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Protein
Submitted name:

Collagen type XVIII alpha 1 chain

Gene

Col18a1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • extracellular matrix structural constituent Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-1442490 Collagen degradation
R-RNO-1592389 Activation of Matrix Metalloproteinases
R-RNO-1650814 Collagen biosynthesis and modifying enzymes
R-RNO-2022090 Assembly of collagen fibrils and other multimeric structures
R-RNO-216083 Integrin cell surface interactions
R-RNO-3000157 Laminin interactions
R-RNO-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen type XVIII alpha 1 chainImported
Submitted name:
Procollagen, type XVIII, alpha 1, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Col18a1Imported
ORF Names:rCG_60896Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Rat genome database

More...
RGDi
70936 Col18a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501408912026 – 1311Sequence analysisAdd BLAST1286

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondSAAS annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000001229 Expressed in 10 organ(s), highest expression level in liver

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000047962

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 221LAM_G_DOMAINInterPro annotationAdd BLAST189

Keywords - Domaini

CollagenSAAS annotationImported, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3546 Eukaryota
ENOG410XQ04 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158212

KEGG Orthology (KO)

More...
KOi
K06823

Identification of Orthologs from Complete Genome Data

More...
OMAi
GQWTRFA

Database of Orthologous Groups

More...
OrthoDBi
1362001at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00247 Endostatin-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR039075 COL18A1
IPR008160 Collagen
IPR010515 Collagenase_NC10/endostatin
IPR013320 ConA-like_dom_sf
IPR016187 CTDL_fold
IPR001791 Laminin_G

The PANTHER Classification System

More...
PANTHERi
PTHR45362 PTHR45362, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 5 hits
PF06482 Endostatin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit
SSF56436 SSF56436, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1LR02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPRWHLLDM LTSLVLLLVA RVSWAEPENV AEDVGLLQLL GDPLPQKISQ
60 70 80 90 100
VEDPHVGLAY VFGPYSKSSQ MAQYHFPKLF FRDFSLLFEV RPTTEAAGVL
110 120 130 140 150
FAITDAAQVV VSLGVKLSEV RDGQQNISLL YTEPGASQTQ TGASFRLPAF
160 170 180 190 200
VGQWTHFALS VDGSSVALYV DCEEFQRVPF ARSPHGLELE RGAGLFVGQA
210 220 230 240 250
GAADPDKFQG MISELRVRKT PRVSPVHCLD EEDDDDDRAS GDFGSGLEES
260 270 280 290 300
SNLHRQETYL RPGLPQPPPV TSPPLAGGSA TEDSRTEEKE EEATVDSKGA
310 320 330 340 350
DTLPVTDSSG VWDGDVQNPG GGLIKGGLKG QKGEPGAQGP PGPAGPQGPA
360 370 380 390 400
GPAVQSPSSQ PVPGAQGPPG PQGPPGKDGI PGRDGEPGDP GEDGRPGDTG
410 420 430 440 450
PQGFPGTPGD VGPKGEKGDP GIGPRGPPGP PGPPGPSFRQ DKLTFIDMEG
460 470 480 490 500
SGGFSGDLES LRGPRGFPGP PGPPGVPGLP GEPGRFGVNS SYAPGPAGLP
510 520 530 540 550
GVPGKEGPPG FPGPPGPPGK EGPPGVAGQK GSVGDAGSPG PKGSKGDLGP
560 570 580 590 600
IGMPGKSGLP GLPGPVGPPG PPGPPGPPGP GFAAGFDDME GSGTPLWSTA
610 620 630 640 650
RSSDGLQGDP GVTGPPGAKG EVGADGVQGI PGLPGREGVA GPPGPKGEKG
660 670 680 690 700
TQGEKGNPGK DGVGRPGLPG PPGPPGPVIY VSNEDRAVVS TPGPEGKPGY
710 720 730 740 750
AGFPGPAGPK GDLGSKGEQG LPGPKGEKGE PGSIFSPDGT ALGQAQKGAK
760 770 780 790 800
GEPGFRGPPG PYGRPGYKGE IGFPGRPGRP GTNGLKGEKG EPGEASLGFS
810 820 830 840 850
MRGLPGPPGP PGPPGPPGVP VYDSNAFVES GRPGLPGQQG VQGPPGPKGD
860 870 880 890 900
KGEVGPPGPP GQFPIDLFHL EAEMKGDKGD RGDAGRKGER GEPGAPGGGF
910 920 930 940 950
FSSSVPGPPG PPGYPGIPGP KGESIRGPPG PPGPQGPPGI GYEGRQGPPG
960 970 980 990 1000
PPGPPGPPSF PGPHRQTVSV PGPPGPPGPP GPPGAMGASA GQVRIWATYQ
1010 1020 1030 1040 1050
TMLDKIREVP EGWLIFVAER EELYVRVRNG FRKVLLEART ALPHGTDNEV
1060 1070 1080 1090 1100
AALQPPLVQL HEGSSYTRRE HSYPTARPWR ADDILANPPR LPDRQPYPGV
1110 1120 1130 1140 1150
PHHHHHHHHH HSSHEHRPPA HPSPSPAHTH QDFHPVLHLV ALNTPLSGGM
1160 1170 1180 1190 1200
RGIRGADFQC FQQARAVGLS GTFRAFLSSR LQDLYSIVRR ADRSSVPIVN
1210 1220 1230 1240 1250
LKDEVLSPSW DTLFSGSQGQ LHSGARIFSF DGRDVLRHPA WPQKSVWHGS
1260 1270 1280 1290 1300
DPSGRRLMES YCETWRTEAT GVTGQASSLL SGRLLEQKAE SCHNSYIVLC
1310
IENSFMTSFS K
Length:1,311
Mass (Da):134,646
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7079C49C842C7745
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07044596 Genomic DNA No translation available.
CH473988 Genomic DNA Translation: EDL97114.1

NCBI Reference Sequences

More...
RefSeqi
NP_445941.2, NM_053489.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Rn.12030

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000045315; ENSRNOP00000047962; ENSRNOG00000001229

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
85251

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:85251

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07044596 Genomic DNA No translation available.
CH473988 Genomic DNA Translation: EDL97114.1
RefSeqiNP_445941.2, NM_053489.2
UniGeneiRn.12030

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047962

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045315; ENSRNOP00000047962; ENSRNOG00000001229
GeneIDi85251
KEGGirno:85251

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80781
RGDi70936 Col18a1

Phylogenomic databases

eggNOGiKOG3546 Eukaryota
ENOG410XQ04 LUCA
GeneTreeiENSGT00940000158212
KOiK06823
OMAiGQWTRFA
OrthoDBi1362001at2759

Enzyme and pathway databases

ReactomeiR-RNO-1442490 Collagen degradation
R-RNO-1592389 Activation of Matrix Metalloproteinases
R-RNO-1650814 Collagen biosynthesis and modifying enzymes
R-RNO-2022090 Assembly of collagen fibrils and other multimeric structures
R-RNO-216083 Integrin cell surface interactions
R-RNO-3000157 Laminin interactions
R-RNO-8948216 Collagen chain trimerization

Gene expression databases

BgeeiENSRNOG00000001229 Expressed in 10 organ(s), highest expression level in liver

Family and domain databases

CDDicd00247 Endostatin-like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR039075 COL18A1
IPR008160 Collagen
IPR010515 Collagenase_NC10/endostatin
IPR013320 ConA-like_dom_sf
IPR016187 CTDL_fold
IPR001791 Laminin_G
PANTHERiPTHR45362 PTHR45362, 1 hit
PfamiView protein in Pfam
PF01391 Collagen, 5 hits
PF06482 Endostatin, 1 hit
SMARTiView protein in SMART
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF56436 SSF56436, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1LR02_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1LR02
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: January 16, 2019
This is version 73 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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