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Entry version 56 (16 Jan 2019)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

Uncharacterized protein

Gene

DICPUDRAFT_52203

Organism
Dictyostelium purpureum (Slime mold)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:DICPUDRAFT_52203Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium purpureum (Slime mold)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5786 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001064 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5786.XP_003283318.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini764 – 877PI3K-RBDInterPro annotationAdd BLAST114
Domaini1000 – 1167C2 PI3K-typeInterPro annotationAdd BLAST168
Domaini1198 – 1375PIK helicalInterPro annotationAdd BLAST178
Domaini1468 – 1729PI3K/PI4KInterPro annotationAdd BLAST262

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0904 Eukaryota
COG5032 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F0Z7E7

KEGG Orthology (KO)

More...
KOi
K00922

Identification of Orthologs from Complete Genome Data

More...
OMAi
LTHILIQ

Database of Orthologous Groups

More...
OrthoDBi
204282at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00891 PI3Kc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR035448 PI3Kc
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
IPR029071 Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR10048 PTHR10048, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF00794 PI3K_rbd, 1 hit
PF00613 PI3Ka, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00142 PI3K_C2, 1 hit
SM00144 PI3K_rbd, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F0Z7E7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVQQQQDVG NLISPLSLSS EEQQNRKSST GSTGSTNSSG SFKKNLQIFN
60 70 80 90 100
SLSSSVNSED VGSTLISPRK NNNINNTNIN FPNKLKVTDL VKTFNNKPLS
110 120 130 140 150
NIHSIHNNIA PSTLEKEKNS LPNGSNTKQL SSAFQILDNS INTPLLSTNN
160 170 180 190 200
RVRSGSTGSK PIIMQTQMPS SISISASSSP PLSSDDQLHN TNKLNSSNPS
210 220 230 240 250
TNSTPTISVS GQKPPTPKIS GSCLNISSNN SNNNNSVLQD LLFNLPMAPT
260 270 280 290 300
SVPKISQTPP SSKKPTTSTT SSPATIGKST SSSTTNTTSS ANNIAPIFPL
310 320 330 340 350
PISQSSSTPS TSSSTTPNQT TPRNLNNNNT NTNNTNTNNT NNGTSNISNN
360 370 380 390 400
SSNSQSQQVN TNSINLITSS SNSNNSQINY INGHPAHISH SNSCSSIINH
410 420 430 440 450
HESSSPSQSQ SSSSSSSSNT PVTTTPILMS NRNSPLLGRS PTQYIISTNT
460 470 480 490 500
GLTAGERVKS KQYSMLNISK KTIIDESDSL SSPRSLTGSP NSLRASISSQ
510 520 530 540 550
APASFGTLPS INSNKPLVVK KSTSEHSAKK ENIWRQTMAP STKEDHIKVV
560 570 580 590 600
FDGLPGKRVI QKFIIDKTPQ EIKSKFLEDL LNTTDFQQPP LNIPINPDQY
610 620 630 640 650
ELKVLSVNST INNETLPLRR QMLMQACNIS RLFPKLHLVI KGSSPSSTAI
660 670 680 690 700
PSPTPSPSTS NTSLGSLITN VPPESLSKLN KSNSSSTLMI DNNEVIDVKG
710 720 730 740 750
HIQAELEIFE LIGTSFTRVL DQGQEVVSFR RDFAHFRLAN FTITRNDLSQ
760 770 780 790 800
MIYVSSEPLP LIIPNKITIM VLLPGDGKII KRVDCDPNES VKEVKNQIFK
810 820 830 840 850
KFAMIDRNHT KDKTADDFVL KVTGFREYIL CHAELGNLTS RQRFYPTGAN
860 870 880 890 900
GDFALIDYDY IRQCVSKNQL IELSLTNNSI LKLNQVEEKV SFIDKILETS
910 920 930 940 950
DFDDYDDEEL ESLSNNSYDD VKQNQNQQHS QQQIFQSRGS FDSSGGGSGL
960 970 980 990 1000
GEQLSTNSGG SNNNSSNNEL LGSAAGVAGT TNNIVGGSNN NSSKLPINIV
1010 1020 1030 1040 1050
KRLFRVNIAG IRNLNFNNNE DAKSKFVDKQ PYCFVMAELY YGGQLLTNPV
1060 1070 1080 1090 1100
YTPITPINIF EVIDFPNWEK GIAFTIPIRV LPRSARASFT LYVTSVSEAT
1110 1120 1130 1140 1150
ESQMEDVVSK SIPIGWSNCL LMNHKGILRM GPAAFRLWED GRRANPIGTC
1160 1170 1180 1190 1200
VDNQSAKAPV ILLVEFESFI RPIVYVPPTP STSNSSNELL NSPPTSPQTA
1210 1220 1230 1240 1250
TKKLDPEEAR KLRSLMESDP LAQFSPEEQK LIYNYKHNYK SKPKALAKFL
1260 1270 1280 1290 1300
LSVCWTDPEQ VSEAYRQMND WALLKPVQAL ELLDAKFADE HVRNFAIKVI
1310 1320 1330 1340 1350
NSFSDAEFSD FLLQLTQVLK YEPYHNSDLT HILIQRALAN RSRIGHFFFW
1360 1370 1380 1390 1400
FLKSEMHTPE IEERYGLLLE GYLRSCGSHR QDLIKQNQVL KSLYGVAMAV
1410 1420 1430 1440 1450
KNTHGASERK KVLQEGLSKI KFPETFQLPL DPRWEAKGLI VDKCRYMDSK
1460 1470 1480 1490 1500
KLPLWLVFEN VEPHAKPLTI IFKVGDDLRQ DILTLQVLRI MDRFWKNNGM
1510 1520 1530 1540 1550
DLRLQPYKCI ATGDGIGMLE VVLNSNTIAN INKDAGGTGA ILEEKTLANW
1560 1570 1580 1590 1600
LKECNPTEAE YNKAVETFIL SCAGYVVATY VLGIGDRHAD NIMITKFGHL
1610 1620 1630 1640 1650
FHIDFGHFLG NYKKKYGFKR ERAPFIFTPQ YMAIVGGKDS ENFKRFVTTC
1660 1670 1680 1690 1700
CLAYNILRKN SDLFLNLFQL MLSTGIPELQ CADDIDYLRK ALAPQLTDEE
1710 1720
AAEEFKKNII VALNTKTVIL NDLFHNFAH
Length:1,729
Mass (Da):191,243
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D1F9911C1B9554E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL870946 Genomic DNA Translation: EGC40128.1

NCBI Reference Sequences

More...
RefSeqi
XP_003283318.1, XM_003283270.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EGC40128; EGC40128; DICPUDRAFT_52203

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10509223

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dpp:DICPUDRAFT_52203

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL870946 Genomic DNA Translation: EGC40128.1
RefSeqiXP_003283318.1, XM_003283270.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5786.XP_003283318.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEGC40128; EGC40128; DICPUDRAFT_52203
GeneIDi10509223
KEGGidpp:DICPUDRAFT_52203

Phylogenomic databases

eggNOGiKOG0904 Eukaryota
COG5032 LUCA
InParanoidiF0Z7E7
KOiK00922
OMAiLTHILIQ
OrthoDBi204282at2759

Family and domain databases

CDDicd00891 PI3Kc, 1 hit
Gene3Di1.10.1070.11, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR035448 PI3Kc
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF00794 PI3K_rbd, 1 hit
PF00613 PI3Ka, 1 hit
SMARTiView protein in SMART
SM00142 PI3K_C2, 1 hit
SM00144 PI3K_rbd, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF0Z7E7_DICPU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F0Z7E7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: January 16, 2019
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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