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Entry version 72 (17 Jun 2020)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Inner nuclear membrane protein Man1

Gene

Lemd3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Inner nuclear membrane protein Man1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lemd3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3580376 Lemd3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei480 – 501HelicalSequence analysisAdd BLAST22
Transmembranei642 – 659HelicalSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
E9QP59

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9QP59

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9QP59

PRoteomics IDEntifications database

More...
PRIDEi
E9QP59

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000048661 Expressed in cleaving embryo and 242 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9QP59 MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9QP59

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 51LEMInterPro annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 39DisorderedSequence analysisAdd BLAST20
Regioni46 – 97DisorderedSequence analysisAdd BLAST52
Regioni136 – 354DisorderedSequence analysisAdd BLAST219
Regioni371 – 397DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi53 – 85PolarSequence analysisAdd BLAST33
Compositional biasi214 – 231AcidicSequence analysisAdd BLAST18
Compositional biasi272 – 289PolyampholyteSequence analysisAdd BLAST18
Compositional biasi298 – 317PolarSequence analysisAdd BLAST20
Compositional biasi381 – 395PolarSequence analysisAdd BLAST15

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0147 Eukaryota
ENOG410XP20 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157643

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017040_0_0_1

KEGG Orthology (KO)

More...
KOi
K19410

Identification of Orthologs from Complete Genome Data

More...
OMAi
NAYSKPK

Database of Orthologous Groups

More...
OrthoDBi
873705at2759

TreeFam database of animal gene trees

More...
TreeFami
TF315385

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12286 RRM_Man1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1180, 1 hit
1.10.720.40, 1 hit
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011015 LEM/LEM-like_dom_sf
IPR003887 LEM_dom
IPR034997 Man1
IPR034394 Man1_RRM
IPR041885 MAN1_winged_helix_dom
IPR018996 MSC
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13428:SF10 PTHR13428:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03020 LEM, 1 hit
PF09402 MSC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00540 LEM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit
SSF63451 SSF63451, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50954 LEM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9QP59-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAATAAAAP QQLSDEELFS QLRRYGLSPG PVTESTRPVY LKKLKKLREE
60 70 80 90 100
EQQQQQQQQQ QQHRAGGRGN KTRNSNNNNT ATAMGGRPGS GDLAYLRSPA
110 120 130 140 150
GLGRLSASAA ESPVAGGSGG AAAVPAAGSK VLLGFSSDES DVEASPREQA
160 170 180 190 200
GGGGARRDRA ALQYRGLRAP PAPPAAGEVT GGHPGERRKP HSWWGARRPA
210 220 230 240 250
GPEPQPPAAG SDGAAEDADE ELADGEDRDP EAEEPLWASR TVNGSRLLPY
260 270 280 290 300
SSCREHYSDS EEEEEEGEED GDVAPARQVL KDDSLARHRP RRSHSKPFSA
310 320 330 340 350
LTAKSGGSRQ ETSVQGGGAL AMNDRAAAAG SLDRSRNLEE AAAEPGGGGG
360 370 380 390 400
GGCGCDPVDS IPRYRAGAKK LAPLLSPPSP DGDSTLESPT GPLLKTNNHI
410 420 430 440 450
GGGAFGVDSP GLYANSLPPG ATAAAAPGTL RINHANHTGS NHTYLKTAYG
460 470 480 490 500
KPKLCEPEEE LLQQFKREEV SPTGSFSAHY LSMFLLTAAC LFFLILGLTY
510 520 530 540 550
LGMRGTGVPE DGGLIKNPFD ETFGKIQESE KNLLMSTLYK LHDRLAQIAG
560 570 580 590 600
DHECGSSSQR MLSVQEAAAY LKNLGPEYED VFNTSLLWIF KNGKDVGIRC
610 620 630 640 650
VGYGPEEDLT NITDVQFLQS TRPQMPFWCR FRRAFITVTH RLLLLCLGVV
660 670 680 690 700
LVCVALRYMR YRWTKEEEET RQMYDMVVKI IDVLRSHNEA CQETKDLQPY
710 720 730 740 750
MPLPHVRDSL IQPQDRKKMK KVWDRAVDFL AANESRVRTE TRRVGGADFL
760 770 780 790 800
VWRWIQPSAS CDKTLVIPSK VWQGQAFHLD RRNSPPNSLT PCLKIRNMFD
810 820 830 840 850
PVMEIGDHWH LAIQEAILEK CSDNDGIVHI AVDRNSREGC VYVKCLSPEY
860 870 880 890 900
AGKAFKALHG SWFDGKLVTV KYLRLDRYHH RFPQALTCNT PLKPANKHMN
910
SLSHLRLRTG LANSQGSS
Length:918
Mass (Da):100,166
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC17647DAD36292E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9WU40MAN1_MOUSE
Inner nuclear membrane protein Man1
Lemd3 Man1
921Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YU56D3YU56_MOUSE
Inner nuclear membrane protein Man1
Lemd3
940Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC140381 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001074662.2, NM_001081193.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000119944; ENSMUSP00000113103; ENSMUSG00000048661

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
380664

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:380664

UCSC genome browser

More...
UCSCi
uc007hfi.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140381 Genomic DNA No translation available.
RefSeqiNP_001074662.2, NM_001081193.2

3D structure databases

SMRiE9QP59
ModBaseiSearch...

Proteomic databases

EPDiE9QP59
jPOSTiE9QP59
MaxQBiE9QP59
PRIDEiE9QP59

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
29213 143 antibodies

Genome annotation databases

EnsembliENSMUST00000119944; ENSMUSP00000113103; ENSMUSG00000048661
GeneIDi380664
KEGGimmu:380664
UCSCiuc007hfi.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23592
MGIiMGI:3580376 Lemd3

Phylogenomic databases

eggNOGiKOG0147 Eukaryota
ENOG410XP20 LUCA
GeneTreeiENSGT00940000157643
HOGENOMiCLU_017040_0_0_1
KOiK19410
OMAiNAYSKPK
OrthoDBi873705at2759
TreeFamiTF315385

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
380664 1 hit in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Lemd3 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000048661 Expressed in cleaving embryo and 242 other tissues
GenevisibleiE9QP59 MM

Family and domain databases

CDDicd12286 RRM_Man1, 1 hit
Gene3Di1.10.10.1180, 1 hit
1.10.720.40, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR011015 LEM/LEM-like_dom_sf
IPR003887 LEM_dom
IPR034997 Man1
IPR034394 Man1_RRM
IPR041885 MAN1_winged_helix_dom
IPR018996 MSC
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
PANTHERiPTHR13428:SF10 PTHR13428:SF10, 1 hit
PfamiView protein in Pfam
PF03020 LEM, 1 hit
PF09402 MSC, 1 hit
SMARTiView protein in SMART
SM00540 LEM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF63451 SSF63451, 1 hit
PROSITEiView protein in PROSITE
PS50954 LEM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9QP59_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9QP59
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 17, 2020
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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