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UniProtKB - F1LQQ7 (F1LQQ7_RAT)
Protein
Sodium channel protein
Gene
Scn7a
Organism
Rattus norvegicus (Rat)
Status
Functioni
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
UniRule annotationCaution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
GO - Molecular functioni
- sodium channel activity Source: RGD
- voltage-gated ion channel activity Source: UniProtKB-KW
- voltage-gated sodium channel activity Source: GO_Central
GO - Biological processi
- membrane depolarization during action potential Source: GO_Central
- muscle contraction Source: InterPro
- neuronal action potential Source: GO_Central
- regulation of ion transmembrane transport Source: UniProtKB-KW
- response to bacterium Source: RGD
- sodium ion homeostasis Source: RGD
- sodium ion transmembrane transport Source: GO_Central
- sodium ion transport Source: RGD
Keywordsi
Molecular function | Ion channel, Sodium channelUniRule annotationARBA annotation, Voltage-gated channelUniRule annotationARBA annotation |
Biological process | Ion transport, Sodium transport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-RNO-5576892, Phase 0 - rapid depolarisation |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium channel proteinUniRule annotation |
Gene namesi | Name:Scn7aImported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 61922, Scn7a |
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: RGD
- voltage-gated sodium channel complex Source: GO_Central
Other locations
- axon Source: GO_Central
- glial cell projection Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 237 – 259 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 369 – 393 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 528 – 546 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 558 – 579 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 644 – 665 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 729 – 755 | HelicalUniRule annotationAdd BLAST | 27 | |
Transmembranei | 955 – 974 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 995 – 1014 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 1079 – 1102 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 1190 – 1214 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 1273 – 1291 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 1303 – 1325 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 1337 – 1356 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 1392 – 1420 | HelicalUniRule annotationAdd BLAST | 29 | |
Transmembranei | 1496 – 1522 | HelicalUniRule annotationAdd BLAST | 27 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSRNOG00000029342, Expressed in esophagus and 20 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 117 – 404 | Ion_transInterPro annotationAdd BLAST | 288 | |
Domaini | 526 – 751 | Ion_transInterPro annotationAdd BLAST | 226 | |
Domaini | 764 – 948 | Na_trans_assocInterPro annotationAdd BLAST | 185 | |
Domaini | 954 – 1221 | Ion_transInterPro annotationAdd BLAST | 268 | |
Domaini | 1271 – 1520 | Ion_transInterPro annotationAdd BLAST | 250 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 829 – 896 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 1670 – 1704 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 829 – 861 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 866 – 882 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1670 – 1690 | Basic and acidic residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
RepeatARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG2301, Eukaryota |
GeneTreei | ENSGT00940000162042 |
HOGENOMi | CLU_000540_5_0_1 |
InParanoidi | F1LQQ7 |
OMAi | VFGMKLF |
Family and domain databases
CDDi | cd13433, Na_channel_gate, 1 hit |
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR028812, Na_channel_a7su IPR001696, Na_channel_asu IPR044564, Na_chnl_inactivation_gate IPR010526, Na_trans_assoc IPR043203, VGCC_Ca_Na IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR10037, PTHR10037, 1 hit PTHR10037:SF14, PTHR10037:SF14, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 4 hits PF06512, Na_trans_assoc, 1 hit |
PRINTSi | PR00170, NACHANNEL |
i Sequence
Sequence statusi: Complete.
F1LQQ7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLTSPEPKGL VPFTAESLEL IKNHIAKKCN EEHEEEDLKP SWGLEAGKKL
60 70 80 90 100
PFAYGTLPQG TVSEPLEDVD PYYYVKRNTF MVLNRNRVIF RFNAVSILCT
110 120 130 140 150
LSPLSSLRRA VIKVLVHPLF RLLILISVLT DSILMCMSNL PEWILAVENT
160 170 180 190 200
LLGIYTFEIL VKVIARGIWA GSFSFLGDLW NWLDFSVTLF ELITRSSPLS
210 220 230 240 250
SLPMFKTIRT LRILKIIPLN HGLQSIVVTL VQCLKKLLGA IALALFFLTV
260 270 280 290 300
SSLFGMGLFM GNLKHKCVRW PQEDGNDVMY NGTGSQYHIL ERENFYYMEG
310 320 330 340 350
ARYALLCGNK TDAGLCPEGY MCVKEGSNPD NGFTSFDNFG WALLAMFRLM
360 370 380 390 400
TQDYPELLYH QILYASGKIY MIFFVLISFW FAFYMASLFL GILTMAYEQE
410 420 430 440 450
KQRASEESRD MDSKCHQTVK EFEEEHEGAE LQCIWFYEEV LDLLGLELCT
460 470 480 490 500
RRMETTQIEM KKRSPTSINT TLDILEDTAL GHKEEPETSR KECPLCWYKF
510 520 530 540 550
TKTCFIWKCS PCWIKLNEFA DRIITHPLFD LFLVICIILN ICFLALEHFP
560 570 580 590 600
MSEELMSLLA IGNLVFIGIY TIEMILKIIA MHPYGYFQIS WHIFDSILVV
610 620 630 640 650
LGLTEMLLAD IEEITVFILV PLIFIKLGKY APPFKNLMRI LGRALVALKD
660 670 680 690 700
LVLLVSIFIY FSAVFGMKLF GRSYKDCVCH VDQDCQRQRW HMSDFLHAYV
710 720 730 740 750
TVFRILCGEW IETLWECMEV AGEAWCIPFY MMVILIGNLL ILYLFVALVS
760 770 780 790 800
SFASYDATTE VSKEAKNLQL AVAWIKMVIN CVLLKILCKE KTVSTEATDQ
810 820 830 840 850
TCDPSVKENI SGHTLSELSN TQTFLRYKDQ SSGTEKTPVT ESESQSLIAS
860 870 880 890 900
PSVSETVPIA SGESDIENLD NKETRSKSAN GSSKEKMKQS SSSECSTVDI
910 920 930 940 950
AISEEEEMVY EHEKSKLHKN GYERKSSAGQ VSRESRNGKI WRNIRKTCCK
960 970 980 990 1000
IVENSWFECF IGLVTLLCTG TLALEDIYID QRKTIKIFLE YGDMIFAYIF
1010 1020 1030 1040 1050
ILEMLLKWVA YGFKAYFSNN WYKLDFMVVI VLCLSLIGKT REDLNPLASI
1060 1070 1080 1090 1100
KFLRALRVLS QFERMKVVLR ALIKTTLPAV SVFLVCLMIW LLFSVMGVFL
1110 1120 1130 1140 1150
FAGKFYECID PTRGERFSVF EVMNKSQCEN LVFNESMPWE NAKLNFDNVG
1160 1170 1180 1190 1200
NGFLSLFQVA TFNGWISIMN SAIDSVGVYM QPSFEHSLHM YTYFIIFVVF
1210 1220 1230 1240 1250
GLFLPLCMLI GVIIRNFNKQ KIKQGGSNIF ITVKQKKQYR ALKKLLYADS
1260 1270 1280 1290 1300
QKPAARPRNK FQGFICDVVT HRVFNVIIIL LICFQATTIM IQNDEQSPQI
1310 1320 1330 1340 1350
ETAVFWMNSL FTMLFTLECI LKLTAFRCHY FTSAWNVHDF MVVVFSITDQ
1360 1370 1380 1390 1400
GLLLPLSIGQ YFVPPSLVQL LLLSRIIHVL RPGKGPKVFH DLMLPLMLSL
1410 1420 1430 1440 1450
PALLNIALLI FLVMFIYAIF GMYNFAYVKK EAGINDVSNF ETFGSSMLCL
1460 1470 1480 1490 1500
FQVTTFSGWD GMLDAIFNSQ WSDCDPDKIN PGTQVRGDCG SPSVGIFYFV
1510 1520 1530 1540 1550
SYILISWLII VNMYVVLIME FLSIPSKRKN RTLSEDDFRR FFKVWNRFDP
1560 1570 1580 1590 1600
DRTQYIDSTK LSDFAAALDP PLFMAKPNKG QLVAMDLPMA AGDRIHCLDI
1610 1620 1630 1640 1650
LLAFTKRVMG KDERVEKILS EIESGFMLAN PFKITYEPIT TTLKRKQEAV
1660 1670 1680 1690 1700
SATIIQRAYK SYRLRQSDKK IQDIPEIDDG REDPNSKGVH SGQIEEKASI
QTQI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07052428 Genomic DNA No translation available. AABR07052429 Genomic DNA No translation available. AABR07072862 Genomic DNA No translation available. AC117350 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSRNOT00000041096; ENSRNOP00000044385; ENSRNOG00000029342 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07052428 Genomic DNA No translation available. AABR07052429 Genomic DNA No translation available. AABR07072862 Genomic DNA No translation available. AC117350 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000044385 |
Proteomic databases
PaxDbi | F1LQQ7 |
Genome annotation databases
Ensembli | ENSRNOT00000041096; ENSRNOP00000044385; ENSRNOG00000029342 |
Organism-specific databases
RGDi | 61922, Scn7a |
Phylogenomic databases
eggNOGi | KOG2301, Eukaryota |
GeneTreei | ENSGT00940000162042 |
HOGENOMi | CLU_000540_5_0_1 |
InParanoidi | F1LQQ7 |
OMAi | VFGMKLF |
Enzyme and pathway databases
Reactomei | R-RNO-5576892, Phase 0 - rapid depolarisation |
Gene expression databases
Bgeei | ENSRNOG00000029342, Expressed in esophagus and 20 other tissues |
Family and domain databases
CDDi | cd13433, Na_channel_gate, 1 hit |
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR028812, Na_channel_a7su IPR001696, Na_channel_asu IPR044564, Na_chnl_inactivation_gate IPR010526, Na_trans_assoc IPR043203, VGCC_Ca_Na IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR10037, PTHR10037, 1 hit PTHR10037:SF14, PTHR10037:SF14, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 4 hits PF06512, Na_trans_assoc, 1 hit |
PRINTSi | PR00170, NACHANNEL |
MobiDBi | Search... |
Entry informationi
Entry namei | F1LQQ7_RAT | |
Accessioni | F1LQQ7Primary (citable) accession number: F1LQQ7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | July 22, 2015 | |
Last modified: | January 19, 2022 | |
This is version 76 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |