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UniProtKB - F1D8N3 (F1D8N3_HUMAN)
Protein
Estrogen receptor beta
Gene
NR3A2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- estrogen receptor activity Source: InterPro
- nuclear receptor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
- steroid binding Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- cellular response to estradiol stimulus Source: InterPro
- intracellular estrogen receptor signaling pathway Source: InterPro
- transcription initiation from RNA polymerase II promoter Source: UniProt
Keywordsi
Molecular function | DNA-bindingARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Estrogen receptor betaARBA annotationAlternative name(s): Nuclear receptor subfamily 3 group A member 2ARBA annotation |
Gene namesi | Name:NR3A2Imported Synonyms:ESR2Imported ORF Names:hCG_21449Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000140009 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Nucleus
- nucleoplasm Source: UniProt
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000140009, Expressed in right adrenal gland and 138 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 146 – 221 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 264 – 495 | NR LBDInterPro annotationAdd BLAST | 232 |
Sequence similaritiesi
Keywords - Domaini
Zinc-fingerARBA annotationFamily and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR028355, ER-beta/gamma IPR024178, Est_rcpt/est-rel_rcp IPR021064, Estrogen_rcpt_beta_N IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF12497, ERbeta_N, 1 hit PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF500102, ER-b, 1 hit PIRSF002527, ER-like_NR, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F1D8N3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS
60 70 80 90 100
PAVMNYSIPS NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA
110 120 130 140 150
EPQKSPWCEA RSLEHTLPVN RETLKRKVSG NRCASPVTGP GSKRDAHFCA
160 170 180 190 200
VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ CTIDKNRRKS
210 220 230 240 250
CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH CAGKAKRSGG
260 270 280 290 300
HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK
310 320 330 340 350
LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH
360 370 380 390 400
PGKLIFAPDL VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV
410 420 430 440 450
KAMILLNSSM YPLVTATQDA DSSRKLAHLL NAVTDALVWV IAKSGISSQQ
460 470 480 490
QSMRLANLLM LLSHVRHARA EKASQTLTSF GMKMETLLPE ATMEQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ692821 mRNA Translation: ADZ17332.1 CH471061 Genomic DNA Translation: EAW80851.1 CH471061 Genomic DNA Translation: EAW80852.1 |
RefSeqi | NP_001035365.1, NM_001040275.1 NP_001278641.1, NM_001291712.1 NP_001278652.1, NM_001291723.1 XP_016876573.1, XM_017021084.1 |
Genome annotation databases
GeneIDi | 2100 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ692821 mRNA Translation: ADZ17332.1 CH471061 Genomic DNA Translation: EAW80851.1 CH471061 Genomic DNA Translation: EAW80852.1 |
RefSeqi | NP_001035365.1, NM_001040275.1 NP_001278641.1, NM_001291712.1 NP_001278652.1, NM_001291723.1 XP_016876573.1, XM_017021084.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 11874, 1745 antibodies from 44 providers |
DNASUi | 2100 |
Genome annotation databases
GeneIDi | 2100 |
Organism-specific databases
CTDi | 2100 |
VEuPathDBi | HostDB:ENSG00000140009 |
Miscellaneous databases
BioGRID-ORCSi | 2100, 8 hits in 1060 CRISPR screens |
ChiTaRSi | ESR2, human |
GenomeRNAii | 2100 |
Gene expression databases
Bgeei | ENSG00000140009, Expressed in right adrenal gland and 138 other tissues |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR028355, ER-beta/gamma IPR024178, Est_rcpt/est-rel_rcp IPR021064, Estrogen_rcpt_beta_N IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF12497, ERbeta_N, 1 hit PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF500102, ER-b, 1 hit PIRSF002527, ER-like_NR, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F1D8N3_HUMAN | |
Accessioni | F1D8N3Primary (citable) accession number: F1D8N3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | January 19, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |