00000003954; ENSRNOG00000002951

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
317389

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:317389

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07037213 Genomic DNA No translation available.
AABR07037214 Genomic DNA No translation available.
AABR07037215 Genomic DNA No translation available.
AABR07037216 Genomic DNA No translation available.
AABR07037217 Genomic DNA No translation available.
HQ634292 mRNA Translation: ADX01544.1
RefSeqiXP_001064448.1, XM_001064448.3
XP_017443666.1, XM_017588177.1
XP_017443667.1, XM_017588178.1
XP_017457747.1, XM_017602258.1
XP_017457748.1, XM_017602259.1
XP_228779.4, XM_228779.6

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003954

Genome annotation databases

EnsembliENSRNOT00000003954; ENSRNOP00000003954; ENSRNOG00000002951
GeneIDi317389
KEGGirno:317389

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85417
RGDi1564367, Ccnb3

Phylogenomic databases

eggNOGiKOG0653, Eukaryota
GeneTreeiENSGT00940000160459
HOGENOMiCLU_006366_0_0_1
InParanoidiF1LVT0
OMAiHMKKPLV
OrthoDBi993640at2759
TreeFamiTF101001

Gene expression databases

BgeeiENSRNOG00000002951, Expressed in female gonad and 5 other tissues

Family and domain databases

CDDicd00043, CYCLIN, 2 hits
InterProiView protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR015452, Cyclin_B3
IPR004367, Cyclin_C-dom
IPR006671, Cyclin_N
PANTHERiPTHR10177, PTHR10177, 1 hit
PTHR10177:SF214, PTHR10177:SF214, 1 hit
PfamiView protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385, CYCLIN, 2 hits
SM01332, Cyclin_C, 1 hit
SUPFAMiSSF47954, SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292, CYCLINS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1LVT0_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1LVT0
Secondary accession number(s): K7NAQ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: June 2, 2021
This is version 76 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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