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Entry version 45 (31 Jul 2019)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

Uncharacterized protein DHKE

Gene

DHKE

Organism
Dictyostelium purpureum (Slime mold)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized protein DHKEImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DHKEImported
ORF Names:DICPUDRAFT_148245Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium purpureum (Slime mold)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5786 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001064 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei380 – 401HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14514-aspartylphosphatePROSITE-ProRule annotation1

Keywords - PTMi

PhosphoproteinPROSITE-ProRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5786.XP_003284476.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini679 – 893Histidine kinaseInterPro annotationAdd BLAST215
Domaini1402 – 1531Response regulatoryInterPro annotationAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni58 – 95DisorderedSequence analysisAdd BLAST38
Regioni132 – 195DisorderedSequence analysisAdd BLAST64
Regioni249 – 277DisorderedSequence analysisAdd BLAST29
Regioni304 – 336DisorderedSequence analysisAdd BLAST33
Regioni992 – 1013DisorderedSequence analysisAdd BLAST22
Regioni1118 – 1159DisorderedSequence analysisAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili104 – 127Sequence analysisAdd BLAST24
Coiled coili1313 – 1333Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi145 – 171PolarSequence analysisAdd BLAST27
Compositional biasi252 – 268AcidicSequence analysisAdd BLAST17
Compositional biasi998 – 1013PolyampholyteSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0519 Eukaryota
ENOG410XNMH LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F0ZAM2

Identification of Orthologs from Complete Genome Data

More...
OMAi
IYRRCCI

Database of Orthologous Groups

More...
OrthoDBi
27870at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00082 HisKA, 1 hit
cd00156 REC, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011006 CheY-like_superfamily
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR004358 Sig_transdc_His_kin-like_C
IPR001789 Sig_transdc_resp-reg_receiver

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PF13188 PAS_8, 1 hit
PF00072 Response_reg, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00344 BCTRLSENSOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SM00091 PAS, 1 hit
SM00448 REC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47384 SSF47384, 1 hit
SSF52172 SSF52172, 1 hit
SSF55785 SSF55785, 1 hit
SSF55874 SSF55874, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00229 sensory_box, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50109 HIS_KIN, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F0ZAM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNNNSNNSD NSDNERKEYL LGLLKKGCQV SNREREELMF KFKITDLSIF
60 70 80 90 100
RQNNNININN NNNNDNNGNP PQEKLSNDFS NLKINNDGNN SKENYLKKYQ
110 120 130 140 150
YRASDDIEQN LNKKNEMEEL AKKERLQKIK EIKQQQKQKH PDLFRDNNNN
160 170 180 190 200
NNNNNNNNIN NISINNHTNN NNDHSDAEED INLSNDPQDL SGDSDEDLLV
210 220 230 240 250
LESKIIKDKK DYACENCKWC DGFEPLNGFG NLEICSSCKC KLIHHIPSYN
260 270 280 290 300
NEEEDDDDGE DYEDYEEDTE DSLHRKLSKN NNSQIYNKFI LSVSQPSSAF
310 320 330 340 350
QLNTLGNSTG IPNNNNNNNN SNNNNNNNNN NNGNSQFLSR QHTLNYFLNK
360 370 380 390 400
KKKSFFERHQ KVFNKFLPPR LKPAIYRRCC IFQNLLVTIT ISILLFIYQL
410 420 430 440 450
VIYKNEKDIE AKEKRFRNIF DTSSEALVIH RNGIIMDVNS TFEKMFEVEA
460 470 480 490 500
DDLLNPVPCA IWELLPEMES YFQSSNRIKD TLRNSNNTNS NNNNNNNSSI
510 520 530 540 550
LNNSNVLNIN NLNFLNNLNN PTNNITNGGN NSTLNSNNNS INNSRSNSFI
560 570 580 590 600
MNGNNMIGGG INIETNSGIG NRMITRTSRS NTGLSDNSSI FDDSDSVDFF
610 620 630 640 650
SLKNINKQPI VFDTIGIKPC GAEFTVQVKI ENKYDKVSSS DFDVVSIIDT
660 670 680 690 700
TARKKLIIAD QQLRRAEEIN DAKIRFLTTV SHEVRTPISG ILSSVGILDE
710 720 730 740 750
SLVDSNQREY LGFIKDSADY LLDLITDILD FSKIEAGKME LERVEFNLLK
760 770 780 790 800
MLEDSINIVY RNAHDRGINV IHFVEPDVPI FLIGDSHRIK QVLLNYLSNA
810 820 830 840 850
IKFTSKGQVM VKVSLVEKTN EGIKVMFSVE DSGVGIKDEF QEQLFQPFHQ
860 870 880 890 900
VGSLRQYLGT GLGLSISKRL TAMMGGEVGF RSTFGVGSTF YFTSLFQINP
910 920 930 940 950
NSLLPLGTMG SILSTTLLNK MDSINLFQKI NGFIYDDNIN VSKSISNFLN
960 970 980 990 1000
LLSIQLKVIN PSNDNNLKFE LTNFLNNLID TQNNKLNNQE ILSDEDDEEH
1010 1020 1030 1040 1050
FDQKQRDGQK EEEEEEYTII ITNSLSNENL NHFKEKYKLI PNTQNIYWFC
1060 1070 1080 1090 1100
LNDNSLQVID PFYDGIVKKP CNFPNIVETI FKVFNQVLQI DHYYVLTNRS
1110 1120 1130 1140 1150
KEDYRLYCKQ RKENDFKNNN NNVNINNSNN TLNISGGSQN LNSSGGNTRH
1160 1170 1180 1190 1200
RNKFNNSKMS PLNRTKQVFV RKNTNGIYSD HVPITRGLIQ DVSPRLSSSP
1210 1220 1230 1240 1250
VSLAIPQINI NNKGNRNISP RLNGSSSNTP ISTSAVVTPT FQSTSSNGVL
1260 1270 1280 1290 1300
VSNININING SGFFSGAECI SSSISPSIQN SNGCFSPTSG TASPTIISTS
1310 1320 1330 1340 1350
PELKSISNDP NDLNNSVNNN NSVNNNINNS NNNIIVKRQI STESIKKENG
1360 1370 1380 1390 1400
TPNTASTKTQ AIIPPLDIQS NSILSALRFA DSSDGSNNNS PNIVPIDRNQ
1410 1420 1430 1440 1450
YKILLVDDNI VNIKIFSKYI KDGGYQHDIA MDGNQAIEAT KKNYYPIIFM
1460 1470 1480 1490 1500
DCHMDPMDGY QATEIIRKFE KSLVNCHGKI HYKKSTIIAL TALDLGGMSS
1510 1520 1530 1540 1550
GKDKCLDIGM DDFLQKPIKP KTIIDTIEKH IKKFNINDIE YGLLSLKEWK

LDVDV
Length:1,555
Mass (Da):175,855
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38EBA0EE2AF8FAF4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL870965 Genomic DNA Translation: EGC39023.1

NCBI Reference Sequences

More...
RefSeqi
XP_003284476.1, XM_003284428.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EGC39023; EGC39023; DICPUDRAFT_148245

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10506103

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dpp:DICPUDRAFT_148245

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL870965 Genomic DNA Translation: EGC39023.1
RefSeqiXP_003284476.1, XM_003284428.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5786.XP_003284476.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEGC39023; EGC39023; DICPUDRAFT_148245
GeneIDi10506103
KEGGidpp:DICPUDRAFT_148245

Phylogenomic databases

eggNOGiKOG0519 Eukaryota
ENOG410XNMH LUCA
InParanoidiF0ZAM2
OMAiIYRRCCI
OrthoDBi27870at2759

Family and domain databases

CDDicd00082 HisKA, 1 hit
cd00156 REC, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR004358 Sig_transdc_His_kin-like_C
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PF13188 PAS_8, 1 hit
PF00072 Response_reg, 1 hit
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SM00091 PAS, 1 hit
SM00448 REC, 1 hit
SUPFAMiSSF47384 SSF47384, 1 hit
SSF52172 SSF52172, 1 hit
SSF55785 SSF55785, 1 hit
SSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50109 HIS_KIN, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF0ZAM2_DICPU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F0ZAM2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: July 31, 2019
This is version 45 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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