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Protein
Submitted name:

DNA mismatch repair protein Msh3

Gene

Msh3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

Names & Taxonomyi

Protein namesi
Submitted name:
DNA mismatch repair protein Msh3Imported
Gene namesi
Name:Msh3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:109519 Msh3

PTM / Processingi

Proteomic databases

MaxQBiE9QPY6
PeptideAtlasiE9QPY6
PRIDEiE9QPY6

Expressioni

Gene expression databases

BgeeiENSMUSG00000014850 Expressed in 242 organ(s), highest expression level in oocyte
ExpressionAtlasiE9QPY6 baseline and differential
GenevisibleiE9QPY6 MM

Structurei

3D structure databases

ProteinModelPortaliE9QPY6
SMRiE9QPY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini927 – 943DNA_MISMATCH_REPAIR_2InterPro annotationAdd BLAST17

Phylogenomic databases

eggNOGiKOG0217 Eukaryota
COG0249 LUCA
GeneTreeiENSGT00550000074949
TreeFamiTF300525

Family and domain databases

Gene3Di3.30.420.110, 1 hit
3.40.1170.10, 1 hit
InterProiView protein in InterPro
IPR007695 DNA_mismatch_repair_MutS-lik_N
IPR017261 DNA_mismatch_repair_MutS/MSH
IPR000432 DNA_mismatch_repair_MutS_C
IPR007696 DNA_mismatch_repair_MutS_core
IPR016151 DNA_mismatch_repair_MutS_N
IPR036187 DNA_mismatch_repair_MutS_sf
IPR007860 DNA_mmatch_repair_MutS_con_dom
IPR036678 MutS_con_dom_sf
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01624 MutS_I, 1 hit
PF05188 MutS_II, 1 hit
PF05192 MutS_III, 1 hit
PF00488 MutS_V, 1 hit
PIRSFiPIRSF037677 DNA_mis_repair_Msh6, 1 hit
SMARTiView protein in SMART
SM00534 MUTSac, 1 hit
SM00533 MUTSd, 1 hit
SUPFAMiSSF48334 SSF48334, 1 hit
SSF52540 SSF52540, 1 hit
SSF53150 SSF53150, 2 hits
SSF55271 SSF55271, 1 hit
PROSITEiView protein in PROSITE
PS00486 DNA_MISMATCH_REPAIR_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.iShow all

E9QPY6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRGKSASGG STAAGPGPGR QTVLSRFFRS AGSLRSSASS TEPAEKVTEG
60 70 80 90 100
DSRKRSLGNG GPTKKKARKV PEKEEENISV AAHHPEAKKC LRPRIVLKSL
110 120 130 140 150
EKLKEFCCDS ALPQNRVQTE ALRERLEVLP RCTDFEDITL QRAKNAVLSE
160 170 180 190 200
DSKSQANQKD SQFGPCPEVF QKTSDCKPFN KRSKSVYTPL ELQYLDMKQQ
210 220 230 240 250
HKDAVLCVEC GYKYRFFGED AEIAARELNI YCHLDHNFMT ASIPTHRLFV
260 270 280 290 300
HVRRLVAKGY KVGVVKQTET AALKAIGDNK SSVFSRKLTA LYTKSTLIGE
310 320 330 340 350
DVNPLIRLDD SVNIDEVMTD TSTNYLLCIY EEKENIKDKK KGNLSVGIVG
360 370 380 390 400
VQPATGEVVF DCFQDSASRL ELETRISSLQ PVELLLPSDL SVPTEMLIQR
410 420 430 440 450
ATNVSVRDDR IRVERMNNTY FEYSHAFQTV TEFYAREIVD SQGSQSLSGV
460 470 480 490 500
INLEKPVICA LAAVIRYLKE FNLEKMLSKP ESFKQLSSGM EFMRINGTTL
510 520 530 540 550
RNLEILQNQT DMKTKGSLLW VLDHTKTSFG RRKLKNWVTQ PLLKLREINA
560 570 580 590 600
RLDAVSDVLH SESSVFEQIE NLLRKLPDVE RGLCSIYHKK CSTQEFFLIV
610 620 630 640 650
KSLCQLKSEL QALMPAVNSH VQSDLLRALI VEAPELLSPV EHYLKVLNGP
660 670 680 690 700
AAKVGDKTEL FKDLSDFPLI KKRKNEIQEV IHSIQMRLQE FRKILKLPSL
710 720 730 740 750
QYVTVSGQEF MIEIKNSAVS CIPADWVKVG STKAVSRFHP PFIVESYRRL
760 770 780 790 800
NQLREQLVLD CNAEWLGFLE NFGEHYHTLC KAVDHLATVD CIFSLAKVAK
810 820 830 840 850
QGNYCRPTLQ EEKKIIIKNG RHPMIDVLLG EQDQFVPNST SLSDSERVMI
860 870 880 890 900
ITGPNMGGKS SYIKQVALVT IMAQIGSYVP AEEATIGIVD GIFTRMGAAD
910 920 930 940 950
NIYKGRSTFM EELTDTAEII RRASPQSLVI LDELGRGTST HDGIAIAYAT
960 970 980 990 1000
LEYFIRDVKS LTLFVTHYPP VCELEKCYPE QVGNYHMGFL VNEDESKQDS
1010 1020 1030 1040 1050
GDMEQMPDSV TFLYQITRGI AARSYGLNVA KLADVPREVL QKAAHKSKEL
1060 1070 1080 1090
EGLVSLRRKR LECFTDLWTT HSVKDLHTWA DKLEMEEIQT SLPH
Length:1,094
Mass (Da):123,277
Last modified:October 29, 2014 - v2
Checksum:i64F2F5864CF0AC6E
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P13705MSH3_MOUSE
DNA mismatch repair protein Msh3
Msh3 Rep-3
1,091Annotation score:
A0A087WQ16A0A087WQ16_MOUSE
DNA mismatch repair protein Msh3
Msh3
1,095Annotation score:
A0A087WSS2A0A087WSS2_MOUSE
DNA mismatch repair protein Msh3
Msh3
360Annotation score:
A0A087WQZ2A0A087WQZ2_MOUSE
DNA mismatch repair protein Msh3
Msh3
129Annotation score:
A0A087WP43A0A087WP43_MOUSE
DNA mismatch repair protein Msh3
Msh3
101Annotation score:
A0A087WRJ5A0A087WRJ5_MOUSE
DNA mismatch repair protein Msh3
Msh3
159Annotation score:
A0A087WP45A0A087WP45_MOUSE
DNA mismatch repair protein Msh3
Msh3
167Annotation score:
A0A087WSR8A0A087WSR8_MOUSE
DNA mismatch repair protein Msh3
Msh3
56Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155263 Genomic DNA No translation available.
AC161588 Genomic DNA No translation available.
RefSeqiNP_001298049.1, NM_001311120.1
UniGeneiMm.343101

Genome annotation databases

EnsembliENSMUST00000022220; ENSMUSP00000022220; ENSMUSG00000014850
GeneIDi17686

Similar proteinsi

Entry informationi

Entry nameiE9QPY6_MOUSE
AccessioniPrimary (citable) accession number: E9QPY6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: October 29, 2014
Last modified: September 12, 2018
This is version 66 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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