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Entry version 83 (02 Jun 2021)
Sequence version 4 (02 Jun 2021)
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Protein
Submitted name:

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

Gene

Pik3c2g

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinasePROSITE-ProRule annotationARBA annotation, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gammaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pik3c2gImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1203730, Pik3c2g

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
E9QQ35

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
345331

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030228, Expressed in stomach and 74 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9QQ35, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9QQ35

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.ARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159982

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002191_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
DLLAWTC

TreeFam database of animal gene trees

More...
TreeFami
TF102031

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05177, PI3Kc_C2_gamma, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 2 hits
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR037707, PI3K-C2-gamma_dom
IPR001263, PI3K_accessory_dom
IPR042236, PI3K_accessory_sf
IPR002420, PI3K_C2_dom
IPR015433, PI_Kinase
IPR001683, PX_dom
IPR036871, PX_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10048, PTHR10048, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF00792, PI3K_C2, 1 hit
PF00613, PI3Ka, 1 hit
PF00787, PX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit
SM00142, PI3K_C2, 1 hit
SM00145, PI3Ka, 1 hit
SM00146, PI3Kc, 1 hit
SM00312, PX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit
SSF64268, SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS51547, PI3K_C2, 1 hit
PS51545, PIK_HELICAL, 1 hit
PS50195, PX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

E9QQ35-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
KDMEEKHLSS MFSGNQHTSQ PHVNNVLEEV KNICSVLGCI ETKQVSDAVK
60 70 80 90 100
ELNLILQRPS QNFHQNSETS KKGFIERVTA ELSRSIYQLI DVYCSTFCTD
110 120 130 140 150
FQPVHTPGGV SRVHAGLQSH LSFTVCSLHN VPETWAHSYK AFSFSCWLTY
160 170 180 190 200
AGKKLCQVKS CRPLPVTKSF SLLVNWNEII NFPLEIKSLP RESMLIIKLF
210 220 230 240 250
GIDSATHSTN LLAWTCLPLF PRQESVLGSR LFSVTLQSEP PIEMIAPGVW
260 270 280 290 300
DGSQPSPLTL QIDFPDAGWE YLKPESEENR TDHEEPPREC LKHIAKLSQK
310 320 330 340 350
KSPLLLSEEK RRYLWFYRLY CNNENSSLPL VLGSAPGWDE ETVSEMHAIL
360 370 380 390 400
RRWTFSHPWE ALGLLTSRFP DQDIREVAVQ QLDTLLTDEL LDCLPQLVQA
410 420 430 440 450
VKFEWNLESP LVELLLRRSL QSIRVAHRLY WLLRDAQGEA YFKSWYQELL
460 470 480 490 500
AALQFCAGEA LNEELSKEQK LVKLLGDIGE KVKSASDPQR KDVLKKEIGS
510 520 530 540 550
LEEFFKDIKT CHLPLNPALC IKGIDRDACS YFTSNASPLK ITFINANPMG
560 570 580 590 600
KNISVIFKAG DDLRQDMLAL QIIQVMDNAW LQEGLDMQMI TYGCLSTGRA
610 620 630 640 650
QGFIEMVPDA VTLAKIHLHS GLIGPLKENT IKKWFSQHNH LKEDYEKALR
660 670 680 690 700
NFFYSCAGWC VVTFILGVCD RHNDNIMLTK SGHMFHIDFG KFLGHAQTFG
710 720 730 740 750
GIKRDRAPFI FTSEMEYFIT EGGKNTQHFQ DFVELCCRAY NIVRKHSQLI
760 770 780 790 800
LSLLEMMLHA GLPELRGIED LKYVHNNLRP QDTDLEATSH FTKKIKESLE
810 820 830 840 850
CFPVKLNNLI HTLAQMPALS LAKPAPQTLL QESCILNKTR TIQRVTILGF
860 870 880 890 900
SKTHSNLYLM EVTCSDNRRS LTKKSFEQFY RLHSQMQKQF SSLALPEFPH
910 920 930 940 950
WWHLPFTDSD HKRIRDLSHY VEQVLRGSYE VANSDCVLSF FLSEHIQPTL
960 970 980 990 1000
EDSPFVDPGE NSLDKSPKVQ LLMTYEDSRL TILVKHLKNI HLPDGSVPSA
1010 1020 1030 1040 1050
HVEIYLLPHP SEVRRKKTKC VPKCTDPTYN EIVVYDEVLG LQGHVLMLIV
1060 1070 1080
KSKTVFVGAV NIQLCSVPLN EEKWYPLGNS II
Length:1,082
Mass (Da):123,590
Last modified:June 2, 2021 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B3FA369AF439571
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O70167P3C2G_MOUSE
Phosphatidylinositol 4-phosphate 3-...
Pik3c2g
1,506Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WQW4A0A087WQW4_MOUSE
Phosphatidylinositol 4-phosphate 3-...
Pik3c2g
402Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q4FZD4Q4FZD4_MOUSE
Phosphatidylinositol 4-phosphate 3-...
Pik3c2g
401Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P6I9A0A1W2P6I9_MOUSE
Phosphatidylinositol 4-phosphate 3-...
Pik3c2g
903Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WQB5A0A087WQB5_MOUSE
Phosphatidylinositol 4-phosphate 3-...
Pik3c2g
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z6L6D3Z6L6_MOUSE
Phosphatidylinositol 4-phosphate 3-...
Pik3c2g
653Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000111868; ENSMUSP00000107499; ENSMUSG00000030228

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiE9QQ35
ModBaseiSearch...

Proteomic databases

PRIDEiE9QQ35
ProteomicsDBi345331

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23850, 116 antibodies

Genome annotation databases

EnsembliENSMUST00000111868; ENSMUSP00000107499; ENSMUSG00000030228

Organism-specific databases

MGIiMGI:1203730, Pik3c2g

Phylogenomic databases

GeneTreeiENSGT00940000159982
HOGENOMiCLU_002191_0_0_1
OMAiDLLAWTC
TreeFamiTF102031

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pik3c2g, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030228, Expressed in stomach and 74 other tissues
ExpressionAtlasiE9QQ35, baseline and differential

Family and domain databases

CDDicd05177, PI3Kc_C2_gamma, 1 hit
Gene3Di1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 2 hits
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR037707, PI3K-C2-gamma_dom
IPR001263, PI3K_accessory_dom
IPR042236, PI3K_accessory_sf
IPR002420, PI3K_C2_dom
IPR015433, PI_Kinase
IPR001683, PX_dom
IPR036871, PX_dom_sf
PANTHERiPTHR10048, PTHR10048, 1 hit
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF00792, PI3K_C2, 1 hit
PF00613, PI3Ka, 1 hit
PF00787, PX, 1 hit
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00142, PI3K_C2, 1 hit
SM00145, PI3Ka, 1 hit
SM00146, PI3Kc, 1 hit
SM00312, PX, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit
SSF64268, SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS51547, PI3K_C2, 1 hit
PS51545, PIK_HELICAL, 1 hit
PS50195, PX, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9QQ35_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9QQ35
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: June 2, 2021
Last modified: June 2, 2021
This is version 83 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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