UniProtKB - F1LP42 (F1LP42_RAT)
Protein
Hedgehog protein
Gene
Ihh
Organism
Rattus norvegicus (Rat)
Status
Functioni
Intercellular signal essential for a variety of patterning events during development.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 94 | Calcium 1UniRule annotation | 1 | |
Metal bindingi | 95 | Calcium 1UniRule annotation | 1 | |
Metal bindingi | 95 | Calcium 2UniRule annotation | 1 | |
Metal bindingi | 100 | Calcium 1UniRule annotation | 1 | |
Metal bindingi | 130 | Calcium 1; via carbonyl oxygenUniRule annotation | 1 | |
Metal bindingi | 131 | Calcium 1UniRule annotation | 1 | |
Metal bindingi | 131 | Calcium 2UniRule annotation | 1 | |
Metal bindingi | 134 | Calcium 2UniRule annotation | 1 | |
Metal bindingi | 136 | Calcium 2UniRule annotation | 1 | |
Metal bindingi | 145 | ZincUniRule annotation | 1 | |
Metal bindingi | 152 | ZincUniRule annotation | 1 | |
Metal bindingi | 187 | ZincUniRule annotation | 1 | |
Sitei | 248 | Involved in cholesterol transferUniRule annotation | 1 | |
Sitei | 272 | Involved in auto-cleavageUniRule annotation | 1 | |
Sitei | 275 | Essential for auto-cleavageUniRule annotation | 1 |
GO - Molecular functioni
- calcium ion binding Source: RGD
- patched binding Source: RGD
- peptidase activity Source: UniProtKB-UniRule
GO - Biological processi
- bone resorption Source: RGD
- branching involved in blood vessel morphogenesis Source: RGD
- camera-type eye development Source: RGD
- camera-type eye photoreceptor cell fate commitment Source: RGD
- cartilage development Source: RGD
- cell-cell signaling Source: InterPro
- cell differentiation Source: RGD
- cell fate specification Source: RGD
- cell maturation Source: RGD
- chondrocyte differentiation involved in endochondral bone morphogenesis Source: RGD
- chondrocyte proliferation Source: RGD
- embryonic camera-type eye morphogenesis Source: RGD
- embryonic digestive tract morphogenesis Source: RGD
- embryonic digit morphogenesis Source: RGD
- embryonic pattern specification Source: RGD
- embryonic skeletal joint development Source: RGD
- epithelial cell-cell adhesion Source: RGD
- epithelial cell morphogenesis Source: RGD
- head morphogenesis Source: RGD
- heart looping Source: RGD
- intein-mediated protein splicing Source: InterPro
- in utero embryonic development Source: RGD
- liver regeneration Source: RGD
- maternal process involved in female pregnancy Source: RGD
- morphogenesis of a branching structure Source: RGD
- multicellular organism growth Source: RGD
- negative regulation of alpha-beta T cell differentiation Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of cell differentiation Source: RGD
- negative regulation of eye pigmentation Source: RGD
- negative regulation of immature T cell proliferation in thymus Source: RGD
- negative regulation of T cell differentiation in thymus Source: RGD
- neuron development Source: RGD
- ossification Source: RGD
- osteoblast differentiation Source: RGD
- pancreas development Source: RGD
- pattern specification process Source: RGD
- positive regulation of alpha-beta T cell differentiation Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of collagen biosynthetic process Source: RGD
- positive regulation of epithelial cell proliferation Source: RGD
- positive regulation of mesenchymal cell proliferation Source: RGD
- positive regulation of smoothened signaling pathway Source: RGD
- positive regulation of T cell differentiation in thymus Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- protein autoprocessing Source: InterPro
- proteoglycan metabolic process Source: RGD
- regulation of gene expression Source: GO_Central
- regulation of growth Source: RGD
- response to estradiol Source: RGD
- response to mechanical stimulus Source: RGD
- retinal pigment epithelium development Source: RGD
- skeletal system development Source: RGD
- smoothened signaling pathway Source: RGD
- smooth muscle tissue development Source: RGD
- somite development Source: RGD
- vasculature development Source: RGD
- vitelline membrane formation Source: RGD
Keywordsi
Molecular function | Developmental proteinUniRule annotation, Hydrolase, ProteaseUniRule annotationARBA annotation |
Ligand | CalciumUniRule annotationARBA annotation, Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotation |
Enzyme and pathway databases
Reactomei | R-RNO-5358346, Hedgehog ligand biogenesis R-RNO-5362798, Release of Hh-Np from the secreting cell R-RNO-5632681, Ligand-receptor interactions R-RNO-5635838, Activation of SMO |
Protein family/group databases
MEROPSi | C46.003 |
Names & Taxonomyi
Protein namesi | Recommended name: Hedgehog proteinUniRule annotation |
Gene namesi | Name:IhhImported ORF Names:rCG_23994Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620021, Ihh |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Lipid-anchor ARBA annotation; Extracellular side ARBA annotation
Extracellular region or secreted
- extracellular space ARBA annotation
Extracellular region or secreted
- extracellular matrix Source: RGD
- extracellular space Source: GO_Central
Plasma Membrane
- plasma membrane Source: RGD
Keywords - Cellular componenti
Cell membraneUniRule annotationARBA annotation, Membrane, SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_5014089147 | 28 – 411 | Hedgehog proteinSequence analysisAdd BLAST | 384 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 202 – 203 | Cleavage; by autolysisUniRule annotation | 2 |
Keywords - PTMi
Autocatalytic cleavageUniRule annotationARBA annotation, Lipoprotein, PalmitateARBA annotationProteomic databases
PRIDEi | F1LP42 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000018059, Expressed in duodenum and 17 other tissues |
Interactioni
GO - Molecular functioni
- patched binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000024419 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 201 – 308 | HintNInterPro annotationAdd BLAST | 108 | |
Domaini | 309 – 353 | HintCInterPro annotationAdd BLAST | 45 |
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG3638, Eukaryota |
GeneTreei | ENSGT00940000159207 |
HOGENOMi | CLU_034686_0_0_1 |
OMAi | WGSWTLG |
OrthoDBi | 1169356at2759 |
TreeFami | TF106458 |
Family and domain databases
Gene3Di | 3.30.1380.10, 1 hit |
InterProi | View protein in InterPro IPR001657, Hedgehog IPR001767, Hedgehog_Hint IPR009045, Hedgehog_sig/DD-Pept_Zn-bd_sf IPR000320, Hedgehog_signalling_dom IPR003586, Hint_dom_C IPR003587, Hint_dom_N IPR036844, Hint_dom_sf IPR033385, IHH IPR006141, Intein_N |
PANTHERi | PTHR11889:SF39, PTHR11889:SF39, 1 hit |
Pfami | View protein in Pfam PF01085, HH_signal, 1 hit PF01079, Hint, 1 hit |
PIRSFi | PIRSF009400, Peptidase_C46, 1 hit |
PRINTSi | PR00632, SONICHHOG |
SMARTi | View protein in SMART SM00305, HintC, 1 hit SM00306, HintN, 1 hit |
SUPFAMi | SSF51294, SSF51294, 1 hit SSF55166, SSF55166, 1 hit |
PROSITEi | View protein in PROSITE PS50817, INTEIN_N_TER, 1 hit |
i Sequence
Sequence statusi: Complete.
F1LP42-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPAWLRPRL RFCLLLLLLL LVPAARGCGP GRVVGSRRRP PRKLVPLAYK
60 70 80 90 100
QFSPNVPEKT LGASGRYEGK IARSSERFKE LTPNYNPDII FKDEENTGAD
110 120 130 140 150
RLMTQRCKDR LNSLAISVMN QWPGVKLRVT EGWDEDGHHS EESLHYEGRA
160 170 180 190 200
VDITTSDRDR NKYGLLARLA VEAGFDWVYY ESKAHVHCSV KSEHSAAAKT
210 220 230 240 250
GGCFPAGAQV HLETGERVAL SAVKPGDRVL AMGEDGNPTF SDVLIFLDRE
260 270 280 290 300
PNRLRAFQVI ETQDPPRRLA LTPAHLLFIA DNHTEPAARF RATFASHVQP
310 320 330 340 350
GQYVLVAGVP GLQPARVAAI STHVALGSYA PLTRHGTLVV EDVVASCFAA
360 370 380 390 400
VSDHHLAQLA FWPLRLFPSL PWGSWTPSEG VHWYPQLLYR LGRLLLEEST
410
FHPLGMSGAG S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07068084 Genomic DNA No translation available. CH474004 Genomic DNA Translation: EDL75378.1 |
RefSeqi | NP_445836.1, NM_053384.1 |
Genome annotation databases
Ensembli | ENSRNOT00000024419; ENSRNOP00000024419; ENSRNOG00000018059 |
GeneIDi | 84399 |
KEGGi | rno:84399 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07068084 Genomic DNA No translation available. CH474004 Genomic DNA Translation: EDL75378.1 |
RefSeqi | NP_445836.1, NM_053384.1 |
3D structure databases
SMRi | F1LP42 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000024419 |
Protein family/group databases
MEROPSi | C46.003 |
Proteomic databases
PRIDEi | F1LP42 |
Genome annotation databases
Ensembli | ENSRNOT00000024419; ENSRNOP00000024419; ENSRNOG00000018059 |
GeneIDi | 84399 |
KEGGi | rno:84399 |
Organism-specific databases
CTDi | 3549 |
RGDi | 620021, Ihh |
Phylogenomic databases
eggNOGi | KOG3638, Eukaryota |
GeneTreei | ENSGT00940000159207 |
HOGENOMi | CLU_034686_0_0_1 |
OMAi | WGSWTLG |
OrthoDBi | 1169356at2759 |
TreeFami | TF106458 |
Enzyme and pathway databases
Reactomei | R-RNO-5358346, Hedgehog ligand biogenesis R-RNO-5362798, Release of Hh-Np from the secreting cell R-RNO-5632681, Ligand-receptor interactions R-RNO-5635838, Activation of SMO |
Gene expression databases
Bgeei | ENSRNOG00000018059, Expressed in duodenum and 17 other tissues |
Family and domain databases
Gene3Di | 3.30.1380.10, 1 hit |
InterProi | View protein in InterPro IPR001657, Hedgehog IPR001767, Hedgehog_Hint IPR009045, Hedgehog_sig/DD-Pept_Zn-bd_sf IPR000320, Hedgehog_signalling_dom IPR003586, Hint_dom_C IPR003587, Hint_dom_N IPR036844, Hint_dom_sf IPR033385, IHH IPR006141, Intein_N |
PANTHERi | PTHR11889:SF39, PTHR11889:SF39, 1 hit |
Pfami | View protein in Pfam PF01085, HH_signal, 1 hit PF01079, Hint, 1 hit |
PIRSFi | PIRSF009400, Peptidase_C46, 1 hit |
PRINTSi | PR00632, SONICHHOG |
SMARTi | View protein in SMART SM00305, HintC, 1 hit SM00306, HintN, 1 hit |
SUPFAMi | SSF51294, SSF51294, 1 hit SSF55166, SSF55166, 1 hit |
PROSITEi | View protein in PROSITE PS50817, INTEIN_N_TER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1LP42_RAT | |
Accessioni | F1LP42Primary (citable) accession number: F1LP42 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | April 3, 2013 | |
Last modified: | February 10, 2021 | |
This is version 84 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |