UniProtKB - E9QK04 (E9QK04_MOUSE)
Protein
Submitted name:
Neogenin
Gene
Neo1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- co-receptor binding Source: Ensembl
- signaling receptor activity Source: InterPro
GO - Biological processi
- axon guidance Source: InterPro
- iron ion homeostasis Source: Ensembl
- positive regulation of BMP signaling pathway Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: NeogeninImported |
Gene namesi | Name:Neo1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1097159, Neo1 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Golgi apparatus
- Golgi apparatus Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
Plasma Membrane
- integral component of plasma membrane Source: InterPro
- plasma membrane protein complex Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1135 – 1159 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 41 | Sequence analysisAdd BLAST | 41 | |
ChainiPRO_5003246243 | 42 – 1492 | Sequence analysisAdd BLAST | 1451 |
Proteomic databases
jPOSTi | E9QK04 |
MaxQBi | E9QK04 |
PeptideAtlasi | E9QK04 |
PRIDEi | E9QK04 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032340, Expressed in external carotid artery and 394 other tissues |
ExpressionAtlasi | E9QK04, baseline and differential |
Genevisiblei | E9QK04, MM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 63 – 158 | Ig-likeInterPro annotationAdd BLAST | 96 | |
Domaini | 163 – 249 | Ig-likeInterPro annotationAdd BLAST | 87 | |
Domaini | 254 – 347 | Ig-likeInterPro annotationAdd BLAST | 94 | |
Domaini | 352 – 437 | Ig-likeInterPro annotationAdd BLAST | 86 | |
Domaini | 472 – 566 | Fibronectin type-IIIInterPro annotationAdd BLAST | 95 | |
Domaini | 572 – 662 | Fibronectin type-IIIInterPro annotationAdd BLAST | 91 | |
Domaini | 667 – 762 | Fibronectin type-IIIInterPro annotationAdd BLAST | 96 | |
Domaini | 772 – 862 | Fibronectin type-IIIInterPro annotationAdd BLAST | 91 | |
Domaini | 887 – 986 | Fibronectin type-IIIInterPro annotationAdd BLAST | 100 | |
Domaini | 988 – 1085 | Fibronectin type-IIIInterPro annotationAdd BLAST | 98 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1072 – 1128 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 1205 – 1237 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 1266 – 1300 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 1321 – 1396 | DisorderedSequence analysisAdd BLAST | 76 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1218 – 1237 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1321 – 1382 | PolarSequence analysisAdd BLAST | 62 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domainARBA annotation, RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000156684 |
HOGENOMi | CLU_004256_0_0_1 |
OrthoDBi | 217780at2759 |
TreeFami | TF321506 |
Family and domain databases
CDDi | cd00063, FN3, 6 hits |
Gene3Di | 2.60.40.10, 10 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR033024, Neogenin IPR010560, Neogenin_C |
PANTHERi | PTHR44170:SF14, PTHR44170:SF14, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 6 hits PF07679, I-set, 3 hits PF13895, Ig_2, 1 hit PF06583, Neogenin_C, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 6 hits SM00409, IG, 4 hits SM00408, IGc2, 4 hits |
SUPFAMi | SSF48726, SSF48726, 4 hits SSF49265, SSF49265, 3 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 6 hits PS50835, IG_LIKE, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
E9QK04-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAEREAGRL LCTSSSRRCC PPPPLLLLLP LLLLLGRPAS GAAATKSGSP
60 70 80 90 100
PQSAGASVRT FTPFYFLVEP VDTLSVRGSS VILNCSAYSE PSPNIEWKKD
110 120 130 140 150
GTFLNLESDD RRQLLPDGSL FISNVVHSKH NKPDEGFYQC VATVDNLGTI
160 170 180 190 200
VSRTAKLTVA GLPRFTSQPE PSSVYVGNSA ILNCEVNADL VPFVRWEQNR
210 220 230 240 250
QPLLLDDRIV KLPSGTLVIS NATEGDGGLY RCIVESGGPP KFSDEAELKV
260 270 280 290 300
LQDPEEIVDL VFLMRPSSMM KVTGQSAVLP CVVSGLPAPV VRWMKNEEVL
310 320 330 340 350
DTESSGRLVL LAGGCLEISD VTEDDAGTYF CIADNGNKTV EAQAELTVQV
360 370 380 390 400
PPGFLKQPAN IYAHESMDIV FECEVTGKPT PTVKWVKNGD VVIPSDYFKI
410 420 430 440 450
VKEHNLQVLG LVKSDEGFYQ CIAENDVGNA QAGAQLIILE HDVAIPTLPP
460 470 480 490 500
TSLTSATTDH LAPATTGPLP SAPRDVVASL VSTRFIKLTW RTPASDPHGD
510 520 530 540 550
NLTYSVFYTK EGVARERVEN TSQPGEMQVT IQNLMPATVY IFKVMAQNKH
560 570 580 590 600
GSGESSAPLR VETQPEVQLP GPAPNIRAYA TSPTSITVTW ETPLSGNGEI
610 620 630 640 650
QNYKLYYMEK GTDKEQDIDV SSHSYTINGL KKYTEYSFRV VAYNKHGPGV
660 670 680 690 700
STQDVAVRTL SDVPSAAPQN LSLEVRNSKS IVIHWQPPSS TTQNGQITGY
710 720 730 740 750
KIRYRKASRK SDVTETLVTG TQLSQLIEGL DRGTEYNFRV AALTVNGTGP
760 770 780 790 800
ATDWLSAETF ESDLDETRVP EVPSSLHVRP LVTSIVVSWT PPENQNIVVR
810 820 830 840 850
GYAIGYGIGS PHAQTIKVDY KQRYYTIENL DPSSHYVITL KAFNNVGEGI
860 870 880 890 900
PLYESAVTRP HTDTSEVDLF VINAPYTPVP DPTPMMPPVG VQASILSHDT
910 920 930 940 950
IRITWADNSL PKHQKITDSR YYTVRWKTNI PANTKYKNAN ATTLSYLVTG
960 970 980 990 1000
LKPNTLYEFS VMVTKGRRSS TWSMTAHGAT FELVPTSPPK DVTVVSKEGK
1010 1020 1030 1040 1050
PRTIIVNWQP PSEANGKITG YIIYYSTDVN AEIHDWVIEP VVGNRLTHQI
1060 1070 1080 1090 1100
QELTLDTPYY FKIQARNSKG MGPMSEAVQF RTPKADSSDK MPNDQALGSA
1110 1120 1130 1140 1150
GKGSRLPDLG SDYKPPMSGS NSPHGSPTSP LDSNMLLVII VSVGVITIVV
1160 1170 1180 1190 1200
VVVIAVFCTR RTTSHQKKKR AACKSVNGSH KYKGNCKDVK PPDLWIHHER
1210 1220 1230 1240 1250
LELKPIDKSP DPNPVMTDTP IPRNSQDITP VDNSMDSNIH QRRNSYRGHE
1260 1270 1280 1290 1300
SEDSMSTLAG RRGMRPKMMM PFDSQPPQPV ISAHPIHSLD NPHHHFHSSS
1310 1320 1330 1340 1350
LASPARSHLY HPSSPWPIGT SMSLSDRANS TESVRNTPST DTMPASSSQT
1360 1370 1380 1390 1400
CCTDHQDPEG ATSSSYLASS QEEDSGQSLP TAHVRPSHPL KSFAVPAIPP
1410 1420 1430 1440 1450
PGPPLYDPAL PSTPLLSQQA LNHHIHSVKT ASIGTLGRSR PPMPVVVPSA
1460 1470 1480 1490
PEVQETTRML EDSESSYEPD ELTKEMAHLE GLMKDLNAIT TA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP97798 | NEO1_MOUSE | Neogenin | Neo1 Ngn | 1,493 | Annotation score: | ||
Q7TQG5 | Q7TQG5_MOUSE | Neogenin | Neo1 | 1,465 | Annotation score: | ||
A0A1L1SRD6 | A0A1L1SRD6_MOUSE | Neogenin | Neo1 | 405 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC110530 Genomic DNA No translation available. CT033754 Genomic DNA No translation available. |
RefSeqi | NP_032710.2, NM_008684.2 |
Genome annotation databases
Ensembli | ENSMUST00000068664; ENSMUSP00000063656; ENSMUSG00000032340 |
GeneIDi | 18007 |
UCSCi | uc009pxk.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC110530 Genomic DNA No translation available. CT033754 Genomic DNA No translation available. |
RefSeqi | NP_032710.2, NM_008684.2 |
3D structure databases
SMRi | E9QK04 |
ModBasei | Search... |
Proteomic databases
jPOSTi | E9QK04 |
MaxQBi | E9QK04 |
PeptideAtlasi | E9QK04 |
PRIDEi | E9QK04 |
Protocols and materials databases
Antibodypediai | 3989, 186 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000068664; ENSMUSP00000063656; ENSMUSG00000032340 |
GeneIDi | 18007 |
UCSCi | uc009pxk.1, mouse |
Organism-specific databases
CTDi | 4756 |
MGIi | MGI:1097159, Neo1 |
Phylogenomic databases
GeneTreei | ENSGT00940000156684 |
HOGENOMi | CLU_004256_0_0_1 |
OrthoDBi | 217780at2759 |
TreeFami | TF321506 |
Miscellaneous databases
BioGRID-ORCSi | 18007, 2 hits in 17 CRISPR screens |
ChiTaRSi | Neo1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032340, Expressed in external carotid artery and 394 other tissues |
ExpressionAtlasi | E9QK04, baseline and differential |
Genevisiblei | E9QK04, MM |
Family and domain databases
CDDi | cd00063, FN3, 6 hits |
Gene3Di | 2.60.40.10, 10 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR033024, Neogenin IPR010560, Neogenin_C |
PANTHERi | PTHR44170:SF14, PTHR44170:SF14, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 6 hits PF07679, I-set, 3 hits PF13895, Ig_2, 1 hit PF06583, Neogenin_C, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 6 hits SM00409, IG, 4 hits SM00408, IGc2, 4 hits |
SUPFAMi | SSF48726, SSF48726, 4 hits SSF49265, SSF49265, 3 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 6 hits PS50835, IG_LIKE, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9QK04_MOUSE | |
Accessioni | E9QK04Primary (citable) accession number: E9QK04 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | December 2, 2020 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |