NR2A1

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	57 – 132	Nuclear receptorPROSITE-ProRule annotationAdd BLAST		76

GO - Molecular functionⁱ

nuclear receptor activity Source: InterPro
RNA polymerase II activating transcription factor binding Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
steroid hormone receptor activity Source: InterPro
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: Ensembl
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: Ensembl
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cholesterol homeostasis Source: Ensembl
glucose homeostasis Source: Ensembl
hepatocyte differentiation Source: InterPro
lipid metabolic process Source: Ensembl
phospholipid homeostasis Source: Ensembl
regulation of gastrulation Source: Ensembl
regulation of insulin secretion Source: Ensembl
response to glucose Source: Ensembl
sex differentiation Source: Ensembl
signal transduction involved in regulation of gene expression Source: Ensembl
SMAD protein signal transduction Source: Ensembl
triglyceride homeostasis Source: Ensembl
type B pancreatic cell development Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological process	Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Hepatocyte nuclear factor 4 4 alpha variant 2Imported
Gene namesⁱ	Name:NR2A1Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101076.16

EuPathDBⁱ

HostDB:ENSG00000101076.16

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	F1D8T1

PRIDEⁱ

F1D8T1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000101076 Expressed in 113 organ(s), highest expression level in liver
ExpressionAtlasⁱ	F1D8T1 baseline and differential
Genevisibleⁱ	F1D8T1 HS

Interactionⁱ

GO - Molecular functionⁱ

RNA polymerase II activating transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	F1D8T1
SMRⁱ	F1D8T1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	57 – 132	Nuclear receptorInterPro annotationAdd BLAST		76
Domainⁱ	147 – 377	NR LBDInterPro annotationAdd BLAST		231

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG4215 Eukaryota ENOG410XQT8 LUCA
KEGG Orthology (KO) More...KOⁱ	K07292
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A89
PhylomeDBⁱ	F1D8T1

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR003068 COUP_TF IPR039067 HNF4A IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
PANTHERⁱ	PTHR24083:SF41 PTHR24083:SF41, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01282 COUPTNFACTOR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

F1D8T1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRLSKTLVDM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGTNLNA 
        60         70         80         90        100
PNSLGVSALC AICGDRATGK HYGASSCDGC KGFFRRSVRK NHMYSCRFSR 
       110        120        130        140        150
QCVVDKDKRN QCRYCRLKKC FRAGMKKEAV QNERDRISTR RSSYEDSSLP 
       160        170        180        190        200
SINALLQAEV LSRQITSPVS GINGDIRAKK IASIADVCES MKEQLLVLVE 
       210        220        230        240        250
WAKYIPAFCE LPLDDQVALL RAHAGEHLLL GATKRSMVFK DVLLLGNDYI 
       260        270        280        290        300
VPRHCPELAE MSRVSIRILD ELVLPFQELQ IDDNEYAYLK AIIFFDPDAK 
       310        320        330        340        350
GLSDPGKIKR LRSQVQVSLE DYINDRQYDS RGRFGELLLL LPTLQSITWQ 
       360        370        380        390        400
MIEQIQFIKL FGMAKIDNLL QEMLLGGSPS DAPHAHHPLH PHLMQEHMGT 
       410        420        430        440        450
NVIVANTMPT HLSNGQMCEW PRPRGQAATP ETPQPSPPGG SGSEPYKLLP 
       460        470 
GAVATIVKPL SAIPQPTITK QEVI

Length:474

Mass (Da):52,785

Last modified:May 3, 2011 - v1

Checksum:ⁱ5F1309B89D95DCAF

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HQ692869 mRNA Translation: ADZ17380.1
NCBI Reference Sequences More...RefSeqⁱ	NP_000448.3, NM_000457.4 NP_001245284.1, NM_001258355.1
UniGeneⁱ	Hs.116462

Genome annotation databases

GeneIDⁱ	3172
KEGGⁱ	hsa:3172

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
F1D8T1	Hepatocyte nuclear factor 4-alpha	)	HUMAN		474	UniRef100_P41235

Protein	Similar proteins		Species	Score	Length	Source
F1D8T1	Hepatocyte nuclear factor 4-alpha	)	HUMAN		474	UniRef90_P41235
Uncharacterized protein		MACMU		527
Uncharacterized protein		MACFA		527
Uncharacterized protein		PAPAN		474
Uncharacterized protein		RHIRO		474
+247

Protein	Similar proteins		Species	Score	Length	Source
F1D8T1	Hepatocyte nuclear factor 4-alpha	)	HUMAN		474	UniRef50_P41235
Uncharacterized protein		MACFA		527
Uncharacterized protein		MACMU		527
Uncharacterized protein		PAPAN		474
Hepatocyte nuclear factor 4 alpha		SAIBB		474
+279

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HQ692869 mRNA Translation: ADZ17380.1
RefSeqⁱ	NP_000448.3, NM_000457.4 NP_001245284.1, NM_001258355.1
UniGeneⁱ	Hs.116462

3D structure databases

ProteinModelPortalⁱ	F1D8T1
SMRⁱ	F1D8T1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	F1D8T1

PRIDEⁱ

F1D8T1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	3172
KEGGⁱ	hsa:3172

Organism-specific databases

CTDⁱ	3172
EuPathDBⁱ	HostDB:ENSG00000101076.16

Phylogenomic databases

eggNOGⁱ	KOG4215 Eukaryota ENOG410XQT8 LUCA
KOⁱ	K07292
OrthoDBⁱ	EOG091G0A89
PhylomeDBⁱ	F1D8T1

Miscellaneous databases

ChiTaRSⁱ	HNF4A human
GenomeRNAiⁱ	3172

Gene expression databases

Bgeeⁱ	ENSG00000101076 Expressed in 113 organ(s), highest expression level in liver
ExpressionAtlasⁱ	F1D8T1 baseline and differential
Genevisibleⁱ	F1D8T1 HS

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR003068 COUP_TF IPR039067 HNF4A IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
PANTHERⁱ	PTHR24083:SF41 PTHR24083:SF41, 1 hit
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01282 COUPTNFACTOR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F1D8T1_HUMAN
Accessionⁱ	F1D8T1Primary (citable) accession number: F1D8T1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 3, 2011
	Last sequence update:	May 3, 2011
	Last modified:	September 12, 2018
	This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - F1D8T1 (F1D8T1_HUMAN)

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Hepatocyte nuclear factor 4 4 alpha variant 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ