UniProtKB - E9QKH8 (E9QKH8_MOUSE)
Protein
Submitted name:
Catenin delta-2
Gene
Ctnnd2
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- beta-catenin binding Source: Ensembl
GO - Biological processi
- cell-cell adhesion Source: InterPro
- dendritic spine morphogenesis Source: Ensembl
- regulation of canonical Wnt signaling pathway Source: Ensembl
Keywordsi
Biological process | Cell adhesionARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Catenin delta-2Imported |
Gene namesi | Name:Ctnnd2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1195966, Ctnnd2 |
Subcellular locationi
Other locations
- cell junction Source: UniProtKB-KW
- perikaryon Source: Ensembl
Keywords - Cellular componenti
Cell junctionARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000022240, Expressed in CA1 field of hippocampus and 225 other tissues |
ExpressionAtlasi | E9QKH8, baseline and differential |
Genevisiblei | E9QKH8, MM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 588 – 621 | ARMPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 632 – 675 | ARMPROSITE-ProRule annotationAdd BLAST | 44 | |
Repeati | 913 – 950 | ARMPROSITE-ProRule annotationAdd BLAST | 38 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 50 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 133 – 168 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 181 – 237 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 255 – 308 | DisorderedSequence analysisAdd BLAST | 54 | |
Regioni | 428 – 479 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 1063 – 1130 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 1151 – 1175 | DisorderedSequence analysisAdd BLAST | 25 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 55 – 82 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 22 – 50 | PolarSequence analysisAdd BLAST | 29 | |
Compositional biasi | 135 – 168 | PolarSequence analysisAdd BLAST | 34 | |
Compositional biasi | 181 – 209 | PolarSequence analysisAdd BLAST | 29 | |
Compositional biasi | 215 – 229 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 256 – 276 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 294 – 308 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 429 – 479 | PolarSequence analysisAdd BLAST | 51 | |
Compositional biasi | 1063 – 1096 | PolarSequence analysisAdd BLAST | 34 | |
Compositional biasi | 1153 – 1170 | PolarSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the beta-catenin family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000154952 |
HOGENOMi | CLU_007897_0_0_1 |
OMAi | GQSFSQX |
OrthoDBi | 233858at2759 |
TreeFami | TF321877 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR028435, Plakophilin/d_Catenin |
PANTHERi | PTHR10372, PTHR10372, 1 hit |
Pfami | View protein in Pfam PF00514, Arm, 4 hits |
SMARTi | View protein in SMART SM00185, ARM, 8 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
E9QKH8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFARKQSGAA PFGAMPVPDQ PPSASEKNSS LSPGLNTSNG DGSETETTSA
60 70 80 90 100
ILASVKEQEL QFERLTRELE AERQIVASQL ERCKLGSETG SMSSISSAEQ
110 120 130 140 150
FHWQTQDGQK DIEDELTTGL ELVDSCIRSL QESGILDPQD YSTSERPSLL
160 170 180 190 200
SQSALQLNSK PEGSFQYPAS YHSNQTLALG DTAPSQLPAR STQARAAGQS
210 220 230 240 250
FSQGTTGRAG HLAGSEPAPP PPPPREPFAP SLGSAFHLPD APPAAAALYY
260 270 280 290 300
SSSTLPAPPR GGSPLTTTQG GSPTKLQRGG SAPEGAAYAA PRGSSPKQSP
310 320 330 340 350
SRLAKSYSTS SPINIVVSSA GLSPIRVTSP PTVQSTISSS PIHQLSSTIG
360 370 380 390 400
TYATLSPTKR LVHASEQYSK HSQELYATAT LQRPGSLAAG SRASYSSQHG
410 420 430 440 450
HLAPELRALQ SPEHHIDPIY EDRVYQKPPM RSLSQSQGDP LPPAHTGTFR
460 470 480 490 500
TSTAPSSPGV DSVPLQRTGS QHGPQNAAAA TFQRASYAAG PASNYADPYR
510 520 530 540 550
QLQYCASVDS PYSKSGPALP PEGTLARSPS IDSIQKDPRE FGWRDPELPE
560 570 580 590 600
VIQMLQHQFP SVQSNAAAYL QHLCFGDNKI KAEIRRQGGI QLLVDLLDHR
610 620 630 640 650
MTEVHRSACG ALRNLVYGKA NDDNKIALKN CGGIPALVRL LRKTTDLEIR
660 670 680 690 700
ELVTGVLWNL SSCDALKMPI IQDALAVLTN AVIIPHSGWE NSPLQDDRKI
710 720 730 740 750
QLHSSQVLRN ATGCLRNVSS AGEEARRRMR ECDGLTDALL YVIQSALGSS
760 770 780 790 800
EIDSKTVENC VCILRNLSYR LAAETSQGQH MGTDELDGLL CGETNGKDTE
810 820 830 840 850
SSGCWGKKKK KKKSQDQWDG VGPLPDCAEP PKGIQMLWHP SIVKPYLTLL
860 870 880 890 900
SECSNPDTLE GAAGALQNLA AGSWKGWAED VAGMAYALRS LPEGAPCLPQ
910 920 930 940 950
WSVYIRAAVR KEKGLPILVE LLRIDNDRVV CAVATALRNM ALDVRNKELI
960 970 980 990 1000
GKYAMRDLVH RLPGGNNSNN SGSKAMSDDT VTAVCCTLHE VITKNMENAK
1010 1020 1030 1040 1050
ALRDAGGIEK LVGISKSKGD KHSPKVVKAA SQVLNSMWQY RDLRSLYKKD
1060 1070 1080 1090 1100
GWSQYHFVAS SSTIERDRQR PYSSSRTPSI SPVRVSPNNR SASAPASPRE
1110 1120 1130 1140 1150
MISLKERKTD YESAGNNATY HGTKGEHTSR KDTMTAQNTG VSTLYRNSYG
1160 1170 1180 1190 1200
APAEDIKQNQ VSTQPVPQEP SRKDYETYQP FPNSTRNYDE SFFEDQVHHR
1210 1220 1230 1240
PPASEYTMHL GLKSTGNYVD FYSAARPYSE LNYETSHYPA SPDSWV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO35927 | CTND2_MOUSE | Catenin delta-2 | Ctnnd2 Catnd2, Nprap | 1,247 | Annotation score: | ||
B7ZNF6 | B7ZNF6_MOUSE | Catenin delta-2 | Ctnnd2 | 1,221 | Annotation score: | ||
A0A2I3BQV7 | A0A2I3BQV7_MOUSE | Catenin delta-2 | Ctnnd2 | 103 | Annotation score: | ||
A0A2I3BQV6 | A0A2I3BQV6_MOUSE | Catenin delta-2 | Ctnnd2 | 145 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC105408 Genomic DNA No translation available. AC110569 Genomic DNA No translation available. AC123531 Genomic DNA No translation available. AC124675 Genomic DNA No translation available. AC124993 Genomic DNA No translation available. AC134414 Genomic DNA No translation available. AC139197 Genomic DNA No translation available. |
RefSeqi | NP_032755.2, NM_008729.2 |
Genome annotation databases
Ensembli | ENSMUST00000081728; ENSMUSP00000080427; ENSMUSG00000022240 |
GeneIDi | 18163 |
KEGGi | mmu:18163 |
UCSCi | uc007vjz.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC105408 Genomic DNA No translation available. AC110569 Genomic DNA No translation available. AC123531 Genomic DNA No translation available. AC124675 Genomic DNA No translation available. AC124993 Genomic DNA No translation available. AC134414 Genomic DNA No translation available. AC139197 Genomic DNA No translation available. |
RefSeqi | NP_032755.2, NM_008729.2 |
3D structure databases
SMRi | E9QKH8 |
ModBasei | Search... |
PTM databases
SwissPalmi | E9QKH8 |
Proteomic databases
MaxQBi | E9QKH8 |
PRIDEi | E9QKH8 |
Protocols and materials databases
Antibodypediai | 9404, 188 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000081728; ENSMUSP00000080427; ENSMUSG00000022240 |
GeneIDi | 18163 |
KEGGi | mmu:18163 |
UCSCi | uc007vjz.1, mouse |
Organism-specific databases
CTDi | 1501 |
MGIi | MGI:1195966, Ctnnd2 |
Phylogenomic databases
GeneTreei | ENSGT00940000154952 |
HOGENOMi | CLU_007897_0_0_1 |
OMAi | GQSFSQX |
OrthoDBi | 233858at2759 |
TreeFami | TF321877 |
Miscellaneous databases
BioGRID-ORCSi | 18163, 4 hits in 17 CRISPR screens |
ChiTaRSi | Ctnnd2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022240, Expressed in CA1 field of hippocampus and 225 other tissues |
ExpressionAtlasi | E9QKH8, baseline and differential |
Genevisiblei | E9QKH8, MM |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR028435, Plakophilin/d_Catenin |
PANTHERi | PTHR10372, PTHR10372, 1 hit |
Pfami | View protein in Pfam PF00514, Arm, 4 hits |
SMARTi | View protein in SMART SM00185, ARM, 8 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9QKH8_MOUSE | |
Accessioni | E9QKH8Primary (citable) accession number: E9QKH8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | December 2, 2020 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |