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Entry version 64 (11 Dec 2019)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

SUMO-specific isopeptidase USPL1

Gene

Uspl1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SUMO-specific isopeptidase USPL1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Uspl1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2442342 Uspl1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000041264 Expressed in 239 organ(s), highest expression level in pes

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini215 – 488USPInterPro annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni90 – 128DisorderedSequence analysisAdd BLAST39
Regioni695 – 739DisorderedSequence analysisAdd BLAST45
Regioni791 – 817DisorderedSequence analysisAdd BLAST27
Regioni835 – 868DisorderedSequence analysisAdd BLAST34
Regioni891 – 928DisorderedSequence analysisAdd BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili931 – 951Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi704 – 732PolarSequence analysisAdd BLAST29
Compositional biasi906 – 926PolarSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ9P Eukaryota
ENOG410YB7R LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002316

KEGG Orthology (KO)

More...
KOi
K23008

Database of Orthologous Groups

More...
OrthoDBi
204698at2759

TreeFam database of animal gene trees

More...
TreeFami
TF350670

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029388 DUF4650
IPR038765 Papain-like_cys_pep_sf
IPR028890 Peptidase_C98
IPR028889 USP_dom
IPR033505 USPL1

The PANTHER Classification System

More...
PANTHERi
PTHR15294 PTHR15294, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15509 DUF4650, 1 hit
PF15499 Peptidase_C98, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E9QLC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDDSLKIGN GLPLVGPGTD VGISSLPMLG YLGKNYASAK VTTDGHCPAC
60 70 80 90 100
RAKGKLSALK PYRISFQESV FLCEDLQCIY PLGSESLTNL ISPDSEDCPT
110 120 130 140 150
PSKPQKRKRL ETNCRNSPLP VHSKKTRSHI VTDSEPIVNG KYNGEVCDDF
160 170 180 190 200
SASFPDTSAH QDPASTAASV EQSEALEADD VVVAATEDPA TVSVTSELEM
210 220 230 240 250
PAKSRCLPLC QTLCVQWKNT QALCWLDCIL SALVHLEVLR KTVLEACSRE
260 270 280 290 300
ECVFGRLFEM YHQADELLHT HHLHGVTGED CKKLTSEIFT EIDTCLNKVR
310 320 330 340 350
DEIFAKLQPK LRCTLGDMES PVFALPVLLK LEPHVESLFT YSFSWNFECS
360 370 380 390 400
HCGHQYQNRC VKSLVTFTNI VPEWHPLNAA HFGPCNSCNS KSQIRKMVLE
410 420 430 440 450
RASPILMLHF VEGLPRRDLQ HYAFHFEGSL YQVTSVIQYQ ANNHFITWFL
460 470 480 490 500
DADGSWLECD DLKGPCAKRH VTCEVPASET HIVIWERKSQ VPIEEAACLP
510 520 530 540 550
CMKPNVQPVS GEEQPTCPAL CSLAGTATSE PSVAHPTSMA GAPQTLPEIQ
560 570 580 590 600
AVAHGDSVLS GAKGMVDSIL PSALEETIQE TASVSQVDSK DCLLEDKPVA
610 620 630 640 650
GSAALVRVLA FQPQDSPGSS GSSLVSSLCE GKLVAPCVDS SFPSQAVSTD
660 670 680 690 700
LQAVLSQAGD TVVPNPVTDA PVPVLVQELK SLATEKDSQT QLLPLKTEKL
710 720 730 740 750
DPEQPGKSQA SNLRKRETTA SSKTVAARSA QNQPRKEDQK RAFVGSWVKG
760 770 780 790 800
LLSRGGAFMP TCVLSQSRAV SDLQPSVKGA SNFDGFKTKS ISRRSKRMSR
810 820 830 840 850
KAKHMEELSP RNSSPPLSWT AALTQAAENA TSALLREQEG SRPAPLRHRS
860 870 880 890 900
PGNESAISPA SRGDAAEDQV HKLRLKLLKK LKAKKKKLAA LISSPHREPS
910 920 930 940 950
LSDHSEPASH CGTPASDQSE PVSHCGSPND CESIEDLLKE LQHQIDLADS
960 970 980 990 1000
KSGCTSAPDA TSNNSQSHEE ILAELLSPTA MSEPSESGEL ELRYLEMGDS
1010 1020 1030 1040 1050
TPAQAPSEFS VVSQNTCLKQ DHDYCSPEKG QREVDLHSVM DSACIRTLNL
1060 1070 1080
GSPMKTDIFD DFFSTSALNS LTNDTLDIPH FDDSLFENC
Length:1,089
Mass (Da):118,405
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91DCA31D986EEB1A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3ULM6USPL1_MOUSE
SUMO-specific isopeptidase USPL1
Uspl1
1,089Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YW34D3YW34_MOUSE
SUMO-specific isopeptidase USPL1
Uspl1
1,075Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J1P9A0A0R4J1P9_MOUSE
SUMO-specific isopeptidase USPL1
Uspl1
890Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z5G1D3Z5G1_MOUSE
SUMO-specific isopeptidase USPL1
Uspl1
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RI24D6RI24_MOUSE
SUMO-specific isopeptidase USPL1
Uspl1
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC122546 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001108621.1, NM_001115149.1
NP_001108625.1, NM_001115153.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000050472; ENSMUSP00000050172; ENSMUSG00000041264
ENSMUST00000122160; ENSMUSP00000113247; ENSMUSG00000041264

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
231915

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:231915

UCSC genome browser

More...
UCSCi
uc009aph.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122546 Genomic DNA No translation available.
RefSeqiNP_001108621.1, NM_001115149.1
NP_001108625.1, NM_001115153.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSMUST00000050472; ENSMUSP00000050172; ENSMUSG00000041264
ENSMUST00000122160; ENSMUSP00000113247; ENSMUSG00000041264
GeneIDi231915
KEGGimmu:231915
UCSCiuc009aph.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10208
MGIiMGI:2442342 Uspl1

Phylogenomic databases

eggNOGiENOG410IJ9P Eukaryota
ENOG410YB7R LUCA
GeneTreeiENSGT00390000002316
KOiK23008
OrthoDBi204698at2759
TreeFamiTF350670

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Uspl1 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000041264 Expressed in 239 organ(s), highest expression level in pes

Family and domain databases

InterProiView protein in InterPro
IPR029388 DUF4650
IPR038765 Papain-like_cys_pep_sf
IPR028890 Peptidase_C98
IPR028889 USP_dom
IPR033505 USPL1
PANTHERiPTHR15294 PTHR15294, 1 hit
PfamiView protein in Pfam
PF15509 DUF4650, 1 hit
PF15499 Peptidase_C98, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9QLC6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9QLC6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: December 11, 2019
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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