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Protein

Acyl-coenzyme A oxidase

Gene

Acox2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei437Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

ReactomeiR-RNO-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-RNO-389887 Beta-oxidation of pristanoyl-CoA
R-RNO-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A oxidaseUniRule annotation
Gene namesi
Name:Acox2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi628684 Acox2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiF1LNW3

Expressioni

Gene expression databases

BgeeiENSRNOG00000007378

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiF1LNW3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 148Acyl-CoA_ox_NInterPro annotationAdd BLAST116
Domaini151 – 260Acyl-CoA_dh_MInterPro annotationAdd BLAST110
Domaini496 – 674ACOXInterPro annotationAdd BLAST179

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0136 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00530000062919
KOiK10214
OMAiQKACVIA
OrthoDBiEOG091G0A1P
TreeFamiTF300672

Family and domain databases

CDDicd01150 AXO, 1 hit
Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR034171 ACO
IPR029320 Acyl-CoA_ox_N
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR012258 Acyl-CoA_oxidase
IPR002655 Acyl-CoA_oxidase_C
IPR036250 AcylCo_DH-like_C
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF01756 ACOX, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF14749 Acyl-CoA_ox_N, 1 hit
PIRSFiPIRSF000168 Acyl-CoA_oxidase, 1 hit
SUPFAMiSSF47203 SSF47203, 2 hits
SSF56645 SSF56645, 1 hit

Sequencei

Sequence statusi: Complete.

F1LNW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSPMHRVSL GDTWSWQVHP DIDSERHSPS FSVERLTNIL DGGLPNTVLR
60 70 80 90 100
RKVESIIQSD PVFNLKKLYF MTREELYEDA IQKRFHLEKL AWSLGWSEDG
110 120 130 140 150
PERIYANRVL DGNVNLSLHG VAMNAIRSLG SDEQIAKWGQ LCKNFQIITT
160 170 180 190 200
YAQTELGHGT YLQGLETEAT YDEARQEFVI HSPTMTSTKW WPGDLGWSVT
210 220 230 240 250
HAVVLAQLTC LGVRHGMHAF IVPIRSLEDH TPLPGITVGD IGPKMGLEHI
260 270 280 290 300
DNGFLQLNHV RVPRENMLSR FAEVLPDGTY QRLGTPQSNY LGMLVTRVQL
310 320 330 340 350
LCKGILPSLQ KACIIATRYS VIRHQSRLRP SDPEAKILEY QTQQQKLLPQ
360 370 380 390 400
LAVSYAFHFT ATSLSEFFHS SYSAILKRDF SLLPELHALS TGMKATFADF
410 420 430 440 450
CAQGAEICRR ACGGHGYSKL SGLPTLVARA TASCTYEGEN TVLYLQVARF
460 470 480 490 500
LMKSYLQAQA SPGATPQKPL PQSVMYIATQ RPARCSAQTA ADFRCPDVYT
510 520 530 540 550
TAWAYVSTRL IRDAAHRTQT LMKSGVDQHD AWNQTTVIHL QAAKAYCYFI
560 570 580 590 600
TVKNFKEAVE KLDKEPEIQR VLQRLCDLYA LHGVLTNSGD FLHDGFLSGA
610 620 630 640 650
QVDMAREAFL DLLPLIRKDA ILLTDAFDFS DHCLNSALGC YDGHVYERLF
660 670 680
EWAQKSPANT QENPAYKKYI RPLMLGWRHK M
Length:681
Mass (Da):76,747
Last modified:May 3, 2011 - v1
Checksum:i33B0292B5E2C240E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07017234 Genomic DNA No translation available.
RefSeqiNP_665713.2, NM_145770.2
XP_006251806.1, XM_006251744.2
XP_006251807.1, XM_006251745.2
UniGeneiRn.10622

Genome annotation databases

EnsembliENSRNOT00000010260; ENSRNOP00000010260; ENSRNOG00000007378
GeneIDi252898
KEGGirno:252898

Similar proteinsi

Entry informationi

Entry nameiF1LNW3_RAT
AccessioniPrimary (citable) accession number: F1LNW3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 20, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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