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Entry version 79 (07 Apr 2021)
Sequence version 3 (22 Jul 2015)
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Protein
Submitted name:

Integrin subunit alpha L

Gene

Itgal

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrinUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation
Biological processCell adhesionUniRule annotationARBA annotation
LigandMetal-bindingARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-RNO-202733, Cell surface interactions at the vascular wall
R-RNO-216083, Integrin cell surface interactions
R-RNO-6798695, Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Integrin subunit alpha LImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ItgalImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
631424, Itgal

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1086 – 1108HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23UniRule annotationAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500142432524 – 1161UniRule annotationAdd BLAST1138

Keywords - PTMi

Disulfide bondARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1LP44

PRoteomics IDEntifications database

More...
PRIDEi
F1LP44

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000017980, Expressed in thymus and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000024404

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1LP44

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati28 – 79FG-GAPPROSITE-ProRule annotationAdd BLAST52
Repeati80 – 137FG-GAPPROSITE-ProRule annotationAdd BLAST58
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini152 – 324VWFAInterPro annotationAdd BLAST173
Repeati335 – 386FG-GAPPROSITE-ProRule annotationAdd BLAST52
Repeati389 – 442FG-GAPPROSITE-ProRule annotationAdd BLAST54
Repeati443 – 503FG-GAPPROSITE-ProRule annotationAdd BLAST61
Repeati504 – 560FG-GAPPROSITE-ProRule annotationAdd BLAST57
Repeati564 – 624FG-GAPPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1123 – 1161DisorderedSequence analysisAdd BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationARBA annotation

Keywords - Domaini

RepeatARBA annotation, SignalUniRule annotationARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3637, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161495

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004111_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1LP44

Identification of Orthologs from Complete Genome Data

More...
OMAi
TVCFQLK

Database of Orthologous Groups

More...
OrthoDBi
73876at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105391

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.130, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013517, FG-GAP
IPR013519, Int_alpha_beta-p
IPR000413, Integrin_alpha
IPR013649, Integrin_alpha-2
IPR018184, Integrin_alpha_C_CS
IPR028994, Integrin_alpha_N
IPR032695, Integrin_dom_sf
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01839, FG-GAP, 1 hit
PF08441, Integrin_alpha2, 1 hit
PF00092, VWA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01185, INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00191, Int_alpha, 5 hits
SM00327, VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300, SSF53300, 1 hit
SSF69179, SSF69179, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51470, FG_GAP, 7 hits
PS00242, INTEGRIN_ALPHA, 1 hit
PS50234, VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1LP44-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFRIPGPRL LLLGLQLFVN AWSYNLDTRH AQSFLTQAGR HFGYQVLQFG
60 70 80 90 100
DGVVVGAPGE GNSTGSLYHC HPSSGSCQPV HLGSNHTSKY LGMTMVTDAA
110 120 130 140 150
KGSLLACDPG LSRTCDQNPY LSGLCYLFSQ SLGKPILQNR PAYQECMKGN
160 170 180 190 200
VDLVFLFDGS QSLDKKDFEK IVDFMKDVMR KLSNTSYQFA AVQFSTECKT
210 220 230 240 250
EFTFLDYIKL NKNPDVLLGN VTPMFLLTNT FRAINYVVTH VFKEESGARP
260 270 280 290 300
DATKVLVIIT DGEASDNGNI DAAQDITRYI IGIGKHFSTT QKQEKLHIFA
310 320 330 340 350
SKPVEEFVKI LDTFEKLKDL FTDLQRKIYA IEGTSKQDLA SFNMELSSSG
360 370 380 390 400
ISADLSKGHA VVGAVGAKDW AGGFLDLHED LEGATFVGQE PLTSDERGGY
410 420 430 440 450
LGYTVAWLTS RSSRPLLAAG APRYQHVGQV LLFQAPEAGG HWNQTQKIEG
460 470 480 490 500
TQIGSYFGGE LCSVDLHQDG ETDLLLIGAP LFYGEQRGGR VSVYQRRRSL
510 520 530 540 550
FEMVSELQGD PGYPLGRFGA AISALTDING DGLTDVAVGA PLEEQGAVYI
560 570 580 590 600
FNGKPGGFSS QSSQRIPGTQ VSPGVRWFGR SIHGVKDLGG DRLADVVVGA
610 620 630 640 650
EGQVIVLSSR PVVDIVTELS FSPDEIPVHE VECSYSASQE QKEGVKLKVC
660 670 680 690 700
FQIRPLTSQF QGRLLANLSY TLQLDGHRTR SRGLFPGGSR ELGGNTSVTP
710 720 730 740 750
DKSCMDFHFH FPICIQDLIS PINVSLNFSL LEEEGSPRDQ KGGRDMQPIL
760 770 780 790 800
RPSIHAVTKE IPFEKNCGED KKCEADLALS PPARSGVLRL MSSASLAVEW
810 820 830 840 850
TLRNLGEDAY WVRLDLDFPR GLSFRKVEML QPHSQIPVSC EELTEESSLL
860 870 880 890 900
TKTLKCNVSS PIFKAGKQMT LQVMFNTLLN SSWGDFVELN GTVHCENENS
910 920 930 940 950
SLGKDNSATT RIPVLYPVNI LTEDQENSTL YISFTPKGPK TQQVQHIYKV
960 970 980 990 1000
RIQPSAYDHN MPALEALVEV PQPHSEGPIA HTWTVHTDPL VTCHREDLKK
1010 1020 1030 1040 1050
PTREAEQPCL PGVQFRCPIV FRQETFIRVA GTVELSEKIK ASSTLSLCSS
1060 1070 1080 1090 1100
LSVSFNSSKH FHLYGSKASK AQVLMKVDMI YEKEMLHLYV LSGIGGLLLL
1110 1120 1130 1140 1150
SLIFLALYKV GFFKRKLKEK MEADGGVPNG SPGEDADPLA VPGEETKDMG
1160
CLEPLRESDK D
Length:1,161
Mass (Da):127,657
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7CC9A73B5AB0DC9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07005779 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_006230331.1, XM_006230269.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000024404; ENSRNOP00000024404; ENSRNOG00000017980

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
308995

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07005779 Genomic DNA No translation available.
RefSeqiXP_006230331.1, XM_006230269.3

3D structure databases

SMRiF1LP44
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024404

Proteomic databases

PaxDbiF1LP44
PRIDEiF1LP44

Genome annotation databases

EnsembliENSRNOT00000024404; ENSRNOP00000024404; ENSRNOG00000017980
GeneIDi308995

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3683
RGDi631424, Itgal

Phylogenomic databases

eggNOGiKOG3637, Eukaryota
GeneTreeiENSGT00940000161495
HOGENOMiCLU_004111_3_0_1
InParanoidiF1LP44
OMAiTVCFQLK
OrthoDBi73876at2759
TreeFamiTF105391

Enzyme and pathway databases

ReactomeiR-RNO-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-RNO-202733, Cell surface interactions at the vascular wall
R-RNO-216083, Integrin cell surface interactions
R-RNO-6798695, Neutrophil degranulation

Gene expression databases

BgeeiENSRNOG00000017980, Expressed in thymus and 20 other tissues

Family and domain databases

Gene3Di2.130.10.130, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517, FG-GAP
IPR013519, Int_alpha_beta-p
IPR000413, Integrin_alpha
IPR013649, Integrin_alpha-2
IPR018184, Integrin_alpha_C_CS
IPR028994, Integrin_alpha_N
IPR032695, Integrin_dom_sf
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF01839, FG-GAP, 1 hit
PF08441, Integrin_alpha2, 1 hit
PF00092, VWA, 1 hit
PRINTSiPR01185, INTEGRINA
SMARTiView protein in SMART
SM00191, Int_alpha, 5 hits
SM00327, VWA, 1 hit
SUPFAMiSSF53300, SSF53300, 1 hit
SSF69179, SSF69179, 2 hits
PROSITEiView protein in PROSITE
PS51470, FG_GAP, 7 hits
PS00242, INTEGRIN_ALPHA, 1 hit
PS50234, VWFA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1LP44_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1LP44
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: April 7, 2021
This is version 79 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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