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Entry version 61 (31 Jul 2019)
Sequence version 3 (22 Jul 2015)
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Protein
Submitted name:

Interphotoreceptor matrix proteoglycan 2

Gene

Impg2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Interphotoreceptor matrix proteoglycan 2Imported
Submitted name:
Interphotoreceptor matrix proteoglycan 2, isoform CRA_bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Impg2Imported
ORF Names:rCG_52794Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Rat genome database

More...
RGDi
708358 Impg2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1103 – 1127HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501408906922 – 1241Sequence analysisAdd BLAST1220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1022 ↔ 1039PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000001622 Expressed in 4 organ(s), highest expression level in testis

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini235 – 349SEAInterPro annotationAdd BLAST115
Domaini900 – 1013SEAInterPro annotationAdd BLAST114
Domaini1013 – 1054EGF-likeInterPro annotationAdd BLAST42
Domaini1055 – 1096EGF-likeInterPro annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni206 – 234DisorderedSequence analysisAdd BLAST29
Regioni431 – 456DisorderedSequence analysisAdd BLAST26
Regioni500 – 520DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi206 – 232PolarSequence analysisAdd BLAST27

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH0G Eukaryota
ENOG410Y9FF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063503

KEGG Orthology (KO)

More...
KOi
K19017

Identification of Orthologs from Complete Genome Data

More...
OMAi
SGDQANP

Database of Orthologous Groups

More...
OrthoDBi
112459at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331340

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.960, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR039861 IMPG
IPR032975 IMPG2
IPR000082 SEA_dom
IPR036364 SEA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12199 PTHR12199, 1 hit
PTHR12199:SF4 PTHR12199:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01390 SEA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00200 SEA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82671 SSF82671, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS50024 SEA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1LNC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIMFLPLGRI SLGILILFLT GGNLVSVSEE IQDRMHAVAV LSPKESTDLS
60 70 80 90 100
LPTRKRQLLD ATETGRRWPL RRRRSILFPN GVRICPSDTV AEAVANHVKY
110 120 130 140 150
FKARVCQEAI WEAFRTFWDR LPGREEYQYW MNLCEDGVTS VFEMGTQFSQ
160 170 180 190 200
SVEHRHLIME KLTYTKEAES SSCKDQACGP ELSSPVPIGE TSTLAGAVSS
210 220 230 240 250
ASYPGAASER SAASPQESIS NEIENVTEQP TPPAAEQIAE FSIQLLGKQY
260 270 280 290 300
SEELRDPSSA LYRLLVEEFI SEVEKAFTGL PGYKGIHVLD FRSPKENGSG
310 320 330 340 350
IDVHYAVTFN GEAISNTTWD LISLHSNKVE NHGLVELDDK PTAVYTISNF
360 370 380 390 400
RDYIAETLHQ NFLMGNSSLN PDPKSLQLIN VRGVLLPQTE EIVWNTQSSS
410 420 430 440 450
LQVTTSSILD NTLQAEWLSA DESITTTTTT TISPFGFSSG PPSATGRELH
460 470 480 490 500
SESTLGDIVS TPKLASPSKV VLSSSPEVLG GSSLTLHSVT PAVLQIDLPV
510 520 530 540 550
APEGRTSGSS ILEDDNTEES EDVSIDVLPS SSLIQPVPKE TVPPMEDSDM
560 570 580 590 600
ILLTSSPHLT SSVIEDLAKD ITTPSGLDSL ASRVSDKLEV SPWFPDTSVE
610 620 630 640 650
KEFIFESGLG SGSGKNVDVI DWPWSETSLE KTTEPLSKSW SEEQDTLLPT
660 670 680 690 700
ESIEKLHMYF TEQMIEPSAH RYGDGPIYFT EEESHVRSTI PVFAESATQP
710 720 730 740 750
TSLISSKHTS DVPDIDSYSV TKAPFLLATI ANTASTKETD EVNTLLKKGM
760 770 780 790 800
VQTEPSSPKG LDSKISVARP DMQPVWTILP ESDTVWARTS SLGKLSRDTL
810 820 830 840 850
VSTPESADRL WLKASMTQPA ELPPSTHSIQ LEDEVIMAVQ DISLELDQVG
860 870 880 890 900
TDYYQPELTQ EQNGKVDSYV EMPTHVHYTE MPLVAQPTKG GVLSRTQTAG
910 920 930 940 950
ALVVFFSLRV TNMLFSEDLF NKNSLEYKAL EQRFLELLVP YLQSNLSGFQ
960 970 980 990 1000
NLEILNFRNG SIVVNSRVKF AESVPPNVNN AIYMILEDFC TTAYQTMNLD
1010 1020 1030 1040 1050
IDKYSLDVES GDDANPCKFQ ACNEFSECLV NPWSGEAKCK CHPGYLSVDE
1060 1070 1080 1090 1100
LPCQSVCDLQ PDFCLNDGKC DVMPGHGAIC RCRVGSNWWY RGQHCEEFVS
1110 1120 1130 1140 1150
EPFVIGITIA SVVSLLLVAS AVVFFLAKML QAQNVRRERQ RPTNRQPDSL
1160 1170 1180 1190 1200
SSVENAMKYN PAYESRLAGC EQYEKPYSQH PFYSSASEEV IGGLSREEIR
1210 1220 1230 1240
QMYESSDLSK EEIQERMRIL ELYANDPEFA AFVREHEMEE L
Length:1,241
Mass (Da):137,548
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9161F6D44D5FED8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P70628IMPG2_RAT
Interphotoreceptor matrix proteogly...
Impg2
1,241Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07033974 Genomic DNA No translation available.
AABR07033975 Genomic DNA No translation available.
AABR07033976 Genomic DNA No translation available.
CH473967 Genomic DNA Translation: EDM11050.1

NCBI Reference Sequences

More...
RefSeqi
NP_620788.2, NM_139088.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000044900; ENSRNOP00000046981; ENSRNOG00000001622

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
245919

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:245919

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07033974 Genomic DNA No translation available.
AABR07033975 Genomic DNA No translation available.
AABR07033976 Genomic DNA No translation available.
CH473967 Genomic DNA Translation: EDM11050.1
RefSeqiNP_620788.2, NM_139088.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000044900; ENSRNOP00000046981; ENSRNOG00000001622
GeneIDi245919
KEGGirno:245919

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
50939
RGDi708358 Impg2

Phylogenomic databases

eggNOGiENOG410IH0G Eukaryota
ENOG410Y9FF LUCA
GeneTreeiENSGT00530000063503
KOiK19017
OMAiSGDQANP
OrthoDBi112459at2759
TreeFamiTF331340

Gene expression databases

BgeeiENSRNOG00000001622 Expressed in 4 organ(s), highest expression level in testis

Family and domain databases

Gene3Di3.30.70.960, 1 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR039861 IMPG
IPR032975 IMPG2
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
PANTHERiPTHR12199 PTHR12199, 1 hit
PTHR12199:SF4 PTHR12199:SF4, 1 hit
PfamiView protein in Pfam
PF01390 SEA, 2 hits
SMARTiView protein in SMART
SM00200 SEA, 2 hits
SUPFAMiSSF82671 SSF82671, 2 hits
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS50024 SEA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1LNC8_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1LNC8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: July 31, 2019
This is version 61 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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