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Protein

Ribonuclease H1

Gene

Rnaseh1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionEndonucleaseUniRule annotation, Hydrolase, Nuclease
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease H1UniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase H1UniRule annotation
Gene namesi
Name:Rnaseh1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1335073 Rnaseh1

PTM / Processingi

Proteomic databases

MaxQBiE9QLN8
PeptideAtlasiE9QLN8
PRIDEiE9QLN8

Expressioni

Gene expression databases

BgeeiENSMUSG00000020630 Expressed in 217 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiE9QLN8 baseline and differential
GenevisibleiE9QLN8 MM

Structurei

3D structure databases

ProteinModelPortaliE9QLN8
SMRiE9QLN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 281RNase HInterPro annotationAdd BLAST147

Sequence similaritiesi

Belongs to the RNase H family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3752 Eukaryota
COG0328 LUCA
GeneTreeiENSGT00390000003466
OMAiELWYGLY
OrthoDBiEOG091G0RCI
TreeFamiTF313356

Family and domain databases

Gene3Di3.30.420.10, 1 hit
3.40.970.10, 1 hit
InterProiView protein in InterPro
IPR009027 Ribosomal_L9/RNase_H1_N
IPR017067 RNase_H1_euk
IPR011320 RNase_H1_N
IPR037056 RNase_H1_N_sf
IPR012337 RNaseH-like_sf
IPR002156 RNaseH_domain
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF01693 Cauli_VI, 1 hit
PF00075 RNase_H, 1 hit
PIRSFiPIRSF036852 Ribonuclease_H1_euk, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
SSF55658 SSF55658, 1 hit
PROSITEiView protein in PROSITE
PS50879 RNASE_H, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9QLN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRWLLPLSRT VTLAVVRLRR GICGLGMFYA VRRGRRTGVF LSWSECKAQV
60 70 80 90 100
DRFPAARFKK FATEDEAWAF VRSSSSPDGS KGQESAHEQK SQAKTSKRPR
110 120 130 140 150
EPLGEGEELP EPGPKHTRQD TEPSAVVSKD AFSYMGESVV VYTDGCCSSN
160 170 180 190 200
GRKRARAGIG VYWGPGHPLN VGIRLPGRQT NQRAEIHAAC KAIMQAKAQN
210 220 230 240 250
ISKLVLYTDS MFTINGITNW VQGWKKNGWR TSTGKDVINK EDFMELDELT
260 270 280
QGMDIQWMHI PGHSGFVGNE EADRLAREGA KQSED
Length:285
Mass (Da):31,777
Last modified:April 5, 2011 - v1
Checksum:i5834FB6CE195A720
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O70338RNH1_MOUSE
Ribonuclease H1
Rnaseh1 Rnh1
285Annotation score:
A0A1Y7VM77A0A1Y7VM77_MOUSE
Ribonuclease H1
Rnaseh1
198Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136986 Genomic DNA No translation available.
RefSeqiNP_035405.2, NM_011275.3
UniGeneiMm.10152

Genome annotation databases

EnsembliENSMUST00000020959; ENSMUSP00000020959; ENSMUSG00000020630
GeneIDi19819
UCSCiuc007nft.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136986 Genomic DNA No translation available.
RefSeqiNP_035405.2, NM_011275.3
UniGeneiMm.10152

3D structure databases

ProteinModelPortaliE9QLN8
SMRiE9QLN8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9QLN8
PeptideAtlasiE9QLN8
PRIDEiE9QLN8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020959; ENSMUSP00000020959; ENSMUSG00000020630
GeneIDi19819
UCSCiuc007nft.2 mouse

Organism-specific databases

CTDi246243
MGIiMGI:1335073 Rnaseh1

Phylogenomic databases

eggNOGiKOG3752 Eukaryota
COG0328 LUCA
GeneTreeiENSGT00390000003466
OMAiELWYGLY
OrthoDBiEOG091G0RCI
TreeFamiTF313356

Miscellaneous databases

ChiTaRSiRnaseh1 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020630 Expressed in 217 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiE9QLN8 baseline and differential
GenevisibleiE9QLN8 MM

Family and domain databases

Gene3Di3.30.420.10, 1 hit
3.40.970.10, 1 hit
InterProiView protein in InterPro
IPR009027 Ribosomal_L9/RNase_H1_N
IPR017067 RNase_H1_euk
IPR011320 RNase_H1_N
IPR037056 RNase_H1_N_sf
IPR012337 RNaseH-like_sf
IPR002156 RNaseH_domain
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF01693 Cauli_VI, 1 hit
PF00075 RNase_H, 1 hit
PIRSFiPIRSF036852 Ribonuclease_H1_euk, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
SSF55658 SSF55658, 1 hit
PROSITEiView protein in PROSITE
PS50879 RNASE_H, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9QLN8_MOUSE
AccessioniPrimary (citable) accession number: E9QLN8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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