UniProtKB - F1D8Q5 (F1D8Q5_HUMAN)
Protein
Submitted name:
Retinoid X nuclear receptor alpha
Gene
NR2B1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
- steroid hormone receptor activity Source: InterPro
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationImportedARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Retinoid X nuclear receptor alphaImportedSubmitted name: Retinoid X receptor, alpha, isoform CRA_bImported |
Gene namesi | Name:NR2B1Imported Synonyms:RXRAImported ORF Names:hCG_18150Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000186350.9 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000186350, Expressed in liver and 244 other tissues |
ExpressionAtlasi | F1D8Q5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 132 – 207 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 227 – 458 | NR LBDInterPro annotationAdd BLAST | 232 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 107 | DisorderedSequence analysisAdd BLAST | 107 | |
Regioni | 206 – 228 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 9 – 27 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 46 – 63 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 71 – 103 | PolarSequence analysisAdd BLAST | 33 | |
Compositional biasi | 206 – 222 | PolyampholyteSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the nuclear hormone receptor family.UniRule annotation
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_007368_5_4_1 |
OMAi | ESPGPFM |
OrthoDBi | 912470at2759 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR021780, Nuc_recep-AF1 IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000003, Retinoid-X_rcpt/HNF4 IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF11825, Nuc_recep-AF1, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00545, RETINOIDXR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F1D8Q5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTKHFLPLD FSTQVNSSLT SPTGRGSMAA PSLHPSLGPG IGSPGQLHSP
60 70 80 90 100
ISTLSSPING MGPPFSVISS PMGPHSMSVP TTPTLGFSTG SPQLSSPMNP
110 120 130 140 150
VSSSEDIKPP LGLNGVLKVP AHPSGNMASF TKHICAICGD RSSGKHYGVY
160 170 180 190 200
SCEGCKGFFK RTVRKDLTYT CRDNKDCLID KRQRNRCQYC RYQKCLAMGM
210 220 230 240 250
KREAVQEERQ RGKDRNENEV ESTSSANEDM PVERILEAEL AVEPKTETYV
260 270 280 290 300
EANMGLNPSS PNDPVTNICQ AADKQLFTLV EWAKRIPHFS ELPLDDQVIL
310 320 330 340 350
LRAGWNELLI ASFSHRSIAV KDGILLATGL HVHRNSAHSA GVGAIFDRVL
360 370 380 390 400
TELVSKMRDM QMDKTELGCL RAIVLFNPDS KGLSNPAEVE ALREKVYASL
410 420 430 440 450
EAYCKHKYPE QPGRFAKLLL RLPALRSIGL KCLEHLFFFK LIGDTPIDTF
460
LMEMLEAPHQ MT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ692843 mRNA Translation: ADZ17354.1 CH471090 Genomic DNA Translation: EAW88124.1 |
RefSeqi | NP_002948.1, NM_002957.5 |
Genome annotation databases
GeneIDi | 6256 |
KEGGi | hsa:6256 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ692843 mRNA Translation: ADZ17354.1 CH471090 Genomic DNA Translation: EAW88124.1 |
RefSeqi | NP_002948.1, NM_002957.5 |
3D structure databases
SMRi | F1D8Q5 |
ModBasei | Search... |
Chemistry databases
BindingDBi | F1D8Q5 |
Protocols and materials databases
Antibodypediai | 3881, 416 antibodies |
DNASUi | 6256 |
Genome annotation databases
GeneIDi | 6256 |
KEGGi | hsa:6256 |
Organism-specific databases
CTDi | 6256 |
VEuPathDBi | HostDB:ENSG00000186350.9 |
Phylogenomic databases
HOGENOMi | CLU_007368_5_4_1 |
OMAi | ESPGPFM |
OrthoDBi | 912470at2759 |
Miscellaneous databases
BioGRID-ORCSi | 6256, 45 hits in 1025 CRISPR screens |
ChiTaRSi | RXRA, human |
GenomeRNAii | 6256 |
Gene expression databases
Bgeei | ENSG00000186350, Expressed in liver and 244 other tissues |
ExpressionAtlasi | F1D8Q5, baseline and differential |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR021780, Nuc_recep-AF1 IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000003, Retinoid-X_rcpt/HNF4 IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF11825, Nuc_recep-AF1, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00545, RETINOIDXR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1D8Q5_HUMAN | |
Accessioni | F1D8Q5Primary (citable) accession number: F1D8Q5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | April 7, 2021 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |