UniProtKB - E9QN59 (E9QN59_MOUSE)
Protein
Mitogen-activated protein kinase
Gene
Mapk10
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
Cofactori
Mg2+ARBA annotation
GO - Molecular functioni
- ATP binding Source: InterPro
- MAP kinase activity Source: UniProtKB-EC
GO - Biological processi
- rhythmic process Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseARBA annotation, Transferase |
Biological process | Biological rhythmsARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Mapk10Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1346863, Mapk10 |
PTM / Processingi
Proteomic databases
MaxQBi | E9QN59 |
PeptideAtlasi | E9QN59 |
PRIDEi | E9QN59 |
PTM databases
SwissPalmi | E9QN59 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000046709, Expressed in brain and 242 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 94 – 389 | Protein kinaseInterPro annotationAdd BLAST | 296 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 435 – 494 | DisorderedSequence analysisAdd BLAST | 60 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 436 – 484 | PolarSequence analysisAdd BLAST | 49 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000153692 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR008351, MAPK_JNK IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PRINTSi | PR01772, JNKMAPKINASE |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
E9QN59-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDTGVSGAP MKEMAQVMRI AEVTEDGRVF MSLHFLYYCS EPTLDVKIAF
60 70 80 90 100
CQGFDKHVDV SSIAKHYNMS KSKVDNQFYS VEVGDSTFTV LKRYQNLKPI
110 120 130 140 150
GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH
160 170 180 190 200
KNIISLLNVF TPQKTLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL
210 220 230 240 250
YQMLCGIKHL HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM
260 270 280 290 300
TPYVVTRYYR APEVILGMGY KENVDIWSVG CIMGEMVRHK ILFPGRDYID
310 320 330 340 350
QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN RPKYAGLTFP KLFPDSLFPA
360 370 380 390 400
DSEHNKLKAS QARDLLSKML VIDPAKRISV DDALQHPYIN VWYDPAEVEA
410 420 430 440 450
PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV KGQPSPSGAA
460 470 480 490
VNSSESLPPS SSVNDISSMS TDQTLASDTD SSLEASAGPL GCCR
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ61831 | MK10_MOUSE | Mitogen-activated protein kinase 10 | Mapk10 Jnk3, Prkm10, Serk2 | 464 | Annotation score: | ||
Q8C9D4 | Q8C9D4_MOUSE | Mitogen-activated protein kinase | Mapk10 JNK3A2 | 464 | Annotation score: | ||
Q80W80 | Q80W80_MOUSE | Mitogen-activated protein kinase | Mapk10 JNK3B2 | 464 | Annotation score: | ||
A0A5F8MP75 | A0A5F8MP75_MOUSE | Mitogen-activated protein kinase | Mapk10 | 478 | Annotation score: | ||
Q3TQZ7 | Q3TQZ7_MOUSE | Mitogen-activated protein kinase | Mapk10 | 418 | Annotation score: | ||
A0A0G2JG69 | A0A0G2JG69_MOUSE | Mitogen-activated protein kinase | Mapk10 | 178 | Annotation score: | ||
A0A0G2JGL2 | A0A0G2JGL2_MOUSE | Mitogen-activated protein kinase | Mapk10 | 252 | Annotation score: | ||
A0A0G2JEJ8 | A0A0G2JEJ8_MOUSE | Mitogen-activated protein kinase 10 | Mapk10 | 173 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC123664 Genomic DNA No translation available. AC125252 Genomic DNA No translation available. AC137121 Genomic DNA No translation available. AC160244 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000112848; ENSMUSP00000108469; ENSMUSG00000046709 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC123664 Genomic DNA No translation available. AC125252 Genomic DNA No translation available. AC137121 Genomic DNA No translation available. AC160244 Genomic DNA No translation available. |
3D structure databases
SMRi | E9QN59 |
ModBasei | Search... |
PTM databases
SwissPalmi | E9QN59 |
Proteomic databases
MaxQBi | E9QN59 |
PeptideAtlasi | E9QN59 |
PRIDEi | E9QN59 |
Protocols and materials databases
Antibodypediai | 14345, 515 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000112848; ENSMUSP00000108469; ENSMUSG00000046709 |
Organism-specific databases
MGIi | MGI:1346863, Mapk10 |
Phylogenomic databases
GeneTreei | ENSGT00940000153692 |
Miscellaneous databases
ChiTaRSi | Mapk10, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000046709, Expressed in brain and 242 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR008351, MAPK_JNK IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PRINTSi | PR01772, JNKMAPKINASE |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9QN59_MOUSE | |
Accessioni | E9QN59Primary (citable) accession number: E9QN59 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | February 10, 2021 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |