NR1H3

Functionⁱ

GO - Molecular functionⁱ

DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
nuclear receptor activity Source: Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
zinc ion binding Source: InterPro

GO - Biological processⁱ

cellular response to lipopolysaccharide Source: Ensembl
cholesterol homeostasis Source: Ensembl
negative regulation of cholesterol storage Source: Ensembl
negative regulation of cold-induced thermogenesis Source: Ensembl
negative regulation of inflammatory response Source: Ensembl
negative regulation of macrophage activation Source: Ensembl
negative regulation of pancreatic juice secretion Source: Ensembl
negative regulation of proteolysis Source: Ensembl
negative regulation of response to endoplasmic reticulum stress Source: Ensembl
negative regulation of secretion of lysosomal enzymes Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
phosphatidylcholine acyl-chain remodeling Source: Ensembl
positive regulation of cholesterol efflux Source: Ensembl
triglyceride homeostasis Source: Ensembl

Keywordsⁱ

Molecular function	DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation
Biological process	Transcription, Transcription regulationUniRule annotationARBA annotation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Liver X nuclear receptor alpha variant 1Imported
Gene namesⁱ	Name:NR1H3Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

VEuPathDBⁱ	HostDB:ENSG00000025434

VEuPathDBⁱ

HostDB:ENSG00000025434

Keywords - Cellular componentⁱ

NucleusUniRule annotationARBA annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000025434, Expressed in right lobe of liver and 183 other tissues
ExpressionAtlasⁱ	F1D8N1, baseline and differential
Genevisibleⁱ	F1D8N1, HS

Interactionⁱ

Chemistry databases

BindingDBⁱ	F1D8N1

BindingDBⁱ

F1D8N1

Structureⁱ

3D structure databases

SMRⁱ	F1D8N1
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	95 – 170	Nuclear receptorInterPro annotationAdd BLAST		76
Domainⁱ	209 – 447	NR LBDInterPro annotationAdd BLAST		239

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 37	DisorderedSequence analysisAdd BLAST	37
Regionⁱ	65 – 88	DisorderedSequence analysisAdd BLAST	24
Regionⁱ	180 – 202	DisorderedSequence analysisAdd BLAST	23

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR1 subfamily.ARBA annotation

Keywords - Domainⁱ

Zinc-fingerUniRule annotationARBA annotation

Phylogenomic databases

OMAⁱ	DFPVASH
Database of Orthologous Groups More...OrthoDBⁱ	1137281at2759
PhylomeDBⁱ	F1D8N1

Family and domain databases

Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR023257, Liver_X_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit
PRINTSⁱ	PR02034, LIVERXRECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

F1D8N1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLWLGAPVP DIPPDSAVEL WKPGAQDASS QAQGGSSCIL REEARMPHSA 
        60         70         80         90        100
GGTAGVGLEA AEPTALLTRA EPPSEPTEIR PQKRKKGPAP KMLGNELCSV 
       110        120        130        140        150
CGDKASGFHY NVLSCEGCKG FFRRSVIKGA HYICHSGGHC PMDTYMRRKC 
       160        170        180        190        200
QECRLRKCRQ AGMREECVLS EEQIRLKKLK RQEEEQAHAT SLPPRASSPP 
       210        220        230        240        250
QILPQLSPEQ LGMIEKLVAA QQQCNRRSFS DRLRVTPWPM APDPHSREAR 
       260        270        280        290        300
QQRFAHFTEL AIVSVQEIVD FAKQLPGFLQ LSREDQIALL KTSAIEVMLL 
       310        320        330        340        350
ETSRRYNPGS ESITFLKDFS YNREDFAKAG LQVEFINPIF EFSRAMNELQ 
       360        370        380        390        400
LNDAEFALLI AISIFSADRP NVQDQLQVER LQHTYVEALH AYVSIHHPHD 
       410        420        430        440 
RLMFPRMLMK LVSLRTLSSV HSEQVFALRL QDKKLPPLLS EIWDVHE

Length:447

Mass (Da):50,396

Last modified:May 3, 2011 - v1

Checksum:ⁱ0D27B237440F8C9C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HQ692819 mRNA Translation: ADZ17330.1
NCBI Reference Sequences More...RefSeqⁱ	NP_005684.2, NM_005693.3 XP_005252762.1, XM_005252705.1 XP_005252763.1, XM_005252706.1 XP_005252764.1, XM_005252707.4 XP_006718175.1, XM_006718112.1 XP_006718176.1, XM_006718113.1 XP_011518107.1, XM_011519805.2

Genome annotation databases

GeneIDⁱ	10062
KEGGⁱ	hsa:10062
MANE-Selectⁱ	ENST00000441012.7; ENSP00000387946.2; NM_005693.4; NP_005684.2

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
F1D8N1	Oxysterols receptor LXR-alpha	)	HUMAN		447	UniRef100_Q13133
NR1H3 isoform 12		PANTR		447
Nuclear receptor subfamily 1 group H member 3		PANPA		447
Nuclear receptor subfamily 1 group H member 3		PANTR		447

Protein	Similar proteins		Species	Score	Length	Source
F1D8N1	Oxysterols receptor LXR-alpha	)	HUMAN		447	UniRef90_Q13133
Oxysterols receptor LXR-alpha		BOVIN		447
NR1H3 isoform 12		PANTR		447
Nuclear receptor subfamily 1 group H member 3		PANPA		447
oxysterols receptor LXR-alpha isoform X3		pale spear-nosed bat		466
+157

Protein	Similar proteins		Species	Score	Length	Source
F1D8N1	Oxysterols receptor LXR-alpha	)	HUMAN		447	UniRef50_Q13133
Oxysterols receptor LXR-alpha		BOVIN		447
Oxysterols receptor LXR-alpha	)	MOUSE		445
Oxysterols receptor LXR-alpha		RAT		445
NR1H3 isoform 12		PANTR		447
+545

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HQ692819 mRNA Translation: ADZ17330.1
RefSeqⁱ	NP_005684.2, NM_005693.3 XP_005252762.1, XM_005252705.1 XP_005252763.1, XM_005252706.1 XP_005252764.1, XM_005252707.4 XP_006718175.1, XM_006718112.1 XP_006718176.1, XM_006718113.1 XP_011518107.1, XM_011519805.2

3D structure databases

SMRⁱ	F1D8N1
ModBaseⁱ	Search...

Chemistry databases

BindingDBⁱ	F1D8N1

BindingDBⁱ

F1D8N1

Protocols and materials databases

Antibodypediaⁱ	13611, 578 antibodies from 39 providers
The DNASU plasmid repository More...DNASUⁱ	10062

Genome annotation databases

GeneIDⁱ	10062
KEGGⁱ	hsa:10062
MANE-Selectⁱ	ENST00000441012.7; ENSP00000387946.2; NM_005693.4; NP_005684.2

Organism-specific databases

CTDⁱ	10062
VEuPathDBⁱ	HostDB:ENSG00000025434

Phylogenomic databases

OMAⁱ	DFPVASH
OrthoDBⁱ	1137281at2759
PhylomeDBⁱ	F1D8N1

Miscellaneous databases

BioGRID-ORCSⁱ	10062, 26 hits in 1108 CRISPR screens
GenomeRNAiⁱ	10062

Gene expression databases

Bgeeⁱ	ENSG00000025434, Expressed in right lobe of liver and 183 other tissues
ExpressionAtlasⁱ	F1D8N1, baseline and differential
Genevisibleⁱ	F1D8N1, HS

Family and domain databases

Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR023257, Liver_X_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit
PRINTSⁱ	PR02034, LIVERXRECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F1D8N1_HUMAN
Accessionⁱ	F1D8N1Primary (citable) accession number: F1D8N1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 3, 2011
	Last sequence update:	May 3, 2011
	Last modified:	May 25, 2022
	This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - F1D8N1 (F1D8N1_HUMAN)

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Liver X nuclear receptor alpha variant 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Chemistry databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ