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Protein

Malate dehydrogenase

Gene

mdh

Organism
Desulfurobacterium thermolithotrophum (strain DSM 11699 / BSA)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei96NADUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Active sitei176Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6
Nucleotide bindingi119 – 121NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Dester_0738Imported
OrganismiDesulfurobacterium thermolithotrophum (strain DSM 11699 / BSA)Imported
Taxonomic identifieri868864 [NCBI]
Taxonomic lineageiBacteriaAquificaeDesulfurobacterialesDesulfurobacteriaceaeDesulfurobacterium
Proteomesi
  • UP000007102 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi868864.Dester_0738

Structurei

3D structure databases

ProteinModelPortaliF0S3G2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 143Ldh_1_NInterPro annotationAdd BLAST139
Domaini148 – 310Ldh_1_CInterPro annotationAdd BLAST163

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
KOiK00024
OMAiMDLMQTA
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

F0S3G2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRKKITIVG AGNIGSTLAL LLARRETADI TLIDINEGIA KGKALDIMEA
60 70 80 90 100
SPILGFNAHV VGTGNYEDTA NSDVVVITAG FPRKPGMSRD DLLFKNFEVV
110 120 130 140 150
KSVSEQIKKY SPNAFVIVVT NPLDVMTYTA LKVTGFPKEK VLGMAGALDA
160 170 180 190 200
ARFAYFISEK TKISVENIRA FVIGGHGDDM VPLKNYTTIS GVPVTKFLSE
210 220 230 240 250
EELNKIIERT RFGGGEIVQL LKTGSAFYAP AAAILEMVIS ILWNKRKIIP
260 270 280 290 300
CSVYLDGEIG EYYGASGLCV GVPIVLGRNG VEEIIKLDLS EEEWQQWKKS
310
VESVKRLVEK LHL
Length:313
Mass (Da):34,214
Last modified:May 3, 2011 - v1
Checksum:i1FCB06DA665AE1F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002543 Genomic DNA Translation: ADY73384.1

Genome annotation databases

EnsemblBacteriaiADY73384; ADY73384; Dester_0738
KEGGidte:Dester_0738

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002543 Genomic DNA Translation: ADY73384.1

3D structure databases

ProteinModelPortaliF0S3G2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi868864.Dester_0738

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADY73384; ADY73384; Dester_0738
KEGGidte:Dester_0738

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
KOiK00024
OMAiMDLMQTA
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF0S3G2_DESTD
AccessioniPrimary (citable) accession number: F0S3G2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: November 7, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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