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Protein
Submitted name:

E3 ubiquitin-protein ligase TRIM33

Gene

Trim33

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity

Names & Taxonomyi

Protein namesi
Submitted name:
E3 ubiquitin-protein ligase TRIM33Imported
Gene namesi
Name:Trim33Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2137357 Trim33

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiE9QME5
PeptideAtlasiE9QME5
PRIDEiE9QME5

Expressioni

Gene expression databases

BgeeiENSMUSG00000033014 Expressed in 285 organ(s), highest expression level in primary oocyte
ExpressionAtlasiE9QME5 baseline and differential
GenevisibleiE9QME5 MM

Structurei

3D structure databases

ProteinModelPortaliE9QME5
SMRiE9QME5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 199RING-typeInterPro annotationAdd BLAST61
Domaini226 – 273B box-typeInterPro annotationAdd BLAST48
Domaini285 – 326B box-typeInterPro annotationAdd BLAST42
Domaini900 – 947PHD-typeInterPro annotationAdd BLAST48
Domaini987 – 1059BromoInterPro annotationAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili323 – 343Sequence analysisAdd BLAST21
Coiled coili355 – 375Sequence analysisAdd BLAST21
Coiled coili384 – 404Sequence analysisAdd BLAST21

Keywords - Domaini

BromodomainPROSITE-ProRule annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410ITFN Eukaryota
ENOG410Z421 LUCA
GeneTreeiENSGT00920000148978
OMAiCQLHTQE

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR003649 Bbox_C
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF00628 PHD, 1 hit
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 2 hits
SM00297 BROMO, 1 hit
SM00249 PHD, 2 hits
SM00184 RING, 2 hits
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit
PS50119 ZF_BBOX, 2 hits
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E9QME5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAENKGGGEA ESGGGGSGSA PVTAGAAGPT AQEAEPPLAA VLVEEEEEEG
60 70 80 90 100
GRAGAEGGAA GPDDGGVAAA SSSSAPAASV PAASVGSAVP GGAASTPAPA
110 120 130 140 150
AAPAPAPAPA PAPAPAPAPA PGSSSGPPLG PPASLLDTCA VCQQSLQSRR
160 170 180 190 200
EAEPKLLPCL HSFCLRCLPE PERQLSVPIP GGSNGDVQQV GVIRCPVCRQ
210 220 230 240 250
ECRQIDLVDN YFVKDTSEAP SSSDEKSEQV CTSCEDNASA VGFCVECGEW
260 270 280 290 300
LCKTCIEAHQ RVKFTKDHLI RKKEDVSESV GTSGQRPVFC PVHKQEQLKL
310 320 330 340 350
FCETCDRLTC RDCQLLEHKE HRYQFLEEAF QNQKGAIENL LAKLLEKKNY
360 370 380 390 400
VHFAATQVQN RIKEVNETNK RVEQEIKVAI FTLINEINKK GKSLLQQLEN
410 420 430 440 450
VTKERQMKLL QQQNDITGLS RQVKHVMNFT NWAIASGSST ALLYSKRLIT
460 470 480 490 500
FQLRHILKAR CDPVPAANGA IRFHCDPTFW AKNVVNLGNL VIESKPAPGY
510 520 530 540 550
TPNVVVGQVP PGTNHISKTP GQINLAQLRL QHMQQQVYAQ KHQQLQQMRL
560 570 580 590 600
QQPPAPIPTT TATTQQHPRQ AAPQMLQQQP PRLISVQTMQ RGNMNCGAFQ
610 620 630 640 650
AHQMRLAQNA ARIPGIPRHS APQYSMMQPH LQRQHSNPGH AGPFPVVSAH
660 670 680 690 700
NPINPTSPTT ATMANANRGP TSPSVTAIEL IPSVTNPENL PSLPDIPPIQ
710 720 730 740 750
LEDAGSSSLD NLLSRYISGS HLPPQPTSTM NPSPGPSALS PGSSGLSNSH
760 770 780 790 800
TPVRPPSTSS TGSRGSCGSS GRTAEKSAHS FKSDQVKVKQ EPGTEEEICS
810 820 830 840 850
FSGAVKQEKT EDGRRSACML SSPESSLTPP LSTNLHLESE LDTLTGLENH
860 870 880 890 900
VKTEPTDISE SCKQSGLSNL VNGKSPIRNL MHRSARIGGD GNSKDDDPNE
910 920 930 940 950
DWCAVCQNGG DLLCCEKCPK VFHLTCHVPT LLSFPSGDWI CTFCRDIGKP
960 970 980 990 1000
EVEYDCDNMQ HSKKGKTAQG LSPVDQRKCE RLLLYLYCHE LSIEFQEPVP
1010 1020 1030 1040 1050
VSIPNYYKII KKPMDLSTVK KKLQKKHSQH YQIPDDFVAD VRLIFKNCER
1060 1070 1080 1090 1100
FNEGDSEVAK AGKAVALYFE DKLSEIYSDR TFTPLPEFEQ DEDDGEVTED
1110 1120
SDEDFIQPRR KRLKSDERPV HIK
Length:1,123
Mass (Da):121,682
Last modified:April 5, 2011 - v1
Checksum:iF9575781343763F0
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q99PP7TRI33_MOUSE
E3 ubiquitin-protein ligase TRIM33
Trim33 Kiaa1113
1,142Annotation score:
E9QP19E9QP19_MOUSE
E3 ubiquitin-protein ligase TRIM33
Trim33
1,140Annotation score:
A0A0G2JGY5A0A0G2JGY5_MOUSE
E3 ubiquitin-protein ligase TRIM33
Trim33
193Annotation score:
A0A0G2JFC3A0A0G2JFC3_MOUSE
E3 ubiquitin-protein ligase TRIM33
Trim33
291Annotation score:
A0A0G2JE09A0A0G2JE09_MOUSE
E3 ubiquitin-protein ligase TRIM33
Trim33
402Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164089 Genomic DNA No translation available.
RefSeqiNP_001073299.1, NM_001079830.2
UniGeneiMm.195036

Genome annotation databases

EnsembliENSMUST00000106860; ENSMUSP00000102473; ENSMUSG00000033014
GeneIDi94093
UCSCiuc008qsw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164089 Genomic DNA No translation available.
RefSeqiNP_001073299.1, NM_001079830.2
UniGeneiMm.195036

3D structure databases

ProteinModelPortaliE9QME5
SMRiE9QME5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9QME5
PeptideAtlasiE9QME5
PRIDEiE9QME5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106860; ENSMUSP00000102473; ENSMUSG00000033014
GeneIDi94093
UCSCiuc008qsw.2 mouse

Organism-specific databases

CTDi51592
MGIiMGI:2137357 Trim33

Phylogenomic databases

eggNOGiENOG410ITFN Eukaryota
ENOG410Z421 LUCA
GeneTreeiENSGT00920000148978
OMAiCQLHTQE

Enzyme and pathway databases

ReactomeiR-MMU-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033014 Expressed in 285 organ(s), highest expression level in primary oocyte
ExpressionAtlasiE9QME5 baseline and differential
GenevisibleiE9QME5 MM

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR003649 Bbox_C
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF00628 PHD, 1 hit
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 2 hits
SM00297 BROMO, 1 hit
SM00249 PHD, 2 hits
SM00184 RING, 2 hits
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit
PS50119 ZF_BBOX, 2 hits
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9QME5_MOUSE
AccessioniPrimary (citable) accession number: E9QME5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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