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Entry version 65 (31 Jul 2019)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Solute carrier family 12 member 2

Gene

Slc12a2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Solute carrier family 12 member 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc12a2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:101924 Slc12a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Transmembranei311 – 337HelicalSequence analysisAdd BLAST27
Transmembranei358 – 382HelicalSequence analysisAdd BLAST25
Transmembranei402 – 421HelicalSequence analysisAdd BLAST20
Transmembranei430 – 451HelicalSequence analysisAdd BLAST22
Transmembranei481 – 503HelicalSequence analysisAdd BLAST23
Transmembranei515 – 535HelicalSequence analysisAdd BLAST21
Transmembranei593 – 616HelicalSequence analysisAdd BLAST24
Transmembranei649 – 669HelicalSequence analysisAdd BLAST21
Transmembranei675 – 693HelicalSequence analysisAdd BLAST19
Transmembranei705 – 724HelicalSequence analysisAdd BLAST20
Transmembranei730 – 745HelicalSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
E9QM38

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9QM38

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9QM38

PeptideAtlas

More...
PeptideAtlasi
E9QM38

PRoteomics IDEntifications database

More...
PRIDEi
E9QM38

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024597 Expressed in 320 organ(s), highest expression level in stria vascularis of cochlear duct

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9QM38 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini196 – 249AA_permease_NInterPro annotationAdd BLAST54
Domaini284 – 786AA_permeaseInterPro annotationAdd BLAST503
Domaini795 – 1206SLC12InterPro annotationAdd BLAST412

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 96DisorderedSequence analysisAdd BLAST96
Regioni144 – 188DisorderedSequence analysisAdd BLAST45
Regioni954 – 987DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi166 – 188PolarSequence analysisAdd BLAST23
Compositional biasi954 – 982PolyampholyteSequence analysisAdd BLAST29

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2083 Eukaryota
COG0531 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155742

KEGG Orthology (KO)

More...
KOi
K10951

Identification of Orthologs from Complete Genome Data

More...
OMAi
ERAANWF

Database of Orthologous Groups

More...
OrthoDBi
254933at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313191

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR013612 AA_permease_N
IPR002444 NKCC1
IPR018491 SLC12_C
IPR002443 SLC12A1/SLC12A2
IPR004842 SLC12A_fam

The PANTHER Classification System

More...
PANTHERi
PTHR11827:SF58 PTHR11827:SF58, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324 AA_permease, 1 hit
PF08403 AA_permease_N, 1 hit
PF03522 SLC12, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01207 NAKCLTRNSPRT
PR01208 NAKCLTRSPRT1

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00930 2a30, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9QM38-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGPAAPSS GAPRPARDGD APLAAAAGVD LPGTAVPSGQ EDATTAGRQA
60 70 80 90 100
GGGVRGEGTP AAGDGLGRPL GPTPSQSRFQ VDPVSENAGR AAAAAAAAAA
110 120 130 140 150
AAAAAGAAGK ETPAAGKAGG ESGVAKGSEE AKGRFRVNFV DPAASSSADD
160 170 180 190 200
SLSDAAGVGG DGPNVSFQNG GDTVLSEGSS LHSGGGSGHH QQYYYDTHTN
210 220 230 240 250
TYYLRTFGHN TMDAVPRIDH YRHTAAQLGE KLLRPSLAEL HDELEKEPFE
260 270 280 290 300
DGFANGEEST PTRDAVVAYT AESKGVVKFG WIKGVLVRCM LNIWGVMLFI
310 320 330 340 350
RLSWIVGQAG IGLSVVVIAM ATVVTTITGL STSAIATNGF VRGGGAYYLI
360 370 380 390 400
SRSLGPEFGG AIGLIFAFAN AVAVAMYVVG FAETVVELLK EHSILMIDEI
410 420 430 440 450
NDIRIIGAIT VVILLGISVA GMEWEAKAQI VLLVILLLAI ADFVIGTFIS
460 470 480 490 500
LESKKPKGFF GYKSEIFNEN FGPDFREEET FFSVFAIFFP AATGILAGAN
510 520 530 540 550
ISGDLADPQS AIPKGTLLAI LITTVVYIGI AVSVGSCVVR DATGNVNDTI
560 570 580 590 600
TTELTNCTSA ACKLNFDFSY CESNTCSYGL MNNFQVMSMV SGFAPLISAG
610 620 630 640 650
IFSATLSSAL ASLVSAPKIF QALCKDNIYP AFQMFAKGYG KNNEPLRGYI
660 670 680 690 700
LTFLIALGFI LIAELNVIAP IISNFFLASY ALINFSVFHA SLAKSPGWRP
710 720 730 740 750
AFKYYNMWIS LIGAILCCIV MFVINWWAAL LTYVIVLGLY IYVTYKKPDV
760 770 780 790 800
NWGSSTQALT YLSALQHSIR LSGVEDHVKN FRPQCLVMTG SPNSRPALLH
810 820 830 840 850
LVHDFTKNVG LMICGHVHMG PRRQAMKEMS IDQARYQRWL IKNKMKAFYA
860 870 880 890 900
PVHADDLREG AQYLMQAAGL GRMKPNTLVL GFKKDWLQAD MRDVDMYINL
910 920 930 940 950
FHDAFDIQFG VVVIRLKEGL DISHLQGQEE LLSSQEKSPG TKDVVVNVDY
960 970 980 990 1000
SKKSDQDTCK SSGEKSITQK DEEEDGKTPT QPLLKKESKG PIVPLNVADQ
1010 1020 1030 1040 1050
KLLEASTQFQ KKQGKNTIDV WWLFDDGGLT LLIPYLLTTK KKWKDCKIRV
1060 1070 1080 1090 1100
FIGGKINRID HDRRAMATLL SKFRIDFSDI MVLGDINTKP KKENIIAFDD
1110 1120 1130 1140 1150
MIEPYRLHED DKEQDIADKM KEDEPWRITD NELELYKTKT YRQIRLNELL
1160 1170 1180 1190 1200
KEHSSTANII VMSLPVARKG AVSSALYMAW LEALSKDLPP VLLVRGNHQS

VLTFYS
Length:1,206
Mass (Da):130,668
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12A28852888769E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P55012S12A2_MOUSE
Solute carrier family 12 member 2
Slc12a2 Nkcc1
1,205Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC127678 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_033220.2, NM_009194.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000115366; ENSMUSP00000111023; ENSMUSG00000024597

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20496

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:20496

UCSC genome browser

More...
UCSCi
uc008ezm.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127678 Genomic DNA No translation available.
RefSeqiNP_033220.2, NM_009194.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

EPDiE9QM38
jPOSTiE9QM38
MaxQBiE9QM38
PeptideAtlasiE9QM38
PRIDEiE9QM38

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115366; ENSMUSP00000111023; ENSMUSG00000024597
GeneIDi20496
KEGGimmu:20496
UCSCiuc008ezm.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6558
MGIiMGI:101924 Slc12a2

Phylogenomic databases

eggNOGiKOG2083 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00940000155742
KOiK10951
OMAiERAANWF
OrthoDBi254933at2759
TreeFamiTF313191

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Slc12a2 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024597 Expressed in 320 organ(s), highest expression level in stria vascularis of cochlear duct
GenevisibleiE9QM38 MM

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR013612 AA_permease_N
IPR002444 NKCC1
IPR018491 SLC12_C
IPR002443 SLC12A1/SLC12A2
IPR004842 SLC12A_fam
PANTHERiPTHR11827:SF58 PTHR11827:SF58, 1 hit
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PF08403 AA_permease_N, 1 hit
PF03522 SLC12, 1 hit
PRINTSiPR01207 NAKCLTRNSPRT
PR01208 NAKCLTRSPRT1
TIGRFAMsiTIGR00930 2a30, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9QM38_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9QM38
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 31, 2019
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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