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UniProtKB - F1LMY4 (RYR1_RAT)

Protein

Ryanodine receptor 1

Gene

Ryr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11316255). Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm (By similarity). Can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).By similarity1 Publication

Activity regulationi

Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM) (By similarity). The calcium release is activated by increased cytoplasmic calcium levels, by nitric oxyde (NO), caffeine and ATP (PubMed:11316255). Channel activity is inhibited by magnesium ions, possibly by competition for calcium binding sites (PubMed:11316255).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi3896CalciumBy similarity1
Metal bindingi3970CalciumBy similarity1
Binding sitei4714CaffeineBy similarity1
Metal bindingi4999Calcium; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi4214 – 4218ATPBy similarity5
Nucleotide bindingi4952 – 4957ATPBy similarity6
Nucleotide bindingi4977 – 4983ATPBy similarity7

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionCalcium channel, Calmodulin-binding, Developmental protein, Ion channel, Ligand-gated ion channel, Receptor
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ryanodine receptor 1
Short name:
RYR-1
Short name:
RyR1
Alternative name(s):
Skeletal muscle calcium release channel
Skeletal muscle ryanodine receptor
Skeletal muscle-type ryanodine receptor
Type 1 ryanodine receptor
Gene namesi
Name:Ryr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1586637 Ryr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4556CytoplasmicBy similarityAdd BLAST4556
Transmembranei4557 – 4577Helical; Name=1By similarityAdd BLAST21
Topological domaini4578 – 4638LumenalBy similarityAdd BLAST61
Transmembranei4639 – 4659Helical; Name=2By similarityAdd BLAST21
Topological domaini4660 – 4777CytoplasmicBy similarityAdd BLAST118
Transmembranei4778 – 4800Helical; Name=3By similarityAdd BLAST23
Topological domaini4801LumenalBy similarity1
Transmembranei4802 – 4818Helical; Name=4By similarityAdd BLAST17
Topological domaini4819 – 4833CytoplasmicBy similarityAdd BLAST15
Transmembranei4834 – 4854Helical; Name=5By similarityAdd BLAST21
Topological domaini4855 – 4877LumenalBy similarityAdd BLAST23
Intramembranei4878 – 4897Pore-formingBy similarityAdd BLAST20
Topological domaini4898 – 4917LumenalBy similarityAdd BLAST20
Transmembranei4918 – 4938Helical; Name=6By similarityAdd BLAST21
Topological domaini4939 – 5035CytoplasmicBy similarityAdd BLAST97

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004155671 – 5035Ryanodine receptor 1Add BLAST5035

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1338PhosphoserineCombined sources1
Modified residuei2344PhosphoserineCombined sources1
Modified residuei2840PhosphoserineCombined sources1
Modified residuei3634S-nitrosocysteineBy similarity1
Modified residuei4464PhosphothreonineCombined sources1
Modified residuei4468PhosphoserineCombined sources1
Modified residuei4861PhosphotyrosineBy similarity1
Modified residuei4864PhosphoserineBy similarity1

Post-translational modificationi

Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2840 may increase channel activity. Repeated very high-level exercise increases phosphorylation at Ser-2840.By similarity
Activated by reversible S-nitrosylation (By similarity). Repeated very high-level exercise increases S-nitrosylation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, S-nitrosylation

Proteomic databases

PaxDbiF1LMY4
PRIDEiF1LMY4

PTM databases

CarbonylDBiF1LMY4
iPTMnetiF1LMY4
PhosphoSitePlusiF1LMY4

Expressioni

Tissue specificityi

Detected in skeletal muscle (at protein level) (PubMed:11316255). Detected in myometrium smooth muscle (PubMed:10444400).2 Publications

Interactioni

Subunit structurei

Homotetramer. Can also form heterotetramers with RYR2 (By similarity). Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). Repeated very high-level exercise decreases interaction with PDE4D and protein phosphatase 1 (PP1) (By similarity). Interacts with CALM; CALM with bound calcium inhibits the RYR1 channel activity (By similarity). Interacts with S100A1 (By similarity). Interacts with FKBP1A; this stabilizes the closed conformation of the channel. Interacts with CACNA1S; interaction with CACNA1S is important for activation of the RYR1 channel. Interacts with CACNB1. Interacts with TRDN and ASPH; these interactions stimulate RYR1 channel activity. Interacts with SELENON (By similarity).By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUMiF1LMY4
IntActiF1LMY4, 3 interactors
MINTiF1LMY4
STRINGi10116.ENSRNOP00000027893

Structurei

3D structure databases

ProteinModelPortaliF1LMY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 154MIR 1PROSITE-ProRule annotationAdd BLAST56
Domaini161 – 206MIR 2PROSITE-ProRule annotationAdd BLAST46
Domaini212 – 266MIR 3PROSITE-ProRule annotationAdd BLAST55
Domaini272 – 329MIR 4PROSITE-ProRule annotationAdd BLAST58
Domaini337 – 394MIR 5PROSITE-ProRule annotationAdd BLAST58
Domaini583 – 799B30.2/SPRY 1PROSITE-ProRule annotationAdd BLAST217
Repeati843 – 9561Add BLAST114
Repeati957 – 10702Add BLAST114
Domaini1015 – 1209B30.2/SPRY 2PROSITE-ProRule annotationAdd BLAST195
Repeati1345 – 13603; truncatedAdd BLAST16
Domaini1358 – 1571B30.2/SPRY 3PROSITE-ProRule annotationAdd BLAST214
Repeati1373 – 13884; truncatedAdd BLAST16
Repeati2723 – 28425Add BLAST120
Repeati2843 – 29566Add BLAST114
Domaini4078 – 4106EF-handPROSITE-ProRule annotationAdd BLAST29

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni671 – 682Interaction with FKBP1ABy similarityAdd BLAST12
Regioni843 – 29566 X approximate repeatsAdd BLAST2114
Regioni3613 – 3642Interaction with CALMBy similarityAdd BLAST30

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi4892 – 4898Selectivity filterBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1867 – 2087Glu-richAdd BLAST221
Compositional biasi3681 – 3760Glu-richAdd BLAST80
Compositional biasi4459 – 4525Pro-richAdd BLAST67

Domaini

The calcium release channel activity resides in the C-terminal region while the remaining part of the protein constitutes the 'foot' structure spanning the junctional gap between the sarcoplasmic reticulum (SR) and the T-tubule. Pore opening is mediated via the cytoplasmic calcium-binding domains that mediate a small rotation of the channel-forming transmembrane regions that then leads to channel opening.By similarity

Sequence similaritiesi

Belongs to the ryanodine receptor (TC 1.A.3.1) family. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2243 Eukaryota
ENOG410YCNW LUCA
HOGENOMiHOG000231428
HOVERGENiHBG102939
InParanoidiF1LMY4
TreeFamiTF315244

Family and domain databases

CDDicd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR015925 Ryanodine_recept-rel
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR033215 RyR1
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom
PANTHERiPTHR13715 PTHR13715, 1 hit
PTHR13715:SF15 PTHR13715:SF15, 1 hit
PfamiView protein in Pfam
PF13833 EF-hand_8, 1 hit
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits
PRINTSiPR00795 RYANODINER
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 3 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F1LMY4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDGGGEGED EVQFLRTDDE VVLQCSATVL KEQLKLCLAA EGFGNRLCFL 
        60         70         80         90        100
EPTSNAQNVP PDLAICCFIL EQSLSVRALQ EMLANTVEAG VESSQGGGHR 
       110        120        130        140        150
TLLYGHAILL RHAHSRMYLS CLTTSRSMTD KLAFDVGLQE DATGEACWWT 
       160        170        180        190        200
MHPASKQRSE GEKVRVGDDL ILVSVSSERY LHLSTASGEL QVDASFMQTL 
       210        220        230        240        250
WNMNPICSCC EEGFVTGGHV LRLFHGHMDE CLTISPSDSD DQRRLVYYEG 
       260        270        280        290        300
GPVCTHARSL WRLEPLRISW SGSHLRWGQP LRIRHVTTGR YLALTEDQGL 
       310        320        330        340        350
VVVDASKAHT KATSFCFRIS KEKLDVAPKR DVEGMGPPEI KYGESLCFVQ 
       360        370        380        390        400
HVASGLWLTY AAPDPKALRL GVLKKKAMLH QEGHMDDALS LTRCQQEESQ 
       410        420        430        440        450
AARMIYSTAG LYNQFIKGLD SFSGKPRGSG PPAGSALPIE GVILSLQDLI 
       460        470        480        490        500
GYFEPPSEEL QHEEKQTKLR SLRNRQSLFQ EEGMLSLVLN CIDRLNVYTT 
       510        520        530        540        550
AAHFAEFAGE EAAESWKEIV NLLYELLASL IRGNRTNCAL FSTNLDWLVS 
       560        570        580        590        600
KLDRLEASSG ILEVLYCVLI ESPEVLNIIQ ENHIKSIISL LDKHGRNHKV 
       610        620        630        640        650
LDVLCSLCVC NGVAVRSNQD LITENLLPGR ELLLQTNLIN YVTSIRPNIF 
       660        670        680        690        700
VGRAEGSTQY GKWYFEVMVD EVAPFLTAQA THLRVGWALS EGYSPYPGGG 
       710        720        730        740        750
EGWGGNGVGD DLYSYGFDGL HLWTGHVARP VTSPGQHLLG PEDVVSCCLD 
       760        770        780        790        800
LSVPSISFRI NGCPVQGVFE SFNLDGLFFP VVSFSAGIKV RFLLGGRHGE 
       810        820        830        840        850
FKFLPPPGYA PCHEAVLPRE RLHLQPIKEY RREGPRGPHL VGPSRCLSHL 
       860        870        880        890        900
DFVPCPVDTI QIVLPPHLER IREKLAENIH ELWALTRIEQ GWTYGPVRDD 
       910        920        930        940        950
NKRLHPCLVD FHSLPEPERN YNLQMSGETL KTLLALGCHV GMADEKAEDN 
       960        970        980        990       1000
LKKTKLPKTY MMNNGYKPAP LDLSHVRLTP AQTTLVDRLA ENGHNVWARD 
      1010       1020       1030       1040       1050
RVAQGWSYSA VQDIPARRNP RLVPYRLLDE ATKRSNRDSL CQAVRTLLGY 
      1060       1070       1080       1090       1100
GYNIEPPDQE PSQVDSQSRG DRARIFRAEK SYAVQSGRWY FEFEAVTTGR 
      1110       1120       1130       1140       1150
ELGWARPELR PDVELGADDL AYVFNGHRGQ RWHLGSEPFG RPWQSGDVVG 
      1160       1170       1180       1190       1200
CMIDLTENTI IFTLNGEVLM SDSGSETAFR EIEIGDGFLP VCSLGPGQVG 
      1210       1220       1230       1240       1250
HLNLGQDVSS LRFFAICGLQ EGFEPFAINM QRPVTTWFSK SLPQFEPVPL 
      1260       1270       1280       1290       1300
EHPHYEVARM DGTVDTPPCL RLTHRTWGSQ NSLVEMLFLR LSLPVQFHQH 
      1310       1320       1330       1340       1350
FRCTAGATPL ASPGLQPPAE DEARAAEPDT DYENLRRSAG GWGEAEAGKD 
      1360       1370       1380       1390       1400
GTAKEGTPGG AAQPGVEAQP ARAENEKDAT TEKNKKRGFL FKAKKVAMMT 
      1410       1420       1430       1440       1450
QPPSTPALPR LPRDVVPADN RDDPEIILNT TTYYYSVRVF AGQEPSCVWV 
      1460       1470       1480       1490       1500
GWVTPDYHQH DMSFDLSKVR AVTVTMGDEQ GNVHSSLKCS NCYMVWGGDF 
      1510       1520       1530       1540       1550
VSPGQQGRIS HTDLVIGCLV DLATGLMTFT ANGKESNTFF QVEPNTKLFP 
      1560       1570       1580       1590       1600
AVFVLPTHQN VVQFDLRPGA NIMPLSAAMF LSERKNPAPQ CPPRLEVQML 
      1610       1620       1630       1640       1650
MPVSWSRMPN HFLHVDTRRA GERLGWAVQC QEPLMMMALH IPEENSEPYI 
      1660       1670       1680       1690       1700
HLKRAQLDPR DLRDYRDTKF DSESSDSDQT PQPGCYHVDQ AQLLHALEDA 
      1710       1720       1730       1740       1750
HLPGPLRAGY YDLLISIHLE SACRSRRSML SEYIVPLTEE TRAITLFPPG 
      1760       1770       1780       1790       1800
RSAEDGPRRH GLPGVGVTTS LRPPHHFSPP CFVVALPAAG AAEAPARLSP 
      1810       1820       1830       1840       1850
AIPLEALRDK ALRMLGEAVR DGGQHARDPV GGSVEFQFVP VLKLVSTLLV 
      1860       1870       1880       1890       1900
MGVFSDEDVK QILKMIEPEV FTEEEEVEEE EEEEEEDEEE KEEDEEEEAH 
      1910       1920       1930       1940       1950
EKEDEEKEEA EEAAEEEKEE LEEGLLQMKL PESVKLQMCH LLEYFCDQEL 
      1960       1970       1980       1990       2000
QHRVESLAAF AERYVDKLQS NQRGRYGLLM KAFTMSAAET ARRTREFRSP 
      2010       2020       2030       2040       2050
PQEQINMLLQ FKNGADEEDC PLPEEIREDL VNFHQDLLAH CGIQLEGEEE 
      2060       2070       2080       2090       2100
EPEEESTLGS RLMSLLEKVR LVKKKEEKPE EEPAAEEHKP QSLQELVSHT 
      2110       2120       2130       2140       2150
VVRWAQEDFV QSPELVRAMF SLLHRQYDGL GELLRALPRA YTISLSSVED 
      2160       2170       2180       2190       2200
TMSLLECLGQ IRSLLIVQMG PQEENLMIQS IGNIMNNKVF YQHPNLMRAL 
      2210       2220       2230       2240       2250
GMHETVMEVM VNVLGGGESK EIRFPKMVTS CCRFLCYFCR ISRQNQRSMF 
      2260       2270       2280       2290       2300
DHLSYLLENS GIGLGMQGST PLDVAAASVI DNNELALALQ EQDLEKVVSY 
      2310       2320       2330       2340       2350
LAGCGLQSCP MLLAKGYPDI GWNPCGGERY LDFLRFAVFV NGESVEENAN 
      2360       2370       2380       2390       2400
VVVRLLIRKP ECFGPALRGE GGSGLLAAIE EAIRISEDPA RDGPGVRRDR 
      2410       2420       2430       2440       2450
RREHFGEEPP EENRVHLGHA IMSFYAALID LLGRCAPEMH LIQAGKGEAL 
      2460       2470       2480       2490       2500
RIRAILRSLV PLDDLVGIIS LPLQIPTLGK DGALVQPKMS ASFVPDHKAS 
      2510       2520       2530       2540       2550
MVLFLDRVYG IENQDFLLHV LDVGFLPDMR AAASLDTATF SRRWALALTR 
      2560       2570       2580       2590       2600
YLCAVLPLIT KCAPLLRGTE HRAIMVDSML HTVYRLSRGR SLTKAQRDVI 
      2610       2620       2630       2640       2650
EDCLMALCRY IRPSMLQHLL RRLVFDVPIL NEFAKMPLKL LTNHYERCWK 
      2660       2670       2680       2690       2700
YYCLPTGWAN FGVTSEEELH LTRKLFWGIF DSLAHKKYDQ ELYRIAMPCL 
      2710       2720       2730       2740       2750
CAIAGALPPD YVDASYSSKT EKKATVDAEG NFDPRPVETL NVIIPEKLDS 
      2760       2770       2780       2790       2800
FINKFAEYAH EKWAFDKIQN NWSYGENIDE ELKTHPMLRP YKTFSEKDKE 
      2810       2820       2830       2840       2850
IYRWPIKESL KAMIAWEWTV EKAREGEEEK TEKKKTRKIS QTAQTYDPRE 
      2860       2870       2880       2890       2900
GYNPQPPDLS VVTLSRELQA MAEQLAENYH NTWGRKKKQE LEAKGGGSHP 
      2910       2920       2930       2940       2950
LLVPYDTLTA KEKARDREKA QELLKFLQMN GYAVTRHGKD MELDTSSIEK 
      2960       2970       2980       2990       3000
RFAFGFLQQL LRWMDISQEF IAHLEAVVSS GRVEKSPHEQ EIKFFAKILL 
      3010       3020       3030       3040       3050
PLINQYFTNH CLYFLSTPAK VLGSGGHASN KEKEMITSLF CKLAALVRHR 
      3060       3070       3080       3090       3100
VSLFGTDAPA VVNCLHILAR SLDARTVMKS GPEIVKAGLR SFFESASEDI 
      3110       3120       3130       3140       3150
EKMVENLRLG KVSQARTQVK GVGQNLTYTT VALLPVLTTL FQHIAQHQFG 
      3160       3170       3180       3190       3200
DDVILDDVQV SCYRTLCSIY SLGTTRNPYV EKLRPALGEC LARLAAAMPV 
      3210       3220       3230       3240       3250
AFLEPELNEY NACSVYTTKS PRERAILGLP NSVEEMCPDI PVLERLMAEI 
      3260       3270       3280       3290       3300
GGLAESGARY TEMPHVIEIT LPMLCSYLPR WWERGPEAPP PALPAGAPPP 
      3310       3320       3330       3340       3350
CTAVTSDHLN SLLGNILRII VNNLGIDEAS WMKRLAVFAQ PIVSRARPEL 
      3360       3370       3380       3390       3400
LRSHFIPTIG RLRKRAGKVV AEEEQLRLEA KAEAEEGELL VRDEFSVLCR 
      3410       3420       3430       3440       3450
DLYALYPLLI RYVDNNRSAW PRLPPSPSSS FSLPSPSELG RWLMKDHGHQ 
      3460       3470       3480       3490       3500
LYEESFTVPL ILDNAAFPLA RNQSRAIGCA GVVRSGGSDQ ERTKKKRRGD 
      3510       3520       3530       3540       3550
RYSVQTSLIV ATLKKMLPIG LNMCAPTDQD LIVLAKARYA LKDTDEEVRE 
      3560       3570       3580       3590       3600
FLQNNLNLQG KVEGSPSLRW QMALYRGVPG REEDADDPEK IVRRVQEVSA 
      3610       3620       3630       3640       3650
VLYHLDQTEH PYKSKKAVWH KLLSKQRRRA VVACFRMTPL YNLPTHRACN 
      3660       3670       3680       3690       3700
MFLESYKASW ILTEDHSFED RMIDDLSKAG EQEEEEEEVE EKKPDPLHQL 
      3710       3720       3730       3740       3750
VLHFSRTALT EKSKLDEDYL YMAYADIMAK SCHLEEGGEN VEEGGEEEEV 
      3760       3770       3780       3790       3800
EVSFEEKEME KQRLLYQQSR LHNRGAAEMV LQMISACKGE TGAMVSSTLK 
      3810       3820       3830       3840       3850
LGISILNGGN AEVQQKMLDY LKDKKEVGFF QSIQALMQTC RWPHKTLSQR 
      3860       3870       3880       3890       3900
EGQEERVMKV QTSGTLVIIN RQNGEKVMAD DEFTQDLFRF LQLLCEGHNN 
      3910       3920       3930       3940       3950
DFQNYLRTQT GNTTTINIII CTVDYLLRLQ ESISDFYWYY SGKDVIEEQG 
      3960       3970       3980       3990       4000
KRNFSKAMSV AKQVFNSLTE YIQGPCTGNQ QSLAHSRLWD AVVGFLHVFA 
      4010       4020       4030       4040       4050
HMMMKLAQDS SQIELLKELL DLQKDMVVML LSLLEGNVVN GMIARQMVDM 
      4060       4070       4080       4090       4100
LVESSSNVEM ILKFFDMFLK LKDIVGSEAF QDYVTDPRGL ISKKDFQKAM 
      4110       4120       4130       4140       4150
DSQKQFTGPE IQFLLSCSEA DENEMINCEE FANRFQEPAR DIGFNVAVLL 
      4160       4170       4180       4190       4200
TNLSEHVPHD PRLRNFLELA ESILDYFRPY LGRIEIMGAS RRIERIYFEI 
      4210       4220       4230       4240       4250
SETNRAQWEM PQVKESKRQF IFDVVNEGGE SEKMELFVSF CEDTIFEMQI 
      4260       4270       4280       4290       4300
AAQISEPEGE PEEDDDEGAE EAEEGAAGPD GSGSAAAAGV WTWLATAAGR 
      4310       4320       4330       4340       4350
TLRGLSYRSL RRRVRRLRRL TAREAATAVA VLLWAMVARA GGAGAGAAAG 
      4360       4370       4380       4390       4400
VLRLLWGSLF GGGLVDSAKK VTVTELLAGM PDPTGDEVHG QQPSGAGSDA 
      4410       4420       4430       4440       4450
EGEGQGEGEG DAAEGVGDEE VAADQAGTGG ADRTVAVADG SPFRPEGAGG 
      4460       4470       4480       4490       4500
LGDMGDTTPV EPPTPEGSPI LKRKLGVDGE EEEPQPEPEP EPEPEPEKAD 
      4510       4520       4530       4540       4550
TENGEKEVPE PPPEPPKKAP PPPPPKKEEA GGAGLEEFWG ELEVQRVKFL 
      4560       4570       4580       4590       4600
NYLSRNFYTL RFLALFLAFA INFILLFYKV SDSPPGEDDI EGSGAGDMSG 
      4610       4620       4630       4640       4650
AGSGDGSGWG SRASEEVEGD EDENMVYYFL EESTGYMEPA LRCLSLLHTL 
      4660       4670       4680       4690       4700
VAFLCIIGYN CLKVPLVIFK REKELARKLE FDGLYITEQP EDDDVKGQWD 
      4710       4720       4730       4740       4750
RLVLNTPSFP SNYWDKFVKR KVLDKHGDIF GRERIAELLG MDLASLEITA 
      4760       4770       4780       4790       4800
HNERKPDPPP GLLTWIMSID VKYQIWKFGV IFTDNSFLYL GWYMVMSLLG 
      4810       4820       4830       4840       4850
HYNNFFFAAH LLDIAMGVKT LRTILSSVTH NGKQLVMTVG LLAVVVYLYT 
      4860       4870       4880       4890       4900
VVAFNFFRKF YNKSEDEDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE 
      4910       4920       4930       4940       4950
DPAGDEYELY RVVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVKE 
      4960       4970       4980       4990       5000
DMETKCFICG IGSDYFDTTP HGFETHTLEE HNLANYMFFL MYLINKDETE 
      5010       5020       5030 
HTGQESYVWK MYQERCWDFF PAGDCFRKQY EDQLG
Length:5,035
Mass (Da):565,483
Last modified:May 3, 2011 - v1
Checksum:i51705805EDCAF5CB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K5J1A0A0G2K5J1_RAT
Ryanodine receptor 1
Ryr1
5,012Annotation score:
V9GZ83V9GZ83_RAT
Ryanodine receptor 1
Ryr1
3,903Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti673A → V in AAD48899 (PubMed:10444400).Curated1
Sequence conflicti4728D → H in AAD31270 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112256 mRNA Translation: AAD48899.1
AF130879 mRNA Translation: AAD31270.1
AF011788 mRNA Translation: AAB65756.1
UniGeneiRn.225306
Rn.87520

Genome annotation databases

UCSCiRGD:620313 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112256 mRNA Translation: AAD48899.1
AF130879 mRNA Translation: AAD31270.1
AF011788 mRNA Translation: AAB65756.1
UniGeneiRn.225306
Rn.87520

3D structure databases

ProteinModelPortaliF1LMY4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiF1LMY4
IntActiF1LMY4, 3 interactors
MINTiF1LMY4
STRINGi10116.ENSRNOP00000027893

PTM databases

CarbonylDBiF1LMY4
iPTMnetiF1LMY4
PhosphoSitePlusiF1LMY4

Proteomic databases

PaxDbiF1LMY4
PRIDEiF1LMY4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:620313 rat

Organism-specific databases

RGDi1586637 Ryr1

Phylogenomic databases

eggNOGiKOG2243 Eukaryota
ENOG410YCNW LUCA
HOGENOMiHOG000231428
HOVERGENiHBG102939
InParanoidiF1LMY4
TreeFamiTF315244

Miscellaneous databases

PROiPR:F1LMY4

Family and domain databases

CDDicd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR015925 Ryanodine_recept-rel
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR033215 RyR1
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom
PANTHERiPTHR13715 PTHR13715, 1 hit
PTHR13715:SF15 PTHR13715:SF15, 1 hit
PfamiView protein in Pfam
PF13833 EF-hand_8, 1 hit
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits
PRINTSiPR00795 RYANODINER
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 3 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRYR1_RAT
AccessioniPrimary (citable) accession number: F1LMY4
Secondary accession number(s): O35208, Q9R1G1, Q9R272
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: May 3, 2011
Last modified: November 7, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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