UniProtKB - F1D8S2 (F1D8S2_HUMAN)
Protein
Submitted name:
Hepatocyte nuclear factor 4 4 alpha variant 1
Gene
NR2A1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- hepatocyte differentiation Source: InterPro
- lipid homeostasis Source: InterPro
- regulation of insulin secretion Source: InterPro
- type B pancreatic cell development Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Hepatocyte nuclear factor 4 4 alpha variant 1Imported |
Gene namesi | Name:NR2A1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000101076.16 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000101076, Expressed in liver and 129 other tissues |
ExpressionAtlasi | F1D8S2, baseline and differential |
Genevisiblei | F1D8S2, HS |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 57 – 132 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 147 – 377 | NR LBDInterPro annotationAdd BLAST | 231 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 410 – 437 | DisorderedSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the nuclear hormone receptor family.UniRule annotation
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_007368_5_2_1 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR039067, HNF4A IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR24083:SF41, PTHR24083:SF41, 1 hit |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F1D8S2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLSKTLVDM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGTNLNA
60 70 80 90 100
PNSLGVSALC AICGDRATGK HYGASSCDGC KGFFRRSVRK NHMYSCRFSR
110 120 130 140 150
QCVVDKDKRN QCRYCRLKKC FRAGMKKEAV QNERDRISTR RSSYEDSSLP
160 170 180 190 200
SINALLQAEV LSRQITSPVS GINGDIRAKK IASIADVCES MKEQLLVLVE
210 220 230 240 250
WAKYIPAFCE LPLDDQVALL RAHAGEHLLL GATKRSMVFK DVLLLGNDYI
260 270 280 290 300
VPRHCPELAE MSRVSIRILD ELVLPFQELQ IDDNEYAYLK AIIFFDPDAK
310 320 330 340 350
GLSDPGKIKR LRSQVQVSLE DYINDRQYDS RGRFGELLLL LPTLQSITWQ
360 370 380 390 400
MIEQIQFIKL FGMAKIDNLL QEMLLGGSPS DAPHAHHPLH PHLMQEHMGT
410 420 430 440 450
NVIVANTMPT HLSNGQMSTP ETPQPSPPGG SGSEPYKLLP GAVATIVKPL
460
SAIPQPTITK QEVI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ692860 mRNA Translation: ADZ17371.1 |
RefSeqi | NP_849180.1, NM_178849.2 |
Genome annotation databases
GeneIDi | 3172 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ692860 mRNA Translation: ADZ17371.1 |
RefSeqi | NP_849180.1, NM_178849.2 |
3D structure databases
SMRi | F1D8S2 |
ModBasei | Search... |
PTM databases
iPTMneti | F1D8S2 |
Protocols and materials databases
Antibodypediai | 1326, 947 antibodies |
DNASUi | 3172 |
Genome annotation databases
GeneIDi | 3172 |
Organism-specific databases
CTDi | 3172 |
VEuPathDBi | HostDB:ENSG00000101076.16 |
Phylogenomic databases
HOGENOMi | CLU_007368_5_2_1 |
Miscellaneous databases
BioGRID-ORCSi | 3172, 24 hits in 1009 CRISPR screens |
ChiTaRSi | HNF4A, human |
GenomeRNAii | 3172 |
Gene expression databases
Bgeei | ENSG00000101076, Expressed in liver and 129 other tissues |
ExpressionAtlasi | F1D8S2, baseline and differential |
Genevisiblei | F1D8S2, HS |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR039067, HNF4A IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR24083:SF41, PTHR24083:SF41, 1 hit |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1D8S2_HUMAN | |
Accessioni | F1D8S2Primary (citable) accession number: F1D8S2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | April 7, 2021 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |