Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 70 (02 Dec 2020)
Sequence version 2 (03 Apr 2013)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

WD repeat domain 33

Gene

Wdr33

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • mRNA polyadenylation Source: GO_Central

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-RNO-72163, mRNA Splicing - Major Pathway
R-RNO-72187, mRNA 3'-end processing
R-RNO-73856, RNA Polymerase II Transcription Termination
R-RNO-77595, Processing of Intronless Pre-mRNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
WD repeat domain 33Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Wdr33Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Rat genome database

More...
RGDi
1309230, Wdr33

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1LT09

PRoteomics IDEntifications database

More...
PRIDEi
F1LT09

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
F1LT09

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
F1LT09

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000011382, Expressed in thymus and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000017075

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1LT09

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini115 – 412WD_REPEATS_REGIONInterPro annotationAdd BLAST298
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati157 – 189WDPROSITE-ProRule annotationAdd BLAST33
Repeati198 – 230WDPROSITE-ProRule annotationAdd BLAST33
Repeati240 – 266WDPROSITE-ProRule annotationAdd BLAST27
Repeati284 – 325WDPROSITE-ProRule annotationAdd BLAST42
Repeati327 – 361WDPROSITE-ProRule annotationAdd BLAST35
Repeati371 – 402WDPROSITE-ProRule annotationAdd BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni566 – 1331DisorderedSequence analysisAdd BLAST766

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili522 – 551Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi570 – 610PolarSequence analysisAdd BLAST41
Compositional biasi705 – 729Pro-richSequence analysisAdd BLAST25
Compositional biasi736 – 750Pro-richSequence analysisAdd BLAST15
Compositional biasi874 – 897PolarSequence analysisAdd BLAST24
Compositional biasi961 – 976PolyampholyteSequence analysisAdd BLAST16
Compositional biasi990 – 1036PolyampholyteSequence analysisAdd BLAST47
Compositional biasi1072 – 1113PolyampholyteSequence analysisAdd BLAST42
Compositional biasi1131 – 1148PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1166 – 1208PolyampholyteSequence analysisAdd BLAST43
Compositional biasi1231 – 1250PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1272 – 1287PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1292 – 1322PolarSequence analysisAdd BLAST31

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, WD repeatPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0284, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111130

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_77_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1LT09

Identification of Orthologs from Complete Genome Data

More...
OMAi
GPPQGSM

Database of Orthologous Groups

More...
OrthoDBi
604979at2759

TreeFam database of animal gene trees

More...
TreeFami
TF317659

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400, WD40, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082, WD_REPEATS_2, 6 hits
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1LT09-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATEIGSPPR FFHMPRFQHQ APRQLFYKRP DFAQQQAMQQ LTFDGKRMRK
60 70 80 90 100
AVNRKTIDYN PSVIKYLENR IWQRDQRDMR AIQPDAGYYN DLVPPIGMLN
110 120 130 140 150
NPMNAVTTKF VRTSTNKVKC PVFVVRWTPE GRRLVTGASS GEFTLWNGLT
160 170 180 190 200
FNFETILQAH DSPVRAMTWS HNDMWMLTAD HGGYVKYWQS NMNNVKMFQA
210 220 230 240 250
HKEAIREASF SPTDNKFATC SDDGTVRIWD FLRCHEERIL RGHGADVKCV
260 270 280 290 300
DWHPTKGLVV SGSKDSQQPI KFWDPKTGQS LATLHAHKNT VMEVKLNLNG
310 320 330 340 350
NWLLTASRDH LCKLFDIRNL KEELQVFRGH KKEATAVAWH PVHEGLFASG
360 370 380 390 400
GSDGSLLFWH VGVEKEVGGM EMAHEGMIWS LAWHPLGHIL CSGSNDHTSK
410 420 430 440 450
FWTRNRPGDK MRDRYNLNLL PGMSEDGVEY DDLEPNSLAV IPGMGIPEQL
460 470 480 490 500
KLAMEQEQMG KDESNDIEMT IPGLDWGMEE VMQKDQKKVP QKKVPYAKPI
510 520 530 540 550
PAQFQQAWMQ NKVPIPAPNE VLNDRKEDIK LEEKKKTQAE IEQEMATLQY
560 570 580 590 600
TNPQLLEQLK IERLAQKQAD QIQPPPSSGT PLLGPQPFSG QGPMSQIPQG
610 620 630 640 650
FQQPHPSQQM PLVAQMGPPG PQGQFRAPGP QGQMGPQGPP LHQGGGGPQG
660 670 680 690 700
FMGPQGPQGP PQGLPRPQDM HGPQGMQRHP GPHGPLGPQG PPGPQGSSGP
710 720 730 740 750
QGHMGPQGPP GPQGHIGPQG PPAPQGHMGP QGPPGTQGMQ GPPGPRGMQG
760 770 780 790 800
PPHPHGIQGG PTSQGIQGPL MGLNPRGMQG PPGPRENQGP APQGIMIGHP
810 820 830 840 850
PQEMRGPHPP SGLLGHGPQE MRGPQEMRGM QGPPPQGSML GPPQELRGPS
860 870 880 890 900
GSQGQQGPPQ GSLGPPPQGG MQGPPGPQGQ QNPARGPHPS QGPIPFQQQK
910 920 930 940 950
APLLGDGPRA PFNQEGQSTG PPPLIPGLGQ QGAQGRIPPL NPGQGPGPNK
960 970 980 990 1000
GDSRGPPNHH LGPMSERRHE QSGGPEHGPD RGPFRGGQDC RGPPDRRGSH
1010 1020 1030 1040 1050
PDFPDDFSRP DDFHPDKRFG HRLREFEGRG GPLPQEEKWR RGGPGPPFPP
1060 1070 1080 1090 1100
DHREFNEGDG RGAARGPPGA WEGRRPGDER FPRDPDDPRF RGRREESFRR
1110 1120 1130 1140 1150
GAPPRHEGRA PPRGRDNFPG PDDFGPEEVF DASDEAARGR DLRGRGRGTP
1160 1170 1180 1190 1200
RGGSRKCLLP TPDEFPRFEG GRKPDSWDGN REPGPGHEHF RDAPRPDHPP
1210 1220 1230 1240 1250
HDGHSPASRE RSSSLQGMDM ASLPPRKRPW HDGSGTSEHR EMEAQGGPSE
1260 1270 1280 1290 1300
DRGSKGRGGP GPSQRVPKSG RSSSLDGDHH DGYHRDEPFG GPPGSSSSSR
1310 1320 1330
GGRSGSNWGR GSNMNSGPPR RGTSRGSGRG R
Length:1,331
Mass (Da):145,409
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6094D216486BDF96
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07031669 Genomic DNA No translation available.
AABR07031670 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001100868.2, NM_001107398.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000017075; ENSRNOP00000017075; ENSRNOG00000011382

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
307524

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:307524

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07031669 Genomic DNA No translation available.
AABR07031670 Genomic DNA No translation available.
RefSeqiNP_001100868.2, NM_001107398.2

3D structure databases

SMRiF1LT09
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017075

PTM databases

iPTMnetiF1LT09
PhosphoSitePlusiF1LT09

Proteomic databases

PaxDbiF1LT09
PRIDEiF1LT09

Genome annotation databases

EnsembliENSRNOT00000017075; ENSRNOP00000017075; ENSRNOG00000011382
GeneIDi307524
KEGGirno:307524

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55339
RGDi1309230, Wdr33

Phylogenomic databases

eggNOGiKOG0284, Eukaryota
GeneTreeiENSGT00730000111130
HOGENOMiCLU_000288_77_3_1
InParanoidiF1LT09
OMAiGPPQGSM
OrthoDBi604979at2759
TreeFamiTF317659

Enzyme and pathway databases

ReactomeiR-RNO-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-RNO-72163, mRNA Splicing - Major Pathway
R-RNO-72187, mRNA 3'-end processing
R-RNO-73856, RNA Polymerase II Transcription Termination
R-RNO-77595, Processing of Intronless Pre-mRNAs

Gene expression databases

BgeeiENSRNOG00000011382, Expressed in thymus and 21 other tissues

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400, WD40, 5 hits
SMARTiView protein in SMART
SM00320, WD40, 7 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082, WD_REPEATS_2, 6 hits
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1LT09_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1LT09
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: December 2, 2020
This is version 70 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again