UniProtKB - F1D8P7 (F1D8P7_HUMAN)
Protein
Submitted name:
Liver X nuclear receptor beta
Gene
NR1H2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- nuclear receptor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- lipid metabolic process Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationImportedARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Liver X nuclear receptor betaImportedSubmitted name: Nuclear receptor subfamily 1, group H, member 2, isoform CRA_cImported |
Gene namesi | Name:NR1H2Imported ORF Names:hCG_22944Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationInteractioni
Binary interactionsi
Hide detailsF1D8P7
Protein-protein interaction databases
IntActi | F1D8P7, 9 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 84 – 161 | Nuclear receptorInterPro annotationAdd BLAST | 78 | |
Domaini | 223 – 461 | NR LBDInterPro annotationAdd BLAST | 239 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 78 | DisorderedSequence analysisAdd BLAST | 78 | |
Regioni | 169 – 217 | DisorderedSequence analysisAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 64 – 78 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 175 – 217 | PolarSequence analysisAdd BLAST | 43 |
Sequence similaritiesi
Belongs to the nuclear hormone receptor family.UniRule annotation
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
OrthoDBi | 1137281at2759 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR023257, Liver_X_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR02034, LIVERXRECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F1D8P7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSPTTSSLD TPLPGNGPPQ PGAPSSSPTV KEEGPEPWPG GPDPDVPGTD
60 70 80 90 100
EASSACSTDW VIPDPEEEPE RKRKKGPAPK MLGHELCRVC GDKASGFHYN
110 120 130 140 150
VLSCEGCKGF FRRSVVRGGA RRYACRGGGT CQMDAFMRRK CQQCRLRKCK
160 170 180 190 200
EAGMREQCVL SEEQIRKKKI RKQQQQESQS QSQSPVGPQG SSSSASGPGA
210 220 230 240 250
SPGGSEAGSQ GSGEGEGVQL TAAQELMIQQ LVAAQLQCNK RSFSDQPKVT
260 270 280 290 300
PWPLGADPQS RDARQQRFAH FTELAIISVQ EIVDFAKQVP GFLQLGREDQ
310 320 330 340 350
IALLKASTIE IMLLETARRY NHETECITFL KDFTYSKDDF HRAGLQVEFI
360 370 380 390 400
NPIFEFSRAM RRLGLDDAEY ALLIAINIFS ADRPNVQEPG RVEALQQPYV
410 420 430 440 450
EALLSYTRIK RPQDQLRFPR MLMKLVSLRT LSSVHSEQVF ALRLQDKKLP
460
PLLSEIWDVH E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ692835 mRNA Translation: ADZ17346.1 CH471135 Genomic DNA Translation: EAW71852.1 CH471135 Genomic DNA Translation: EAW71853.1 CH471135 Genomic DNA Translation: EAW71854.1 |
RefSeqi | NP_009052.3, NM_007121.5 |
Genome annotation databases
GeneIDi | 7376 |
KEGGi | hsa:7376 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ692835 mRNA Translation: ADZ17346.1 CH471135 Genomic DNA Translation: EAW71852.1 CH471135 Genomic DNA Translation: EAW71853.1 CH471135 Genomic DNA Translation: EAW71854.1 |
RefSeqi | NP_009052.3, NM_007121.5 |
3D structure databases
SMRi | F1D8P7 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | F1D8P7, 9 interactors |
Protocols and materials databases
DNASUi | 7376 |
Genome annotation databases
GeneIDi | 7376 |
KEGGi | hsa:7376 |
Organism-specific databases
CTDi | 7376 |
Phylogenomic databases
OrthoDBi | 1137281at2759 |
Miscellaneous databases
BioGRID-ORCSi | 7376, 10 hits in 900 CRISPR screens |
ChiTaRSi | NR1H2, human |
GenomeRNAii | 7376 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR023257, Liver_X_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR02034, LIVERXRECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1D8P7_HUMAN | |
Accessioni | F1D8P7Primary (citable) accession number: F1D8P7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | February 10, 2021 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |