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Entry version 68 (26 Feb 2020)
Sequence version 2 (22 Jul 2015)
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Protein
Submitted name:

FYVE, RhoGEF and PH domain-containing 5

Gene

Fgd5

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1304 – 1357FYVE-typePROSITE-ProRule annotationAdd BLAST54

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FYVE, RhoGEF and PH domain-containing 5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fgd5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Rat genome database

More...
RGDi
1305589 Fgd5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1LTE6

PRoteomics IDEntifications database

More...
PRIDEi
F1LTE6

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
F1LTE6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000010213 Expressed in lung and 8 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000040013

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1LTE6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini947 – 1140DHInterPro annotationAdd BLAST194
Domaini1169 – 1263PHInterPro annotationAdd BLAST95
Domaini1304 – 1357FYVE-typeInterPro annotationAdd BLAST54
Domaini1420 – 1518PHInterPro annotationAdd BLAST99

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 70DisorderedSequence analysisAdd BLAST70
Regioni110 – 242DisorderedSequence analysisAdd BLAST133
Regioni257 – 411DisorderedSequence analysisAdd BLAST155
Regioni638 – 667DisorderedSequence analysisAdd BLAST30
Regioni726 – 745DisorderedSequence analysisAdd BLAST20
Regioni886 – 944DisorderedSequence analysisAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi23 – 42PolarSequence analysisAdd BLAST20
Compositional biasi116 – 164PolyampholyteSequence analysisAdd BLAST49
Compositional biasi193 – 212PolyampholyteSequence analysisAdd BLAST20
Compositional biasi224 – 239PolyampholyteSequence analysisAdd BLAST16
Compositional biasi283 – 317PolarSequence analysisAdd BLAST35
Compositional biasi335 – 351PolyampholyteSequence analysisAdd BLAST17
Compositional biasi366 – 380PolyampholyteSequence analysisAdd BLAST15
Compositional biasi396 – 411PolarSequence analysisAdd BLAST16
Compositional biasi642 – 667PolarSequence analysisAdd BLAST26
Compositional biasi727 – 743PolarSequence analysisAdd BLAST17

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1304 – 1357FYVE-typePROSITE-ProRule annotationAdd BLAST54

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4424 Eukaryota
ENOG410XRXV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157922

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004088_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1LTE6

Identification of Orthologs from Complete Genome Data

More...
OMAi
EDSGPWA

Database of Orthologous Groups

More...
OrthoDBi
652460at2759

TreeFam database of animal gene trees

More...
TreeFami
TF343077

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 2 hits
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS50178 ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1LTE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHRADSPKPP VAPKPKVTTN PSTPPAKFPA SQRPNSFPSP NSMSRGPKPP
60 70 80 90 100
IAPKPRLAGP SEYGAGVYLN NSLSKCSNGR LLCEDPSLYD GHHSTLNCLE
110 120 130 140 150
LETDEQYIMV PRAPQRDDAL TDRATEKQGF EGEAQEHGTE QTGTERDLAA
160 170 180 190 200
PDEEAPSRDS EEGVDHALED EEDCDHDLET DGTPTAPGEG APSRDGEKGE
210 220 230 240 250
EDCGQDPGVE EHPMSEEEGE EEEAKECVHN RDDRAPWDGG EPFLNEVVLT
260 270 280 290 300
HVCSQSPEVP CWEPGLPETP GEVDEDSEDI CNNTELGKPN QDTGQDTEDA
310 320 330 340 350
SMGSPESEVS PDVQEQEAAT DSPEVFEEDS VDAAEGEDQI ARDEPPNCEE
360 370 380 390 400
DTNNRETAAA TMQAGEDHGE DGDRVQEDPA EENCQIIPFE SDSVEEDCSP
410 420 430 440 450
TLTENPYELF PTESTSFCNN SGSLAESDKG QESVCKICVE EVPGIGPSLS
460 470 480 490 500
QGDSLQDGSG EEAPVPEVVV VPENEDPMDD ALSSPYVMGV GLLSLGEGAQ
510 520 530 540 550
SDTQAASGTL SGYSTWEEGD SDGGQVPVDR KNIATRARPH SGKVAGHVPE
560 570 580 590 600
TVLEETGPEA CSSAMGIRDT GDEVRKIGIL PEGKPSESLR ALPAKPRAFT
610 620 630 640 650
LYPRSFSVEG RESPLSMFRE PEGAGLDMHR VRRKEDNLSL PGAIGSSGSF
660 670 680 690 700
SQRSHLPSSG TSTPSSVVDI PPPFDLACIT KRPITKSSPS LLIDGDTLEK
710 720 730 740 750
ASKKKKSSFK RFLELTFRKK TESKVHVDMS LSSSRSSSES SYHGPARVLE
760 770 780 790 800
LDRRSLSNSP QLKCHTGKLR ASDSPASLIF YRDSKRKGVP FSRTVSRVES
810 820 830 840 850
FEDRSRPPFL PLPLTKPRSI SFPNADTSDY ENIPAMNSDY ENIQIPPRRP
860 870 880 890 900
ARTGTFTKLF EEQSRALSTA NENDGYVDMS SFNAFESKQQ SSEQEAESAY
910 920 930 940 950
TEPYKVCPIS TTPKEDLTSD EEQGSSEEED NASRDPSLSH KGEGQSRAFV
960 970 980 990 1000
IAQELLSSEK AYVQMLQHLS LDFHGAVLRA LENVEQEGRE PLAQEELRQG
1010 1020 1030 1040 1050
LRELPAICDL HQGILESLEQ RLGDCGEGQQ QVADIFLARE QEFEHHAAHI
1060 1070 1080 1090 1100
LQFDRYLGLL AESCLLSPRL ATTVREFEQS SQGGGQSMKH RMLRVVQRLF
1110 1120 1130 1140 1150
QYQVLLTDYL NNLCPDSAEY DNTQSALNLI SKVTDRANES MEQGENLQKL
1160 1170 1180 1190 1200
VHIEYSVRGQ GDLLQPGREF LKEGTLMRVR GKSRHPRHLF LMNDTLLYTH
1210 1220 1230 1240 1250
PQKDGKYRLK SSLPVANMKV SRPVMDKVPY ALKIETPESC LTLSASSCAE
1260 1270 1280 1290 1300
RDEWHYCLSR ALPEDYKTQA LAAFHHSVEI RERLGISLGE RLPTLVPVTH
1310 1320 1330 1340 1350
AMMCMNCGCD FSLTVRRHHC HACGKIVCRN CSRNKYPLKC LKNRMAKVCD
1360 1370 1380 1390 1400
GCFRELKLRN GPVPGPIRER PVSMSFPLSS SRFSSGSTFS SVFQSISPST
1410 1420 1430 1440 1450
FKKQKKVPSA LAEVAASGEG SAISGYLSRC KSGKRRWKKL WLVIKGKVLY
1460 1470 1480 1490 1500
TYLASEDKVA MESIPLLGFT IAPEKEEGSS EVGPVFHLYH KKTLFYSFKA
1510
EDSSSAQRWM EAMEDASVL
Length:1,519
Mass (Da):167,193
Last modified:July 22, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE04DA1C0A13C9A03
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07073048 Genomic DNA No translation available.
AC110333 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_006225056.1, XM_006224994.3
XP_006236988.1, XM_006236926.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000051022; ENSRNOP00000040013; ENSRNOG00000010213

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
362402

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07073048 Genomic DNA No translation available.
AC110333 Genomic DNA No translation available.
RefSeqiXP_006225056.1, XM_006224994.3
XP_006236988.1, XM_006236926.3

3D structure databases

SMRiF1LTE6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040013

PTM databases

PhosphoSitePlusiF1LTE6

Proteomic databases

PaxDbiF1LTE6
PRIDEiF1LTE6

Genome annotation databases

EnsembliENSRNOT00000051022; ENSRNOP00000040013; ENSRNOG00000010213
GeneIDi362402

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
152273
RGDi1305589 Fgd5

Phylogenomic databases

eggNOGiKOG4424 Eukaryota
ENOG410XRXV LUCA
GeneTreeiENSGT00940000157922
HOGENOMiCLU_004088_1_0_1
InParanoidiF1LTE6
OMAiEDSGPWA
OrthoDBi652460at2759
TreeFamiTF343077

Gene expression databases

BgeeiENSRNOG00000010213 Expressed in lung and 8 other tissues

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 2 hits
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS50178 ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1LTE6_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1LTE6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: February 26, 2020
This is version 68 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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