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Protein
Submitted name:

DNA repair protein-complementing XP-G cells homolog

Gene

Ercc5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-5696395 Formation of Incision Complex in GG-NER
R-MMU-5696400 Dual Incision in GG-NER
R-MMU-6782135 Dual incision in TC-NER

Names & Taxonomyi

Protein namesi
Submitted name:
DNA repair protein-complementing XP-G cells homologImported
Gene namesi
Name:Ercc5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:103582 Ercc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

MaxQBiE9QM61
PRIDEiE9QM61

Expressioni

Gene expression databases

BgeeiENSMUSG00000026048 Expressed in 273 organ(s), highest expression level in embryonic stem cell
GenevisibleiE9QM61 MM

Structurei

3D structure databases

ProteinModelPortaliE9QM61
SMRiE9QM61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 98XPGNInterPro annotationAdd BLAST98
Domaini776 – 845XPGIInterPro annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili732 – 755Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2520 Eukaryota
COG0258 LUCA
GeneTreeiENSGT00640000091542
KOiK10846
OMAiAIDSSIW
OrthoDBiEOG091G0OMB
TreeFamiTF101235

Family and domain databases

InterProiView protein in InterPro
IPR036279 5-3_exonuclease_C_sf
IPR008918 HhH2
IPR029060 PIN-like_dom_sf
IPR006086 XPG-I_dom
IPR006084 XPG/Rad2
IPR001044 XPG/Rad2_eukaryotes
IPR019974 XPG_CS
IPR006085 XPG_DNA_repair_N
PfamiView protein in Pfam
PF00867 XPG_I, 1 hit
PF00752 XPG_N, 1 hit
PRINTSiPR00853 XPGRADSUPER
PR00066 XRODRMPGMNTG
SMARTiView protein in SMART
SM00279 HhH2, 1 hit
SM00484 XPGI, 1 hit
SM00485 XPGN, 1 hit
SUPFAMiSSF47807 SSF47807, 1 hit
SSF88723 SSF88723, 1 hit
TIGRFAMsiTIGR00600 rad2, 1 hit
PROSITEiView protein in PROSITE
PS00841 XPG_1, 1 hit
PS00842 XPG_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9QM61-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVQGLWKLL ECSGHRVSPE ALEGKVLAVD ISIWLNQALK GVRDSHGNVI
60 70 80 90 100
ENAHLLTLFH RLCKLLFFRI RPIFVFDGDA PLLKKQTLAK RRQRKDSASI
110 120 130 140 150
DSRKTTEKLL KTFLKRQALK TAFRSSRHEA PPSLTQVQRQ DDIYVLPPLP
160 170 180 190 200
EEEKHSSEEE DEKQWQARMD QKQALQEEFF HNPQAIDIES EDFSSLPPEV
210 220 230 240 250
KHEILTDMKE FTKRRRTLFE AMPEESNDFS QYQLKGLLKK NYLNQHIENV
260 270 280 290 300
QKEMNQQHSG QIQRQYQDEG GFLKEVESRR VVSEDTSHYI LIKGIQGKKV
310 320 330 340 350
MDVDSESLPS SSNVHSVSSN LKSSPHEKVK PEREPEAAPP SPRTLLAIQA
360 370 380 390 400
AMLGSSSEDE PESREGRQSK ERNSGATADA GSISPRTCAA IQKALDDDND
410 420 430 440 450
EKVSGSSDDL AEKMLLGSGL EQEEHADETA ERGGGVPFDT APLTPSVTEV
460 470 480 490 500
KECVTSGSSA NGQTDSAHSF TTASHRCDTP KETVSLARAV KEASQISSEC
510 520 530 540 550
EVEGRPAALS PAFIGTPSSH VSGVLSEREP TLAPPTTRTH SDQGIDIHPE
560 570 580 590 600
DPELQNGLYP LETKCNSSRL SSDDETEGGQ NPAPKACSTV HVPAEAMSNL
610 620 630 640 650
ENALPSNAEE RGDFQETIQL REVPEAAARE LISAPKPMGP MEMESEESES
660 670 680 690 700
DGSFIEVQSV VSNSELQTES SEASTHLSEK DAEEPRETLE EGTSRDTECL
710 720 730 740 750
LQDSSDIEAM EGHREADIDA EDMPNEWQDI NLEELDALES NLLAEQNSLK
760 770 780 790 800
AQKQQQDRIA ASVTGQMFLE SQELLRLFGV PYIQAPMEAE AQCAMLDLTD
810 820 830 840 850
QTSGTITDDS DIWLFGARHV YKNFFNKNKF VEYYQYVDFY SQLGLDRNKL
860 870 880 890 900
INLAYLLGSD YTEGIPTVGC VTAMEILNEF PGRGLDPLLK FSEWWHEAQN
910 920 930 940 950
NKKVAENPYD TKVKKKLRKL QLTPGFPNPA VADAYLRPVV DDSRGSFLWG
960 970 980 990 1000
KPDVDKIREF CQRYFGWNRM KTDESLYPVL KHLNAHQTQL RIDSFFRLAQ
1010 1020 1030 1040 1050
QEKQDAKLIK SHRLNRAVTC ILRKEREEKA PELTKVTEAL DDAKGKTQKR
1060 1070 1080 1090 1100
ELPYKKETSV PKRRRPSGNG GFLGDPYCSE SPQESSCEDG EGSSVMSARQ
1110 1120 1130 1140 1150
RSAAESSKIS CSDVPDLVRD PPHGRQGCVS TSSSSEDDED KAKTVLVTAR
1160 1170
PVFGKKKLKL KSMKRRKKKT
Length:1,170
Mass (Da):130,812
Last modified:April 5, 2011 - v1
Checksum:iAEB8F387BE7690FF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P35689ERCC5_MOUSE
DNA repair protein complementing XP...
Ercc5 Ercc-5, Xpg
1,170Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123800 Genomic DNA No translation available.
RefSeqiNP_035859.2, NM_011729.2
UniGeneiMm.2213

Genome annotation databases

EnsembliENSMUST00000027214; ENSMUSP00000027214; ENSMUSG00000026048
GeneIDi22592
KEGGimmu:22592
UCSCiuc007awi.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123800 Genomic DNA No translation available.
RefSeqiNP_035859.2, NM_011729.2
UniGeneiMm.2213

3D structure databases

ProteinModelPortaliE9QM61
SMRiE9QM61
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9QM61
PRIDEiE9QM61

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027214; ENSMUSP00000027214; ENSMUSG00000026048
GeneIDi22592
KEGGimmu:22592
UCSCiuc007awi.2 mouse

Organism-specific databases

CTDi2073
MGIiMGI:103582 Ercc5

Phylogenomic databases

eggNOGiKOG2520 Eukaryota
COG0258 LUCA
GeneTreeiENSGT00640000091542
KOiK10846
OMAiAIDSSIW
OrthoDBiEOG091G0OMB
TreeFamiTF101235

Enzyme and pathway databases

ReactomeiR-MMU-5696395 Formation of Incision Complex in GG-NER
R-MMU-5696400 Dual Incision in GG-NER
R-MMU-6782135 Dual incision in TC-NER

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026048 Expressed in 273 organ(s), highest expression level in embryonic stem cell
GenevisibleiE9QM61 MM

Family and domain databases

InterProiView protein in InterPro
IPR036279 5-3_exonuclease_C_sf
IPR008918 HhH2
IPR029060 PIN-like_dom_sf
IPR006086 XPG-I_dom
IPR006084 XPG/Rad2
IPR001044 XPG/Rad2_eukaryotes
IPR019974 XPG_CS
IPR006085 XPG_DNA_repair_N
PfamiView protein in Pfam
PF00867 XPG_I, 1 hit
PF00752 XPG_N, 1 hit
PRINTSiPR00853 XPGRADSUPER
PR00066 XRODRMPGMNTG
SMARTiView protein in SMART
SM00279 HhH2, 1 hit
SM00484 XPGI, 1 hit
SM00485 XPGN, 1 hit
SUPFAMiSSF47807 SSF47807, 1 hit
SSF88723 SSF88723, 1 hit
TIGRFAMsiTIGR00600 rad2, 1 hit
PROSITEiView protein in PROSITE
PS00841 XPG_1, 1 hit
PS00842 XPG_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9QM61_MOUSE
AccessioniPrimary (citable) accession number: E9QM61
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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