UniProtKB - F1D8R8 (F1D8R8_HUMAN)
Protein
Submitted name:
Steroidogenic factor 1 nuclear receptor
Gene
NR5A1
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 436 | Lipid headgroupUniRule annotation | 1 | |
Binding sitei | 440 | Lipid headgroupUniRule annotation | 1 |
GO - Molecular functioni
- chromatin binding Source: Ensembl
- nuclear receptor activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- zinc ion binding Source: InterPro
GO - Biological processi
- adrenal gland development Source: Ensembl
- calcineurin-mediated signaling Source: Ensembl
- cell differentiation Source: Ensembl
- hormone-mediated signaling pathway Source: Ensembl
- hormone metabolic process Source: Ensembl
- luteinization Source: Ensembl
- maintenance of protein location in nucleus Source: Ensembl
- male gonad development Source: Ensembl
- multicellular organism aging Source: Ensembl
- negative regulation of female gonad development Source: Ensembl
- positive regulation of male gonad development Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- response to gonadotropin-releasing hormone Source: Ensembl
- tissue development Source: Ensembl
- transcription by RNA polymerase II Source: Ensembl
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationImportedARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Steroidogenic factor 1 nuclear receptorImported |
Gene namesi | Name:NR5A1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000136931.9 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- RNA polymerase II transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000136931, Expressed in right adrenal gland cortex and 75 other tissues |
ExpressionAtlasi | F1D8R8, baseline and differential |
Genevisiblei | F1D8R8, HS |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 85 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 222 – 459 | NR LBDInterPro annotationAdd BLAST | 238 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 119 – 157 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 262 – 310 | Ligand-bindingUniRule annotationAdd BLAST | 49 | |
Regioni | 339 – 344 | Lipid bindingUniRule annotation | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 124 – 143 | Pro-richSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the nuclear hormone receptor family.UniRule annotation
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_011437_0_0_1 |
OMAi | KAECPDY |
OrthoDBi | 619653at2759 |
PhylomeDBi | F1D8R8 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR016355, NR5_fam IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR24086, PTHR24086, 1 hit |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF002530, Nuc_orph_FTZ-F1, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F1D8R8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDYSYDEDLD ELCPVCGDKV SGYHYGLLTC ESCKGFFKRT VQNNKHYTCT
60 70 80 90 100
ESQSCKIDKT QRKRCPFCRF QKCLTVGMRL EAVRADRMRG GRNKFGPMYK
110 120 130 140 150
RDRALKQQKK AQIRANGFKL ETGPPMGVPP PPPPAPDYVL PPSLHGPEPK
160 170 180 190 200
GLAAGPPAGP LGDFGAPALP MAVPGAHGPL AGYLYPAFPG RAIKSEYPEP
210 220 230 240 250
YASPPQPGLP YGYPEPFSGG PNVPELILQL LQLEPDEDQV RARILGCLQE
260 270 280 290 300
PTKSRPDQPA AFGLLCRMAD QTFISIVDWA RRCMVFKELE VADQMTLLQN
310 320 330 340 350
CWSELLVFDH IYRQVQHGKE GSILLVTGQE VELTTVATQA GSLLHSLVLR
360 370 380 390 400
AQELVLQLLA LQLDRQEFVC LKFIILFSLD LKFLNNHILV KDAQEKANAA
410 420 430 440 450
LLDYTLCHYP HCGDKFQQLL LCLVEVRALS MQAKEYLYHK HLGNEMPRNN
460
LLIEMLQAKQ T
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ692856 mRNA Translation: ADZ17367.1 |
RefSeqi | NP_004950.2, NM_004959.4 XP_005251928.1, XM_005251871.3 XP_011516757.1, XM_011518455.2 |
Genome annotation databases
GeneIDi | 2516 |
KEGGi | hsa:2516 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ692856 mRNA Translation: ADZ17367.1 |
RefSeqi | NP_004950.2, NM_004959.4 XP_005251928.1, XM_005251871.3 XP_011516757.1, XM_011518455.2 |
3D structure databases
SMRi | F1D8R8 |
ModBasei | Search... |
Chemistry databases
BindingDBi | F1D8R8 |
Protocols and materials databases
Antibodypediai | 16333, 411 antibodies |
DNASUi | 2516 |
Genome annotation databases
GeneIDi | 2516 |
KEGGi | hsa:2516 |
Organism-specific databases
CTDi | 2516 |
VEuPathDBi | HostDB:ENSG00000136931.9 |
Phylogenomic databases
HOGENOMi | CLU_011437_0_0_1 |
OMAi | KAECPDY |
OrthoDBi | 619653at2759 |
PhylomeDBi | F1D8R8 |
Miscellaneous databases
BioGRID-ORCSi | 2516, 12 hits in 901 CRISPR screens |
GenomeRNAii | 2516 |
Gene expression databases
Bgeei | ENSG00000136931, Expressed in right adrenal gland cortex and 75 other tissues |
ExpressionAtlasi | F1D8R8, baseline and differential |
Genevisiblei | F1D8R8, HS |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR016355, NR5_fam IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR24086, PTHR24086, 1 hit |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF002530, Nuc_orph_FTZ-F1, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1D8R8_HUMAN | |
Accessioni | F1D8R8Primary (citable) accession number: F1D8R8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | February 10, 2021 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |