NR2B1

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	132 – 207	Nuclear receptorPROSITE-ProRule annotationAdd BLAST		76

GO - Molecular functionⁱ

9-cis retinoic acid receptor activity Source: Ensembl
chromatin DNA binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
sequence-specific DNA binding Source: Ensembl
steroid hormone receptor activity Source: InterPro
transcription factor binding Source: Ensembl
transcription regulatory region DNA binding Source: Ensembl
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

camera-type eye development Source: Ensembl
cardiac muscle cell proliferation Source: Ensembl
embryo implantation Source: Ensembl
in utero embryonic development Source: Ensembl
maternal placenta development Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: Ensembl
positive regulation of translational initiation by iron Source: Ensembl
regulation of branching involved in prostate gland morphogenesis Source: Ensembl
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Source: Ensembl
transcription, DNA-templated Source: UniProtKB-UniRule
ventricular cardiac muscle cell differentiation Source: Ensembl
ventricular cardiac muscle tissue morphogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological process	Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Retinoid X nuclear receptor alphaImported Submitted name: Retinoid X receptor, alpha, isoform CRA_bImported
Gene namesⁱ	Name:NR2B1Imported Synonyms:RXRAImported ORF Names:hCG_18150Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000186350.9

EuPathDBⁱ

HostDB:ENSG00000186350.9

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	F1D8Q5

PRIDEⁱ

F1D8Q5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000186350 Expressed in 231 organ(s), highest expression level in liver
ExpressionAtlasⁱ	F1D8Q5 baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl
transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	F1D8Q5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	132 – 207	Nuclear receptorInterPro annotationAdd BLAST		76
Domainⁱ	227 – 458	NR LBDInterPro annotationAdd BLAST		232

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
KEGG Orthology (KO) More...KOⁱ	K08524
OMAⁱ	LTCGMKR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0YX6

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR021780 Nuc_recep-AF1 IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR000003 Retinoid-X_rcpt/HNF4 IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF11825 Nuc_recep-AF1, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR00545 RETINOIDXR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

F1D8Q5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDTKHFLPLD FSTQVNSSLT SPTGRGSMAA PSLHPSLGPG IGSPGQLHSP 
        60         70         80         90        100
ISTLSSPING MGPPFSVISS PMGPHSMSVP TTPTLGFSTG SPQLSSPMNP 
       110        120        130        140        150
VSSSEDIKPP LGLNGVLKVP AHPSGNMASF TKHICAICGD RSSGKHYGVY 
       160        170        180        190        200
SCEGCKGFFK RTVRKDLTYT CRDNKDCLID KRQRNRCQYC RYQKCLAMGM 
       210        220        230        240        250
KREAVQEERQ RGKDRNENEV ESTSSANEDM PVERILEAEL AVEPKTETYV 
       260        270        280        290        300
EANMGLNPSS PNDPVTNICQ AADKQLFTLV EWAKRIPHFS ELPLDDQVIL 
       310        320        330        340        350
LRAGWNELLI ASFSHRSIAV KDGILLATGL HVHRNSAHSA GVGAIFDRVL 
       360        370        380        390        400
TELVSKMRDM QMDKTELGCL RAIVLFNPDS KGLSNPAEVE ALREKVYASL 
       410        420        430        440        450
EAYCKHKYPE QPGRFAKLLL RLPALRSIGL KCLEHLFFFK LIGDTPIDTF 
       460 
LMEMLEAPHQ MT

Length:462

Mass (Da):50,811

Last modified:May 3, 2011 - v1

Checksum:ⁱ7F952B580AD84C42

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HQ692843 mRNA Translation: ADZ17354.1 CH471090 Genomic DNA Translation: EAW88124.1
NCBI Reference Sequences More...RefSeqⁱ	NP_002948.1, NM_002957.5
UniGeneⁱ	Hs.590886

Genome annotation databases

GeneIDⁱ	6256
KEGGⁱ	hsa:6256

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
F1D8Q5	Retinoic acid receptor RXR-alpha	)	HUMAN		462	UniRef100_P19793
Retinoic acid receptor RXR-alpha		MACMU		462
RXRA protein (Fragment)		HUMAN		516

Protein	Similar proteins		Species	Score	Length	Source
F1D8Q5	Retinoic acid receptor RXR-alpha	)	HUMAN		462	UniRef90_P19793
Retinoic acid receptor RXR-alpha		MACMU		462
UPI00084D6AF8		XENLA		463
RXRA protein (Fragment)		HUMAN		516

Protein	Similar proteins		Species	Score	Length	Source
F1D8Q5	Retinoic acid receptor RXR-alpha	)	HUMAN		462	UniRef50_P19793
Retinoic acid receptor RXR-alpha		MACMU		462
Retinoic acid receptor RXR-gamma-A		HETGA		616
UPI00084D6AF8		XENLA		463
UPI0004DFE50F		URSMA		496
+1

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HQ692843 mRNA Translation: ADZ17354.1 CH471090 Genomic DNA Translation: EAW88124.1
RefSeqⁱ	NP_002948.1, NM_002957.5
UniGeneⁱ	Hs.590886

3D structure databases

SMRⁱ	F1D8Q5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	F1D8Q5

PRIDEⁱ

F1D8Q5

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6256
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	6256
KEGGⁱ	hsa:6256

Organism-specific databases

CTDⁱ	6256
EuPathDBⁱ	HostDB:ENSG00000186350.9

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
KOⁱ	K08524
OMAⁱ	LTCGMKR
OrthoDBⁱ	EOG091G0YX6

Miscellaneous databases

ChiTaRSⁱ	RXRA human
GenomeRNAiⁱ	6256

Gene expression databases

Bgeeⁱ	ENSG00000186350 Expressed in 231 organ(s), highest expression level in liver
ExpressionAtlasⁱ	F1D8Q5 baseline and differential

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR021780 Nuc_recep-AF1 IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR000003 Retinoid-X_rcpt/HNF4 IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF11825 Nuc_recep-AF1, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR00545 RETINOIDXR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F1D8Q5_HUMAN
Accessionⁱ	F1D8Q5Primary (citable) accession number: F1D8Q5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 3, 2011
	Last sequence update:	May 3, 2011
	Last modified:	September 12, 2018
	This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - F1D8Q5 (F1D8Q5_HUMAN)

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Retinoid X nuclear receptor alpha

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ