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Protein

Fibroblast growth factor receptor

Gene

Fgfr3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei613Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190371 FGFR3b ligand binding and activation
R-MMU-190372 FGFR3c ligand binding and activation
R-MMU-5654227 Phospholipase C-mediated cascade, FGFR3
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654704 SHC-mediated cascade:FGFR3
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654710 PI-3K cascade:FGFR3
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654732 Negative regulation of FGFR3 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:Fgfr3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:95524 Fgfr3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei368 – 392HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501509038021 – 802Fibroblast growth factor receptorSequence analysisAdd BLAST782

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000054252 Expressed in 315 organ(s), highest expression level in telencephalon

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 108Ig-likeInterPro annotationAdd BLAST70
Domaini145 – 238Ig-likeInterPro annotationAdd BLAST94
Domaini247 – 336Ig-likeInterPro annotationAdd BLAST90
Domaini468 – 757Protein kinaseInterPro annotationAdd BLAST290

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
OMAiQYSPTCQ
OrthoDBiEOG091G0CQZ
TreeFamiTF316307

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR016248 FGF_rcpt_fam
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000628 FGFR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.iShow all

E9QNJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVPACVLVF CVAVVAGATS EPPGPEQRVV RRAAEVPGPE PSQQEQVAFG
60 70 80 90 100
SGDTVELSCH PPGGAPTGPT VWAKDGTGLV ASHRILVGPQ RLQVLNASHE
110 120 130 140 150
DAGVYSCQHR LTRRVLCHFS VRVTDAPSSG DDEDGEDVAE DTGAPYWTRP
160 170 180 190 200
ERMDKKLLAV PAANTVRFRC PAAGNPTPSI SWLKNGKEFR GEHRIGGIKL
210 220 230 240 250
RHQQWSLVME SVVPSDRGNY TCVVENKFGS IRQTYTLDVL ERSPHRPILQ
260 270 280 290 300
AGLPANQTAI LGSDVEFHCK VYSDAQPHIQ WLKHVEVNGS KVGPDGTPYV
310 320 330 340 350
TVLKSWISEN VEADARLRLA NVSERDGGEY LCRATNFIGV AEKAFWLRVH
360 370 380 390 400
GPQAAEEELM ETDEAGSVYA GVLSYGVVFF LFILVVAAVI LCRLRSPPKK
410 420 430 440 450
GLGSPTVHKV SRFPLKRQVS LESNSSMNSN TPLVRIARLS SGEGPVLANV
460 470 480 490 500
SELELPADPK WELSRTRLTL GKPLGEGCFG QVVMAEAIGI DKDRTAKPVT
510 520 530 540 550
VAVKMLKDDA TDKDLSDLVS EMEMMKMIGK HKNIINLLGA CTQGGPLYVL
560 570 580 590 600
VEYAAKGNLR EFLRARRPPG MDYSFDACRL PEEQLTCKDL VSCAYQVARG
610 620 630 640 650
MEYLASQKCI HRDLAARNVL VTEDNVMKIA DFGLARDVHN LDYYKKTTNG
660 670 680 690 700
RLPVKWMAPE ALFDRVYTHQ SDVWSFGVLL WEIFTLGGSP YPGIPVEELF
710 720 730 740 750
KLLKEGHRMD KPASCTHDLY MIMRECWHAV PSQRPTFKQL VEDLDRILTV
760 770 780 790 800
TSTDEYLDLS VPFEQYSPGG QDTPSSSSSG DDSVFTHDLL PPGPPSNGGP

RT
Length:802
Mass (Da):88,165
Last modified:April 5, 2011 - v1
Checksum:i6DADCB5A2F20731F
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q61851FGFR3_MOUSE
Fibroblast growth factor receptor 3
Fgfr3 Mfr3, Sam3
801Annotation score:
F6TK14F6TK14_MOUSE
Fibroblast growth factor receptor
Fgfr3
801Annotation score:
Q61563Q61563_MOUSE
Fibroblast growth factor receptor
Fgfr3 FR3, mCG_16331
782Annotation score:
Q7TSI8Q7TSI8_MOUSE
Fibroblast growth factor receptor
Fgfr3 mCG_16331
800Annotation score:
A0A0J9YUB8A0A0J9YUB8_MOUSE
Fibroblast growth factor receptor 3
Fgfr3
222Annotation score:
A0A0J9YUX1A0A0J9YUX1_MOUSE
Fibroblast growth factor receptor 3
Fgfr3
194Annotation score:
A0A0J9YTQ5A0A0J9YTQ5_MOUSE
Fibroblast growth factor receptor 3
Fgfr3
257Annotation score:
D3Z7U5D3Z7U5_MOUSE
Fibroblast growth factor receptor 3
Fgfr3
47Annotation score:
A0A0J9YU20A0A0J9YU20_MOUSE
Fibroblast growth factor receptor 3
Fgfr3
200Annotation score:
A0A0J9YU04A0A0J9YU04_MOUSE
Fibroblast growth factor receptor 3
Fgfr3
216Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC162898 Genomic DNA No translation available.
RefSeqiNP_001156689.1, NM_001163217.2
XP_006503791.1, XM_006503728.1
UniGeneiMm.6904

Genome annotation databases

EnsembliENSMUST00000114411; ENSMUSP00000110053; ENSMUSG00000054252
ENSMUST00000171509; ENSMUSP00000131845; ENSMUSG00000054252
GeneIDi14184
UCSCiuc012dut.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC162898 Genomic DNA No translation available.
RefSeqiNP_001156689.1, NM_001163217.2
XP_006503791.1, XM_006503728.1
UniGeneiMm.6904

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114411; ENSMUSP00000110053; ENSMUSG00000054252
ENSMUST00000171509; ENSMUSP00000131845; ENSMUSG00000054252
GeneIDi14184
UCSCiuc012dut.2 mouse

Organism-specific databases

CTDi2261
MGIiMGI:95524 Fgfr3

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
OMAiQYSPTCQ
OrthoDBiEOG091G0CQZ
TreeFamiTF316307

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190371 FGFR3b ligand binding and activation
R-MMU-190372 FGFR3c ligand binding and activation
R-MMU-5654227 Phospholipase C-mediated cascade, FGFR3
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654704 SHC-mediated cascade:FGFR3
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654710 PI-3K cascade:FGFR3
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654732 Negative regulation of FGFR3 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Miscellaneous databases

ChiTaRSiFgfr3 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054252 Expressed in 315 organ(s), highest expression level in telencephalon

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR016248 FGF_rcpt_fam
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000628 FGFR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9QNJ9_MOUSE
AccessioniPrimary (citable) accession number: E9QNJ9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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