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Protein

Cholesterol side-chain cleavage enzyme, mitochondrial

Gene
N/A
Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.UniRule annotation

Catalytic activityi

Cholesterol + 6 reduced adrenodoxin + 3 O2 + 6 H+ = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.UniRule annotation

Cofactori

hemeUniRule annotation

Pathwayi: C21-steroid hormone metabolism

This protein is involved in the pathway C21-steroid hormone metabolism, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway C21-steroid hormone metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
Biological processCholesterol metabolismUniRule annotation, Lipid metabolism, Steroid metabolism, SteroidogenesisUniRule annotation, Sterol metabolism
LigandHemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00229

Names & Taxonomyi

Protein namesi
Recommended name:
Cholesterol side-chain cleavage enzyme, mitochondrialUniRule annotation (EC:1.14.15.6UniRule annotation)
Alternative name(s):
Cholesterol desmolaseUniRule annotation
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation, MitochondrionUniRule annotation

Expressioni

Gene expression databases

ExpressionAtlasiF1D8K7 differential
GenevisibleiF1D8K7 SS

Structurei

3D structure databases

ProteinModelPortaliF1D8K7
SMRiF1D8K7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG0159 Eukaryota
COG2124 LUCA
KOiK00498
OrthoDBiEOG091G04MV

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR033283 CYP11A1
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PANTHERiPTHR24279:SF3 PTHR24279:SF3, 1 hit
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

F1D8K7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLARGLALRS VLVKGCQPFL SAPRECPGHP RVGTGEGACI STKTPRPFSE
60 70 80 90 100
IPSPGDNGWI NLYRFWKEKG TQKIHYHHVQ NFQKYGPIYR EKLGNLESVY
110 120 130 140 150
IIDPEDVALL FKFEGPNPER YNIPPWVAYH QHYQKPVGVL LKKSGAWKKD
160 170 180 190 200
RLVLNTEVMA PEAIKNFIPL LDTVSQDFVG VLHRRIKQQG SGKFSGDIRE
210 220 230 240 250
DLFRFAFESI TNVIFGERLG MLEEIVDPEA QKFIDAVYQM FHTSVPMLNL
260 270 280 290 300
PPDLFRLFRT KTWRDHVAAW DTIFNKAEKY TQNFYWDLRR KREFNNYPGI
310 320 330 340 350
LYRLLGNDKL LSEDVKANVT EMLAGGVDTT SMTLQWHLYE MARSLNVQEM
360 370 380 390 400
LREEVLNARR QAQGDTSKML QLVPLLKASI KETLRLHPIS VTLQRYLVND
410 420 430 440 450
LVLRDYMIPA KTLVQVAVYA MGRDPAFFSN PGQFDPTRWL GKERDLIHFR
460 470 480 490 500
NLGFGWGVRQ CVGRRIAELE MTLFLIHILE NFKVELQHFS DVDTIFNLIL
510 520
MPDKPIFLVF RPFNQDPLQA
Length:520
Mass (Da):60,258
Last modified:May 3, 2011 - v1
Checksum:i6C6D0D6FE34F9C33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ687747 Genomic DNA Translation: ADR82371.1
RefSeqiNP_999592.1, NM_214427.1
UniGeneiSsc.8776

Genome annotation databases

GeneIDi403329
KEGGissc:403329

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ687747 Genomic DNA Translation: ADR82371.1
RefSeqiNP_999592.1, NM_214427.1
UniGeneiSsc.8776

3D structure databases

ProteinModelPortaliF1D8K7
SMRiF1D8K7
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403329
KEGGissc:403329

Organism-specific databases

CTDi1583

Phylogenomic databases

eggNOGiKOG0159 Eukaryota
COG2124 LUCA
KOiK00498
OrthoDBiEOG091G04MV

Enzyme and pathway databases

UniPathwayi
UPA00229

Gene expression databases

ExpressionAtlasiF1D8K7 differential
GenevisibleiF1D8K7 SS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR033283 CYP11A1
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PANTHERiPTHR24279:SF3 PTHR24279:SF3, 1 hit
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1D8K7_PIG
AccessioniPrimary (citable) accession number: F1D8K7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: July 18, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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