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Entry version 71 (31 Jul 2019)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

Early endosome antigen 1

Gene

Eea1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1352 – 1410FYVE-typePROSITE-ProRule annotationAdd BLAST59

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Early endosome antigen 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Eea1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Rat genome database

More...
RGDi
1310167 Eea1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
F1LUA1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1LUA1

PRoteomics IDEntifications database

More...
PRIDEi
F1LUA1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000021681 Expressed in 9 organ(s), highest expression level in adult mammalian kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1LUA1 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000029575

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1LUA1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 69C2H2-typeInterPro annotationAdd BLAST29
Domaini1352 – 1410FYVE-typeInterPro annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni476 – 501DisorderedSequence analysisAdd BLAST26
Regioni1195 – 1218DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili78 – 98Sequence analysisAdd BLAST21
Coiled coili130 – 199Sequence analysisAdd BLAST70
Coiled coili241 – 275Sequence analysisAdd BLAST35
Coiled coili283 – 310Sequence analysisAdd BLAST28
Coiled coili346 – 408Sequence analysisAdd BLAST63
Coiled coili563 – 650Sequence analysisAdd BLAST88
Coiled coili662 – 840Sequence analysisAdd BLAST179
Coiled coili887 – 1002Sequence analysisAdd BLAST116
Coiled coili1014 – 1034Sequence analysisAdd BLAST21
Coiled coili1042 – 1164Sequence analysisAdd BLAST123
Coiled coili1264 – 1347Sequence analysisAdd BLAST84

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1352 – 1410FYVE-typePROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFA7 Eukaryota
ENOG4111F3Q LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156910

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1LUA1

Database for complete collections of gene phylogenies

More...
PhylomeDBi
F1LUA1

TreeFam database of animal gene trees

More...
TreeFami
TF329698

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013087 Znf_C2H2_type
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01363 FYVE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00064 FYVE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50178 ZF_FYVE, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1LUA1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
IFLSSLFQTP GRVGSQGSDL DSSATPINTV DVNNESSSEG FICPQCMKSL
60 70 80 90 100
GSADELFKHY QAVHDAGNDS GHGGEASLAL TRDDIALLRQ EVQDLQASLK
110 120 130 140 150
EEKWYSEELK KELEKYQGLQ QQEAKSDGLV TDSSAELQSL EQQLEEAQTE
160 170 180 190 200
NFNIKQMKDL FEQKAAQLAT EIADIKSKYD EEKGLRAAAE QKATHLTEEL
210 220 230 240 250
SKQTTVIQDL KTELLQRPGI EDVAVLKKEL VQVQTLMDNM TLERERESEK
260 270 280 290 300
LKDECKKLQS EHANSEATIN QLRSELAKGP QEVAVYVQEI QKLKGSVNEL
310 320 330 340 350
TQKSQTLMEK LQKKDLDYTH LEEKHNEEAL SRKNTQAALH QRDLDCQQLQ
360 370 380 390 400
ARLTASEGSL QRIQGELREK GEAAQKLKEE LREVETKHQH LKVEFKQLQQ
410 420 430 440 450
QREEKEQHGL QLQGEVSQLH SKLLETERQL GEAHGRLKEQ RQLSSEKLMD
460 470 480 490 500
KEQQVADLQL KLSRLEEQLK EKVTNSTELQ HQLEKSKQQH QEQQALQQST
510 520 530 540 550
TAKLREAQND LEQVLRQIGD KDQKIQNLEA LLQKSKENIS LLEKEREDLY
560 570 580 590 600
AKIQAGEGET AVLNQLQEKN HALQQQLTQL MEKLKNQSES HKQAEENLHD
610 620 630 640 650
QVQEQKAHLR AAQDRVLSLE TSVSELSSQL NESKEKVSQL DIQIKAKTEL
660 670 680 690 700
LLSAEAAKTA QRADLQNHLD TAQNALQDKQ QELNKVSAQL DQVTAKFQEK
710 720 730 740 750
QEHCTQLESH LKDYKEKHLS LEQKAEDLEG QIKKLEANNL EVKASREQAV
760 770 780 790 800
QSLQQQRQLS TDLELRNAEL RKQLQEQKEV VSHTKLDLQN KSEALENIKQ
810 820 830 840 850
TLTKKEEEKV VLKQEFEKLS QDSEAQHKEL SDRMQAAITE LMVMTAQKDA
860 870 880 890 900
LLAELSTTKG KLSKVSDSLQ TSRSEFEKES QKGKAAVLDL EKACKELKHQ
910 920 930 940 950
LQQQTESALK EQSELKKSLE KERETSQQLM IELNSVKGEV TQAQNTLKQK
960 970 980 990 1000
EKEEQQLQGN INQLKQATEQ KKKQMEALQG ELKNVTSQKA QLESKLQQQA
1010 1020 1030 1040 1050
AQAAQELAVE KGKLSALQST YDKCQADLQQ LQSDLYGKES ELLATRQDLK
1060 1070 1080 1090 1100
CVEEKLALAQ EDLISNRNQI GNQNKSIQEL QAAKAALEQD LAKKEEVLKE
1110 1120 1130 1140 1150
QSKALQDAQR EKSVKEKELV TEKSKLAEME EIKCRQEKEI AKLKEELKSH
1160 1170 1180 1190 1200
KQESIKEVTN LKDAKQLLIQ QKLELQGKVD SLKAALEQEK ERQQLMREQM
1210 1220 1230 1240 1250
RKEEEKRKEE FSEKEAKLHS EIKEKEAGVK KHEENEAKLT MQVTTLNENL
1260 1270 1280 1290 1300
GTVKKEWQSS QRRVSELEKQ TDDLRGEIAV LEATVQNNQD ERRALLERCL
1310 1320 1330 1340 1350
KGEGEIEKLQ TKVLELQRKL DNTTAAVQEL GRENQSLQIK HTQALNRKWA
1360 1370 1380 1390 1400
EDNEVQNCMS CGKCFSVTVR RHHCRQCGNI FCAECSAKNA LTPSSKKPVR
1410
VCDACFNDLQ G
Length:1,411
Mass (Da):161,106
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6611A38755CD350
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K051A0A0G2K051_RAT
Early endosome antigen 1
Eea1
1,449Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07056691 Genomic DNA No translation available.
AABR07056692 Genomic DNA No translation available.
AABR07056693 Genomic DNA No translation available.
AABR07056694 Genomic DNA No translation available.
AABR07056695 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000029764; ENSRNOP00000029575; ENSRNOG00000021681

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07056691 Genomic DNA No translation available.
AABR07056692 Genomic DNA No translation available.
AABR07056693 Genomic DNA No translation available.
AABR07056694 Genomic DNA No translation available.
AABR07056695 Genomic DNA No translation available.

3D structure databases

SMRiF1LUA1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029575

Proteomic databases

jPOSTiF1LUA1
PaxDbiF1LUA1
PRIDEiF1LUA1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000029764; ENSRNOP00000029575; ENSRNOG00000021681

Organism-specific databases

RGDi1310167 Eea1

Phylogenomic databases

eggNOGiENOG410IFA7 Eukaryota
ENOG4111F3Q LUCA
GeneTreeiENSGT00940000156910
InParanoidiF1LUA1
PhylomeDBiF1LUA1
TreeFamiTF329698

Gene expression databases

BgeeiENSRNOG00000021681 Expressed in 9 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiF1LUA1 baseline and differential

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR013087 Znf_C2H2_type
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50178 ZF_FYVE, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1LUA1_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1LUA1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: July 31, 2019
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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