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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

AURANDRAFT_58612

Organism
Aureococcus anophagefferens (Harmful bloom alga)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotationSAAS annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei68S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei143S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Active sitei146UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotation, RNA-binding, Transferase, tRNA-bindingUniRule annotationSAAS annotation
Biological processtRNA processingUniRule annotationSAAS annotation
LigandS-adenosyl-L-methionineUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
ORF Names:AURANDRAFT_58612Imported
OrganismiAureococcus anophagefferens (Harmful bloom alga)Imported
Taxonomic identifieri44056 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesPelagophyceaePelagomonadalesAureococcus
Proteomesi
  • UP000002729 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni90 – 91S-adenosyl-L-methionine bindingUniRule annotation2
Regioni123 – 124S-adenosyl-L-methionine bindingUniRule annotation2
Regioni219 – 221S-adenosyl-L-methionine bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotationSAAS annotation

Phylogenomic databases

InParanoidiF0XYS3
KOiK03439
OMAiIGMEIRV

Family and domain databases

HAMAPiMF_03055 tRNA_methyltr_TrmB_euk, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR025763 Trm8_euk
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
PTHR23417:SF16 PTHR23417:SF16, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

F0XYS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAIQDVSLE DFGHPCKKFF RSRAHCNPLS NNDGFEYPTT PDDMDWTDVF
60 70 80 90 100
PALGDARAGD RVRHLDVGCG FGGLAVALGA LSPELTLALE IRPKVCEYVR
110 120 130 140 150
QRLDALRRQH PGAYGNVGCL RHNAMLYLPN IIRKYQLAKI FFCFPDPHFK
160 170 180 190 200
AKNHRRRIVS SALLAEYAYA LRPGGLLYAI TDVRELHEWH VAKLDAHPCF
210 220 230 240 250
ARVDAHPGDP YVAAIAESTE EGKKVARQGG HMTDGSKRLI ATFSRISTIS

WVRGSRRT
Length:258
Mass (Da):28,841
Last modified:May 3, 2011 - v1
Checksum:iB9247787757288E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL833121 Genomic DNA Translation: EGB12473.1
RefSeqiXP_009033497.1, XM_009035249.1

Genome annotation databases

EnsemblProtistsiEGB12473; EGB12473; AURANDRAFT_58612
GeneIDi20222628
KEGGiaaf:AURANDRAFT_58612

Similar proteinsi

Entry informationi

Entry nameiF0XYS3_AURAN
AccessioniPrimary (citable) accession number: F0XYS3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: January 31, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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