Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
1 to 25 of 487  Show
  1. 1
    "Detection of new mutation in a chronic phase-chronic myeloid leukemia patient with tyrosine kinase inhibitors resistance."
    Hokama P.O., Capannacci J., Hokama N.K., Bertolucci B., Coelho R.F., Colturato V.R.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).
  2. 2
    "ABL1 methylation is a distinct molecular event associated with clonal evolution of chronic myeloid leukemia."
    Asimakopoulos F.A., Shteper P.J., Krichevsky S., Fibach E., Polliack A., Rachmilewitz E., Ben-Neriah Y., Ben-Yehuda D.
    Blood 94:2452-2460(1999) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Associated with CANCER: clonal evolution of chronic myeloid leukemia.
    Source: GAD:114799.

    This publication is mapped to 22 other entries.

  3. 3
    "Real time quantitative PCR."
    Kim D.W.
    Exp Mol Med 33:101-109(2001) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: The abl protein was analyzed by real time quantitative PCR.
    Source: GeneRIF:25.

    This publication is mapped to 22 other entries.

  4. 4
    "Structure of the Bcr-Abl oncoprotein oligomerization domain."
    Zhao X., Ghaffari S., Lodish H., Malashkevich V.N., Kim P.S.
    Nat. Struct. Biol. 9:117-120(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Structure.
    Annotation: crystal structure of the Bcr-Abl oncoprotein oligomerization domain.
    Source: GeneRIF:25.

    This publication is mapped to 22 other entries.

  5. 5
    "Regulation of p73 by c-Abl through the p38 MAP kinase pathway."
    Sanchez-Prieto R., Sanchez-Arevalo V.J., Servitja J.M., Gutkind J.S.
    Oncogene 21:974-979(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: regulates p73 through p38 MAP kinase pathway.
    Source: GeneRIF:25.

    This publication is mapped to 31 other entries.

  6. 6
    "c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage."
    Yoshida K., Komatsu K., Wang H.-G., Kufe D.
    Mol. Cell. Biol. 22:3292-3300(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function, PTM / Processing, Interaction.
    Annotation: These findings indicate that Rad9 is regulated by a c-Abl-dependent mechanism in the apoptotic response to genotoxic stress. (c-abl protein).
    Source: GeneRIF:25.

    This publication is cited by 1 and mapped to 23 other entries.

  7. 7
    "Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation."
    Foray N., Marot D., Randrianarison V., Venezia N.D., Picard D., Perricaudet M., Favaudon V., Jeggo P.
    Mol Cell Biol 22:4020-4032(2002) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing.
    Annotation: C terminus of BRCA1 is phosphorylated by c-Abl in vitro (PROTO-ONCOGENE C-ABL).
    Source: GeneRIF:25.

    This publication is mapped to 22 other entries.

  8. 8
    "Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment."
    Roche-Lestienne C., Soenen-Cornu V., Grardel-Duflos N., Lai J.L., Philippe N., Facon T., Fenaux P., Preudhomme C.
    Blood 100:1014-1018(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571 and they can pre-exist to the onset of treatment.
    Source: GeneRIF:25.

    This publication is mapped to 22 other entries.

  9. 9
    "Bcr-Abl is a "molecular switch" for the decision for growth and differentiation in hematopoietic stem cells."
    Era T.
    Int J Hematol 76:35-43(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: This review focuses on how Bcr-Abl affects HSCs and how Bcr-Abl expression alters the properties of HSCs.
    Source: GeneRIF:25.

    This publication is mapped to 22 other entries.

  10. 10
    "Comprehensive comparison of FISH, RT-PCR, and RQ-PCR for monitoring the BCR-ABL gene after hematopoietic stem cell transplantation in CML."
    Kim Y.J., Kim D.W., Lee S., Kim H.J., Kim Y.L., Hwang J.Y., Oh I.H., Park Y.H., Lee Y.K., Min C.K., Kim T.G., Han T.H., Min W.S., Kim C.C.
    Eur J Haematol 68:272-280(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: chronic myelogenous leukemia characterized by translocation between chromosomes 9 and 22 forming a BCR-ABL gene a specific marker for this disease.
    Source: GeneRIF:25.

    This publication is mapped to 22 other entries.

  11. 11
    "Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop."
    Roumiantsev S., Shah N.P., Gorre M.E., Nicoll J., Brasher B.B., Sawyers C.L., Van Etten R.A.
    Proc Natl Acad Sci U S A 99:10700-10705(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: mutations of Tyr-253 in the nucleotide-binding (P) loop of the Abl kinase domain to Phe or His in patients with advanced CML and acquired STI-571 resistance.
    Source: GeneRIF:25.

    This publication is mapped to 22 other entries.

  12. 12
    "The expression of the non-receptor tyrosine kinases Arg and c-abl is differently modulated in B lymphoid cells at different stages of differentiation."
    Bianchi C., Muradore I., Corizzato M., Cornacchini G., Beretta L., Erba E., Del Monte U.d., A Perego R.
    FEBS Lett 527:216-222(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Expression, Sequences.
    Annotation: The data showed that c-abl expression is differently modified in lymphoid B cell lines.
    Source: GeneRIF:25.

    This publication is mapped to 23 other entries.

  13. 13
    "The Abl family kinases: mechanisms of regulation and signaling."
    Pendergast A.M.
    Adv Cancer Res 85:51-100(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Review. ABL protein tyrosine kinases regulate cell proliferation survival adhesion migration stress responses and cytoskeletal dynamics.
    Source: GeneRIF:25.

    This publication is mapped to 23 other entries.

  14. 14
    "Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide."
    Donaldson L.W., Gish G., Pawson T., Kay L.E., Forman-Kay J.D.
    Proc. Natl. Acad. Sci. U.S.A. 99:14053-14058(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Structure.
    Annotation: determined the NMR solution structure of the ternary complex of the Abl SH3 domain with the Crk SH2 domain bound to a Crk pY221 phosphopeptide.
    Source: GeneRIF:25.

    This publication is cited by 1 and mapped to 33 other entries.

  15. 15
    "Dual-specific Src and Abl kinase inhibitors, PP1 and CGP76030, inhibit growth and survival of cells expressing imatinib mesylate-resistant Bcr-Abl kinases."
    Warmuth M., Simon N., Mitina O., Mathes R., Fabbro D., Manley P.W., Buchdunger E., Forster K., Moarefi I., Hallek M.
    Blood 101:664-672(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: point mutations in Abl that rendered Bcr-Abl imatinib mesylate-resistant including a mutation that destabilized the inactive conformation of Abl suggesting that the inhibitor required inactivation of the kinase prior to binding.
    Source: GeneRIF:25.

    This publication is mapped to 22 other entries.

  16. 16
    "Clinical significance of dual color-dual fusion translocation fluorescence in situ hybridization in the detection of bcr/abl fusion gene."
    Wu B., Zhou S., Song L., Liu X.
    Zhonghua Zhong Liu Za Zhi 24:364-366(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: expression of bcr/abl hybridized gene in chronic myeloid leukemia (CML) acute lymphatic leukemia (ALL) and polycythemia vera (PV) and its clinical significance.
    Source: GeneRIF:25.

    This publication is mapped to 51 other entries.

  17. 17
    "Chronic myelocytic leukemia with eosinophilia, t(9;12)(q34;p13), and ETV6-ABL gene rearrangement: case report and review of the literature."
    Keung Y.K., Beaty M., Steward W., Jackle B., Pettnati M.
    Cancer Genet Cytogenet 138:139-142(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Chronic myelocytic leukemia with eosinophilia t(9;12)(q34;p13) and ETV6-ABL gene rearrangement: case report and review of the literature.
    Source: GeneRIF:25.

    This publication is mapped to 28 other entries.

  18. 18
    "Deletion in the ABL gene resulting from a meiotic recombination of a maternal (3;22;9)(q22;q12;q34.1) translocation."
    Aboura A., Labrune P., Perreaux F., Poncet V., Brisset S., Foix-L'Helias L., Tachdjian G.
    J Med Genet 40:e6-e6(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: An inherited apparently balanced translocation involving chromosomes 3(q22) 22(q12) and 9(q34.1 resulting from meiotic recombination leads to deletion in the ABL gene in a child with axial hypotonia and dysmorphism. ).
    Source: GeneRIF:25.

    This publication is mapped to 22 other entries.

  19. 19
    "Direct evidence that Bcr-Abl tyrosine kinase activity disrupts normal synergistic interactions between Kit ligand and cytokines in primary primitive progenitor cells."
    Strife A., Wisniewski D., Liu C., Lambek C.L., Darzynkiewicz Z., Silver R.T., Clarkson B.
    Mol Cancer Res 1:176-185(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: constitutively activated Bcr-Abl kinase pathways in primitive CML progenitors cooperate with growth factors producing a growth response and disrupt the normally required synergistic interactions between kit ligand and other cytokines to achieve activation.
    Source: GeneRIF:25.

    This publication is mapped to 57 other entries.

  20. 20
    "BCR-ABL binds to IRS-1 and IRS-1 phosphorylation is inhibited by imatinib in K562 cells."
    Traina F., Carvalheira J.B., Saad M.J., Costa F.F., Saad S.T.
    FEBS Lett 535:17-22(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: concluded that the IRS-1 protein is involved in the signalling pathway of the BCR-ABL tyrosine kinase.
    Source: GeneRIF:25.

    This publication is mapped to 58 other entries.

  21. 21
    "Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis."
    Branford S., Rudzki Z., Walsh S., Parkinson I., Grigg A., Szer J., Taylor K., Herrmann R., Seymour J.F., Arthur C., Joske D., Lynch K., Hughes T.
    Blood 102:276-283(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: detection of kinase domain mutations was almost always associated with imatinib resistance and patients with mutations in the P-loop had a particularly poor prognosis.
    Source: GeneRIF:25.

    This publication is mapped to 22 other entries.

  22. 22
    "Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM(-/-) and c-Abl(-/-) cells."
    Yuan S.S., Chang H.L., Lee E.Y.
    Mutat Res 525:85-92(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: In conclusion effective and prompt IR-induced Rad51 focus formation is cell cycle-regulated and requires both ATM and c-Abl.
    Source: GeneRIF:25.

    This publication is mapped to 27 other entries.

  23. 23
    Category: PTM / Processing.
    Annotation: This gene is regulated by a myristoyl/phosphotyrosine switch.
    Source: GeneRIF:25.

    This publication is mapped to 22 other entries.

  24. 24
    "Caspase-dependent cleavage of c-Abl contributes to apoptosis."
    Barila D., Rufini A., Condo I., Ventura N., Dorey K., Superti-Furga G., Testi R.
    Mol Cell Biol 23:2790-2799(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: mechanism by which caspases can recruit c-Abl to the nuclear compartment and to the mammalian apoptotic program.
    Source: GeneRIF:25.

    This publication is mapped to 22 other entries.

  25. 25
    "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase."
    Tani K., Sato S., Sukezane T., Kojima H., Hirose H., Hanafusa H., Shishido T.
    J. Biol. Chem. 278:21685-21692(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: c-Abl-mediated phosphorylation of Mena is regulated by Abi-1.
    Source: GeneRIF:25.

    This publication is cited by 2 and mapped to 74 other entries.

1 to 25 of 487  Show
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again