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Protein
Submitted name:

Ubiquitin-like modifier-activating enzyme 2

Gene

Uba2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei2ATPUniRule annotation1
Binding sitei26ATPUniRule annotation1
Metal bindingi112ZincUniRule annotation1
Metal bindingi115ZincUniRule annotation1
Active sitei127Glycyl thioester intermediateUniRule annotation1
Metal bindingi394ZincUniRule annotation1
Metal bindingi397ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 13ATPUniRule annotation4
Nucleotide bindingi49 – 50ATPUniRule annotation2
Nucleotide bindingi71 – 76ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-3065676 SUMO is conjugated to E1 (UBA2:SAE1)
R-RNO-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin-like modifier-activating enzyme 2Imported
Gene namesi
Name:Uba2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1312023 Uba2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)UniRule annotation
Cross-linki144Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)UniRule annotation
Cross-linki190Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)UniRule annotation
Cross-linki211Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)UniRule annotation
Cross-linki373Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)UniRule annotation
Cross-linki578Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)UniRule annotation

Proteomic databases

PaxDbiF1LS72
PeptideAtlasiF1LS72
PRIDEiF1LS72

Expressioni

Gene expression databases

BgeeiENSRNOG00000021113 Expressed in 9 organ(s), highest expression level in spleen

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028672

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 394ThiFInterPro annotationAdd BLAST394
Domaini405 – 490UAE_UbLInterPro annotationAdd BLAST86
Domaini502 – 590UBA2_CInterPro annotationAdd BLAST89

Phylogenomic databases

eggNOGiKOG2013 Eukaryota
COG0476 LUCA
GeneTreeiENSGT00550000074924
InParanoidiF1LS72
OMAiYPGCTIR
OrthoDBiEOG091G07PV
TreeFamiTF300765

Family and domain databases

Gene3Di1.10.10.520, 1 hit
InterProiView protein in InterPro
IPR000594 ThiF_NAD_FAD-bd
IPR028077 UAE_UbL_dom
IPR023318 Ub_act_enz_dom_a_sf
IPR030661 Uba2
IPR032426 UBA2_C
IPR035985 Ubiquitin-activating_enz
IPR018074 UBQ-activ_enz_E1_CS
IPR033127 UBQ-activ_enz_E1_Cys_AS
PANTHERiPTHR10953:SF5 PTHR10953:SF5, 1 hit
PfamiView protein in Pfam
PF00899 ThiF, 1 hit
PF14732 UAE_UbL, 1 hit
PF16195 UBA2_C, 1 hit
PIRSFiPIRSF039133 SUMO_E1B, 1 hit
SUPFAMiSSF69572 SSF69572, 2 hits
PROSITEiView protein in PROSITE
PS00536 UBIQUITIN_ACTIVAT_1, 1 hit
PS00865 UBIQUITIN_ACTIVAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

F1LS72-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
IDLDTIDVSN LNRQFLFQKK HVGRSKAQVA KESVLQFHPQ ANIEAHHDSI
60 70 80 90 100
MNPDYNVEFF RQFILVMNAL DNRAARNHVN RMCLAADVPL IESGTAGYLG
110 120 130 140 150
QVTTIKKGVT ECYECHPKPT QRTFPGCTIR NTPSEPIHCI VWAKYLFNQL
160 170 180 190 200
FGEEDADQEV SPDRADPEAA WEPTEAEARA RASNEDGDIK RISTKEWAKS
210 220 230 240 250
TGYDPVKLFT KLFKDDIRYL LTMDKLWRKR KPPVPLDWAE VQSQGEEANA
260 270 280 290 300
DQQSEPQLGL KDQQVLDVKS YASLFSKSIE TLRVRLAEKG DGAELIWDKD
310 320 330 340 350
DPPAMDFVTS AANLRMHIFS MNMKSRFDIK SMAGNIIPAI ATTNAVIAGL
360 370 380 390 400
IVLEGLKILS GKIDQCRTIF LNKQPNPRKK LLVPCALDPP NTNCYVCASK
410 420 430 440 450
PEVTVRLNVH KVTVLTLQDK IVKEKFAMVA PDVQIEDGKG TILISSEEGE
460 470 480 490 500
TEANNPKKLS DFGIRNGSRL QADDFLQDYT LLINILHSED LGKDVEFEVV
510 520 530 540 550
GDTPEKVGPK QAEDAAKSIA NGSDDGAQPS TSTEQAQEQD DVLIVDSDEE
560 570 580 590
GPSNSADGSR DDRTRKRKLE ENEGASTKKS RLEQVEDQDD VIALD
Length:595
Mass (Da):66,339
Last modified:July 22, 2015 - v3
Checksum:i2AB1C8B362FCFC30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07002945 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000028672; ENSRNOP00000028672; ENSRNOG00000021113

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07002945 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028672

Proteomic databases

PaxDbiF1LS72
PeptideAtlasiF1LS72
PRIDEiF1LS72

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028672; ENSRNOP00000028672; ENSRNOG00000021113

Organism-specific databases

RGDi1312023 Uba2

Phylogenomic databases

eggNOGiKOG2013 Eukaryota
COG0476 LUCA
GeneTreeiENSGT00550000074924
InParanoidiF1LS72
OMAiYPGCTIR
OrthoDBiEOG091G07PV
TreeFamiTF300765

Enzyme and pathway databases

ReactomeiR-RNO-3065676 SUMO is conjugated to E1 (UBA2:SAE1)
R-RNO-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)

Gene expression databases

BgeeiENSRNOG00000021113 Expressed in 9 organ(s), highest expression level in spleen

Family and domain databases

Gene3Di1.10.10.520, 1 hit
InterProiView protein in InterPro
IPR000594 ThiF_NAD_FAD-bd
IPR028077 UAE_UbL_dom
IPR023318 Ub_act_enz_dom_a_sf
IPR030661 Uba2
IPR032426 UBA2_C
IPR035985 Ubiquitin-activating_enz
IPR018074 UBQ-activ_enz_E1_CS
IPR033127 UBQ-activ_enz_E1_Cys_AS
PANTHERiPTHR10953:SF5 PTHR10953:SF5, 1 hit
PfamiView protein in Pfam
PF00899 ThiF, 1 hit
PF14732 UAE_UbL, 1 hit
PF16195 UBA2_C, 1 hit
PIRSFiPIRSF039133 SUMO_E1B, 1 hit
SUPFAMiSSF69572 SSF69572, 2 hits
PROSITEiView protein in PROSITE
PS00536 UBIQUITIN_ACTIVAT_1, 1 hit
PS00865 UBIQUITIN_ACTIVAT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1LS72_RAT
AccessioniPrimary (citable) accession number: F1LS72
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: September 12, 2018
This is version 59 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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