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Entry version 75 (29 Sep 2021)
Sequence version 3 (22 Jul 2015)
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Protein

Sodium channel protein

Gene

Scn7a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.

UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotationARBA annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-5576892, Phase 0 - rapid depolarisation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Scn7aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Rat genome database

More...
RGDi
61922, Scn7a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei237 – 259HelicalUniRule annotationAdd BLAST23
Transmembranei369 – 393HelicalUniRule annotationAdd BLAST25
Transmembranei528 – 546HelicalUniRule annotationAdd BLAST19
Transmembranei558 – 579HelicalUniRule annotationAdd BLAST22
Transmembranei644 – 665HelicalUniRule annotationAdd BLAST22
Transmembranei729 – 755HelicalUniRule annotationAdd BLAST27
Transmembranei955 – 974HelicalUniRule annotationAdd BLAST20
Transmembranei995 – 1014HelicalUniRule annotationAdd BLAST20
Transmembranei1079 – 1102HelicalUniRule annotationAdd BLAST24
Transmembranei1190 – 1214HelicalUniRule annotationAdd BLAST25
Transmembranei1273 – 1291HelicalUniRule annotationAdd BLAST19
Transmembranei1303 – 1325HelicalUniRule annotationAdd BLAST23
Transmembranei1337 – 1356HelicalUniRule annotationAdd BLAST20
Transmembranei1392 – 1420HelicalUniRule annotationAdd BLAST29
Transmembranei1496 – 1522HelicalUniRule annotationAdd BLAST27

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1LQQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000029342, Expressed in esophagus and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000044385

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini117 – 404Ion_transInterPro annotationAdd BLAST288
Domaini526 – 751Ion_transInterPro annotationAdd BLAST226
Domaini764 – 948Na_trans_assocInterPro annotationAdd BLAST185
Domaini954 – 1221Ion_transInterPro annotationAdd BLAST268
Domaini1271 – 1520Ion_transInterPro annotationAdd BLAST250

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni829 – 896DisorderedSequence analysisAdd BLAST68
Regioni1670 – 1704DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi829 – 861Polar residuesSequence analysisAdd BLAST33
Compositional biasi866 – 882Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi1670 – 1690Basic and acidic residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2301, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162042

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000540_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1LQQ7

Identification of Orthologs from Complete Genome Data

More...
OMAi
VFGMKLF

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13433, Na_channel_gate, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821, Ion_trans_dom
IPR028812, Na_channel_a7su
IPR001696, Na_channel_asu
IPR044564, Na_chnl_inactivation_gate
IPR010526, Na_trans_assoc
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037, PTHR10037, 1 hit
PTHR10037:SF14, PTHR10037:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520, Ion_trans, 4 hits
PF06512, Na_trans_assoc, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00170, NACHANNEL

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1LQQ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTSPEPKGL VPFTAESLEL IKNHIAKKCN EEHEEEDLKP SWGLEAGKKL
60 70 80 90 100
PFAYGTLPQG TVSEPLEDVD PYYYVKRNTF MVLNRNRVIF RFNAVSILCT
110 120 130 140 150
LSPLSSLRRA VIKVLVHPLF RLLILISVLT DSILMCMSNL PEWILAVENT
160 170 180 190 200
LLGIYTFEIL VKVIARGIWA GSFSFLGDLW NWLDFSVTLF ELITRSSPLS
210 220 230 240 250
SLPMFKTIRT LRILKIIPLN HGLQSIVVTL VQCLKKLLGA IALALFFLTV
260 270 280 290 300
SSLFGMGLFM GNLKHKCVRW PQEDGNDVMY NGTGSQYHIL ERENFYYMEG
310 320 330 340 350
ARYALLCGNK TDAGLCPEGY MCVKEGSNPD NGFTSFDNFG WALLAMFRLM
360 370 380 390 400
TQDYPELLYH QILYASGKIY MIFFVLISFW FAFYMASLFL GILTMAYEQE
410 420 430 440 450
KQRASEESRD MDSKCHQTVK EFEEEHEGAE LQCIWFYEEV LDLLGLELCT
460 470 480 490 500
RRMETTQIEM KKRSPTSINT TLDILEDTAL GHKEEPETSR KECPLCWYKF
510 520 530 540 550
TKTCFIWKCS PCWIKLNEFA DRIITHPLFD LFLVICIILN ICFLALEHFP
560 570 580 590 600
MSEELMSLLA IGNLVFIGIY TIEMILKIIA MHPYGYFQIS WHIFDSILVV
610 620 630 640 650
LGLTEMLLAD IEEITVFILV PLIFIKLGKY APPFKNLMRI LGRALVALKD
660 670 680 690 700
LVLLVSIFIY FSAVFGMKLF GRSYKDCVCH VDQDCQRQRW HMSDFLHAYV
710 720 730 740 750
TVFRILCGEW IETLWECMEV AGEAWCIPFY MMVILIGNLL ILYLFVALVS
760 770 780 790 800
SFASYDATTE VSKEAKNLQL AVAWIKMVIN CVLLKILCKE KTVSTEATDQ
810 820 830 840 850
TCDPSVKENI SGHTLSELSN TQTFLRYKDQ SSGTEKTPVT ESESQSLIAS
860 870 880 890 900
PSVSETVPIA SGESDIENLD NKETRSKSAN GSSKEKMKQS SSSECSTVDI
910 920 930 940 950
AISEEEEMVY EHEKSKLHKN GYERKSSAGQ VSRESRNGKI WRNIRKTCCK
960 970 980 990 1000
IVENSWFECF IGLVTLLCTG TLALEDIYID QRKTIKIFLE YGDMIFAYIF
1010 1020 1030 1040 1050
ILEMLLKWVA YGFKAYFSNN WYKLDFMVVI VLCLSLIGKT REDLNPLASI
1060 1070 1080 1090 1100
KFLRALRVLS QFERMKVVLR ALIKTTLPAV SVFLVCLMIW LLFSVMGVFL
1110 1120 1130 1140 1150
FAGKFYECID PTRGERFSVF EVMNKSQCEN LVFNESMPWE NAKLNFDNVG
1160 1170 1180 1190 1200
NGFLSLFQVA TFNGWISIMN SAIDSVGVYM QPSFEHSLHM YTYFIIFVVF
1210 1220 1230 1240 1250
GLFLPLCMLI GVIIRNFNKQ KIKQGGSNIF ITVKQKKQYR ALKKLLYADS
1260 1270 1280 1290 1300
QKPAARPRNK FQGFICDVVT HRVFNVIIIL LICFQATTIM IQNDEQSPQI
1310 1320 1330 1340 1350
ETAVFWMNSL FTMLFTLECI LKLTAFRCHY FTSAWNVHDF MVVVFSITDQ
1360 1370 1380 1390 1400
GLLLPLSIGQ YFVPPSLVQL LLLSRIIHVL RPGKGPKVFH DLMLPLMLSL
1410 1420 1430 1440 1450
PALLNIALLI FLVMFIYAIF GMYNFAYVKK EAGINDVSNF ETFGSSMLCL
1460 1470 1480 1490 1500
FQVTTFSGWD GMLDAIFNSQ WSDCDPDKIN PGTQVRGDCG SPSVGIFYFV
1510 1520 1530 1540 1550
SYILISWLII VNMYVVLIME FLSIPSKRKN RTLSEDDFRR FFKVWNRFDP
1560 1570 1580 1590 1600
DRTQYIDSTK LSDFAAALDP PLFMAKPNKG QLVAMDLPMA AGDRIHCLDI
1610 1620 1630 1640 1650
LLAFTKRVMG KDERVEKILS EIESGFMLAN PFKITYEPIT TTLKRKQEAV
1660 1670 1680 1690 1700
SATIIQRAYK SYRLRQSDKK IQDIPEIDDG REDPNSKGVH SGQIEEKASI

QTQI
Length:1,704
Mass (Da):195,075
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0756CAEA5186E68C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07052428 Genomic DNA No translation available.
AABR07052429 Genomic DNA No translation available.
AABR07072862 Genomic DNA No translation available.
AC117350 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000041096; ENSRNOP00000044385; ENSRNOG00000029342

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07052428 Genomic DNA No translation available.
AABR07052429 Genomic DNA No translation available.
AABR07072862 Genomic DNA No translation available.
AC117350 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044385

Proteomic databases

PaxDbiF1LQQ7

Genome annotation databases

EnsembliENSRNOT00000041096; ENSRNOP00000044385; ENSRNOG00000029342

Organism-specific databases

RGDi61922, Scn7a

Phylogenomic databases

eggNOGiKOG2301, Eukaryota
GeneTreeiENSGT00940000162042
HOGENOMiCLU_000540_5_0_1
InParanoidiF1LQQ7
OMAiVFGMKLF

Enzyme and pathway databases

ReactomeiR-RNO-5576892, Phase 0 - rapid depolarisation

Gene expression databases

BgeeiENSRNOG00000029342, Expressed in esophagus and 20 other tissues

Family and domain databases

CDDicd13433, Na_channel_gate, 1 hit
Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821, Ion_trans_dom
IPR028812, Na_channel_a7su
IPR001696, Na_channel_asu
IPR044564, Na_chnl_inactivation_gate
IPR010526, Na_trans_assoc
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR10037, PTHR10037, 1 hit
PTHR10037:SF14, PTHR10037:SF14, 1 hit
PfamiView protein in Pfam
PF00520, Ion_trans, 4 hits
PF06512, Na_trans_assoc, 1 hit
PRINTSiPR00170, NACHANNEL

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1LQQ7_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1LQQ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: September 29, 2021
This is version 75 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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