UniProtKB - F1D8N1 (F1D8N1_HUMAN)
Protein
Submitted name:
Liver X nuclear receptor alpha variant 1
Gene
NR1H3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- nuclear receptor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- lipid metabolic process Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationImportedARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Liver X nuclear receptor alpha variant 1Imported |
Gene namesi | Name:NR1H3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000025434.18 |
Subcellular locationi
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000025434, Expressed in right lobe of liver and 182 other tissues |
ExpressionAtlasi | F1D8N1, baseline and differential |
Genevisiblei | F1D8N1, HS |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 95 – 170 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 209 – 447 | NR LBDInterPro annotationAdd BLAST | 239 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 37 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 65 – 88 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 180 – 202 | DisorderedSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the nuclear hormone receptor family.UniRule annotation
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
OrthoDBi | 1137281at2759 |
PhylomeDBi | F1D8N1 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR023257, Liver_X_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR02034, LIVERXRECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F1D8N1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLWLGAPVP DIPPDSAVEL WKPGAQDASS QAQGGSSCIL REEARMPHSA
60 70 80 90 100
GGTAGVGLEA AEPTALLTRA EPPSEPTEIR PQKRKKGPAP KMLGNELCSV
110 120 130 140 150
CGDKASGFHY NVLSCEGCKG FFRRSVIKGA HYICHSGGHC PMDTYMRRKC
160 170 180 190 200
QECRLRKCRQ AGMREECVLS EEQIRLKKLK RQEEEQAHAT SLPPRASSPP
210 220 230 240 250
QILPQLSPEQ LGMIEKLVAA QQQCNRRSFS DRLRVTPWPM APDPHSREAR
260 270 280 290 300
QQRFAHFTEL AIVSVQEIVD FAKQLPGFLQ LSREDQIALL KTSAIEVMLL
310 320 330 340 350
ETSRRYNPGS ESITFLKDFS YNREDFAKAG LQVEFINPIF EFSRAMNELQ
360 370 380 390 400
LNDAEFALLI AISIFSADRP NVQDQLQVER LQHTYVEALH AYVSIHHPHD
410 420 430 440
RLMFPRMLMK LVSLRTLSSV HSEQVFALRL QDKKLPPLLS EIWDVHE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ692819 mRNA Translation: ADZ17330.1 |
RefSeqi | NP_005684.2, NM_005693.3 XP_005252762.1, XM_005252705.1 XP_005252763.1, XM_005252706.1 XP_005252764.1, XM_005252707.4 XP_006718175.1, XM_006718112.1 XP_006718176.1, XM_006718113.1 XP_011518107.1, XM_011519805.2 |
Genome annotation databases
GeneIDi | 10062 |
KEGGi | hsa:10062 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ692819 mRNA Translation: ADZ17330.1 |
RefSeqi | NP_005684.2, NM_005693.3 XP_005252762.1, XM_005252705.1 XP_005252763.1, XM_005252706.1 XP_005252764.1, XM_005252707.4 XP_006718175.1, XM_006718112.1 XP_006718176.1, XM_006718113.1 XP_011518107.1, XM_011519805.2 |
3D structure databases
SMRi | F1D8N1 |
ModBasei | Search... |
Chemistry databases
BindingDBi | F1D8N1 |
Protocols and materials databases
Antibodypediai | 13611, 559 antibodies |
DNASUi | 10062 |
Genome annotation databases
GeneIDi | 10062 |
KEGGi | hsa:10062 |
Organism-specific databases
CTDi | 10062 |
EuPathDBi | HostDB:ENSG00000025434.18 |
Phylogenomic databases
OrthoDBi | 1137281at2759 |
PhylomeDBi | F1D8N1 |
Miscellaneous databases
BioGRID-ORCSi | 10062, 17 hits in 868 CRISPR screens |
GenomeRNAii | 10062 |
Gene expression databases
Bgeei | ENSG00000025434, Expressed in right lobe of liver and 182 other tissues |
ExpressionAtlasi | F1D8N1, baseline and differential |
Genevisiblei | F1D8N1, HS |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR023257, Liver_X_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR02034, LIVERXRECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1D8N1_HUMAN | |
Accessioni | F1D8N1Primary (citable) accession number: F1D8N1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | December 2, 2020 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |