UniProtKB - F1D8S4 (F1D8S4_HUMAN)
Protein
Nuclear receptor subfamily 1 group C member 1
Gene
NR1C1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- lipid binding Source: Ensembl
- MDM2/MDM4 family protein binding Source: Ensembl
- NFAT protein binding Source: Ensembl
- nuclear receptor activity Source: Ensembl
- phosphatase binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- signaling receptor activity Source: Ensembl
- transcription coactivator binding Source: Ensembl
- zinc ion binding Source: InterPro
GO - Biological processi
- behavioral response to nicotine Source: Ensembl
- cellular response to starvation Source: Ensembl
- circadian regulation of gene expression Source: Ensembl
- enamel mineralization Source: Ensembl
- epidermis development Source: Ensembl
- fatty acid metabolic process Source: Ensembl
- heart development Source: Ensembl
- lipid localization Source: Ensembl
- lipoprotein metabolic process Source: Ensembl
- negative regulation of appetite Source: Ensembl
- negative regulation of blood pressure Source: Ensembl
- negative regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
- negative regulation of neuron death Source: Ensembl
- negative regulation of protein binding Source: Ensembl
- positive regulation of fatty acid oxidation Source: Ensembl
- positive regulation of gluconeogenesis Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of circadian rhythm Source: Ensembl
- regulation of lipid storage Source: Ensembl
- response to ethanol Source: Ensembl
- response to hypoxia Source: Ensembl
- response to insulin Source: Ensembl
- response to organic cyclic compound Source: Ensembl
- wound healing Source: Ensembl
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationImportedARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor subfamily 1 group C member 1ARBA annotationAlternative name(s): Peroxisome proliferator-activated receptor alphaARBA annotation |
Gene namesi | Name:NR1C1Imported Synonyms:PPARAImported ORF Names:hCG_41801Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000186951.16 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000186951, Expressed in liver and 225 other tissues |
Interactioni
GO - Molecular functioni
- MDM2/MDM4 family protein binding Source: Ensembl
- NFAT protein binding Source: Ensembl
- phosphatase binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- transcription coactivator binding Source: Ensembl
Chemistry databases
BindingDBi | F1D8S4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 99 – 173 | Nuclear receptorInterPro annotationAdd BLAST | 75 | |
Domaini | 239 – 466 | NR LBDInterPro annotationAdd BLAST | 228 |
Sequence similaritiesi
Belongs to the nuclear hormone receptor family.UniRule annotation
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_007368_4_1_1 |
OMAi | FSFTEYQ |
OrthoDBi | 1240230at2759 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR003074, 1Cnucl_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003076, PPAR-alpha IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01288, PROXISOMEPAR PR01289, PROXISOMPAAR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F1D8S4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVDTESPLCP LSPLEAGDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFG
60 70 80 90 100
FTEYQYLGSC PGSDGSVITD TLSPASSPSS VTYPVVPGSV DESPSGALNI
110 120 130 140 150
ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR
160 170 180 190 200
NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE KAKLKAEILT CEHDIEDSET
210 220 230 240 250
ADLKSLAKRI YEAYLKNFNM NKVKARVILS GKASNNPPFV IHDMETLCMA
260 270 280 290 300
EKTLVAKLVA NGIQNKEAEV RIFHCCQCTS VETVTELTEF AKAIPGFANL
310 320 330 340 350
DLNDQVTLLK YGVYEAIFAM LSSVMNKDGM LVAYGNGFIT REFLKSLRKP
360 370 380 390 400
FCDIMEPKFD FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNVGHIEKM
410 420 430 440 450
QEGIVHVLRL HLQSNHPDDI FLFPKLLQKM ADLRQLVTEH AQLVQIIKKT
460
ESDAALHPLL QEIYRDMY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ692862 mRNA Translation: ADZ17373.1 CH471138 Genomic DNA Translation: EAW73404.1 |
RefSeqi | NP_001001928.1, NM_001001928.2 NP_005027.2, NM_005036.4 XP_005261712.1, XM_005261655.3 XP_005261713.1, XM_005261656.3 XP_006724332.1, XM_006724269.3 XP_006724333.1, XM_006724270.3 XP_011528541.1, XM_011530239.2 XP_011528542.1, XM_011530240.2 XP_011528543.1, XM_011530241.2 XP_011528544.1, XM_011530242.2 XP_011528545.1, XM_011530243.2 |
Genome annotation databases
GeneIDi | 5465 |
KEGGi | hsa:5465 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ692862 mRNA Translation: ADZ17373.1 CH471138 Genomic DNA Translation: EAW73404.1 |
RefSeqi | NP_001001928.1, NM_001001928.2 NP_005027.2, NM_005036.4 XP_005261712.1, XM_005261655.3 XP_005261713.1, XM_005261656.3 XP_006724332.1, XM_006724269.3 XP_006724333.1, XM_006724270.3 XP_011528541.1, XM_011530239.2 XP_011528542.1, XM_011530240.2 XP_011528543.1, XM_011530241.2 XP_011528544.1, XM_011530242.2 XP_011528545.1, XM_011530243.2 |
3D structure databases
SMRi | F1D8S4 |
ModBasei | Search... |
Chemistry databases
BindingDBi | F1D8S4 |
Protocols and materials databases
Antibodypediai | 13823, 763 antibodies |
DNASUi | 5465 |
Genome annotation databases
GeneIDi | 5465 |
KEGGi | hsa:5465 |
Organism-specific databases
CTDi | 5465 |
EuPathDBi | HostDB:ENSG00000186951.16 |
Phylogenomic databases
HOGENOMi | CLU_007368_4_1_1 |
OMAi | FSFTEYQ |
OrthoDBi | 1240230at2759 |
Miscellaneous databases
BioGRID-ORCSi | 5465, 9 hits in 867 CRISPR screens |
ChiTaRSi | PPARA, human |
GenomeRNAii | 5465 |
Gene expression databases
Bgeei | ENSG00000186951, Expressed in liver and 225 other tissues |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR003074, 1Cnucl_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003076, PPAR-alpha IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01288, PROXISOMEPAR PR01289, PROXISOMPAAR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1D8S4_HUMAN | |
Accessioni | F1D8S4Primary (citable) accession number: F1D8S4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | December 2, 2020 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |