UniProtKB - F1LMY4 (RYR1_RAT)
Ryanodine receptor 1
Ryr1
Functioni
Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11316255).
Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm (By similarity).
Can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).
By similarity1 PublicationActivity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 3896 | CalciumBy similarity | 1 | |
Metal bindingi | 3970 | CalciumBy similarity | 1 | |
Binding sitei | 4714 | CaffeineBy similarity | 1 | |
Metal bindingi | 4999 | Calcium; via carbonyl oxygenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 4214 – 4218 | ATPBy similarity | 5 | |
Nucleotide bindingi | 4952 – 4957 | ATPBy similarity | 6 | |
Nucleotide bindingi | 4977 – 4983 | ATPBy similarity | 7 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- calcium channel activity Source: UniProtKB
- calcium-induced calcium release activity Source: RGD
- calcium ion binding Source: UniProtKB
- calmodulin binding Source: UniProtKB-KW
- enzyme binding Source: RGD
- protease binding Source: RGD
- ryanodine-sensitive calcium-release channel activity Source: UniProtKB
- voltage-gated calcium channel activity Source: UniProtKB
GO - Biological processi
- calcium ion transport Source: BHF-UCL
- cellular response to ATP Source: UniProtKB
- cellular response to caffeine Source: UniProtKB
- cellular response to calcium ion Source: UniProtKB
- muscle contraction Source: UniProtKB
- ossification involved in bone maturation Source: UniProtKB
- outflow tract morphogenesis Source: UniProtKB
- protein homotetramerization Source: UniProtKB
- regulation of cytosolic calcium ion concentration Source: BHF-UCL
- release of sequestered calcium ion into cytosol Source: BHF-UCL
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: UniProtKB
- response to caffeine Source: BHF-UCL
- response to estradiol Source: RGD
- response to hypoxia Source: RGD
- sarcoplasmic reticulum calcium ion transport Source: RGD
- skeletal muscle fiber development Source: UniProtKB
- skin development Source: UniProtKB
Keywordsi
Molecular function | Calcium channel, Calmodulin-binding, Developmental protein, Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | ATP-binding, Calcium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-RNO-2672351, Stimuli-sensing channels R-RNO-5578775, Ion homeostasis |
Names & Taxonomyi
Protein namesi | Recommended name: Ryanodine receptor 1Short name: RYR-1 Short name: RyR1 Alternative name(s): Skeletal muscle calcium release channel Skeletal muscle ryanodine receptor Skeletal muscle-type ryanodine receptor Type 1 ryanodine receptor |
Gene namesi | Name:Ryr1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1586637, Ryr1 |
Subcellular locationi
Other locations
- Sarcoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein By similarity
- Sarcoplasmic reticulum By similarity
- Membrane By similarity; Multi-pass membrane protein By similarity
Note: The number of predicted transmembrane domains varies between orthologs, but the 3D-structures show the presence of six transmembrane regions. Both N-terminus and C-terminus are cytoplasmic.By similarity
Endoplasmic reticulum
- ryanodine receptor complex Source: UniProtKB
- sarcoplasmic reticulum Source: RGD
- sarcoplasmic reticulum membrane Source: UniProtKB
- smooth endoplasmic reticulum Source: RGD
- terminal cisterna Source: UniProtKB
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: RGD
- plasma membrane Source: RGD
- ryanodine receptor complex Source: UniProtKB
- sarcolemma Source: RGD
- T-tubule Source: RGD
Other locations
- calcium channel complex Source: GO_Central
- cell cortex Source: RGD
- cytoplasm Source: RGD
- cytoplasmic vesicle membrane Source: GO_Central
- I band Source: RGD
- integral component of organelle membrane Source: UniProtKB
- junctional membrane complex Source: RGD
- membrane Source: RGD
- protein-containing complex Source: RGD
- Z disc Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 4556 | CytoplasmicBy similarityAdd BLAST | 4556 | |
Transmembranei | 4557 – 4577 | Helical; Name=1By similarityAdd BLAST | 21 | |
Topological domaini | 4578 – 4638 | LumenalBy similarityAdd BLAST | 61 | |
Transmembranei | 4639 – 4659 | Helical; Name=2By similarityAdd BLAST | 21 | |
Topological domaini | 4660 – 4777 | CytoplasmicBy similarityAdd BLAST | 118 | |
Transmembranei | 4778 – 4800 | Helical; Name=3By similarityAdd BLAST | 23 | |
Topological domaini | 4801 | LumenalBy similarity | 1 | |
Transmembranei | 4802 – 4818 | Helical; Name=4By similarityAdd BLAST | 17 | |
Topological domaini | 4819 – 4833 | CytoplasmicBy similarityAdd BLAST | 15 | |
Transmembranei | 4834 – 4854 | Helical; Name=5By similarityAdd BLAST | 21 | |
Topological domaini | 4855 – 4877 | LumenalBy similarityAdd BLAST | 23 | |
Intramembranei | 4878 – 4897 | Pore-formingBy similarityAdd BLAST | 20 | |
Topological domaini | 4898 – 4917 | LumenalBy similarityAdd BLAST | 20 | |
Transmembranei | 4918 – 4938 | Helical; Name=6By similarityAdd BLAST | 21 | |
Topological domaini | 4939 – 5035 | CytoplasmicBy similarityAdd BLAST | 97 |
Keywords - Cellular componenti
Membrane, Sarcoplasmic reticulumPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000415567 | 1 – 5035 | Ryanodine receptor 1Add BLAST | 5035 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1338 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2344 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2840 | PhosphoserineCombined sources | 1 | |
Modified residuei | 3634 | S-nitrosocysteineBy similarity | 1 | |
Modified residuei | 4464 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 4468 | PhosphoserineCombined sources | 1 | |
Modified residuei | 4861 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 4864 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, S-nitrosylationProteomic databases
PaxDbi | F1LMY4 |
PRIDEi | F1LMY4 |
PTM databases
CarbonylDBi | F1LMY4 |
iPTMneti | F1LMY4 |
PhosphoSitePlusi | F1LMY4 |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
Homotetramer. Can also form heterotetramers with RYR2 (By similarity).
Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). Repeated very high-level exercise decreases interaction with PDE4D and protein phosphatase 1 (PP1) (By similarity).
Interacts with CALM; CALM with bound calcium inhibits the RYR1 channel activity (By similarity).
Interacts with S100A1 (By similarity).
Interacts with FKBP1A; this stabilizes the closed conformation of the channel.
Interacts with CACNA1S; interaction with CACNA1S is important for activation of the RYR1 channel.
Interacts with CACNB1.
Interacts with TRDN and ASPH; these interactions stimulate RYR1 channel activity.
Interacts with SELENON (By similarity).
Interacts with scorpion calcins (AC P0DPT1; AC P0DM30; AC A0A1L4BJ42; AC P59868; AC P60254; AC B8QG00; AC L0GBR1; AC P60252; AC P60253) (By similarity).
By similarityGO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
- enzyme binding Source: RGD
- protease binding Source: RGD
Protein-protein interaction databases
CORUMi | F1LMY4 |
IntActi | F1LMY4, 3 interactors |
MINTi | F1LMY4 |
STRINGi | 10116.ENSRNOP00000027893 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 99 – 154 | MIR 1PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 161 – 206 | MIR 2PROSITE-ProRule annotationAdd BLAST | 46 | |
Domaini | 212 – 266 | MIR 3PROSITE-ProRule annotationAdd BLAST | 55 | |
Domaini | 272 – 329 | MIR 4PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 337 – 394 | MIR 5PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 583 – 799 | B30.2/SPRY 1PROSITE-ProRule annotationAdd BLAST | 217 | |
Repeati | 843 – 956 | 1Add BLAST | 114 | |
Repeati | 957 – 1070 | 2Add BLAST | 114 | |
Domaini | 1015 – 1209 | B30.2/SPRY 2PROSITE-ProRule annotationAdd BLAST | 195 | |
Repeati | 1345 – 1360 | 3; truncatedAdd BLAST | 16 | |
Domaini | 1358 – 1571 | B30.2/SPRY 3PROSITE-ProRule annotationAdd BLAST | 214 | |
Repeati | 1373 – 1388 | 4; truncatedAdd BLAST | 16 | |
Repeati | 2723 – 2842 | 5Add BLAST | 120 | |
Repeati | 2843 – 2956 | 6Add BLAST | 114 | |
Domaini | 4078 – 4106 | EF-handPROSITE-ProRule annotationAdd BLAST | 29 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 671 – 682 | Interaction with FKBP1ABy similarityAdd BLAST | 12 | |
Regioni | 843 – 2956 | 6 X approximate repeatsAdd BLAST | 2114 | |
Regioni | 1308 – 1386 | DisorderedSequence analysisAdd BLAST | 79 | |
Regioni | 1666 – 1685 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1870 – 1923 | DisorderedSequence analysisAdd BLAST | 54 | |
Regioni | 2389 – 2411 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 2824 – 2855 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 3613 – 3642 | Interaction with CALMBy similarityAdd BLAST | 30 | |
Regioni | 4255 – 4284 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 4378 – 4531 | DisorderedSequence analysisAdd BLAST | 154 | |
Regioni | 4586 – 4618 | DisorderedSequence analysisAdd BLAST | 33 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 4892 – 4898 | Selectivity filterBy similarity | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1371 – 1386 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1871 – 1921 | Acidic residuesSequence analysisAdd BLAST | 51 | |
Compositional biasi | 2824 – 2840 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 4257 – 4274 | Acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 4404 – 4418 | Acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 4482 – 4496 | Acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 4497 – 4513 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 4514 – 4528 | Pro residuesSequence analysisAdd BLAST | 15 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2243, Eukaryota |
InParanoidi | F1LMY4 |
TreeFami | TF315244 |
Family and domain databases
CDDi | cd12877, SPRY1_RyR, 1 hit cd12878, SPRY2_RyR, 1 hit cd12879, SPRY3_RyR, 1 hit |
Gene3Di | 2.60.120.920, 3 hits |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR013320, ConA-like_dom_sf IPR011992, EF-hand-dom_pair IPR014821, Ins145_P3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR013333, Ryan_recept IPR003032, Ryanodine_rcpt IPR009460, Ryanrecept_TM4-6 IPR035910, RyR/IP3R_RIH_dom_sf IPR033215, RyR1 IPR035761, SPRY1_RyR IPR035764, SPRY2_RyR IPR035762, SPRY3_RyR IPR003877, SPRY_dom |
PANTHERi | PTHR13715:SF15, PTHR13715:SF15, 1 hit |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF06459, RR_TM4-6, 1 hit PF01365, RYDR_ITPR, 2 hits PF02026, RyR, 4 hits PF00622, SPRY, 3 hits |
PRINTSi | PR00795, RYANODINER |
SMARTi | View protein in SMART SM00472, MIR, 4 hits SM00449, SPRY, 3 hits |
SUPFAMi | SSF100909, SSF100909, 2 hits SSF47473, SSF47473, 1 hit SSF49899, SSF49899, 3 hits SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 3 hits PS50919, MIR, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MGDGGGEGED EVQFLRTDDE VVLQCSATVL KEQLKLCLAA EGFGNRLCFL
60 70 80 90 100
EPTSNAQNVP PDLAICCFIL EQSLSVRALQ EMLANTVEAG VESSQGGGHR
110 120 130 140 150
TLLYGHAILL RHAHSRMYLS CLTTSRSMTD KLAFDVGLQE DATGEACWWT
160 170 180 190 200
MHPASKQRSE GEKVRVGDDL ILVSVSSERY LHLSTASGEL QVDASFMQTL
210 220 230 240 250
WNMNPICSCC EEGFVTGGHV LRLFHGHMDE CLTISPSDSD DQRRLVYYEG
260 270 280 290 300
GPVCTHARSL WRLEPLRISW SGSHLRWGQP LRIRHVTTGR YLALTEDQGL
310 320 330 340 350
VVVDASKAHT KATSFCFRIS KEKLDVAPKR DVEGMGPPEI KYGESLCFVQ
360 370 380 390 400
HVASGLWLTY AAPDPKALRL GVLKKKAMLH QEGHMDDALS LTRCQQEESQ
410 420 430 440 450
AARMIYSTAG LYNQFIKGLD SFSGKPRGSG PPAGSALPIE GVILSLQDLI
460 470 480 490 500
GYFEPPSEEL QHEEKQTKLR SLRNRQSLFQ EEGMLSLVLN CIDRLNVYTT
510 520 530 540 550
AAHFAEFAGE EAAESWKEIV NLLYELLASL IRGNRTNCAL FSTNLDWLVS
560 570 580 590 600
KLDRLEASSG ILEVLYCVLI ESPEVLNIIQ ENHIKSIISL LDKHGRNHKV
610 620 630 640 650
LDVLCSLCVC NGVAVRSNQD LITENLLPGR ELLLQTNLIN YVTSIRPNIF
660 670 680 690 700
VGRAEGSTQY GKWYFEVMVD EVAPFLTAQA THLRVGWALS EGYSPYPGGG
710 720 730 740 750
EGWGGNGVGD DLYSYGFDGL HLWTGHVARP VTSPGQHLLG PEDVVSCCLD
760 770 780 790 800
LSVPSISFRI NGCPVQGVFE SFNLDGLFFP VVSFSAGIKV RFLLGGRHGE
810 820 830 840 850
FKFLPPPGYA PCHEAVLPRE RLHLQPIKEY RREGPRGPHL VGPSRCLSHL
860 870 880 890 900
DFVPCPVDTI QIVLPPHLER IREKLAENIH ELWALTRIEQ GWTYGPVRDD
910 920 930 940 950
NKRLHPCLVD FHSLPEPERN YNLQMSGETL KTLLALGCHV GMADEKAEDN
960 970 980 990 1000
LKKTKLPKTY MMNNGYKPAP LDLSHVRLTP AQTTLVDRLA ENGHNVWARD
1010 1020 1030 1040 1050
RVAQGWSYSA VQDIPARRNP RLVPYRLLDE ATKRSNRDSL CQAVRTLLGY
1060 1070 1080 1090 1100
GYNIEPPDQE PSQVDSQSRG DRARIFRAEK SYAVQSGRWY FEFEAVTTGR
1110 1120 1130 1140 1150
ELGWARPELR PDVELGADDL AYVFNGHRGQ RWHLGSEPFG RPWQSGDVVG
1160 1170 1180 1190 1200
CMIDLTENTI IFTLNGEVLM SDSGSETAFR EIEIGDGFLP VCSLGPGQVG
1210 1220 1230 1240 1250
HLNLGQDVSS LRFFAICGLQ EGFEPFAINM QRPVTTWFSK SLPQFEPVPL
1260 1270 1280 1290 1300
EHPHYEVARM DGTVDTPPCL RLTHRTWGSQ NSLVEMLFLR LSLPVQFHQH
1310 1320 1330 1340 1350
FRCTAGATPL ASPGLQPPAE DEARAAEPDT DYENLRRSAG GWGEAEAGKD
1360 1370 1380 1390 1400
GTAKEGTPGG AAQPGVEAQP ARAENEKDAT TEKNKKRGFL FKAKKVAMMT
1410 1420 1430 1440 1450
QPPSTPALPR LPRDVVPADN RDDPEIILNT TTYYYSVRVF AGQEPSCVWV
1460 1470 1480 1490 1500
GWVTPDYHQH DMSFDLSKVR AVTVTMGDEQ GNVHSSLKCS NCYMVWGGDF
1510 1520 1530 1540 1550
VSPGQQGRIS HTDLVIGCLV DLATGLMTFT ANGKESNTFF QVEPNTKLFP
1560 1570 1580 1590 1600
AVFVLPTHQN VVQFDLRPGA NIMPLSAAMF LSERKNPAPQ CPPRLEVQML
1610 1620 1630 1640 1650
MPVSWSRMPN HFLHVDTRRA GERLGWAVQC QEPLMMMALH IPEENSEPYI
1660 1670 1680 1690 1700
HLKRAQLDPR DLRDYRDTKF DSESSDSDQT PQPGCYHVDQ AQLLHALEDA
1710 1720 1730 1740 1750
HLPGPLRAGY YDLLISIHLE SACRSRRSML SEYIVPLTEE TRAITLFPPG
1760 1770 1780 1790 1800
RSAEDGPRRH GLPGVGVTTS LRPPHHFSPP CFVVALPAAG AAEAPARLSP
1810 1820 1830 1840 1850
AIPLEALRDK ALRMLGEAVR DGGQHARDPV GGSVEFQFVP VLKLVSTLLV
1860 1870 1880 1890 1900
MGVFSDEDVK QILKMIEPEV FTEEEEVEEE EEEEEEDEEE KEEDEEEEAH
1910 1920 1930 1940 1950
EKEDEEKEEA EEAAEEEKEE LEEGLLQMKL PESVKLQMCH LLEYFCDQEL
1960 1970 1980 1990 2000
QHRVESLAAF AERYVDKLQS NQRGRYGLLM KAFTMSAAET ARRTREFRSP
2010 2020 2030 2040 2050
PQEQINMLLQ FKNGADEEDC PLPEEIREDL VNFHQDLLAH CGIQLEGEEE
2060 2070 2080 2090 2100
EPEEESTLGS RLMSLLEKVR LVKKKEEKPE EEPAAEEHKP QSLQELVSHT
2110 2120 2130 2140 2150
VVRWAQEDFV QSPELVRAMF SLLHRQYDGL GELLRALPRA YTISLSSVED
2160 2170 2180 2190 2200
TMSLLECLGQ IRSLLIVQMG PQEENLMIQS IGNIMNNKVF YQHPNLMRAL
2210 2220 2230 2240 2250
GMHETVMEVM VNVLGGGESK EIRFPKMVTS CCRFLCYFCR ISRQNQRSMF
2260 2270 2280 2290 2300
DHLSYLLENS GIGLGMQGST PLDVAAASVI DNNELALALQ EQDLEKVVSY
2310 2320 2330 2340 2350
LAGCGLQSCP MLLAKGYPDI GWNPCGGERY LDFLRFAVFV NGESVEENAN
2360 2370 2380 2390 2400
VVVRLLIRKP ECFGPALRGE GGSGLLAAIE EAIRISEDPA RDGPGVRRDR
2410 2420 2430 2440 2450
RREHFGEEPP EENRVHLGHA IMSFYAALID LLGRCAPEMH LIQAGKGEAL
2460 2470 2480 2490 2500
RIRAILRSLV PLDDLVGIIS LPLQIPTLGK DGALVQPKMS ASFVPDHKAS
2510 2520 2530 2540 2550
MVLFLDRVYG IENQDFLLHV LDVGFLPDMR AAASLDTATF SRRWALALTR
2560 2570 2580 2590 2600
YLCAVLPLIT KCAPLLRGTE HRAIMVDSML HTVYRLSRGR SLTKAQRDVI
2610 2620 2630 2640 2650
EDCLMALCRY IRPSMLQHLL RRLVFDVPIL NEFAKMPLKL LTNHYERCWK
2660 2670 2680 2690 2700
YYCLPTGWAN FGVTSEEELH LTRKLFWGIF DSLAHKKYDQ ELYRIAMPCL
2710 2720 2730 2740 2750
CAIAGALPPD YVDASYSSKT EKKATVDAEG NFDPRPVETL NVIIPEKLDS
2760 2770 2780 2790 2800
FINKFAEYAH EKWAFDKIQN NWSYGENIDE ELKTHPMLRP YKTFSEKDKE
2810 2820 2830 2840 2850
IYRWPIKESL KAMIAWEWTV EKAREGEEEK TEKKKTRKIS QTAQTYDPRE
2860 2870 2880 2890 2900
GYNPQPPDLS VVTLSRELQA MAEQLAENYH NTWGRKKKQE LEAKGGGSHP
2910 2920 2930 2940 2950
LLVPYDTLTA KEKARDREKA QELLKFLQMN GYAVTRHGKD MELDTSSIEK
2960 2970 2980 2990 3000
RFAFGFLQQL LRWMDISQEF IAHLEAVVSS GRVEKSPHEQ EIKFFAKILL
3010 3020 3030 3040 3050
PLINQYFTNH CLYFLSTPAK VLGSGGHASN KEKEMITSLF CKLAALVRHR
3060 3070 3080 3090 3100
VSLFGTDAPA VVNCLHILAR SLDARTVMKS GPEIVKAGLR SFFESASEDI
3110 3120 3130 3140 3150
EKMVENLRLG KVSQARTQVK GVGQNLTYTT VALLPVLTTL FQHIAQHQFG
3160 3170 3180 3190 3200
DDVILDDVQV SCYRTLCSIY SLGTTRNPYV EKLRPALGEC LARLAAAMPV
3210 3220 3230 3240 3250
AFLEPELNEY NACSVYTTKS PRERAILGLP NSVEEMCPDI PVLERLMAEI
3260 3270 3280 3290 3300
GGLAESGARY TEMPHVIEIT LPMLCSYLPR WWERGPEAPP PALPAGAPPP
3310 3320 3330 3340 3350
CTAVTSDHLN SLLGNILRII VNNLGIDEAS WMKRLAVFAQ PIVSRARPEL
3360 3370 3380 3390 3400
LRSHFIPTIG RLRKRAGKVV AEEEQLRLEA KAEAEEGELL VRDEFSVLCR
3410 3420 3430 3440 3450
DLYALYPLLI RYVDNNRSAW PRLPPSPSSS FSLPSPSELG RWLMKDHGHQ
3460 3470 3480 3490 3500
LYEESFTVPL ILDNAAFPLA RNQSRAIGCA GVVRSGGSDQ ERTKKKRRGD
3510 3520 3530 3540 3550
RYSVQTSLIV ATLKKMLPIG LNMCAPTDQD LIVLAKARYA LKDTDEEVRE
3560 3570 3580 3590 3600
FLQNNLNLQG KVEGSPSLRW QMALYRGVPG REEDADDPEK IVRRVQEVSA
3610 3620 3630 3640 3650
VLYHLDQTEH PYKSKKAVWH KLLSKQRRRA VVACFRMTPL YNLPTHRACN
3660 3670 3680 3690 3700
MFLESYKASW ILTEDHSFED RMIDDLSKAG EQEEEEEEVE EKKPDPLHQL
3710 3720 3730 3740 3750
VLHFSRTALT EKSKLDEDYL YMAYADIMAK SCHLEEGGEN VEEGGEEEEV
3760 3770 3780 3790 3800
EVSFEEKEME KQRLLYQQSR LHNRGAAEMV LQMISACKGE TGAMVSSTLK
3810 3820 3830 3840 3850
LGISILNGGN AEVQQKMLDY LKDKKEVGFF QSIQALMQTC RWPHKTLSQR
3860 3870 3880 3890 3900
EGQEERVMKV QTSGTLVIIN RQNGEKVMAD DEFTQDLFRF LQLLCEGHNN
3910 3920 3930 3940 3950
DFQNYLRTQT GNTTTINIII CTVDYLLRLQ ESISDFYWYY SGKDVIEEQG
3960 3970 3980 3990 4000
KRNFSKAMSV AKQVFNSLTE YIQGPCTGNQ QSLAHSRLWD AVVGFLHVFA
4010 4020 4030 4040 4050
HMMMKLAQDS SQIELLKELL DLQKDMVVML LSLLEGNVVN GMIARQMVDM
4060 4070 4080 4090 4100
LVESSSNVEM ILKFFDMFLK LKDIVGSEAF QDYVTDPRGL ISKKDFQKAM
4110 4120 4130 4140 4150
DSQKQFTGPE IQFLLSCSEA DENEMINCEE FANRFQEPAR DIGFNVAVLL
4160 4170 4180 4190 4200
TNLSEHVPHD PRLRNFLELA ESILDYFRPY LGRIEIMGAS RRIERIYFEI
4210 4220 4230 4240 4250
SETNRAQWEM PQVKESKRQF IFDVVNEGGE SEKMELFVSF CEDTIFEMQI
4260 4270 4280 4290 4300
AAQISEPEGE PEEDDDEGAE EAEEGAAGPD GSGSAAAAGV WTWLATAAGR
4310 4320 4330 4340 4350
TLRGLSYRSL RRRVRRLRRL TAREAATAVA VLLWAMVARA GGAGAGAAAG
4360 4370 4380 4390 4400
VLRLLWGSLF GGGLVDSAKK VTVTELLAGM PDPTGDEVHG QQPSGAGSDA
4410 4420 4430 4440 4450
EGEGQGEGEG DAAEGVGDEE VAADQAGTGG ADRTVAVADG SPFRPEGAGG
4460 4470 4480 4490 4500
LGDMGDTTPV EPPTPEGSPI LKRKLGVDGE EEEPQPEPEP EPEPEPEKAD
4510 4520 4530 4540 4550
TENGEKEVPE PPPEPPKKAP PPPPPKKEEA GGAGLEEFWG ELEVQRVKFL
4560 4570 4580 4590 4600
NYLSRNFYTL RFLALFLAFA INFILLFYKV SDSPPGEDDI EGSGAGDMSG
4610 4620 4630 4640 4650
AGSGDGSGWG SRASEEVEGD EDENMVYYFL EESTGYMEPA LRCLSLLHTL
4660 4670 4680 4690 4700
VAFLCIIGYN CLKVPLVIFK REKELARKLE FDGLYITEQP EDDDVKGQWD
4710 4720 4730 4740 4750
RLVLNTPSFP SNYWDKFVKR KVLDKHGDIF GRERIAELLG MDLASLEITA
4760 4770 4780 4790 4800
HNERKPDPPP GLLTWIMSID VKYQIWKFGV IFTDNSFLYL GWYMVMSLLG
4810 4820 4830 4840 4850
HYNNFFFAAH LLDIAMGVKT LRTILSSVTH NGKQLVMTVG LLAVVVYLYT
4860 4870 4880 4890 4900
VVAFNFFRKF YNKSEDEDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE
4910 4920 4930 4940 4950
DPAGDEYELY RVVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVKE
4960 4970 4980 4990 5000
DMETKCFICG IGSDYFDTTP HGFETHTLEE HNLANYMFFL MYLINKDETE
5010 5020 5030
HTGQESYVWK MYQERCWDFF PAGDCFRKQY EDQLG
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K5J1 | A0A0G2K5J1_RAT | Ryanodine receptor 1 | Ryr1 | 5,061 | Annotation score: | ||
V9GZ83 | V9GZ83_RAT | Ryanodine receptor 1 | Ryr1 | 5,035 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 673 | A → V in AAD48899 (PubMed:10444400).Curated | 1 | |
Sequence conflicti | 4728 | D → H in AAD31270 (Ref. 3) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF112256 mRNA Translation: AAD48899.1 AF130879 mRNA Translation: AAD31270.1 AF011788 mRNA Translation: AAB65756.1 |
Genome annotation databases
UCSCi | RGD:620313, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF112256 mRNA Translation: AAD48899.1 AF130879 mRNA Translation: AAD31270.1 AF011788 mRNA Translation: AAB65756.1 |
3D structure databases
SMRi | F1LMY4 |
ModBasei | Search... |
Protein-protein interaction databases
CORUMi | F1LMY4 |
IntActi | F1LMY4, 3 interactors |
MINTi | F1LMY4 |
STRINGi | 10116.ENSRNOP00000027893 |
PTM databases
CarbonylDBi | F1LMY4 |
iPTMneti | F1LMY4 |
PhosphoSitePlusi | F1LMY4 |
Proteomic databases
PaxDbi | F1LMY4 |
PRIDEi | F1LMY4 |
Genome annotation databases
UCSCi | RGD:620313, rat |
Organism-specific databases
RGDi | 1586637, Ryr1 |
Phylogenomic databases
eggNOGi | KOG2243, Eukaryota |
InParanoidi | F1LMY4 |
TreeFami | TF315244 |
Enzyme and pathway databases
Reactomei | R-RNO-2672351, Stimuli-sensing channels R-RNO-5578775, Ion homeostasis |
Miscellaneous databases
PROi | PR:F1LMY4 |
Family and domain databases
CDDi | cd12877, SPRY1_RyR, 1 hit cd12878, SPRY2_RyR, 1 hit cd12879, SPRY3_RyR, 1 hit |
Gene3Di | 2.60.120.920, 3 hits |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR013320, ConA-like_dom_sf IPR011992, EF-hand-dom_pair IPR014821, Ins145_P3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR013333, Ryan_recept IPR003032, Ryanodine_rcpt IPR009460, Ryanrecept_TM4-6 IPR035910, RyR/IP3R_RIH_dom_sf IPR033215, RyR1 IPR035761, SPRY1_RyR IPR035764, SPRY2_RyR IPR035762, SPRY3_RyR IPR003877, SPRY_dom |
PANTHERi | PTHR13715:SF15, PTHR13715:SF15, 1 hit |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF06459, RR_TM4-6, 1 hit PF01365, RYDR_ITPR, 2 hits PF02026, RyR, 4 hits PF00622, SPRY, 3 hits |
PRINTSi | PR00795, RYANODINER |
SMARTi | View protein in SMART SM00472, MIR, 4 hits SM00449, SPRY, 3 hits |
SUPFAMi | SSF100909, SSF100909, 2 hits SSF47473, SSF47473, 1 hit SSF49899, SSF49899, 3 hits SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 3 hits PS50919, MIR, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | RYR1_RAT | |
Accessioni | F1LMY4Primary (citable) accession number: F1LMY4 Secondary accession number(s): O35208, Q9R1G1, Q9R272 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 22, 2012 |
Last sequence update: | May 3, 2011 | |
Last modified: | May 25, 2022 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families