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UniProtKB - E9QKH8 (E9QKH8_MOUSE)

Entry version 82 (29 Sep 2021)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Catenin delta-2

Gene

Ctnnd2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Catenin delta-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ctnnd2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1195966, Ctnnd2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000022240

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		E9QKH8

PRoteomics IDEntifications database

More...PRIDEi		E9QKH8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		314860

PTM databases

SwissPalm database of S-palmitoylation events

More...SwissPalmi		E9QKH8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000022240, Expressed in CA1 field of hippocampus and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		E9QKH8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		E9QKH8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E9QKH8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati588 – 621ARMPROSITE-ProRule annotationAdd BLAST34
Repeati632 – 675ARMPROSITE-ProRule annotationAdd BLAST44
Repeati913 – 950ARMPROSITE-ProRule annotationAdd BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 50DisorderedSequence analysisAdd BLAST50
Regioni133 – 168DisorderedSequence analysisAdd BLAST36
Regioni181 – 237DisorderedSequence analysisAdd BLAST57
Regioni255 – 308DisorderedSequence analysisAdd BLAST54
Regioni428 – 479DisorderedSequence analysisAdd BLAST52
Regioni1063 – 1130DisorderedSequence analysisAdd BLAST68
Regioni1151 – 1175DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili55 – 82Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 50Polar residuesSequence analysisAdd BLAST29
Compositional biasi135 – 168Polar residuesSequence analysisAdd BLAST34
Compositional biasi181 – 209Polar residuesSequence analysisAdd BLAST29
Compositional biasi215 – 229Pro residuesSequence analysisAdd BLAST15
Compositional biasi256 – 276Polar residuesSequence analysisAdd BLAST21
Compositional biasi294 – 308Polar residuesSequence analysisAdd BLAST15
Compositional biasi429 – 479Polar residuesSequence analysisAdd BLAST51
Compositional biasi1063 – 1096Polar residuesSequence analysisAdd BLAST34
Compositional biasi1153 – 1170Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta-catenin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154952

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007897_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		GQSFSQX

Database of Orthologous Groups

More...OrthoDBi		233858at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		E9QKH8

TreeFam database of animal gene trees

More...TreeFami		TF321877

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR028435, Plakophilin/d_Catenin

The PANTHER Classification System

More...PANTHERi		PTHR10372, PTHR10372, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00514, Arm, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00185, ARM, 8 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50176, ARM_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E9QKH8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFARKQSGAA PFGAMPVPDQ PPSASEKNSS LSPGLNTSNG DGSETETTSA 
        60         70         80         90        100
ILASVKEQEL QFERLTRELE AERQIVASQL ERCKLGSETG SMSSISSAEQ 
       110        120        130        140        150
FHWQTQDGQK DIEDELTTGL ELVDSCIRSL QESGILDPQD YSTSERPSLL 
       160        170        180        190        200
SQSALQLNSK PEGSFQYPAS YHSNQTLALG DTAPSQLPAR STQARAAGQS 
       210        220        230        240        250
FSQGTTGRAG HLAGSEPAPP PPPPREPFAP SLGSAFHLPD APPAAAALYY 
       260        270        280        290        300
SSSTLPAPPR GGSPLTTTQG GSPTKLQRGG SAPEGAAYAA PRGSSPKQSP 
       310        320        330        340        350
SRLAKSYSTS SPINIVVSSA GLSPIRVTSP PTVQSTISSS PIHQLSSTIG 
       360        370        380        390        400
TYATLSPTKR LVHASEQYSK HSQELYATAT LQRPGSLAAG SRASYSSQHG 
       410        420        430        440        450
HLAPELRALQ SPEHHIDPIY EDRVYQKPPM RSLSQSQGDP LPPAHTGTFR 
       460        470        480        490        500
TSTAPSSPGV DSVPLQRTGS QHGPQNAAAA TFQRASYAAG PASNYADPYR 
       510        520        530        540        550
QLQYCASVDS PYSKSGPALP PEGTLARSPS IDSIQKDPRE FGWRDPELPE 
       560        570        580        590        600
VIQMLQHQFP SVQSNAAAYL QHLCFGDNKI KAEIRRQGGI QLLVDLLDHR 
       610        620        630        640        650
MTEVHRSACG ALRNLVYGKA NDDNKIALKN CGGIPALVRL LRKTTDLEIR 
       660        670        680        690        700
ELVTGVLWNL SSCDALKMPI IQDALAVLTN AVIIPHSGWE NSPLQDDRKI 
       710        720        730        740        750
QLHSSQVLRN ATGCLRNVSS AGEEARRRMR ECDGLTDALL YVIQSALGSS 
       760        770        780        790        800
EIDSKTVENC VCILRNLSYR LAAETSQGQH MGTDELDGLL CGETNGKDTE 
       810        820        830        840        850
SSGCWGKKKK KKKSQDQWDG VGPLPDCAEP PKGIQMLWHP SIVKPYLTLL 
       860        870        880        890        900
SECSNPDTLE GAAGALQNLA AGSWKGWAED VAGMAYALRS LPEGAPCLPQ 
       910        920        930        940        950
WSVYIRAAVR KEKGLPILVE LLRIDNDRVV CAVATALRNM ALDVRNKELI 
       960        970        980        990       1000
GKYAMRDLVH RLPGGNNSNN SGSKAMSDDT VTAVCCTLHE VITKNMENAK 
      1010       1020       1030       1040       1050
ALRDAGGIEK LVGISKSKGD KHSPKVVKAA SQVLNSMWQY RDLRSLYKKD 
      1060       1070       1080       1090       1100
GWSQYHFVAS SSTIERDRQR PYSSSRTPSI SPVRVSPNNR SASAPASPRE 
      1110       1120       1130       1140       1150
MISLKERKTD YESAGNNATY HGTKGEHTSR KDTMTAQNTG VSTLYRNSYG 
      1160       1170       1180       1190       1200
APAEDIKQNQ VSTQPVPQEP SRKDYETYQP FPNSTRNYDE SFFEDQVHHR 
      1210       1220       1230       1240 
PPASEYTMHL GLKSTGNYVD FYSAARPYSE LNYETSHYPA SPDSWV
Length:1,246
Mass (Da):134,943
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3440C07756C700C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O35927CTND2_MOUSE
Catenin delta-2
Ctnnd2 Catnd2, Nprap
1,247Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZNF6B7ZNF6_MOUSE
Catenin delta-2
Ctnnd2
1,221Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQV7A0A2I3BQV7_MOUSE
Catenin delta-2
Ctnnd2
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQV6A0A2I3BQV6_MOUSE
Catenin delta-2
Ctnnd2
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		NP_032755.2, NM_008729.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000081728; ENSMUSP00000080427; ENSMUSG00000022240

Database of genes from NCBI RefSeq genomes

More...GeneIDi		18163

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:18163

UCSC genome browser

More...UCSCi		uc007vjz.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_032755.2, NM_008729.2

3D structure databases

SMRiE9QKH8
ModBaseiSearch...

PTM databases

SwissPalmiE9QKH8

Proteomic databases

MaxQBiE9QKH8
PRIDEiE9QKH8
ProteomicsDBi314860

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		9404, 197 antibodies

The DNASU plasmid repository

More...DNASUi		18163

Genome annotation databases

EnsembliENSMUST00000081728; ENSMUSP00000080427; ENSMUSG00000022240
GeneIDi18163
KEGGimmu:18163
UCSCiuc007vjz.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1501
MGIiMGI:1195966, Ctnnd2
VEuPathDBiHostDB:ENSMUSG00000022240

Phylogenomic databases

GeneTreeiENSGT00940000154952
HOGENOMiCLU_007897_0_0_1
OMAiGQSFSQX
OrthoDBi233858at2759
PhylomeDBiE9QKH8
TreeFamiTF321877

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		18163, 4 hits in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ctnnd2, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000022240, Expressed in CA1 field of hippocampus and 233 other tissues
ExpressionAtlasiE9QKH8, baseline and differential
GenevisibleiE9QKH8, MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR028435, Plakophilin/d_Catenin
PANTHERiPTHR10372, PTHR10372, 1 hit
PfamiView protein in Pfam
PF00514, Arm, 4 hits
SMARTiView protein in SMART
SM00185, ARM, 8 hits
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176, ARM_REPEAT, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9QKH8_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9QKH8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 29, 2021
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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