UniProtKB - F1DAM0 (F1DAM0_HUMAN)
Protein
Submitted name:
Steroidogenic factor 1
Gene
NR5A1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- nuclear receptor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationImportedARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Steroidogenic factor 1ImportedSubmitted name: Steroidogenic factor 1 nuclear receptorImported |
Gene namesi | Name:NR5A1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7983, NR5A1 |
VEuPathDBi | HostDB:ENSG00000136931.9 |
Subcellular locationi
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000136931, Expressed in right adrenal gland cortex and 75 other tissues |
ExpressionAtlasi | F1DAM0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 419 | NR LBDInterPro annotationAdd BLAST | 419 | |
Domaini | 10 – 85 | Nuclear receptorInterPro annotationAdd BLAST | 76 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 119 – 157 | DisorderedSequence analysisAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 124 – 143 | Pro-richSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the nuclear hormone receptor family.UniRule annotation
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000153391 |
Family and domain databases
Gene3Di | 1.10.565.10, 2 hits 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR016355, NR5_fam IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR24086, PTHR24086, 2 hits |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF002530, Nuc_orph_FTZ-F1, 2 hits |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
F1DAM0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDYSYDEDLD ELCPVCGDKV SGYHYGLLTC ESCKGFFKRT VQNNKHYTCT
60 70 80 90 100
ESQSCKIDKT QRKRCPFCRF QKCLTVGMRL EAVRADRMRG GRNKFGPMYK
110 120 130 140 150
RDRALKQQKK AQIRANGFKL ETGPPMGVPP PPPPAPDYVL PPSLHGPEPK
160 170 180 190 200
GLAAGPPAGP LGDFGAPALP MAVPGAHGPL AGYLYPAFPG RAIKSEYPEP
210 220 230 240 250
YASPPQPGLP YGYPEPFSGG PNVPELILQL LQLEPDEDQV RARILGCLQE
260 270 280 290 300
PTKSRPDQPA AFGLLCRMAD QTFISIVDWA RRCMVFKELE VELTTVATQA
310 320 330 340 350
GSLLHSLVLR AQELVLQLLA LQLDRQEFVC LKFIILFSLD LKFLNNHILV
360 370 380 390 400
KDAQEKANAA LLDYTLCHYP HCGDKFQQLL LCLVEVRALS MQAKEYLYHK
410 420
HLGNEMPRNN LLIEMLQAKQ T
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ13285 | STF1_HUMAN | Steroidogenic factor 1 | NR5A1 AD4BP, FTZF1, SF1 | 461 | Annotation score: | ||
Q5T6F6 | Q5T6F6_HUMAN | Steroidogenic factor 1 | NR5A1 | 177 | Annotation score: | ||
Q5T6F7 | Q5T6F7_HUMAN | Steroidogenic factor 1 | NR5A1 | 245 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL137846 Genomic DNA No translation available. AL354979 Genomic DNA No translation available. HQ709184 mRNA Translation: ADZ17391.1 |
Genome annotation databases
Ensembli | ENST00000620110; ENSP00000483309; ENSG00000136931 |
UCSCi | uc022bnh.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL137846 Genomic DNA No translation available. AL354979 Genomic DNA No translation available. HQ709184 mRNA Translation: ADZ17391.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | F1DAM0 |
Protocols and materials databases
Antibodypediai | 16333, 411 antibodies |
Genome annotation databases
Ensembli | ENST00000620110; ENSP00000483309; ENSG00000136931 |
UCSCi | uc022bnh.2, human |
Organism-specific databases
HGNCi | HGNC:7983, NR5A1 |
OpenTargetsi | ENSG00000136931 |
VEuPathDBi | HostDB:ENSG00000136931.9 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000153391 |
Gene expression databases
Bgeei | ENSG00000136931, Expressed in right adrenal gland cortex and 75 other tissues |
ExpressionAtlasi | F1DAM0, baseline and differential |
Family and domain databases
Gene3Di | 1.10.565.10, 2 hits 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR016355, NR5_fam IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR24086, PTHR24086, 2 hits |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF002530, Nuc_orph_FTZ-F1, 2 hits |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1DAM0_HUMAN | |
Accessioni | F1DAM0Primary (citable) accession number: F1DAM0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | February 10, 2021 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |