UniProtKB - F1CT76 (F1CT76_HUMAN)
Protein
Submitted name:
MHC class II antigen
Gene
HLA-DRB1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
Keywordsi
Biological process | Adaptive immunity, Immunity |
Names & Taxonomyi
Protein namesi | Submitted name: MHC class II antigenImported |
Gene namesi | Name:HLA-DRB1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Endosome
- Endosome membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Lysosome
- Lysosome membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Endosome
- endosome membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
Plasma Membrane
- MHC class II protein complex Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 194 – 216 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
EndosomeARBA annotation, LysosomeARBA annotation, Membrane, MHC IIARBA annotationPTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationProteomic databases
PeptideAtlasi | F1CT76 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 92 – 180 | Ig-likeInterPro annotationAdd BLAST | 89 |
Keywords - Domaini
SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysisFamily and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Fragment.
F1CT76-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
RFLEYSTSEC HFFNGTERVR FLDRYFHNQE EYVRFDSDVG EFRAVTELGR
60 70 80 90 100
PDEEYWNSQK DFLEDRRAAV DTYCRHNYGV VESFTVQRRV HPKVTVYPSK
110 120 130 140 150
TQPLQHHNLL VCSVSGFYPG SIEVRWFRNG QEEKTGVVST GLIHNGDWTF
160 170 180 190 200
QTLVMLETVP RSGEVYTCQV EHPSVTSPLT VEWRARSESA QSKMLSGVGG
210 220
FVLGLLFLGA GLFIYFRNQK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 220 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ538841 Genomic DNA Translation: ADX31869.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ538841 Genomic DNA Translation: ADX31869.1 |
3D structure databases
SMRi | F1CT76 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | F1CT76 |
Miscellaneous databases
ChiTaRSi | HLA-DRB1, human |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F1CT76_HUMAN | |
Accessioni | F1CT76Primary (citable) accession number: F1CT76 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | October 7, 2020 | |
This is version 45 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |