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Protein
Submitted name:

Eukaryotic translation initiation factor 2-alpha kinase 3

Gene

Eif2ak3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-381042 PERK regulates gene expression

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic translation initiation factor 2-alpha kinase 3Imported
Gene namesi
Name:Eif2ak3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1341830 Eif2ak3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500324631829 – 1114Sequence analysisAdd BLAST1086

Proteomic databases

MaxQBiE9QQ30
PeptideAtlasiE9QQ30
PRIDEiE9QQ30

Expressioni

Gene expression databases

BgeeiENSMUSG00000031668
ExpressionAtlasiE9QQ30 baseline and differential
GenevisibleiE9QQ30 MM

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9QQ30
SMRiE9QQ30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini589 – 1075Protein kinaseInterPro annotationAdd BLAST487

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1033 Eukaryota
ENOG410XS0B LUCA
GeneTreeiENSGT00530000062984
OMAiKWKPLIH
OrthoDBiEOG091G01X1
TreeFamiTF101511

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR011047 Quinoprotein_ADH-like_supfam
IPR008271 Ser/Thr_kinase_AS
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF50998 SSF50998, 2 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

E9QQ30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERATRPGPR ALLLLLFLLL GCAAGISAVA PARSLLAPAS ETVFGLGAAA
60 70 80 90 100
APTSAARVPA VATAEVTVED AEALPAAAGE PESRATEPDD DVELRPRGRS
110 120 130 140 150
LVIISTLDGR IAALDAENDG KKQWDLDVGS GSLVSSSLSK PEVFGNKMII
160 170 180 190 200
PSLDGDLFQW DRDRESMEAV PFTVESLLES SYKFGDDVVL VGGKSLTTYG
210 220 230 240 250
LSAYSGKLRY ICSALGCRRW DSDEMEEEED ILLLQRTQKT VRAVGPRSGS
260 270 280 290 300
EKWNFSVGHF ELRYIPDMET RAGFIESTFK PGGNKEDSKI ISDVEEQEAT
310 320 330 340 350
MLDTVIKVSV ADWKVMAFSR KGGRLEWEYQ FCTPIASAWL VRDGKVIPIS
360 370 380 390 400
LFDDTSYTAS EEALGDEEDI VEAARGATEN SVYLGMYRGQ LYLQSSVRVS
410 420 430 440 450
EKFPTSPKAL ESVNGENAII PLPTIKWKPL IHSPSRTPVL VGSDEFDKCL
460 470 480 490 500
SNDKYSHEEY SNGALSILQY PYDNGYYLPY YKRERNKRST QITVRFLDSP
510 520 530 540 550
HYSKNIRKKD PILLLHWWKE IFGTILLCIV ATTFIVRRLF HPQPHRQRKE
560 570 580 590 600
SETQCQTESK YDSVSADVSD NSWNDMKYSG YVSRYLTDFE PIQCMGRGGF
610 620 630 640 650
GVVFEAKNKV DDCNYAIKRI RLPNRELARE KVMREVKALA KLEHPGIVRY
660 670 680 690 700
FNAWLETPPE KWQEEMDEIW LKDESTDWPL SSPSPMDAPS VKIRRMDPFS
710 720 730 740 750
TKEQIEVIAP SPERSRSFSV GISCGQTSSS ESQFSPLEFS GTDCGDNSDS
760 770 780 790 800
ADAAYNLQDS CLTDCEDVED GTVDGNDEGH SFELCPSEAS PYTRSREGTS
810 820 830 840 850
SSIVFEDSGC GNASSKEEPR GNRLHDGNHY VNKLTDLKCS SSRSSSEATT
860 870 880 890 900
LSTSPTRPTT LSLDFTKNTV GQLQPSSPKV YLYIQMQLCR KENLKDWMNR
910 920 930 940 950
RCSLEDREHG VCLHIFLQIA EAVEFLHSKG LMHRDLKPSN IFFTMDDVVK
960 970 980 990 1000
VGDFGLVTAM DQDEEEQTVL TPMPAYATHT GQVGTKLYMS PEQIHGNNYS
1010 1020 1030 1040 1050
HKVDIFSLGL ILFELLYPFS TQMERVRILT DVRNLKFPLL FTQKYPQEHM
1060 1070 1080 1090 1100
MVQDMLSPSP TERPEATDII ENAIFENLEF PGKTVLRQRS RSMSSSGTKH
1110
SRQPSCSYSP LPGN
Length:1,114
Mass (Da):124,670
Last modified:April 5, 2011 - v1
Checksum:i12B93CBCE4E152B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155842 Genomic DNA No translation available.
AC156398 Genomic DNA No translation available.
RefSeqiNP_034251.2, NM_010121.3
UniGeneiMm.247167

Genome annotation databases

EnsembliENSMUST00000034093; ENSMUSP00000034093; ENSMUSG00000031668
GeneIDi13666
UCSCiuc009cgb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiE9QQ30_MOUSE
AccessioniPrimary (citable) accession number: E9QQ30
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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