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Entry version 79 (02 Jun 2021)
Sequence version 3 (11 May 2016)
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Protein
Submitted name:

Ankyrin 2

Gene

Ank2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ank2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Rat genome database

More...
RGDi
620156, Ank2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
F1LM42

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000011076, Expressed in frontal cortex and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F1LM42, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1LM42

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 786ANK_REP_REGIONInterPro annotationAdd BLAST784
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati36 – 68ANKPROSITE-ProRule annotationAdd BLAST33
Repeati69 – 101ANKPROSITE-ProRule annotationAdd BLAST33
Repeati102 – 134ANKPROSITE-ProRule annotationAdd BLAST33
Repeati205 – 237ANKPROSITE-ProRule annotationAdd BLAST33
Repeati238 – 270ANKPROSITE-ProRule annotationAdd BLAST33
Repeati271 – 303ANKPROSITE-ProRule annotationAdd BLAST33
Repeati304 – 336ANKPROSITE-ProRule annotationAdd BLAST33
Repeati337 – 369ANKPROSITE-ProRule annotationAdd BLAST33
Repeati370 – 402ANKPROSITE-ProRule annotationAdd BLAST33
Repeati408 – 435ANKPROSITE-ProRule annotationAdd BLAST28
Repeati436 – 468ANKPROSITE-ProRule annotationAdd BLAST33
Repeati469 – 501ANKPROSITE-ProRule annotationAdd BLAST33
Repeati502 – 534ANKPROSITE-ProRule annotationAdd BLAST33
Repeati535 – 567ANKPROSITE-ProRule annotationAdd BLAST33
Repeati568 – 600ANKPROSITE-ProRule annotationAdd BLAST33
Repeati601 – 633ANKPROSITE-ProRule annotationAdd BLAST33
Repeati634 – 666ANKPROSITE-ProRule annotationAdd BLAST33
Repeati667 – 699ANKPROSITE-ProRule annotationAdd BLAST33
Repeati700 – 732ANKPROSITE-ProRule annotationAdd BLAST33
Repeati733 – 765ANKPROSITE-ProRule annotationAdd BLAST33
Domaini940 – 1095ZU5InterPro annotationAdd BLAST156
Domaini1097 – 1243ZU5InterPro annotationAdd BLAST147
Domaini3500 – 3584DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1583 – 1996DisorderedSequence analysisAdd BLAST414
Regioni2157 – 2241DisorderedSequence analysisAdd BLAST85
Regioni2306 – 2418DisorderedSequence analysisAdd BLAST113
Regioni2444 – 2886DisorderedSequence analysisAdd BLAST443
Regioni2907 – 2926DisorderedSequence analysisAdd BLAST20
Regioni3007 – 3034DisorderedSequence analysisAdd BLAST28
Regioni3079 – 3397DisorderedSequence analysisAdd BLAST319
Regioni3421 – 3442DisorderedSequence analysisAdd BLAST22
Regioni3621 – 3643DisorderedSequence analysisAdd BLAST23
Regioni3738 – 3764DisorderedSequence analysisAdd BLAST27
Regioni3831 – 3851DisorderedSequence analysisAdd BLAST21
Regioni3909 – 3937DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1598 – 1634Polar residuesSequence analysisAdd BLAST37
Compositional biasi1649 – 1681Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi1703 – 1741Basic and acidic residuesSequence analysisAdd BLAST39
Compositional biasi1744 – 1789Polar residuesSequence analysisAdd BLAST46
Compositional biasi1817 – 1835Polar residuesSequence analysisAdd BLAST19
Compositional biasi1938 – 1980Basic and acidic residuesSequence analysisAdd BLAST43
Compositional biasi2196 – 2225Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi2456 – 2494Polar residuesSequence analysisAdd BLAST39
Compositional biasi2501 – 2559Basic and acidic residuesSequence analysisAdd BLAST59
Compositional biasi2584 – 2614Polar residuesSequence analysisAdd BLAST31
Compositional biasi2630 – 2646Polar residuesSequence analysisAdd BLAST17
Compositional biasi2657 – 2685Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi2753 – 2767Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi2768 – 2809Polar residuesSequence analysisAdd BLAST42
Compositional biasi2824 – 2839Polar residuesSequence analysisAdd BLAST16
Compositional biasi2851 – 2886Polar residuesSequence analysisAdd BLAST36
Compositional biasi3113 – 3130Acidic residuesSequence analysisAdd BLAST18
Compositional biasi3138 – 3152Polar residuesSequence analysisAdd BLAST15
Compositional biasi3159 – 3194Polar residuesSequence analysisAdd BLAST36
Compositional biasi3195 – 3210Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi3293 – 3307Polar residuesSequence analysisAdd BLAST15
Compositional biasi3336 – 3365Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi3374 – 3389Polar residuesSequence analysisAdd BLAST16
Compositional biasi3421 – 3435Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi3621 – 3640Basic and acidic residuesSequence analysisAdd BLAST20

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155279

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1LM42

TreeFam database of animal gene trees

More...
TreeFami
TF351263

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

F1LM42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
QSDSNASFLR AARAGNLDKV VEYLKGGIDI NTCNQNGLNA LHLAAKEGHV
60 70 80 90 100
GLVQELLGRG SSVDSATKKG NTALHIASLA GQAEVVKVLV KEGANINAQS
110 120 130 140 150
QNGFTPLYMA AQENHIDVVK YLLENGANQS TATEDGFTPL AVALQQGHNQ
160 170 180 190 200
AVAILLENDT KGKVRLPALH IAARKDDTKS AALLLQNDHN ADVQSKMMVN
210 220 230 240 250
RTTESGFTPL HIAAHYGNVN VATLLLNRGA AVDFTARNGI TPLHVASKRG
260 270 280 290 300
NTNMVKLLLD RGGQIDAKTR DGLTPLHCAA RSGHDQVVEL LLERGAPLLA
310 320 330 340 350
RTKNGLSPLH MAAQGDHVEC VKHLLQHKAP VDDVTLDYLT ALHVAAHCGH
360 370 380 390 400
YRVTKLLLDK RANPNARALN GFTPLHIACK KNRIKVMELL VKYGASIQSV
410 420 430 440 450
EKFWPHTIHV AAFMGHLNIV LLLLQNGASP DVTNIRGETA LHMAARAGQV
460 470 480 490 500
EVVRCLLRNG ALVDARAREE QTPLHIASRL GKTEIVQLLL QHMAHPDAAT
510 520 530 540 550
TNGYTPLHIS AREGQVDVAS VLLEAGAAHS LATKKGFTPL HVAAKYGSLD
560 570 580 590 600
VAKLLLQRRA AADSAGKNGL TPLHVAAHYD NQKVALLLLE KGASPHATAK
610 620 630 640 650
NGYTPLHIAA KKNQMQIAST LLNYGAETNT VTKQGVTPLH LASQEGHTDM
660 670 680 690 700
VTLLLEKGAN IHMSTKSGLT SLHLAAQEDK VNVADILTKH GADQDAYTKL
710 720 730 740 750
GYTPLIVACH YGNVKMVNFL LKQGANVNAK TKNGYTPLHQ AAQQGHTHII
760 770 780 790 800
NVLLQHGAKP NATTANGNTA LAIAKRLGYI SVVDTLKVVT EEVTTTTTTI
810 820 830 840 850
TEKHKLNVPE TMTEVLDVSD EEGDDTVTGD GEYLRPEDLK ELGDDSLPSS
860 870 880 890 900
QFLDGMNYLR YSLEGGRSDS LRSFSSDRSH TLSHASYLRD SAMIDDTVVI
910 920 930 940 950
PSHQVSALAK EAERNSYRLS WGTENLDNVA LSSSPIHSGF LVSFMVDARG
960 970 980 990 1000
GAMRGCRHNG LRIIIPPRKC TAPTRVTCRL VKRHRLATMP PMVEGEGLAS
1010 1020 1030 1040 1050
RLIEVGPSGA QFLGPVIVEI PHFAALRGKE RELVVLRSEN GDSWKEHFCE
1060 1070 1080 1090 1100
YTEDELNEIL NGMDEVLDSP EDLEKKRICR IITRDFPQYF AVVSRIKQDS
1110 1120 1130 1140 1150
NLIGPEGGVL SSTVVSQVQA VFPEGALTKR IRVGLQAQPM HSELVKKILG
1160 1170 1180 1190 1200
NKATFSPIVT LEPRRRKFHK PITMTIPVPK ASSDVMLNGF GGDAPTLRLL
1210 1220 1230 1240 1250
CSITGGTTPA QWEDITGTTP LTFVNECVSF TTNVSARFWL IDCRQIQESV
1260 1270 1280 1290 1300
AFASQVYREI ICVPYMAKFV VFAKSHDPIE ARLRCFCMTD DKVDKTLEQQ
1310 1320 1330 1340 1350
ENFSEVARSR DVEVLEGKPI YVDCFGNLVP LTKSGQHHIF SFFAFKENRL
1360 1370 1380 1390 1400
PLFVKVRDTT QEPCGRLSFM KEPKSTRGLV HQAICNLNIT LPIYAKESES
1410 1420 1430 1440 1450
DQEQEEEICM TSEKNDETES TETSVLKSHL VNEVPVLASP DLLSEVSEMK
1460 1470 1480 1490 1500
QDLIKMTAIL TTDVSDKAGS IKVKELAKAG EEEPGEPFEI VERVKEDLEK
1510 1520 1530 1540 1550
VNAILRSGTY MRDEGSVRSS QSERELEEEW VIVSDEEIEE AKQHAPVEIA
1560 1570 1580 1590 1600
EHPCVEVRVD RETKTKVEKD STGLVNYLTD DLNSYTGTHE KKPQTAPEKS
1610 1620 1630 1640 1650
GETSQASAIV KSSESNKGKT SPAEEKQSAQ KQVKPSLVIK KPVRRKLKEK
1660 1670 1680 1690 1700
QKQKEESPQG SEEKTELKKG SSEESVDEDR GLAPEPLPTA KATSPLIEET
1710 1720 1730 1740 1750
PIGSIKDKVK ALQKRVEDEQ KGRSKLPVRV KGKEDVPKKT TPRTHPVVSP
1760 1770 1780 1790 1800
SSKSSPSSKM ERHSSLTSSA KTERHSPVSP SSKNEKHSPV SPSAKAERHS
1810 1820 1830 1840 1850
PVFSGKPEKH SPGSPSTKNE RHSPVSSIKT ERHTPVSPSG KTDKRPPVPS
1860 1870 1880 1890 1900
SGRTEKHPPV SPGKTEKRSP GAPSIRTPEK QAPGSATGKH EKHLPVSPGK
1910 1920 1930 1940 1950
TEKQPPISPT SKTERIEETM SVRELMKAFQ SGQDPSKHKT GLFEHKSAKQ
1960 1970 1980 1990 2000
KQSQDKSKSR VEKEKGHSVT QRETQRIENQ TAKRGQRFQV TGAMESRRFR
2010 2020 2030 2040 2050
STTITVGLRT EDPVRERFER TPVIKTPEAV PPVAAAVAAA AAEESHRGAE
2060 2070 2080 2090 2100
TLQEKTVDEQ EDMDLQISPD RKTSTDFSDV IKQELEDNDK YQQFRLTENT
2110 2120 2130 2140 2150
EKAQIHLDQV ITSPFNTTFP LDYMKDEFLP ALSLQSGALG GSSESLKQEV
2160 2170 2180 2190 2200
IAGSPCGSLM EGTPQISSEE SYKHEGLAET PETSPESLSF SPKKSKEQIG
2210 2220 2230 2240 2250
EAKETIKVET PTDIHSEKEL PITNDIADSS EKQGAGVPGD SEHVLKEVTQ
2260 2270 2280 2290 2300
VPPKDVCSKQ EDCPGSHSVS LANETCQALT EEGSCRDSQL PLVSSACKTQ
2310 2320 2330 2340 2350
AVSETQESLA TSEVTKAFPP SDATVKTVEG TEPKPQGVIR SPQGLELPLH
2360 2370 2380 2390 2400
NRDSEVLSPM ADESLAVSHK DSLEASPVLE DNSSHKTPDS LEPSPLKESP
2410 2420 2430 2440 2450
CRDSLESSPV EPKMKAGILP SHFPLPAAIA KTDLVAEVAS MRSRLLRDPD
2460 2470 2480 2490 2500
GSAEDDSLEQ TSLMESSGKS PLSPDTPSSE EVSYEVTPKP SDSSTPKPAV
2510 2520 2530 2540 2550
IHECAEEDDS ENGEKKRFTP EEEMFKMVTK IKTFDELEQE AKQKRDYKRE
2560 2570 2580 2590 2600
PRQDESSSSS DPDADCSAEV DEQKQMGSTE GESDVPVLVT SESRKASSSS
2610 2620 2630 2640 2650
ESEPELTQLS KGADSGLLTE PVIRVQPPSP LPSSIDSNSS PEEAQFQPIV
2660 2670 2680 2690 2700
PKQYTFKMNE EVKEDPGNPE EDKDCKSHLA EDSQTHSADG ADGSHADLNR
2710 2720 2730 2740 2750
ETPQLEACDG HGCKAVSPSN SATPVSLGVQ SPECHDVDKP LAIDNDSLAL
2760 2770 2780 2790 2800
QDTHGSDLEE REFDPSRVES TQASLPSEHS SLSSSSHCAV PEENESAKEI
2810 2820 2830 2840 2850
SSPSSPVKVE VTVTDPVLES MSEDCPTQEA STTTHTERFA MDGPVSDIAE
2860 2870 2880 2890 2900
TDENSHPQIT SPYENVASSS FFSGEPSNFQ TDTCHPTVVH SPEVYSVIIR
2910 2920 2930 2940 2950
SSPEDVIMTS SSSRTDSGEA SNCEGHDLDT ECEQKSALWP MQSDEPPLSV
2960 2970 2980 2990 3000
APTTPNAPVV TGEQVSKVII TKTDVDADSW SEIREDDAAF EARVKEEEQK
3010 3020 3030 3040 3050
IFGLMVDRQS QGTTPDTTPA RTPTEEGTPT SEQNPFLFQE GKLFEMTRSG
3060 3070 3080 3090 3100
AIDMTKRSYA DESLHFFQIG QDSNEETISE DLKEGATGAE PPQTETTSES
3110 3120 3130 3140 3150
LELSGPKEAM DDEGELVPDD VSEEIEDLPA SDADLDSKVV ISASTETPTK
3160 3170 3180 3190 3200
EAVSTVAEEP ATMQWSDSLS TVKQTSCPTF PEPVGQLDFS TVTRSVYSDR
3210 3220 3230 3240 3250
DDESPDSSPE EQKSVIEIPT APMENVPSAE IKPQIPIRTL PTSVSAPPSA
3260 3270 3280 3290 3300
EDESAFSDDF PSGLDGESEE DGAKPKSKIP IKAPPQRTEW HPSHPDISLQ
3310 3320 3330 3340 3350
KSGVPQGQDV LSRGPDGRSK SESDASSLDA KTKCPVKARS YIETETESRE
3360 3370 3380 3390 3400
RAEGFESESE EGATKPKLFA SRLPVKSRST SSSSRTGTSP TRESREHFFD
3410 3420 3430 3440 3450
LYRNSIEFFE EISDEASKLV DRLTQSEREQ EPPSDDESSS ALEVSVIENL
3460 3470 3480 3490 3500
PPVDTEHSAP EDIFDTRPIW DESIETMIER IPDENGHDRA EDPQDEQERM
3510 3520 3530 3540 3550
EERLAYIADH LGFSWTELAR ELDFTEEQIH QIRIENPNSL QDQSHALLKY
3560 3570 3580 3590 3600
WLERDGKHAT DTVLIECLTK INRMDIVHLL ETNTEPLQER MGRTYAEMEQ
3610 3620 3630 3640 3650
TITLDHSEGF SVLPEELCAV KEKKEQEASK ESESSDHPPM VSEEDISVGY
3660 3670 3680 3690 3700
STFQDCIPKT EGDSPAAALS PQMHQESVQQ DFSGKMQDQQ EYYVTTPGAE
3710 3720 3730 3740 3750
VEDTQKATVI PDSLCKTPED ISTPPEEAKP CLQTPVAIEH ASPIVQEPEE
3760 3770 3780 3790 3800
ASEPKEESSP RKTSLVIVES TDDQPQVFEK LDGDAAFQKG DDMPDIPPET
3810 3820 3830 3840 3850
VTEEEYVDEN GHTVVKKVTR KIIRRYVSSD GTEKEEITMQ GMPQEPVNIE
3860 3870 3880 3890 3900
DGDSYSKVIK RVVLKSDTQL SEVTLSEPSI VSGTSQFQAE PVEGRRVSKV
3910 3920 3930
VKTTMVHGER MEKSLGDSSL ATDLPSAKED FEEVQKE
Length:3,937
Mass (Da):430,806
Last modified:May 11, 2016 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A2AE1FB1123EEEC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2KBB9A0A0G2KBB9_RAT
Ankyrin 2
Ank2
3,963Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1M9N9F1M9N9_RAT
Ankyrin 2
Ank2
3,908Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1M5N3F1M5N3_RAT
Ankyrin 2
Ank2
3,908Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JZ56A0A0G2JZ56_RAT
Ankyrin 2
Ank2
1,848Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K6R9A0A0G2K6R9_RAT
Ankyrin 2
Ank2
3,931Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2KAS9A0A0G2KAS9_RAT
Ankyrin 2
Ank2
1,854Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LZM2F1LZM2_RAT
Ankyrin 2
Ank2
443Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D4A4Q9D4A4Q9_RAT
Ankyrin 2
Ank2
480Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R511M0R511_RAT
Ankyrin 2
Ank2
416Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07013271 Genomic DNA No translation available.
AABR07013272 Genomic DNA No translation available.
AABR07013273 Genomic DNA No translation available.
AABR07013274 Genomic DNA No translation available.
AABR07013275 Genomic DNA No translation available.
AABR07013276 Genomic DNA No translation available.
AABR07013277 Genomic DNA No translation available.
AABR07013278 Genomic DNA No translation available.
AABR07013279 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000015386; ENSRNOP00000015386; ENSRNOG00000011076

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07013271 Genomic DNA No translation available.
AABR07013272 Genomic DNA No translation available.
AABR07013273 Genomic DNA No translation available.
AABR07013274 Genomic DNA No translation available.
AABR07013275 Genomic DNA No translation available.
AABR07013276 Genomic DNA No translation available.
AABR07013277 Genomic DNA No translation available.
AABR07013278 Genomic DNA No translation available.
AABR07013279 Genomic DNA No translation available.

3D structure databases

SMRiF1LM42
ModBaseiSearch...

Proteomic databases

PRIDEiF1LM42

Genome annotation databases

EnsembliENSRNOT00000015386; ENSRNOP00000015386; ENSRNOG00000011076

Organism-specific databases

RGDi620156, Ank2

Phylogenomic databases

GeneTreeiENSGT00940000155279
InParanoidiF1LM42
TreeFamiTF351263

Gene expression databases

BgeeiENSRNOG00000011076, Expressed in frontal cortex and 20 other tissues
ExpressionAtlasiF1LM42, baseline and differential

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1LM42_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1LM42
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 11, 2016
Last modified: June 2, 2021
This is version 79 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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