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Protein
Submitted name:

Dedicator of cytokinesis protein 9

Gene

Dock9

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Submitted name:
Dedicator of cytokinesis protein 9Imported
Gene namesi
Name:Dock9Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:106321 Dock9

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiE9QMR2
PRIDEiE9QMR2

PTM databases

iPTMnetiE9QMR2

Expressioni

Gene expression databases

BgeeiENSMUSG00000025558 Expressed in 286 organ(s), highest expression level in lung
ExpressionAtlasiE9QMR2 baseline and differential
GenevisibleiE9QMR2 MM

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9QMR2
SMRiE9QMR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 280PHInterPro annotationAdd BLAST108
Domaini637 – 815DHR-1InterPro annotationAdd BLAST179
Domaini1593 – 2020DHR-2InterPro annotationAdd BLAST428

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1903 – 1923Sequence analysisAdd BLAST21
Coiled coili1997 – 2017Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1997 Eukaryota
ENOG410XNVY LUCA
GeneTreeiENSGT00760000119234

Family and domain databases

CDDicd08697 C2_Dock-D, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037809 C2_Dock-D
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR026796 DOCK9
IPR010703 DOCK_C
IPR021816 DOCK_C/D_N
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR23317 PTHR23317, 1 hit
PTHR23317:SF77 PTHR23317:SF77, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF11878 DUF3398, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF48371 SSF48371, 4 hits
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E9QMR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQQQLPVST ETRKFTRALS KPGTAAELRQ SVSEVVRGSV LLAKPKLIEP
60 70 80 90 100
LDYENVIVQK KTQILNDCLR EMLLFPYDDF QTAILRRQGR YLRSTVPANA
110 120 130 140 150
EEEAQSLFVT ECIKTYNSDW HLVTYKYEDY SGEFRQLPNK VPKLDKLPVH
160 170 180 190 200
VYEVDEEADK DEDAASLGSQ KGGITKHGWL YKGNMNSAIS VTMRSFKRRF
210 220 230 240 250
FHLIQLGDGS YNLNFYKDEK ISKEPKGSIF LDSCMGVIQN NRVRRFAFEL
260 270 280 290 300
KMQDKSSYLL AADSEAEMEE WVTVLNKILQ LNFEAAMQEK RNGDPHEDDE
310 320 330 340 350
QSKLEGSGSG LDSYLPELAK STREAEIKLK SESRVKLFYL DPDTQKLDFS
360 370 380 390 400
SAEPEVKPFE EKFGKRILVK CNDLSFNLQC CVAENEEGPT TNVEPFFVTL
410 420 430 440 450
SLFDIKYNRK ISADFHVDLN HFSVRQMLTP TSPALMNGGQ SPPAFQDALH
460 470 480 490 500
TAMQYPKQGI FSVTCPHPDI FLVARIEKVL QGSITHCAEP YMRSSDSSKV
510 520 530 540 550
AQKVLKNAKQ ACQRLGQYRM PFAWAARTLF KDTSGNLDKN ARFSAIYRQD
560 570 580 590 600
SNKLSNDDML KLLADFRKPE KMAKLPVILG NLDITIDSVS CDFPNYLNSS
610 620 630 640 650
YIPMRQFETC SKSPITFEVE EFVPCIPKHT QPYTVYSNHL YVYPKYLKYD
660 670 680 690 700
SQKSFAKARN IAICIEFKDS DEEDSQPLKC IYGRPGGPVF TRSALAAVLH
710 720 730 740 750
HQQNPEFYDE IKIELPAQLH ERHHLLFTFF HVSCDNSTKG STKKKDAVET
760 770 780 790 800
QVGFSWLPLL KDGRVLTSEQ HIPVSANLPS GYLGYQELGM GRHYGPEVKW
810 820 830 840 850
VEGGKPLLKI STHLVSTVYT QDQHLHNFFQ YCQKTESGAQ ASGSELVKYL
860 870 880 890 900
KSLHAMEGHV MIAFLPTILN QLFRVLTRAT QEEVAVNVTR VIIHVVAQCH
910 920 930 940 950
EEGLESHLRS YVKFAYKAEP YVASEYKTVH EELTKSMTTI LKPSADFLTS
960 970 980 990 1000
NKLLKYSWFF FDVLIKSMAQ HLIENNKVKL LRNQRFPASY HHAVETVVNM
1010 1020 1030 1040 1050
LMPHITQKFR DNPEASKNAN HSLAVFIKRC FTFMDRGFVF KQINNYISCF
1060 1070 1080 1090 1100
APGDPKTLFE YKFEFLRVVC NHEHYIPLNL PMPFGKGRIQ RYQDLQLDYS
1110 1120 1130 1140 1150
LTDEFCRNHF LVGLLLREVG TALQEFREVR VIAISMLKNL LIKHSFDDRY
1160 1170 1180 1190 1200
NSRSHQARIA TLYLPLFGLL IENVQRINVR DVSPFPVNPG SIVKDEALAV
1210 1220 1230 1240 1250
PAGNPLMTPQ KGNTLDHSLH KDLLGAISGI ASPYTASTPN INSVRNADSR
1260 1270 1280 1290 1300
GSLISTDSGN SLPDRNPEKS NSLDKQQSGM LGNSVVRCDK LDQSEIKSLL
1310 1320 1330 1340 1350
MCFLYVLKSM SDDALFTYWN KASTAELMDF FTISEVCLHQ FQYMGKRYIA
1360 1370 1380 1390 1400
SVRKISSVLG ISVDNGYGHS EADVVHQSLL EANIATEVCL TALDTLSLFT
1410 1420 1430 1440 1450
LAFKNQLLAD HGHNPLMKKV FDVYLCFLQK HQSEMALKNV FTALRSLIYK
1460 1470 1480 1490 1500
FPSAFYEGRA DMCASLCYEV LKCCNSKLSS IRTEASQLLY FLMRNNFDYT
1510 1520 1530 1540 1550
GKKSFVRTHL QVIISVSQLI ADVVGIGGTR FQQSLSIINN CANSDRIIKH
1560 1570 1580 1590 1600
TSFSSDVKDL TKRIRTVLMA TAQMKEHEND PEMLVDLQYS LAKSYASTPE
1610 1620 1630 1640 1650
LRKTWLDSMA RIHVKNGDLS EAAMCYVHVT ALVAEYLTRK GMFRQGCTAF
1660 1670 1680 1690 1700
RVITPNIDEE ASMMEDVGMQ DVHFNEDVLM ELLEQCADGL WKAERYELIA
1710 1720 1730 1740 1750
DIYKLIIPIY EKRRDFERLA HLYDTLHRAY SKVTEVMHSG RRLLGTYFRV
1760 1770 1780 1790 1800
AFFGQGFFED EDGKEYIYKE PKLTPLSEIS QRLLKLYSDK FGSENVKMIQ
1810 1820 1830 1840 1850
DSGKVNPKDL DSKFAYIQVT HVTPFFDEKE LQERRTEFER CHNIRRFMFE
1860 1870 1880 1890 1900
MPFTQTGKRQ GGVEEQCKRR TILTAIHCFP YVKKRIPVMY QHHTDLNPIE
1910 1920 1930 1940 1950
VAIDEMSKKV AELRQLCSSA EVDMIKLQLK LQGSVSVQVN AGPLAYARAF
1960 1970 1980 1990 2000
LDDTNTKRYP DNKVKLLKEV FRQFVEACGQ ALAVNERLIK EDQLEYQEEM
2010 2020 2030 2040 2050
KANYREMAKE LSDIMREQIC PLEEKTSVLP NSLHIFNAIS GTPTSTVVQG

LTSSSSVV
Length:2,058
Mass (Da):234,917
Last modified:April 5, 2011 - v1
Checksum:i41AA35D85D3CA372
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BIK4DOCK9_MOUSE
Dedicator of cytokinesis protein 9
Dock9 D14Wsu89e, Kiaa1058, Ziz1
2,055Annotation score:
F8VPN7F8VPN7_MOUSE
Dedicator of cytokinesis protein 9
Dock9
2,113Annotation score:
A0A1D5RLE0A0A1D5RLE0_MOUSE
Dedicator of cytokinesis protein 9
Dock9
2,042Annotation score:
A0A1D5RMM1A0A1D5RMM1_MOUSE
Dedicator of cytokinesis protein 9
Dock9
2,088Annotation score:
A0A1D5RLB8A0A1D5RLB8_MOUSE
Dedicator of cytokinesis protein 9
Dock9
166Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126253 Genomic DNA No translation available.
AC165155 Genomic DNA No translation available.
AC165272 Genomic DNA No translation available.
RefSeqiNP_598835.2, NM_134074.2
UniGeneiMm.378591
Mm.441054

Genome annotation databases

EnsembliENSMUST00000100299; ENSMUSP00000097872; ENSMUSG00000025558
GeneIDi105445
UCSCiuc011zqi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126253 Genomic DNA No translation available.
AC165155 Genomic DNA No translation available.
AC165272 Genomic DNA No translation available.
RefSeqiNP_598835.2, NM_134074.2
UniGeneiMm.378591
Mm.441054

3D structure databases

ProteinModelPortaliE9QMR2
SMRiE9QMR2
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiE9QMR2

Proteomic databases

MaxQBiE9QMR2
PRIDEiE9QMR2

Protocols and materials databases

DNASUi105445
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100299; ENSMUSP00000097872; ENSMUSG00000025558
GeneIDi105445
UCSCiuc011zqi.1 mouse

Organism-specific databases

CTDi23348
MGIiMGI:106321 Dock9

Phylogenomic databases

eggNOGiKOG1997 Eukaryota
ENOG410XNVY LUCA
GeneTreeiENSGT00760000119234

Enzyme and pathway databases

ReactomeiR-MMU-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRSiDock9 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025558 Expressed in 286 organ(s), highest expression level in lung
ExpressionAtlasiE9QMR2 baseline and differential
GenevisibleiE9QMR2 MM

Family and domain databases

CDDicd08697 C2_Dock-D, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037809 C2_Dock-D
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR026796 DOCK9
IPR010703 DOCK_C
IPR021816 DOCK_C/D_N
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR23317 PTHR23317, 1 hit
PTHR23317:SF77 PTHR23317:SF77, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF11878 DUF3398, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF48371 SSF48371, 4 hits
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9QMR2_MOUSE
AccessioniPrimary (citable) accession number: E9QMR2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 10, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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