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Protein
Submitted name:

Tryptase beta-2

Gene

Tpsb2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-1592389 Activation of Matrix Metalloproteinases

Names & Taxonomyi

Protein namesi
Submitted name:
Tryptase beta-2Imported
Gene namesi
Name:Tpsb2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:96942 Tpsb2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500324332822 – 276Sequence analysisAdd BLAST255

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiE9QJW9
PRIDEiE9QJW9

Expressioni

Gene expression databases

BgeeiENSMUSG00000033825 Expressed in 121 organ(s), highest expression level in skin epidermis
GenevisibleiE9QJW9 MM

Structurei

3D structure databases

ProteinModelPortaliE9QJW9
SMRiE9QJW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 273Peptidase S1InterPro annotationAdd BLAST242

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00900000140944
KOiK01340
OMAiCAGNSRR
OrthoDBiEOG091G0AH5
TreeFamiTF351676

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9QJW9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKRLLLLLW ALSLLASLVY SAPRPANQRV GIVGGHEASE SKWPWQVSLR
60 70 80 90 100
FKLNYWIHFC GGSLIHPQWV LTAAHCVGPH IKSPQLFRVQ LREQYLYYGD
110 120 130 140 150
QLLSLNRIVV HPHYYTAEGG ADVALLELEV PVNVSTHLHP ISLPPASETF
160 170 180 190 200
PPGTSCWVTG WGDIDNDEPL PPPYPLKQVK VPIVENSLCD RKYHTGLYTG
210 220 230 240 250
DDFPIVHDGM LCAGNTRRDS CQGDSGGPLV CKVKGTWLQA GVVSWGEGCA
260 270
QPNKPGIYTR VTYYLDWIHR YVPEHS
Length:276
Mass (Da):30,884
Last modified:April 5, 2011 - v1
Checksum:i506CBE75E6A82206
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P21845TRYB2_MOUSE
Tryptase beta-2
Tpsb2 Mcpt6
276Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122454 Genomic DNA No translation available.
RefSeqiNP_034911.3, NM_010781.3
XP_006523803.1, XM_006523740.2
UniGeneiMm.7409

Genome annotation databases

EnsembliENSMUST00000069616; ENSMUSP00000063499; ENSMUSG00000033825
GeneIDi17229
KEGGimmu:17229
UCSCiuc008bas.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122454 Genomic DNA No translation available.
RefSeqiNP_034911.3, NM_010781.3
XP_006523803.1, XM_006523740.2
UniGeneiMm.7409

3D structure databases

ProteinModelPortaliE9QJW9
SMRiE9QJW9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9QJW9
PRIDEiE9QJW9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069616; ENSMUSP00000063499; ENSMUSG00000033825
GeneIDi17229
KEGGimmu:17229
UCSCiuc008bas.1 mouse

Organism-specific databases

CTDi64499
MGIiMGI:96942 Tpsb2

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00900000140944
KOiK01340
OMAiCAGNSRR
OrthoDBiEOG091G0AH5
TreeFamiTF351676

Enzyme and pathway databases

ReactomeiR-MMU-1592389 Activation of Matrix Metalloproteinases

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033825 Expressed in 121 organ(s), highest expression level in skin epidermis
GenevisibleiE9QJW9 MM

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9QJW9_MOUSE
AccessioniPrimary (citable) accession number: E9QJW9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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